JP2011528442A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011528442A5 JP2011528442A5 JP2011518921A JP2011518921A JP2011528442A5 JP 2011528442 A5 JP2011528442 A5 JP 2011528442A5 JP 2011518921 A JP2011518921 A JP 2011518921A JP 2011518921 A JP2011518921 A JP 2011518921A JP 2011528442 A5 JP2011528442 A5 JP 2011528442A5
- Authority
- JP
- Japan
- Prior art keywords
- pcdeterminant
- subject
- sample
- level
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 claims description 105
- 206010028980 Neoplasm Diseases 0.000 claims description 57
- 201000011510 cancer Diseases 0.000 claims description 29
- 230000014509 gene expression Effects 0.000 claims description 24
- 210000004027 cell Anatomy 0.000 claims description 23
- 238000011282 treatment Methods 0.000 claims description 19
- 206010060862 Prostate cancer Diseases 0.000 claims description 18
- 208000037819 metastatic cancer Diseases 0.000 claims description 16
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims description 16
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 15
- 150000001875 compounds Chemical class 0.000 claims description 15
- 238000011830 transgenic mouse model Methods 0.000 claims description 15
- 238000001514 detection method Methods 0.000 claims description 12
- 230000000694 effects Effects 0.000 claims description 12
- 102100040557 Osteopontin Human genes 0.000 claims description 11
- 101710168942 Sphingosine-1-phosphate phosphatase 1 Proteins 0.000 claims description 11
- 238000001574 biopsy Methods 0.000 claims description 10
- 239000003153 chemical reaction reagent Substances 0.000 claims description 10
- 101710143112 Mothers against decapentaplegic homolog 4 Proteins 0.000 claims description 9
- 239000003112 inhibitor Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 claims description 7
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 claims description 7
- 102000049937 Smad4 Human genes 0.000 claims description 7
- 238000009098 adjuvant therapy Methods 0.000 claims description 7
- 208000010658 metastatic prostate carcinoma Diseases 0.000 claims description 7
- 102100032912 CD44 antigen Human genes 0.000 claims description 6
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 claims description 6
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims description 6
- 206010027476 Metastases Diseases 0.000 claims description 6
- 101150019443 SMAD4 gene Proteins 0.000 claims description 6
- 239000008280 blood Substances 0.000 claims description 6
- 210000004369 blood Anatomy 0.000 claims description 6
- 238000011161 development Methods 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 230000009401 metastasis Effects 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 238000012360 testing method Methods 0.000 claims description 6
- 229940124597 therapeutic agent Drugs 0.000 claims description 6
- 210000001519 tissue Anatomy 0.000 claims description 6
- 238000011269 treatment regimen Methods 0.000 claims description 6
- 102000006311 Cyclin D1 Human genes 0.000 claims description 4
- 108010058546 Cyclin D1 Proteins 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 4
- 206010061309 Neoplasm progression Diseases 0.000 claims description 4
- 230000008238 biochemical pathway Effects 0.000 claims description 4
- 239000000090 biomarker Substances 0.000 claims description 4
- 210000002919 epithelial cell Anatomy 0.000 claims description 4
- 230000000984 immunochemical effect Effects 0.000 claims description 4
- 230000000474 nursing effect Effects 0.000 claims description 4
- 230000000306 recurrent effect Effects 0.000 claims description 4
