JP2011529070A5 - - Google Patents
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- JP2011529070A5 JP2011529070A5 JP2011520187A JP2011520187A JP2011529070A5 JP 2011529070 A5 JP2011529070 A5 JP 2011529070A5 JP 2011520187 A JP2011520187 A JP 2011520187A JP 2011520187 A JP2011520187 A JP 2011520187A JP 2011529070 A5 JP2011529070 A5 JP 2011529070A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- oxy
- carbonyl
- amino
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8362108P | 2008-07-25 | 2008-07-25 | |
| US61/083,621 | 2008-07-25 | ||
| PCT/US2009/051499 WO2010011814A1 (en) | 2008-07-25 | 2009-07-23 | Chemical compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014106310A Division JP5738457B2 (ja) | 2008-07-25 | 2014-05-22 | 化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011529070A JP2011529070A (ja) | 2011-12-01 |
| JP2011529070A5 true JP2011529070A5 (cg-RX-API-DMAC10.html) | 2012-09-06 |
| JP5586602B2 JP5586602B2 (ja) | 2014-09-10 |
Family
ID=41570595
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011520187A Active JP5586602B2 (ja) | 2008-07-25 | 2009-07-23 | 化合物 |
| JP2014106310A Active JP5738457B2 (ja) | 2008-07-25 | 2014-05-22 | 化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014106310A Active JP5738457B2 (ja) | 2008-07-25 | 2014-05-22 | 化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (7) | US8580967B2 (cg-RX-API-DMAC10.html) |
| EP (2) | EP2660239B1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP5586602B2 (cg-RX-API-DMAC10.html) |
| KR (3) | KR101772610B1 (cg-RX-API-DMAC10.html) |
| CN (3) | CN102149385B (cg-RX-API-DMAC10.html) |
| ES (2) | ES2607403T3 (cg-RX-API-DMAC10.html) |
| PT (1) | PT2660239T (cg-RX-API-DMAC10.html) |
| SG (1) | SG192550A1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2010011814A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2660239B1 (en) | 2008-07-25 | 2016-11-23 | VIIV Healthcare Company | Chemical compounds as synthetic intermediates |
| EP3617194B1 (en) * | 2008-12-11 | 2023-11-08 | VIIV Healthcare Company | Processes and intermediates for carbamoylpyridone hiv integrase inhibitors |
| SG171308A1 (en) | 2008-12-11 | 2011-07-28 | Shionogi & Co | Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates |
| ES2645773T3 (es) * | 2008-12-11 | 2017-12-07 | Shionogi & Co., Ltd. | Procedimientos e intermediarios de éter de maltol |
| TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Ｖｉｉｖ醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
| TWI577377B (zh) | 2010-09-16 | 2017-04-11 | Ｖｉｉｖ醫療保健公司 | 醫藥組合物 |
| LT2620436T (lt) * | 2010-09-24 | 2018-08-10 | Shionogi & Co., Ltd. | Pakeistojo policiklinio karbamoilpiridono darinio provaistas |
| EA030003B1 (ru) | 2012-12-21 | 2018-06-29 | Джилид Сайэнс, Инк. | Полициклическое карбамоилпиридоновое соединение и его фармацевтическое применение для лечения вич-инфекции |
| DK3019503T3 (da) | 2013-07-12 | 2017-11-20 | Gilead Sciences Inc | Polycykliske-carbamoylpyridon-forbindelser og anvendelse deraf til behandling af hiv-infektioner |
| NO2865735T3 (cg-RX-API-DMAC10.html) | 2013-07-12 | 2018-07-21 | ||
| US9808428B2 (en) | 2014-01-14 | 2017-11-07 | Board Of Regents Of The University Of Nebraska | Compositions and methods for the delivery of therapeutics |
| TWI744723B (zh) | 2014-06-20 | 2021-11-01 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| NO2717902T3 (cg-RX-API-DMAC10.html) | 2014-06-20 | 2018-06-23 | ||
| WO2016057866A1 (en) | 2014-10-09 | 2016-04-14 | Board Of Regents Of The University Of Nebraska | Compositions and methods for the delivery of therapeutics |
