JP2011528903A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011528903A5 JP2011528903A5 JP2011520029A JP2011520029A JP2011528903A5 JP 2011528903 A5 JP2011528903 A5 JP 2011528903A5 JP 2011520029 A JP2011520029 A JP 2011520029A JP 2011520029 A JP2011520029 A JP 2011520029A JP 2011528903 A5 JP2011528903 A5 JP 2011528903A5
- Authority
- JP
- Japan
- Prior art keywords
- tls
- fus
- als
- detecting
- genetic markers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13568908P | 2008-07-22 | 2008-07-22 | |
| US61/135,689 | 2008-07-22 | ||
| PCT/US2009/004205 WO2010011283A2 (en) | 2008-07-22 | 2009-07-21 | Fus/tls-based compounds and methods for diagnosis, treatment and prevention of amyotrophic lateral sclerosis and related motor neuron diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011528903A JP2011528903A (ja) | 2011-12-01 |
| JP2011528903A5 true JP2011528903A5 (enExample) | 2012-09-06 |
| JP5643200B2 JP5643200B2 (ja) | 2014-12-17 |
Family
ID=41570769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011520029A Active JP5643200B2 (ja) | 2008-07-22 | 2009-07-21 | 筋萎縮性側索硬化症および関連する運動ニューロン疾患の診断、処置および予防のための、ｆｕｓ／ｔｌｓベースの化合物および方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US9150860B2 (enExample) |
| JP (1) | JP5643200B2 (enExample) |
| CA (1) | CA2731643C (enExample) |
| WO (1) | WO2010011283A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9150860B2 (en) | 2008-07-22 | 2015-10-06 | The General Hospital Corporation | FUS/TLS-based compounds and methods for diagnosis, treatment and prevention of amyotrophic lateral sclerosis and related motor neuron diseases |
| US12060396B2 (en) | 2013-04-11 | 2024-08-13 | Vanderbilt University | Fused in sarcoma (FUS) nuclear translocation inhibitors for preventing fibrosis |
| JP6342627B2 (ja) * | 2013-08-02 | 2018-06-13 | 国立大学法人 東京大学 | 筋萎縮性側索硬化症の新規病因遺伝子 |
| CN110770336B (zh) * | 2017-03-22 | 2023-09-12 | 神济昌华(北京)生物科技有限公司 | 用于als的突变型fus模型 |
| WO2018170796A1 (en) * | 2017-03-22 | 2018-09-27 | Tsinghua University | Trim72 as potential therapeutic target for als through ubiquitinating mutant fus protein |
| WO2020096103A1 (ko) * | 2018-11-09 | 2020-05-14 | 순천향대학교 산학협력단 | 신경계 퇴행성 질환 진단용 마커 및 치료용 조성물 |
| EP3892283A1 (en) * | 2020-04-09 | 2021-10-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Nucleic acids encoding human fus protein and use in the treatment of amyotrophic lateral sclerosis (als) |
| US20240229025A1 (en) * | 2020-09-09 | 2024-07-11 | Ohara Pharmaceutical Co., Ltd. | siRNA AND USE THEREOF |
| WO2022082199A1 (en) * | 2020-10-16 | 2022-04-21 | Pluripotent Diagnostics Corp. | Method for detecting amyotrophic lateral sclerosis |
| WO2023060132A1 (en) * | 2021-10-05 | 2023-04-13 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Allele specific editing to treat fus-induced neurodegeneration |
| WO2023171587A1 (ja) * | 2022-03-08 | 2023-09-14 | 大原薬品工業株式会社 | 変異ＦＵＳの発現を選択的に抑制する修飾ｓｉＲＮＡ |
| CN116042619B (zh) * | 2022-12-19 | 2023-09-08 | 神济昌华(北京)生物科技有限公司 | 用于构建人源FUS基因敲入的ALS果蝇模型的gRNA组合及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6582908B2 (en) * | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| US5843641A (en) | 1993-02-26 | 1998-12-01 | Massachusetts Institute Of Technology | Methods for the daignosis, of familial amyotrophic lateral sclerosis |
