JP2011528688A5 - - Google Patents
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- Publication number
- JP2011528688A5 JP2011528688A5 JP2011519144A JP2011519144A JP2011528688A5 JP 2011528688 A5 JP2011528688 A5 JP 2011528688A5 JP 2011519144 A JP2011519144 A JP 2011519144A JP 2011519144 A JP2011519144 A JP 2011519144A JP 2011528688 A5 JP2011528688 A5 JP 2011528688A5
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- JP
- Japan
- Prior art keywords
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- alkyl
- compound
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- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 7
- -1 4- (4′-methoxyphenyl) -phenyl Chemical group 0.000 claims 6
- 102000005741 Metalloproteases Human genes 0.000 claims 6
- 108010006035 Metalloproteases Proteins 0.000 claims 6
- 230000014509 gene expression Effects 0.000 claims 5
- 238000003384 imaging method Methods 0.000 claims 5
- 101000998548 Yersinia ruckeri Alkaline proteinase inhibitor Proteins 0.000 claims 4
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 239000003475 metalloproteinase inhibitor Substances 0.000 claims 4
- 208000015122 neurodegenerative disease Diseases 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 206010002329 Aneurysm Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 208000027932 Collagen disease Diseases 0.000 claims 2
- 206010056370 Congestive cardiomyopathy Diseases 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 2
- 201000010046 Dilated cardiomyopathy Diseases 0.000 claims 2
- 206010014561 Emphysema Diseases 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 208000019693 Lung disease Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010040047 Sepsis Diseases 0.000 claims 2
- 208000007107 Stomach Ulcer Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 230000007170 pathology Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 208000019553 vascular disease Diseases 0.000 claims 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 1
- NJYVEMPWNAYQQN-UHFFFAOYSA-N 5-carboxyfluorescein Chemical compound C12=CC=C(O)C=C2OC2=CC(O)=CC=C2C21OC(=O)C1=CC(C(=O)O)=CC=C21 NJYVEMPWNAYQQN-UHFFFAOYSA-N 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000004442 acylamino group Chemical group 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000000266 alpha-aminoacyl group Chemical group 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 239000013060 biological fluid Substances 0.000 claims 1
- 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical group O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 239000012216 imaging agent Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 claims 1
- 229960004657 indocyanine green Drugs 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08160856.4 | 2008-07-22 | ||
| EP08160856A EP2147684A1 (en) | 2008-07-22 | 2008-07-22 | Diagnostic Agents Selective Against Metalloproteases |
| PCT/EP2009/059338 WO2010010079A1 (en) | 2008-07-22 | 2009-07-21 | Diagnostic agents selective against metalloproteases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011528688A JP2011528688A (ja) | 2011-11-24 |
| JP2011528688A5 true JP2011528688A5 (https=) | 2012-01-12 |
| JP5619740B2 JP5619740B2 (ja) | 2014-11-05 |
Family
ID=39737623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011519144A Expired - Fee Related JP5619740B2 (ja) | 2008-07-22 | 2009-07-21 | メタロプロテアーゼの選択的診断剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9480758B2 (https=) |
| EP (2) | EP2147684A1 (https=) |
| JP (1) | JP5619740B2 (https=) |
| CN (1) | CN102105174B (https=) |
| WO (1) | WO2010010079A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014191467A1 (en) * | 2013-05-30 | 2014-12-04 | Bracco Imaging Spa | Fluorescent solid lipid nanoparticles composition and preparation thereof |