| TWI695003B (zh) | 2014-12-23 | 2020-06-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| CA2980362C (en) | 2015-04-02 | 2020-02-25 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| JP7160466B2 (ja) * | 2016-06-23 | 2022-10-25 | ヴィーブ ヘルスケア カンパニー | 治療薬の送達のための組成物及び方法 |
| US20200138845A1 (en) * | 2017-07-18 | 2020-05-07 | Viiv Healthcare Company | Combination Drug Therapy |
| US11286262B2 (en) | 2017-10-06 | 2022-03-29 | Shionogi & Co., Ltd. | Stereoselective process for preparing substituted polycyclic pyridone derivatives |
| TWI795462B (zh) | 2017-11-17 | 2023-03-11 | 日商鹽野義製藥股份有限公司 | 光安定性及溶出性優異的醫藥製劑 |
| EP3737359A4 (en) | 2018-01-12 | 2021-11-03 | Board of Regents of the University of Nebraska | ANTIVIRAL PRODRUGS AND THEIR FORMULATIONS |
| US11458136B2 (en) | 2018-04-09 | 2022-10-04 | Board Of Regents Of The University Of Nebraska | Antiviral prodrugs and formulations thereof |
| EP4751717A3 (en) * | 2018-10-22 | 2026-08-05 | Board of Regents of the University of Nebraska | Antiviral prodrugs and nanoformulations thereof |
| CN118873676A (zh) | 2018-11-29 | 2024-11-01 | 内布拉斯加大学董事会 | 抗病毒前药及其纳米制剂 |
| KR20240151256A (ko) | 2019-03-22 | 2024-10-17 | 길리애드 사이언시즈, 인코포레이티드 | 가교된 트리시클릭 카르바모일피리돈 화합물 및 그의 제약 용도 |
| WO2020221294A1 (zh) * | 2019-04-30 | 2020-11-05 | 上海拓界生物医药科技有限公司 | 桥环-3,4-二氢-吡啶并[1,2-a]吡嗪-1,8-二酮化合物及其药物用途 |
| CN115135646B (zh) * | 2019-12-23 | 2024-05-17 | 石家庄迪斯凯威医药科技有限公司 | 取代的多环化合物及其药物组合物和用途 |
| EP4110783A1 (en) | 2020-02-24 | 2023-01-04 | Gilead Sciences, Inc. | Tetracyclic compounds for treating hiv infection |
| CN116390924B (zh) | 2020-09-30 | 2025-11-07 | 吉利德科学公司 | 桥连三环氨基甲酰基吡啶酮化合物及其用途 |
| CN114426540B (zh) * | 2020-10-29 | 2024-04-26 | 上海拓界生物医药科技有限公司 | 吡啶并[1,2-a]吡嗪-1,8-二酮类前药衍生物、其制备方法及其应用 |
| CR20260070A (es) | 2021-01-19 | 2026-04-24 | Gilead Sciences Inc | COMPUESTOS DE PIRIDOTRIAZINA SUSTITUIDOS Y USOS DE ESTOS (Divisional 2023-0315) |
| US11958864B2 (en) * | 2021-02-16 | 2024-04-16 | Merck Sharp & Dohme Llc | Tetracyclic heterocycle compounds useful as HIV integrase inhibitors |
| TWI856796B (zh) | 2022-04-06 | 2024-09-21 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
| CN120936599A (zh) * | 2023-01-18 | 2025-11-11 | 歌礼生物科技（杭州）有限公司 | 整合酶抑制剂及其应用 |
| CN120424092B (zh) * | 2025-07-02 | 2025-09-12 | 中国人民解放军军事科学院军事医学研究院 | 布尼亚病毒抑制剂及其制备方法和用途 |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1544199A (en) * | 1922-08-21 | 1925-06-30 | Herman Christensen | Condenser |
| GB427857A (en) | 1934-08-02 | 1935-05-01 | Newsum Sons & Company Ltd H | A new or improved system of construction for skeleton structures, particularly vehicle body frames and door frames |
| US4524149A (en) * | 1982-03-15 | 1985-06-18 | Sterling Drug Inc. | 5-Alkanoyl-6-alkyl-2(1H)-pyridinones, their preparation and their cardiotonic use |
| US4769380A (en) * | 1983-04-29 | 1988-09-06 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates |
| US4812474A (en) * | 1984-08-16 | 1989-03-14 | G. D. Searle & Co. | Kojic acid ether-ester derivatives |
| US4603144A (en) | 1984-08-16 | 1986-07-29 | G. D. Searle & Co. | Kojic acid ether-ester derivatives |
| US4735964A (en) * | 1984-08-16 | 1988-04-05 | G. D. Searle & Co. | Kojic acid ether-ester derivatives |
| CA1317298C (en) * | 1987-03-03 | 1993-05-04 | Upjohn Company (The) | Antibiotic sulfonylaminocarbonyl activated .beta.-lactams |
| GB2280435A (en) | 1993-07-29 | 1995-02-01 | Merck & Co Inc | Anti-viral agent |