| JP2002306179A (ja) * | 2001-04-16 | 2002-10-22 | Japan Science & Technology Corp | Ａｌｓ２ｃｒ６遺伝子と、２型筋萎縮性側索硬化症の診断方法 |
| CA2521999A1 (en) * | 2002-12-20 | 2004-09-02 | Biotrove, Inc. | Assay apparatus and method using microfluidic arrays |
| AU2004245998A1 (en) | 2003-06-04 | 2004-12-16 | The Government of the United States as represented by The Secretary of the Department of Health and Human Services, Centres for Disease Control and Prevention | PNI microarray and uses |
| US20070009899A1 (en) * | 2003-10-02 | 2007-01-11 | Mounts William M | Nucleic acid arrays for detecting gene expression in animal models of inflammatory diseases |
| EP1805197A1 (en) * | 2004-09-27 | 2007-07-11 | Med Biogene Inc | Hematological cancer profiling system |
| US20070202537A1 (en) | 2005-12-05 | 2007-08-30 | Prosetta Corporation | Biomarkers for als |
| WO2008085984A1 (en) | 2007-01-08 | 2008-07-17 | Androscience Corporation | Compounds with (substituted phenyl)-propenal moiety, their derivatives, biological activity, and uses thereof |
| US9150860B2 (en) | 2008-07-22 | 2015-10-06 | The General Hospital Corporation | FUS/TLS-based compounds and methods for diagnosis, treatment and prevention of amyotrophic lateral sclerosis and related motor neuron diseases |
-
2009
- 2009-07-21 US US13/055,482 patent/US9150860B2/en active Active
- 2009-07-21 JP JP2011520029A patent/JP5643200B2/ja active Active
- 2009-07-21 WO PCT/US2009/004205 patent/WO2010011283A2/en not_active Ceased
- 2009-07-21 CA CA2731643A patent/CA2731643C/en active Active
-
2015
- 2015-08-25 US US14/834,737 patent/US11041204B2/en active Active
-
2021
- 2021-05-20 US US17/325,279 patent/US20210388444A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011528903A5 (enExample) | ||
| Martino et al. | Longitudinal, genome-scale analysis of DNA methylation in twins from birth to 18 months of age reveals rapid epigenetic change in early life and pair-specific effects of discordance | |
| JP2014533949A5 (enExample) | ||
| JP5683964B2 (ja) | Ｓｎｐアレイを用いた染色体、遺伝子または特定ヌクレオチド配列のコピー数測定方法 | |
| JP2010075182A5 (enExample) | ||
| JP2012503985A5 (enExample) | ||
| JP2009526524A5 (enExample) | ||
| JP2009509508A5 (enExample) | ||
| JP2008526249A5 (enExample) | ||
| JP2011097925A5 (enExample) | ||
| JP6622731B2 (ja) | 歯周病の重症度および進行を決定するための改良された方法およびキット | |
| JP2010528590A5 (enExample) | ||
| RU2014123511A (ru) | Способы лечения, диагностики и мониторинга болезни альцгеймера | |
| JP2010520745A5 (enExample) | ||
| JP2009523005A5 (enExample) | ||
| CA2735129A1 (en) | Syngap1 dysfunctions and uses thereof in diagnostic and therapeutic applications for mental retardation | |
| ES2744592T3 (es) | Marcadores mitocondriales de enfermedades neurodegenerativas | |
| JP2010532989A5 (enExample) | ||
| CN103865997A (zh) | 高血压易感基因组的鉴定 | |
| CN102808030B (zh) | 单核苷多态性rs3888188在检测结核病易感性中的应用 | |
| JP2011097926A5 (enExample) | ||
| JP2013074888A (ja) | ＩＬ２８Ｂ（ｒｓ８０９９９１７）とＩＴＰＡ（ｒｓ１１２７３５４）の変異を検出する方法 | |
| JP2018504123A5 (enExample) | ||
| US20130157873A1 (en) | Methods of assessing a risk of developing necrotizing meningoencephalitis | |
| TWI661050B (zh) | 評估子宮頸癌風險之方法 |