- 230000009261 transgenic effect Effects 0.000 claims description 4
- 230000005751 tumor progression Effects 0.000 claims description 4
- 102000016736 Cyclin Human genes 0.000 claims description 3
- 108050006400 Cyclin Proteins 0.000 claims description 3
- 108020004459 Small interfering RNA Proteins 0.000 claims description 3
- 238000002560 therapeutic procedure Methods 0.000 claims description 3
- 108091023037 Aptamer Proteins 0.000 claims description 2
- 238000002965 ELISA Methods 0.000 claims description 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims description 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims description 2
- 206010015866 Extravasation Diseases 0.000 claims description 2
- 241000699666 Mus <mouse, genus> Species 0.000 claims description 2
- 241000699670 Mus sp. Species 0.000 claims description 2
- 108091034117 Oligonucleotide Proteins 0.000 claims description 2
- 206010038111 Recurrent cancer Diseases 0.000 claims description 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims description 2
- 239000003098 androgen Substances 0.000 claims description 2
- 230000033115 angiogenesis Effects 0.000 claims description 2
- 230000025164 anoikis Effects 0.000 claims description 2
- 238000003556 assay Methods 0.000 claims description 2
- 230000009286 beneficial effect Effects 0.000 claims description 2
- 239000013060 biological fluid Substances 0.000 claims description 2
- 210000000481 breast Anatomy 0.000 claims description 2
- 230000015556 catabolic process Effects 0.000 claims description 2
- 230000012292 cell migration Effects 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 210000001072 colon Anatomy 0.000 claims description 2
- 230000005757 colony formation Effects 0.000 claims description 2
- 238000006731 degradation reaction Methods 0.000 claims description 2
- 238000001962 electrophoresis Methods 0.000 claims description 2
- 230000001747 exhibiting effect Effects 0.000 claims description 2
- 210000002744 extracellular matrix Anatomy 0.000 claims description 2
- 230000036251 extravasation Effects 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 238000003384 imaging method Methods 0.000 claims description 2
- 238000010166 immunofluorescence Methods 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 210000005265 lung cell Anatomy 0.000 claims description 2
- 239000003550 marker Substances 0.000 claims description 2
- 230000001394 metastastic effect Effects 0.000 claims description 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 230000000750 progressive effect Effects 0.000 claims description 2
- 210000002307 prostate Anatomy 0.000 claims description 2
- 210000005267 prostate cell Anatomy 0.000 claims description 2
- 208000023958 prostate neoplasm Diseases 0.000 claims description 2
- 238000011002 quantification Methods 0.000 claims description 2
- 238000003127 radioimmunoassay Methods 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- 230000005740 tumor formation Effects 0.000 claims description 2
- 229940126062 Compound A Drugs 0.000 claims 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
- 238000002679 ablation Methods 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 101150063780 spp1 gene Proteins 0.000 claims 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8128608P | 2008-07-16 | 2008-07-16 | |
| US61/081,286 | 2008-07-16 | ||
| PCT/US2009/050885 WO2010009337A2 (en) | 2008-07-16 | 2009-07-16 | Signatures and pcdeterminants associated with prostate cancer and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011528442A JP2011528442A (ja) | 2011-11-17 |
| JP2011528442A5 true JP2011528442A5 (cg-RX-API-DMAC7.html) | 2013-06-06 |