| PT768302E (pt) | 1995-09-29 | 2005-11-30 | Novartis Ag | Novas hidroxipiridinonas |
| GB9711093D0 (en) | 1997-05-29 | 1997-07-23 | British Tech Group | Novel orally active iron (III) chelators |
| US6452008B2 (en) * | 1998-02-25 | 2002-09-17 | Sumitomo Pharmaceuticals Company, Limited | Pyridone derivatives and process for preparing the same |
| US7256286B2 (en) * | 1999-11-30 | 2007-08-14 | The Board Of Trustees Of The Leland Stanford Junior University | Bryostatin analogues, synthetic methods and uses |
| JP2005505525A (ja) * | 2001-08-02 | 2005-02-24 | ニューロクライン バイオサイエンシーズ， インコーポレイテッド | 性腺刺激ホルモン放出ホルモンレセプターアンタゴニストおよびそれに関連する方法 |
| US6426418B1 (en) * | 2001-11-02 | 2002-07-30 | Apotex, Inc. | Processes for the manufacturing of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide |
| CA2379370A1 (en) * | 2002-03-28 | 2003-09-28 | Apotex Inc. | Carboxylic acid derivatives of 3-hydroxy-4-oxo-1,4-dihydropyridine as iron chelators |
| WO2004024078A2 (en) | 2002-09-11 | 2004-03-25 | Merck & Co., Inc. | Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors |
| AU2003301439A1 (en) * | 2002-10-16 | 2004-05-04 | Gilead Sciences, Inc. | Pre-organized tricyclic integrase inhibitor compounds |
| TW200510425A (en) * | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| DE10349500A1 (de) * | 2003-10-23 | 2005-06-02 | Bayer Cropscience Ag | Verfahren zum Herstellen von 2-Dihalogenacyl-3-amino-acrylsäureestern und 3-Dihalogenmethyl-pyrazol-4-carbonsäureestern |
| JP4847677B2 (ja) * | 2003-10-28 | 2011-12-28 | 富士通株式会社 | 化合物半導体装置の製造方法 |
| JP2005134333A (ja) * | 2003-10-31 | 2005-05-26 | Espec Corp | 気体流量測定装置、及び気体流量測定方法 |
| NZ529657A (en) * | 2003-11-20 | 2004-07-30 | Apotex Inc | Iron chelating cycloalkyl derivatives of 3-hydroxy-4-pyridinones |
| AU2005221864A1 (en) | 2004-03-09 | 2005-09-22 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | HIV integrase inhibitors |
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| SI1742642T1 (sl) * | 2004-04-14 | 2009-04-30 | Gilead Sciences Inc | Fosfonatni analogi inhibitorskih spojin HIV integraze |
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| JP4953297B2 (ja) * | 2004-09-15 | 2012-06-13 | 塩野義製薬株式会社 | Ｈｉｖインテグラーゼ阻害活性を有するカルバモイルピリドン誘導体 |
| US20060066414A1 (en) * | 2004-09-28 | 2006-03-30 | Rockwell Scientific Licensing, Llc | Method and apparatus for changing the polarization of a signal |
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| CA2634499A1 (en) | 2004-12-23 | 2006-06-29 | Virochem Pharma Inc. | Hydroxydihydropyridopy razine-1,8-diones and methods for inhibiting hiv integrase |
| WO2006088173A1 (ja) | 2005-02-21 | 2006-08-24 | Shionogi & Co., Ltd. | Ｈｉｖインテグラーゼ阻害活性を有する２環性カルバモイルピリドン誘導体 |
| US7730384B2 (en) * | 2005-02-28 | 2010-06-01 | Agere Systems Inc. | Method and apparatus for evaluating performance of a read channel |
| US20060246196A1 (en) | 2005-04-27 | 2006-11-02 | Lawson John A | Low-alcohol, low-calorie wine |
| CN101212903B (zh) * | 2005-04-28 | 2013-07-24 | 史密丝克莱恩比彻姆公司 | 具有hiv整合酶抑制活性的多环氨基甲酰基吡啶酮衍生物 |
| DK3187225T3 (da) * | 2005-04-28 | 2022-02-28 | Viiv Healthcare Co | Polycyklisk carbamoylpyridonderivat med hiv-integrasehæmmende aktivitet |
| US20070072831A1 (en) * | 2005-05-16 | 2007-03-29 | Gilead Sciences, Inc. | Integrase inhibitor compounds |
| JP2006342115A (ja) | 2005-06-10 | 2006-12-21 | Shionogi & Co Ltd | Ｈｉｖインテグラーゼ阻害活性を有する多環性化合物 |
| US20100098640A1 (en) * | 2005-06-20 | 2010-04-22 | Cohen Seth M | Multidentate Pyrone-Derived Chelators for Medicinal Imaging and Chelation |
