JP2011528903A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011528903A5 JP2011528903A5 JP2011520029A JP2011520029A JP2011528903A5 JP 2011528903 A5 JP2011528903 A5 JP 2011528903A5 JP 2011520029 A JP2011520029 A JP 2011520029A JP 2011520029 A JP2011520029 A JP 2011520029A JP 2011528903 A5 JP2011528903 A5 JP 2011528903A5
- Authority
- JP
- Japan
- Prior art keywords
- tls
- fus
- als
- detecting
- genetic markers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13568908P | 2008-07-22 | 2008-07-22 | |
| US61/135,689 | 2008-07-22 | ||
| PCT/US2009/004205 WO2010011283A2 (en) | 2008-07-22 | 2009-07-21 | Fus/tls-based compounds and methods for diagnosis, treatment and prevention of amyotrophic lateral sclerosis and related motor neuron diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011528903A JP2011528903A (ja) | 2011-12-01 |
| JP2011528903A5 true JP2011528903A5 (enExample) | 2012-09-06 |
| JP5643200B2 JP5643200B2 (ja) | 2014-12-17 |
Family
ID=41570769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011520029A Active JP5643200B2 (ja) | 2008-07-22 | 2009-07-21 | 筋萎縮性側索硬化症および関連する運動ニューロン疾患の診断、処置および予防のための、ｆｕｓ／ｔｌｓベースの化合物および方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US9150860B2 (enExample) |
| JP (1) | JP5643200B2 (enExample) |
| CA (1) | CA2731643C (enExample) |
| WO (1) | WO2010011283A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010011283A2 (en) | 2008-07-22 | 2010-01-28 | The General Hospital Corporation | Fus/tls-based compounds and methods for diagnosis, treatment and prevention of amyotrophic lateral sclerosis and related motor neuron diseases |
| JP6342627B2 (ja) * | 2013-08-02 | 2018-06-13 | 国立大学法人 東京大学 | 筋萎縮性側索硬化症の新規病因遺伝子 |
| EP3573637A4 (en) * | 2017-01-27 | 2020-11-11 | Vanderbilt University | INHIBITORS OF NUCLEAR TRANSLOCATION OF FUS PROTEIN ENABLING THE PREVENTION OF FIBROSIS |
| EP3601541A4 (en) * | 2017-03-22 | 2020-10-28 | Tsinghua University | MUTANT FUS MODEL FOR ALS |
| WO2018170796A1 (en) * | 2017-03-22 | 2018-09-27 | Tsinghua University | Trim72 as potential therapeutic target for als through ubiquitinating mutant fus protein |
| JP7295584B2 (ja) * | 2018-11-09 | 2023-06-21 | スンチョニャン ユニヴァーシティ インダストリー アカデミー コーペレーション ファウンデーション | 神経系退行性疾患診断用マーカーおよび治療用組成物 |
| EP3892283A1 (en) * | 2020-04-09 | 2021-10-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Nucleic acids encoding human fus protein and use in the treatment of amyotrophic lateral sclerosis (als) |
| JP7541100B2 (ja) * | 2020-09-09 | 2024-08-27 | 大原薬品工業株式会社 | ｓｉＲＮＡおよびその用途 |
| WO2022082199A1 (en) * | 2020-10-16 | 2022-04-21 | Pluripotent Diagnostics Corp. | Method for detecting amyotrophic lateral sclerosis |
| EP4412708A4 (en) * | 2021-10-05 | 2025-12-03 | The J David Gladstone Inst A Testamentary Trust Established Under The Will Of J David Gladstone | SPECIFIC EDITION OF AN ALLELE TO TREAT FUS-INDUCED NEURODEGENERATION |
| US20250101420A1 (en) * | 2022-03-08 | 2025-03-27 | Ohara Pharmaceutical Co., Ltd. | MODIFIED siRNA FOR SELECTIVELY INHIBITING EXPRESSION OF MUTANT FUS |
| CN116042619B (zh) * | 2022-12-19 | 2023-09-08 | 神济昌华(北京)生物科技有限公司 | 用于构建人源FUS基因敲入的ALS果蝇模型的gRNA组合及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6582908B2 (en) * | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| US5843641A (en) | 1993-02-26 | 1998-12-01 | Massachusetts Institute Of Technology | Methods for the daignosis, of familial amyotrophic lateral sclerosis |