| WO2018204872A2 (en) | 2017-05-05 | 2018-11-08 | Fusion Pharmaceuticals Inc. | Igf-1r monoclonal antibodies and uses thereof |
| MA48861A (fr) | 2017-05-05 | 2020-04-01 | Fusion Pharmaceuticals Inc | Améliorations pharmacocinétiques de chélates bifonctionnels et leurs utilisations |
| US10093741B1 (en) | 2017-05-05 | 2018-10-09 | Fusion Pharmaceuticals Inc. | IGF-1R monoclonal antibodies and uses thereof |
| AU2022273867A1 (en) * | 2021-05-13 | 2023-11-23 | The General Hospital Corporation | Molecular probes for in vivo detection of aldehydes |
Family Cites Families (73)
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| US4093709A (en) | 1975-01-28 | 1978-06-06 | Alza Corporation | Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates) |
| US4131648A (en) | 1975-01-28 | 1978-12-26 | Alza Corporation | Structured orthoester and orthocarbonate drug delivery devices |
| US4180646A (en) | 1975-01-28 | 1979-12-25 | Alza Corporation | Novel orthoester polymers and orthocarbonate polymers |
| US5362476A (en) | 1984-10-18 | 1994-11-08 | Board Of Regents, The University Of Texas System | Alkyl phosphonate polyazamacrocyclic cheates for MRI |
| MX174467B (es) | 1986-01-23 | 1994-05-17 | Squibb & Sons Inc | 1,4,7-triscarboximetil-1,4,7,10-tetraazaciclodo decano substituido en 1 y compuestos analogos |
| IT1213029B (it) | 1986-01-30 | 1989-12-07 | Bracco Ind Chimica Spa | Chelati di ioni metallici paramagnetici. |
| US5021556A (en) | 1987-07-22 | 1991-06-04 | Neorx Corporation | Method of radiolabeling chelating compounds comprising sulfur atoms with metal radionuclides |
| US5075099A (en) | 1988-05-31 | 1991-12-24 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
| US5914095A (en) | 1989-04-07 | 1999-06-22 | Salutar, Inc. | Polychelants containg amide bonds |
| US5364613A (en) | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
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| CA2034042C (en) | 1990-01-18 | 1999-08-17 | Adrian D. Nunn | Boronic acid adducts of rhenium dioxime and technetium-99m dioxime complexes containing a biochemically active group |
| US5578292A (en) | 1991-11-20 | 1996-11-26 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
| US5183653A (en) | 1990-04-13 | 1993-02-02 | E. R. Squibb & Sons, Inc. | Boronic acid adducts of metal dioxime complexes useful in labelling proteins and other amine-containing compounds |
| AU636481B2 (en) | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
| US5367080A (en) | 1990-11-08 | 1994-11-22 | Sterling Winthrop Inc. | Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods |
| US5965107A (en) | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5849261A (en) | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
| DE69230525T2 (de) | 1991-02-08 | 2000-06-21 | Diatide, Inc. | Technetium-99m markierte Polypeptide zur Bildformung |
| US5808091A (en) | 1991-10-29 | 1998-09-15 | Bracco International B.V. | Rhenium and technetium complexes containing a hypoxia localizing moiety |
| IL104084A (en) | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them |
| US5608110A (en) | 1993-06-15 | 1997-03-04 | Bracco International B.V. | Heteroatom-bearing ligands and metal complexes thereof |
| ES2114209T3 (es) | 1993-07-19 | 1998-05-16 | Resolution Pharm Inc | Queladores de radionuclidos de tipo hidrazino que tienen una configuracion n3s. |
| US5409689A (en) | 1993-08-13 | 1995-04-25 | Concat, Ltd. | MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms |
| US5574140A (en) | 1993-09-03 | 1996-11-12 | Resolution Pharmaceutical Inc. | Hydrazino-type N2 S2 chelators |
| US5662885A (en) | 1994-07-22 | 1997-09-02 | Resolution Pharmaceuticals Inc. | Peptide derived radionuclide chelators |
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| DE4445065A1 (de) | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
| GB9502065D0 (en) | 1995-02-02 | 1995-03-22 | Nycomed Imaging As | Contrast media |