| JP2007056107A (ja) * | 2005-08-23 | 2007-03-08 | Sumitomo Rubber Ind Ltd | タイヤ用ゴム組成物およびそれからなる補強層を有するランフラットタイヤ |
| EP1762250A1 (en) * | 2005-09-12 | 2007-03-14 | Fresenius Kabi Deutschland GmbH | Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine |
| TW200800988A (en) * | 2005-10-27 | 2008-01-01 | Shionogi & Amp Co Ltd | Polycyclic carbamoylpyridone derivative having HIV integrase inhibitory activity |
| GB0623768D0 (en) * | 2006-11-28 | 2007-01-10 | Chopra Sunil | A bleomycin preparation for use against skin tumours |
| EP2102158A1 (en) * | 2006-12-11 | 2009-09-23 | Topo Target A/S | Prodrugs of diphenyl ox- indol- 2 -one compounds for the treatment of cancers |
| JP5074042B2 (ja) * | 2007-01-10 | 2012-11-14 | Ｈｏｙａ株式会社 | 情報記録媒体基板用素材、情報記録媒体基板、情報記録媒体それぞれの製造方法 |
| CA2676173A1 (en) | 2007-02-16 | 2008-08-28 | Amgen Inc. | Nitrogen-containing heterocyclyl ketones and their use as c-met inhibitors |
| ES2395705T3 (es) * | 2008-07-25 | 2013-02-14 | Glaxosmithkline Llc | Compuestos químicos |
| WO2010011812A1 (en) * | 2008-07-25 | 2010-01-28 | Smithkline Beecham Corporation | Chemical compounds |
| EP2660239B1 (en) | 2008-07-25 | 2016-11-23 | VIIV Healthcare Company | Chemical compounds as synthetic intermediates |
| US8309008B2 (en) * | 2008-10-30 | 2012-11-13 | Molecular Imprints, Inc. | Separation in an imprint lithography process |
| SG171308A1 (en) | 2008-12-11 | 2011-07-28 | Shionogi & Co | Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates |
| EP3617194B1 (en) * | 2008-12-11 | 2023-11-08 | VIIV Healthcare Company | Processes and intermediates for carbamoylpyridone hiv integrase inhibitors |
| TWI518084B (zh) * | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Ｖｉｉｖ醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
| SMT202100268T1 (it) | 2010-08-05 | 2021-07-12 | Shionogi & Co | Metodo per produrre composti aventi attività di inibizione di integrasi di hiv. |
-
2009
- 2009-07-23 EP EP13178055.3A patent/EP2660239B1/en active Active
- 2009-07-23 PT PT131780553T patent/PT2660239T/pt unknown
- 2009-07-23 CN CN200980135216.6A patent/CN102149385B/zh active Active
- 2009-07-23 SG SG2013056528A patent/SG192550A1/en unknown
- 2009-07-23 KR KR1020167033296A patent/KR101772610B1/ko active Active
- 2009-07-23 CN CN201310734307.XA patent/CN103951643B/zh active Active
- 2009-07-23 EP EP09800991.3A patent/EP2320909B8/en active Active
- 2009-07-23 US US13/054,847 patent/US8580967B2/en active Active
- 2009-07-23 ES ES13178055.3T patent/ES2607403T3/es active Active
- 2009-07-23 KR KR1020117004493A patent/KR101695807B1/ko active Active
- 2009-07-23 ES ES09800991.3T patent/ES2562452T3/es active Active
- 2009-07-23 CN CN201510553892.2A patent/CN105198804B/zh active Active
- 2009-07-23 WO PCT/US2009/051499 patent/WO2010011814A1/en not_active Ceased
- 2009-07-23 KR KR1020167033294A patent/KR101700267B1/ko active Active
- 2009-07-23 JP JP2011520187A patent/JP5586602B2/ja active Active
-
2013
- 2013-10-02 US US14/044,285 patent/US8765965B2/en active Active
- 2013-10-02 US US14/044,258 patent/US8940912B2/en active Active
-
2014
- 2014-05-20 US US14/282,049 patent/US8981129B2/en active Active
- 2014-05-21 US US14/283,465 patent/US9012650B2/en active Active
- 2014-05-22 JP JP2014106310A patent/JP5738457B2/ja active Active
-
2015
- 2015-03-17 US US14/660,063 patent/US9133216B2/en active Active
- 2015-08-05 US US14/818,539 patent/US9707246B2/en active Active
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