JP2009526524A5 - - Google Patents
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- Publication number
- JP2009526524A5 JP2009526524A5 JP2008554415A JP2008554415A JP2009526524A5 JP 2009526524 A5 JP2009526524 A5 JP 2009526524A5 JP 2008554415 A JP2008554415 A JP 2008554415A JP 2008554415 A JP2008554415 A JP 2008554415A JP 2009526524 A5 JP2009526524 A5 JP 2009526524A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- protein
- subject
- cfh
- polymorphism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 claims 13
- 238000000034 method Methods 0.000 claims 10
- 108010053085 Complement Factor H Proteins 0.000 claims 8
- 102100035432 Complement factor H Human genes 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 101150003288 C2 gene Proteins 0.000 claims 4
- 102220500353 Complement factor B_L9H_mutation Human genes 0.000 claims 4
- 102220500344 Complement factor B_R32Q_mutation Human genes 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 208000002780 macular degeneration Diseases 0.000 claims 4
- 102220592822 Complement factor H_Y402H_mutation Human genes 0.000 claims 3
- 108020005187 Oligonucleotide Probes Proteins 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000002751 oligonucleotide probe Substances 0.000 claims 3
- 102000054765 polymorphisms of proteins Human genes 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- 101150030967 CFH gene Proteins 0.000 claims 2
- 102000003712 Complement factor B Human genes 0.000 claims 2
- 108090000056 Complement factor B Proteins 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 230000024203 complement activation Effects 0.000 claims 2
- 230000008482 dysregulation Effects 0.000 claims 2
- 238000002493 microarray Methods 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000023732 binding proteins Human genes 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 230000002250 progressing effect Effects 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77298906P | 2006-02-13 | 2006-02-13 | |
| US60/772,989 | 2006-02-13 | ||
| PCT/US2007/003696 WO2007095185A2 (en) | 2006-02-13 | 2007-02-13 | Variants in complement regulatory genes predict age-related macular degeneration |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009526524A JP2009526524A (ja) | 2009-07-23 |
| JP2009526524A5 true JP2009526524A5 (enExample) | 2011-03-24 |
| JP5290772B2 JP5290772B2 (ja) | 2013-09-18 |
Family
ID=38372062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008554415A Expired - Fee Related JP5290772B2 (ja) | 2006-02-13 | 2007-02-13 | 補体調節遺伝子における変異体が加齢性黄斑変性症を予測する |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1989319A4 (enExample) |
| JP (1) | JP5290772B2 (enExample) |
| CN (1) | CN101421409A (enExample) |
| AU (1) | AU2007215218B2 (enExample) |
| CA (1) | CA2638916A1 (enExample) |
| IL (1) | IL193396A (enExample) |
| NZ (1) | NZ570431A (enExample) |
| WO (1) | WO2007095185A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8012683B2 (en) | 2006-02-13 | 2011-09-06 | University Of Iowa Research Foundation | Variants in complement regulatory genes predict age-related macular degeneration |
| WO2010127176A2 (en) * | 2009-04-29 | 2010-11-04 | Massachusetts Eye And Ear Infirmary | Methods and compositions for prognosing detecting age-related macular degeneration |
| EP2963128A1 (en) | 2009-07-10 | 2016-01-06 | The Regents of the University of Michigan | Compositions and methods for diagnosing and treating macular degeneration |
| US20110104154A1 (en) * | 2009-10-30 | 2011-05-05 | Alcon Research, Ltd. | Single nucleotide polymorphisms and genes associated with age-related macular degeneration |
| US9056874B2 (en) | 2012-05-04 | 2015-06-16 | Novartis Ag | Complement pathway modulators and uses thereof |
| CN102707068B (zh) * | 2012-05-31 | 2015-03-18 | 北京大学 | 补体h因子用作甲基苯丙胺成瘾患者的基因表达产物中的应用 |
| JP6387391B2 (ja) | 2013-03-14 | 2018-09-05 | ノバルティス アーゲー | 眼科疾患の処置に有用な補体因子Ｂ阻害剤としての２−（１Ｈ−インドール−４−イルメチル）−３Ｈ−イミダゾ［４，５−ｂ］ピリジン−６−カルボニトリル誘導体 |
| EP3089963A1 (en) | 2013-10-30 | 2016-11-09 | Novartis AG | 2-benzyl-benzimidazole complement factor b inhibitors and uses thereof |
| EP3102701A1 (en) * | 2014-02-07 | 2016-12-14 | Novartis AG | Impact of genetic factors on disease progression and response to anti-c5 antibody in geographic atrophy |
| WO2016100745A2 (en) * | 2014-12-19 | 2016-06-23 | Children's Hospital Medical Center | Methods and compositions related to transplant-associated thrombotic microangiopathy |
| CN109082460B (zh) * | 2018-09-27 | 2021-07-13 | 领航基因科技（杭州）有限公司 | 应用于snp分型的非竞争性探针设计方法、检测方法及应用 |
| KR102414152B1 (ko) * | 2020-08-20 | 2022-06-29 | (주)지놈오피니언 | 연령 관련 황반변성 진단용 바이오마커 및 이의 용도 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU575586B2 (en) | 1983-09-02 | 1988-08-04 | Syngene, Inc. | Oligonucleotide synthesis employing primer with oxidzable substituents in system |
| GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
| US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
| US5554501A (en) | 1992-10-29 | 1996-09-10 | Beckman Instruments, Inc. | Biopolymer synthesis using surface activated biaxially oriented polypropylene |
| DE69503126T2 (de) | 1994-05-05 | 1998-11-12 | Beckman Instruments Inc | Repetitive oligonukleotide matrix |
| US5985567A (en) | 1997-08-15 | 1999-11-16 | Beckman Coulter, Inc. | Hybridization detection by pretreating bound single-stranded probes |
| US6013789A (en) | 1998-02-20 | 2000-01-11 | Beckman Coulter, Inc. | Covalent attachment of biomolecules to derivatized polypropylene supports |
| WO2006062716A2 (en) * | 2004-11-18 | 2006-06-15 | Yale University | Methods and compositions for treating ocular disorders |
-
2007
- 2007-02-13 JP JP2008554415A patent/JP5290772B2/ja not_active Expired - Fee Related
- 2007-02-13 EP EP07750527A patent/EP1989319A4/en not_active Withdrawn
- 2007-02-13 AU AU2007215218A patent/AU2007215218B2/en not_active Ceased
- 2007-02-13 CN CN200780012906.3A patent/CN101421409A/zh active Pending
- 2007-02-13 WO PCT/US2007/003696 patent/WO2007095185A2/en not_active Ceased
- 2007-02-13 NZ NZ570431A patent/NZ570431A/en not_active IP Right Cessation
- 2007-02-13 CA CA002638916A patent/CA2638916A1/en not_active Abandoned
-
2008
- 2008-08-12 IL IL193396A patent/IL193396A/en not_active IP Right Cessation
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