| ES2233275T3 (es) * | 1995-12-08 | 2005-06-16 | Agouron Pharmaceuticals, Inc. | Intermediarios que sirven para la preparacion de inhibidores de metaloproteinasas. |
| US6500948B1 (en) | 1995-12-08 | 2002-12-31 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof |
| BR9707010B1 (pt) * | 1996-01-23 | 2009-05-05 | compostos, composição farmacêutica e composições para inibir metaloproteinase e colagenase do tipo iv. | |
| JP3795339B2 (ja) | 1996-01-23 | 2006-07-12 | 塩野義製薬株式会社 | スルホン化されたアミノ酸誘導体およびそれを含有するメタロプロティナーゼ阻害剤 |
| WO1998018501A2 (en) | 1996-10-28 | 1998-05-07 | Marsden, John, Christopher | Improvements in or relating to diagnostic/therapeutic agents |
| EP0991427A2 (en) | 1996-10-28 | 2000-04-12 | Marsden, John Christopher | Improvements in or relating to diagnostic/therapeutic agents |
| ATE314097T1 (de) | 1996-10-28 | 2006-01-15 | Amersham Health As | Kontrastmittel |
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| KR100279519B1 (ko) * | 1998-02-18 | 2001-02-01 | 이본수 | 비산계니트로화공정에의한방향족화합물의니트로화방법 |
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| US6656448B1 (en) | 2000-02-15 | 2003-12-02 | Bristol-Myers Squibb Pharma Company | Matrix metalloproteinase inhibitors |
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| MXPA02009309A (es) | 2000-03-21 | 2003-03-12 | Procter & Gamble | Inhibidores de las metaloproteasas n-sustituidas que contienen cadenas laterales carboxiclicas. |
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| US20060093552A1 (en) * | 2002-03-11 | 2006-05-04 | Molecular Insight Pharmaceuticals, Inc. | Technetium-and rhenium-bis(heteroaryl) complexes, and methods of use thereof |
| US20050227994A1 (en) | 2002-03-27 | 2005-10-13 | Shionogi & Co., Ltd. | Decomposition inhibitor for extracellular matrix of cartilage |
| US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| US8231858B2 (en) | 2003-02-10 | 2012-07-31 | Ge Healthcare Limited | Diagnostic imaging agents with MMP inhibitory activity |
| GB0302891D0 (en) * | 2003-02-10 | 2003-03-12 | Amersham Plc | Diagnostic imaging agents for cardiovascular disease |
| GB0326546D0 (en) * | 2003-11-14 | 2003-12-17 | Amersham Plc | Inhibitor imaging agents |
| CA2548513A1 (en) | 2003-12-04 | 2005-07-07 | Wyeth | Biaryl sulfonamides and methods for using same |
| JP2007516288A (ja) | 2003-12-23 | 2007-06-21 | ブラッコ・イメージング・ソシエタ・ペル・アチオニ | 金属キレート剤として有用な新規化合物 |
| DE602005010424D1 (de) | 2004-06-03 | 2008-11-27 | Bracco Research Sa | Liposomale anordnung für die therapeutische und/oder diagnostische anwendung |
| WO2006002873A2 (en) | 2004-07-02 | 2006-01-12 | Bracco Imaging Spa | 1 , 4 -bis (carboxymethyl) -6- ' bis ( carboxymethyl) amino ! -6 -methyl- perhydro-1 , 4 diazepine (aazta) derivatives as ligands in high relaxivity contrast agents for use in magnetic resonance imaging (mri ) |
| GB0421308D0 (en) | 2004-09-24 | 2004-10-27 | Amersham Plc | Enzyme inhibitor imaging agents |
| GB0428012D0 (en) * | 2004-12-22 | 2005-01-26 | Hammersmith Imanet Ltd | Radiolabelling methods |
| ITTO20060575A1 (it) * | 2006-08-02 | 2008-02-03 | Univ Pisa | Inibitori di zinco proteinasi tioaril sostituiti e loro usi |
| EP1972617A1 (en) * | 2007-03-19 | 2008-09-24 | Bracco Imaging, S.P.A. | Compounds having aryl-sulphonamidic structure useful as metalloproteases inhibitors |
-
2008
- 2008-07-22 EP EP08160856A patent/EP2147684A1/en not_active Withdrawn
-
2009
- 2009-07-21 JP JP2011519144A patent/JP5619740B2/ja not_active Expired - Fee Related
- 2009-07-21 CN CN200980128435.1A patent/CN102105174B/zh not_active Expired - Fee Related
- 2009-07-21 WO PCT/EP2009/059338 patent/WO2010010079A1/en not_active Ceased
- 2009-07-21 EP EP09800042.5A patent/EP2320954B1/en active Active
- 2009-07-21 US US13/000,794 patent/US9480758B2/en not_active Expired - Fee Related
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