Family
ID=41551019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011518921A Withdrawn JP2011528442A (ja) | 2008-07-16 | 2009-07-16 | 前立腺癌に関連した兆候およびｐｃｄｅｔｅｒｍｉｎａｎｔ、ならびにそれらの使用方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20110265197A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2318543A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2011528442A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20110052627A (cg-RX-API-DMAC7.html) |
| CN (1) | CN102159727A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009270851A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0916229A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2730614A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL210681A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2011000451A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ590851A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2011105627A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010009337A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201101132B (cg-RX-API-DMAC7.html) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG186940A1 (en) | 2010-07-27 | 2013-02-28 | Genomic Health Inc | Method for using gene expression to determine prognosis of prostate cancer |
| US20140030255A1 (en) * | 2010-11-03 | 2014-01-30 | Merck Sharp & Dohme Corp. | Methods of predicting cancer cell response to therapeutic agents |
| US10260097B2 (en) * | 2011-06-02 | 2019-04-16 | Almac Diagnostics Limited | Method of using a gene expression profile to determine cancer responsiveness to an anti-angiogenic agent |
| WO2012178087A1 (en) * | 2011-06-22 | 2012-12-27 | Oncocyte Corporation | Methods and compositions for the treatment and diagnosis of bladder cancer |
| EP2723905A1 (en) | 2011-06-27 | 2014-04-30 | Dana-Farber Cancer Institute, Inc. | Signatures and determinants associated with prostate cancer progression and methods of use thereof |
| WO2013031757A1 (ja) * | 2011-08-29 | 2013-03-07 | 東レ株式会社 | 膵癌、乳癌、肺癌又は前立腺癌の検出用マーカー及び検査方法 |
| HK1201881A1 (en) | 2012-01-31 | 2015-09-11 | Genomic Health, Inc. | Gene expression profile algorithm and test for determining prognosis of prostate cancer |
| WO2013163134A2 (en) * | 2012-04-23 | 2013-10-31 | The Trustees Of Columbia University In The City Of New York | Biomolecular events in cancer revealed by attractor metagenes |
| BR112014032728A2 (pt) | 2012-06-27 | 2017-11-28 | Berg Llc | uso de marcadores no diagnóstico e tratamento de câncer de próstata |
| US20140011685A1 (en) * | 2012-07-03 | 2014-01-09 | Yixin Wang | Genomic diagnostics using circulating endothelial cells |
| WO2014074821A1 (en) * | 2012-11-09 | 2014-05-15 | Dana-Farber Cancer Institute, Inc. | Metabolic profiling in tissue and serum is indicative of tumor differentiation in prostate cancer |
| SG11201504023SA (en) | 2012-12-03 | 2015-06-29 | Almac Diagnostics Ltd | Molecular diagnostic test for cancer |
| KR101456683B1 (ko) * | 2013-01-04 | 2014-11-06 | 서울대학교산학협력단 | 폐암 진단용 마커 |
| WO2014158287A2 (en) * | 2013-03-14 | 2014-10-02 | Otraces Inc. | A method for improving disease diagnosis using measured analytes |
| US20160024592A1 (en) * | 2013-03-14 | 2016-01-28 | The Board Of Regents Of The University Of Texas System | Single-cell analysis as a sensitive and specific method for early prostate cancer detection |
| CN103602720A (zh) * | 2013-06-24 | 2014-02-26 | 复旦大学附属肿瘤医院 | 前列腺癌基因标记物在标记前列腺癌复发和转移中的用途及方法 |
| GB201322034D0 (en) | 2013-12-12 | 2014-01-29 | Almac Diagnostics Ltd | Prostate cancer classification |