| JP2002306179A (ja) | 2001-04-16 | 2002-10-22 | Japan Science & Technology Corp | Ａｌｓ２ｃｒ６遺伝子と、２型筋萎縮性側索硬化症の診断方法 |
| AU2003302264A1 (en) * | 2002-12-20 | 2004-09-09 | Biotrove, Inc. | Assay apparatus and method using microfluidic arrays |
| CA2528162A1 (en) | 2003-06-04 | 2004-12-16 | The Government Of The United States As Represented By The Secretary Of T He Department Of Health And Human Services, Centers For Disease Control | Pni microarray and uses |
| US20070009899A1 (en) * | 2003-10-02 | 2007-01-11 | Mounts William M | Nucleic acid arrays for detecting gene expression in animal models of inflammatory diseases |
| US20090253583A1 (en) * | 2004-09-27 | 2009-10-08 | Med Biogene Inc. | Hematological Cancer Profiling System |
| US20070202537A1 (en) | 2005-12-05 | 2007-08-30 | Prosetta Corporation | Biomarkers for als |
| NZ578914A (en) | 2007-01-08 | 2012-11-30 | Andhoscience Corp | Compounds with (substituted phenyl)-propenal moiety, their derivatives, biological activity, and uses thereof |
| WO2010011283A2 (en) | 2008-07-22 | 2010-01-28 | The General Hospital Corporation | Fus/tls-based compounds and methods for diagnosis, treatment and prevention of amyotrophic lateral sclerosis and related motor neuron diseases |
-
2009
- 2009-07-21 WO PCT/US2009/004205 patent/WO2010011283A2/en not_active Ceased
- 2009-07-21 CA CA2731643A patent/CA2731643C/en active Active
- 2009-07-21 JP JP2011520029A patent/JP5643200B2/ja active Active
- 2009-07-21 US US13/055,482 patent/US9150860B2/en active Active
-
2015
- 2015-08-25 US US14/834,737 patent/US11041204B2/en active Active
-
2021
- 2021-05-20 US US17/325,279 patent/US20210388444A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011528903A5 (enExample) | ||
| JP2014533949A5 (enExample) | ||
| Martino et al. | Longitudinal, genome-scale analysis of DNA methylation in twins from birth to 18 months of age reveals rapid epigenetic change in early life and pair-specific effects of discordance | |
| JP5683964B2 (ja) | Ｓｎｐアレイを用いた染色体、遺伝子または特定ヌクレオチド配列のコピー数測定方法 | |
| JP2010075182A5 (enExample) | ||
| JP2012503985A5 (enExample) | ||
| JP6622731B2 (ja) | 歯周病の重症度および進行を決定するための改良された方法およびキット | |
| JP2008546403A5 (enExample) | ||
| JP2009526524A5 (enExample) | ||
| JP2009509508A5 (enExample) | ||
| JP2008526249A5 (enExample) | ||
| JP2011097925A5 (enExample) | ||
| JP2010528590A5 (enExample) | ||
| JP2010534069A5 (enExample) | ||
| RU2014123511A (ru) | Способы лечения, диагностики и мониторинга болезни альцгеймера | |
| JP2010520745A5 (enExample) | ||
| JP2009523005A5 (enExample) | ||
| ES2744592T3 (es) | Marcadores mitocondriales de enfermedades neurodegenerativas | |
| CA2735129A1 (en) | Syngap1 dysfunctions and uses thereof in diagnostic and therapeutic applications for mental retardation | |
| CN102808030B (zh) | 单核苷多态性rs3888188在检测结核病易感性中的应用 | |
| JP2011097926A5 (enExample) | ||
| JP2013074888A (ja) | ＩＬ２８Ｂ（ｒｓ８０９９９１７）とＩＴＰＡ（ｒｓ１１２７３５４）の変異を検出する方法 | |
| US20130157873A1 (en) | Methods of assessing a risk of developing necrotizing meningoencephalitis | |
| CN103003428B (zh) | 一种用于预测对于抗癌靶向治疗制剂的敏感性的snp | |
| TWI661050B (zh) | 評估子宮頸癌風險之方法 |