JP2011529330A5 - - Google Patents
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- Publication number
- JP2011529330A5 JP2011529330A5 JP2011504267A JP2011504267A JP2011529330A5 JP 2011529330 A5 JP2011529330 A5 JP 2011529330A5 JP 2011504267 A JP2011504267 A JP 2011504267A JP 2011504267 A JP2011504267 A JP 2011504267A JP 2011529330 A5 JP2011529330 A5 JP 2011529330A5
- Authority
- JP
- Japan
- Prior art keywords
- stem cells
- oct3
- klf4
- sox2
- induced pluripotent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000003074 Dental Pulp Anatomy 0.000 claims 3
- 210000004263 Induced Pluripotent Stem Cells Anatomy 0.000 claims 3
- 101700048573 KLF4 Proteins 0.000 claims 3
- 102100006525 KLF4 Human genes 0.000 claims 3
- 101700079116 QSOX1 Proteins 0.000 claims 3
- 101710019780 SLC22A3 Proteins 0.000 claims 3
- 101700006931 SOX2 Proteins 0.000 claims 3
- 210000000130 stem cell Anatomy 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 2
- 102100015262 MYC Human genes 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000038129 antigens Human genes 0.000 claims 1
- 108091007172 antigens Proteins 0.000 claims 1
- 230000000875 corresponding Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 210000001082 somatic cell Anatomy 0.000 claims 1
Claims (5)
- 歯髄幹細胞に核初期化物質を接触させることを含む、人工多能性幹細胞の製造方法。
- 核初期化物質が、以下の（1）〜（3）のいずれかの組み合わせ、またはそれらをコードする核酸を含む、請求項１記載の方法。
（1）Oct3/4, Klf4およびSox2
（2）Oct3/4, Klf4, Sox2およびc-Myc
（3）Oct3/4, Klf4, Sox2およびL-Myc - 歯髄幹細胞がヒト由来である、請求項１または２記載の方法。
- 人工多能性幹細胞が、個々人、または多種類のHLA抗原の型に対応するバンクの形態である、請求項３記載の方法。
- 人工多能性幹細胞を製造するための体細胞ソースとしての、歯髄幹細胞の使用。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8530808P | 2008-07-31 | 2008-07-31 | |
| US61/085,308 | 2008-07-31 | ||
| PCT/JP2008/068320 WO2010013359A1 (en) | 2008-07-31 | 2008-10-02 | Efficient method for establishing induced pluripotent stem cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011529330A JP2011529330A (ja) | 2011-12-08 |
| JP2011529330A5 true JP2011529330A5 (ja) | 2012-02-02 |
| JP5553178B2 JP5553178B2 (ja) | 2014-07-16 |
Family
ID=41610079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011504267A Active JP5553178B2 (ja) | 2008-07-31 | 2008-10-02 | 効率的な人工多能性幹細胞の樹立方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110201110A1 (ja) |
| JP (1) | JP5553178B2 (ja) |
| KR (1) | KR101372752B1 (ja) |
| AU (1) | AU2008360135A1 (ja) |
| CA (1) | CA2732401C (ja) |
| WO (1) | WO2010013359A1 (ja) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101864392B (zh) | 2005-12-13 | 2016-03-23 | 国立大学法人京都大学 | 核重新编程因子 |
| US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| US9213999B2 (en) | 2007-06-15 | 2015-12-15 | Kyoto University | Providing iPSCs to a customer |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| WO2009124213A2 (en) * | 2008-04-02 | 2009-10-08 | The Trustees Of Columbia University In The City Of New York | Dental stem cell differentiation |
| CN101855350B (zh) | 2008-05-02 | 2014-12-31 | 国立大学法人京都大学 | 核重编程序方法 |
| US10328103B2 (en) | 2009-01-03 | 2019-06-25 | Ray C. Wasielewski | Medical treatment composition comprising mammalian dental pulp stem cells |
| US8470308B2 (en) * | 2009-01-03 | 2013-06-25 | Ray C. Wasielewski | Enhanced medical implant comprising disrupted tooth pulp and tooth particles |
| CA2755870C (en) * | 2009-03-20 | 2019-04-09 | Angioblast Systems, Inc. | Production of reprogrammed pluripotent cells |
| AU2010279913B2 (en) | 2009-08-07 | 2016-04-28 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| US8748179B2 (en) | 2009-08-31 | 2014-06-10 | Osaka University | Method for efficient production of induced pluripotent stem cells utilizing cells derived from oral mucosa |
| JP2011177140A (ja) * | 2010-03-03 | 2011-09-15 | Nippon Dental Univ | 幹細胞培養用の無血清培地 |
| KR101334404B1 (ko) * | 2011-04-28 | 2013-12-12 | 포항공과대학교 산학협력단 | 배아줄기세포 유래의 인공 마이크로베시클을 이용한 역분화 유도만능줄기세포의 제조방법 |
| JP6128511B2 (ja) * | 2012-12-05 | 2017-05-17 | 学校法人日本大学 | ｉＰＳ細胞の高効率な樹立方法 |
| WO2015030111A1 (ja) * | 2013-08-28 | 2015-03-05 | 国立大学法人岐阜大学 | 人工多能性幹細胞の作製方法 |
| US10443044B2 (en) | 2014-04-17 | 2019-10-15 | Ips Heart | Generating cardiac progenitor cells from pluripotent stem cells using isoxazole or isoxazole like compounds |
| US20150297638A1 (en) * | 2014-04-17 | 2015-10-22 | Muhammad Ashraf | Chemically induced pluripotent stem cells for safe therapeutic applications |
| KR101656396B1 (ko) * | 2014-04-21 | 2016-09-09 | 한국생명공학연구원 | Oct4 및 Sox2를 이용한 인간 치수강세포의 리프로그래밍 방법 및 이의 용도 |
| JP6868565B2 (ja) * | 2015-11-05 | 2021-05-12 | 株式会社Ｃｙｓａｙ | 不死化幹細胞、及びその作製方法 |
| WO2018232079A1 (en) | 2017-06-14 | 2018-12-20 | Daley George Q | Hematopoietic stem and progenitor cells derived from hemogenic endothelial cells by episomal plasmid gene transfer |
| US20230073449A1 (en) | 2020-01-23 | 2023-03-09 | The Children's Medical Center Corporation | Stroma-free t cell differentiation from human pluripotent stem cells |
| WO2023223303A1 (en) | 2022-05-20 | 2023-11-23 | Alt Atlas Ltd. | Novel cell lines and systems and methods for a machine learning manufacturing software platform that optimize unique functional ingredients and solutions for the biotech and foodtech industries |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101864392B (zh) * | 2005-12-13 | 2016-03-23 | 国立大学法人京都大学 | 核重新编程因子 |
| US8278104B2 (en) * | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| JP2008307007A (ja) * | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
-
2008
- 2008-10-02 KR KR1020117003453A patent/KR101372752B1/ko active IP Right Grant
- 2008-10-02 JP JP2011504267A patent/JP5553178B2/ja active Active
- 2008-10-02 CA CA2732401A patent/CA2732401C/en active Active
- 2008-10-02 WO PCT/JP2008/068320 patent/WO2010013359A1/en active Application Filing
- 2008-10-02 AU AU2008360135A patent/AU2008360135A1/en not_active Abandoned
- 2008-10-02 US US13/056,526 patent/US20110201110A1/en not_active Abandoned
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