| CA2923092C (en) * | 2014-01-03 | 2019-12-17 | Koninklijke Philips N.V. | Assessment of the pi3k cellular signaling pathway activity using mathematical modelling of target gene expression |
| EP3100054B1 (en) | 2014-01-28 | 2022-02-23 | Quest Diagnostics Investments Incorporated | Method and compositions for detecting an adenoma-adenocarcinoma transition in cancer |
| GB201409479D0 (en) | 2014-05-28 | 2014-07-09 | Almac Diagnostics Ltd | Molecular diagnostic test for cancer |
| US9994912B2 (en) | 2014-07-03 | 2018-06-12 | Abbott Molecular Inc. | Materials and methods for assessing progression of prostate cancer |
| AU2015360694B2 (en) | 2014-12-08 | 2021-10-14 | Berg Llc | Use of markers including filamin a in the diagnosis and treatment of prostate cancer |
| CA2996426A1 (en) * | 2015-10-05 | 2017-04-13 | Cedars-Sinai Medical Center | Method of classifying and diagnosing cancer |
| WO2017079571A1 (en) | 2015-11-05 | 2017-05-11 | Arphion Diagnostics | Process for the indentication of patients at risk for oscc |
| US11079745B2 (en) * | 2015-11-25 | 2021-08-03 | Lawrence Livermore National Security, Llc | Rapid closed-loop control based on machine learning |
| EP3405896A4 (en) | 2016-01-22 | 2019-09-25 | Otraces Inc. | SYSTEMS AND METHOD FOR IMPROVED DIAGNOSIS OF ILLNESSES |
| KR101881874B1 (ko) * | 2016-04-29 | 2018-07-26 | 한국수력원자력 주식회사 | 저선량 방사선 조사에 의한 암화 예방 방법 |
| WO2017213897A1 (en) | 2016-06-09 | 2017-12-14 | Cedars-Sinai Medical Center | Compositions and methods for treating cancer |
| WO2018044940A1 (en) * | 2016-08-30 | 2018-03-08 | Beth Israel Deaconess Medical Center | Compositions and methods for treating a tumor suppressor deficient cancer |
| US10487365B2 (en) | 2016-09-20 | 2019-11-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods for detecting expression of lnc-FANCI-2 in cervical cells |
| CA2984267A1 (en) * | 2016-11-01 | 2018-05-01 | Medarchon, Inc. | Patient handoff device, system and predictive method |
| US11312998B2 (en) * | 2016-11-07 | 2022-04-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods for selecting therapy for a cancer patient |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| WO2020081122A1 (en) * | 2018-10-15 | 2020-04-23 | Illumina, Inc. | Deep learning-based techniques for pre-training deep convolutional neural networks |
| WO2019213133A1 (en) * | 2018-04-30 | 2019-11-07 | City Of Hope | Cancer detection and ablation system and method |
| JP2021535739A (ja) | 2018-08-27 | 2021-12-23 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 下流精製でのラマン分光法の使用 |
| US20220088031A1 (en) * | 2019-02-01 | 2022-03-24 | Health Research, Inc. | Methods and compositions for treating resistant and recurrent forms of cancer |
| US12320812B2 (en) | 2019-02-06 | 2025-06-03 | Bpgbio, Inc. | Markers for the diagnosis of biochemical recurrence in prostate cancer |
| WO2021062261A1 (en) * | 2019-09-25 | 2021-04-01 | The Trustees Of Columbia University In The City Of New York | Prognostic markers of metastatic cancer |
| KR102380529B1 (ko) * | 2020-04-29 | 2022-03-31 | 인제대학교 산학협력단 | 전이성 전립선 암의 진단 및 예후 예측을 위한 혈중종양세포 기반 바이오 마커 조성물 |
| US12271832B2 (en) * | 2021-02-12 | 2025-04-08 | Tempus Ai, Inc. | Artificial intelligence engine for directed hypothesis generation and ranking |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3330875B1 (en) * | 2003-07-10 | 2021-12-01 | Genomic Health, Inc. | Expression profile algorithm and test for prognosing breast cancer recurrence |
| WO2006086345A2 (en) * | 2005-02-07 | 2006-08-17 | The Trustees Of Columbia University In The City Of New York | Methods to treat or prevent hormone-resistant prostate cancer using sirna specific for protocadherin-pc, or other inhibitors of protocadherin-pc expression or activity |
| KR20090006837A (ko) * | 2006-03-24 | 2009-01-15 | 페노미넘 디스커버리스 인코포레이티드 | 전립선 암 진단용 생물표지자 및 그의 제조방법 |
-
2009
- 2009-07-16 AU AU2009270851A patent/AU2009270851A1/en not_active Abandoned
- 2009-07-16 EP EP09744246A patent/EP2318543A2/en not_active Withdrawn
- 2009-07-16 CN CN2009801363207A patent/CN102159727A/zh active Pending
- 2009-07-16 US US13/054,468 patent/US20110265197A1/en not_active Abandoned
- 2009-07-16 RU RU2011105627/15A patent/RU2011105627A/ru unknown
- 2009-07-16 JP JP2011518921A patent/JP2011528442A/ja not_active Withdrawn
- 2009-07-16 MX MX2011000451A patent/MX2011000451A/es not_active Application Discontinuation
- 2009-07-16 BR BRPI0916229A patent/BRPI0916229A2/pt not_active IP Right Cessation
- 2009-07-16 WO PCT/US2009/050885 patent/WO2010009337A2/en not_active Ceased
- 2009-07-16 CA CA2730614A patent/CA2730614A1/en not_active Abandoned
- 2009-07-16 KR KR1020117003408A patent/KR20110052627A/ko not_active Withdrawn
- 2009-07-16 NZ NZ590851A patent/NZ590851A/xx not_active IP Right Cessation
-
2011
- 2011-01-16 IL IL210681A patent/IL210681A0/en unknown
- 2011-02-11 ZA ZA2011/01132A patent/ZA201101132B/en unknown
-
2014
- 2014-02-06 US US14/174,072 patent/US20140235479A1/en not_active Abandoned
-
2016
- 2016-10-28 US US15/337,966 patent/US20170299594A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011528442A5 (cg-RX-API-DMAC7.html) | ||
| RU2011105627A (ru) | Отличительные признаки (рс)-детерминанты, связанные с раком предстательной железы, и способы их применения | |
| Cornu et al. | Urine TMPRSS2: ERG fusion transcript integrated with PCA3 score, genotyping, and biological features are correlated to the results of prostatic biopsies in men at risk of prostate cancer | |
| Van Treijen et al. | Blood transcript profiling for the detection of neuroendocrine tumors: results of a large independent validation study | |
| JP2011526693A5 (cg-RX-API-DMAC7.html) | ||
| JP2013505429A5 (cg-RX-API-DMAC7.html) | ||
| RU2011102743A (ru) | Характерные признаки и детерминанты, связанные с метастазированием, и способы их применения | |
| Meng et al. | Evaluation of serum midkine as a biomarker in differentiated thyroid cancer | |
| CN106662543B (zh) | 肺癌患者中的非侵入性基因突变检测 | |
| ES2882875T3 (es) | Método de pronóstico y predicción de la recurrencia del cáncer de mama, marcadores empleados en el mismo y kit del mismo | |
| JP2014512515A (ja) | 癌診断および処置 | |
| CN113234829B (zh) | 结肠癌预后评估基因集及其构建方法 | |
| Xie et al. | Prognostic value of pretreatment serum alkaline phosphatase in nasopharyngeal carcinoma | |
| Chen et al. | Fructose 1, 6‐Bisphosphatase 1 Expression Reduces 18F‐FDG Uptake in Clear Cell Renal Cell Carcinoma | |
| KR20180069904A (ko) | 마커 분자를 기반으로 화학요법으로 치료되어야 하는 개체를 식별하는 방법 및 관련 용도 | |
| JP2008292424A (ja) | 腫瘍の検出方法 | |
| Li et al. | AGR2 diagnostic value in nasopharyngeal carcinoma prognosis | |
| CN102534009B (zh) | 一种与原发性肺癌辅助诊断相关的snp标志物及其应用 | |
| KR102507439B1 (ko) | 고형 종양의 개시의 유전적 상태 전구증증을 조사하고 확인하는 방법 | |
| US11448650B2 (en) | Methods for diagnosing high-risk cancer using polysialic acid and one or more tissue-specific biomarkers | |
| CN114705859B (zh) | 一种用于肝癌骨转移诊断、治疗和预后的生物标志物及其应用 | |
| Hui et al. | Immunohistochemical detection of cdc2 is useful in predicting survival in patients with mantle cell lymphoma | |
| KR102599695B1 (ko) | 마커 사람 부고환 단백질 4 (he4) 기반의 폐 선암 재발의 발견 방법 및 관련 용도 | |
| Gonzalez et al. | Prognostic value of combined p53 and survivin in pT1G3 urothelial carcinoma of the bladder | |
| RU2521229C1 (ru) | Способ прогнозирования степени злокачественности рака предстательной железы |