JP2011528031A5 - - Google Patents
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- JP2011528031A5 JP2011528031A5 JP2011518059A JP2011518059A JP2011528031A5 JP 2011528031 A5 JP2011528031 A5 JP 2011528031A5 JP 2011518059 A JP2011518059 A JP 2011518059A JP 2011518059 A JP2011518059 A JP 2011518059A JP 2011528031 A5 JP2011528031 A5 JP 2011528031A5
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- 239000000203 mixture Substances 0.000 claims description 26
- 239000000758 substrate Substances 0.000 claims description 21
- 150000002632 lipids Chemical class 0.000 claims description 15
- 150000003904 phospholipids Chemical class 0.000 claims description 5
- 239000013543 active substance Substances 0.000 claims 9
- 239000011159 matrix material Substances 0.000 claims 6
- 230000000399 orthopedic effect Effects 0.000 claims 6
- 229920002988 biodegradable polymer Polymers 0.000 claims 4
- 239000004621 biodegradable polymer Substances 0.000 claims 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- 239000011248 coating agent Substances 0.000 claims 4
- 238000000576 coating method Methods 0.000 claims 4
- 102000008186 Collagen Human genes 0.000 claims 3
- 108010035532 Collagen Proteins 0.000 claims 3
- 210000000988 bone and bone Anatomy 0.000 claims 3
- 229920001436 collagen Polymers 0.000 claims 3
- 239000003960 organic solvent Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229940078581 Bone resorption inhibitor Drugs 0.000 claims 2
- 229920000954 Polyglycolide Polymers 0.000 claims 2
- 229930182558 Sterol Natural products 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 229940121375 antifungal agent Drugs 0.000 claims 2
- 239000002617 bone density conservation agent Substances 0.000 claims 2
- 235000012000 cholesterol Nutrition 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 239000007943 implant Substances 0.000 claims 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims 2
- 239000004633 polyglycolic acid Substances 0.000 claims 2
- 239000004626 polylactic acid Substances 0.000 claims 2
- 150000003432 sterols Chemical class 0.000 claims 2
- 235000003702 sterols Nutrition 0.000 claims 2
- 238000013268 sustained release Methods 0.000 claims 2
- 239000012730 sustained-release form Substances 0.000 claims 2
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 1
- XBBVURRQGJPTHH-UHFFFAOYSA-N 2-hydroxyacetic acid;2-hydroxypropanoic acid Chemical compound OCC(O)=O.CC(O)C(O)=O XBBVURRQGJPTHH-UHFFFAOYSA-N 0.000 claims 1
- 229910000684 Cobalt-chrome Inorganic materials 0.000 claims 1
- 102000009123 Fibrin Human genes 0.000 claims 1
- 108010073385 Fibrin Proteins 0.000 claims 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 229910001069 Ti alloy Inorganic materials 0.000 claims 1
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims 1
- WAIPAZQMEIHHTJ-UHFFFAOYSA-N [Cr].[Co] Chemical compound [Cr].[Co] WAIPAZQMEIHHTJ-UHFFFAOYSA-N 0.000 claims 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000003416 augmentation Effects 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 229920000229 biodegradable polyester Polymers 0.000 claims 1
- 239000004622 biodegradable polyester Substances 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000004568 cement Substances 0.000 claims 1
- 239000000919 ceramic Substances 0.000 claims 1
- 239000010952 cobalt-chrome Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 1
- 238000001704 evaporation Methods 0.000 claims 1
- 238000013265 extended release Methods 0.000 claims 1
- 150000004665 fatty acids Chemical group 0.000 claims 1
- 229950003499 fibrin Drugs 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 235000021588 free fatty acids Nutrition 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 239000008240 homogeneous mixture Substances 0.000 claims 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000002188 osteogenic effect Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims 1
- 201000001245 periodontitis Diseases 0.000 claims 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 1
- 150000003905 phosphatidylinositols Chemical class 0.000 claims 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 150000003408 sphingolipids Chemical class 0.000 claims 1
- 239000010935 stainless steel Substances 0.000 claims 1
- 229910001220 stainless steel Inorganic materials 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 239000003356 suture material Substances 0.000 claims 1
- 229910052715 tantalum Inorganic materials 0.000 claims 1
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims 1
- 229960001295 tocopherol Drugs 0.000 claims 1
- 229930003799 tocopherol Natural products 0.000 claims 1
- 235000010384 tocopherol Nutrition 0.000 claims 1
- 239000011732 tocopherol Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 2
- 150000001982 diacylglycerols Chemical class 0.000 description 2
- 125000005265 dialkylamine group Chemical group 0.000 description 2
- 150000001985 dialkylglycerols Chemical class 0.000 description 2
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 2
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 150000008103 phosphatidic acids Chemical class 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8028908P | 2008-07-14 | 2008-07-14 | |
| US61/080,289 | 2008-07-14 | ||
| US15478509P | 2009-02-24 | 2009-02-24 | |
| US61/154,785 | 2009-02-24 | ||
| PCT/IL2009/000701 WO2010007623A1 (en) | 2008-07-14 | 2009-07-14 | Sustained-release drug carrier composition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015002177A Division JP2015129128A (ja) | 2008-07-14 | 2015-01-08 | 徐放性薬剤キャリア組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011528031A JP2011528031A (ja) | 2011-11-10 |
| JP2011528031A5 true JP2011528031A5 (enExample) | 2012-08-23 |
| JP5681626B2 JP5681626B2 (ja) | 2015-03-11 |
Family
ID=41550058
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011518059A Active JP5681626B2 (ja) | 2008-07-14 | 2009-07-14 | 徐放性薬剤キャリア組成物 |
| JP2015002177A Ceased JP2015129128A (ja) | 2008-07-14 | 2015-01-08 | 徐放性薬剤キャリア組成物 |
| JP2016023906A Active JP6053083B2 (ja) | 2008-07-14 | 2016-02-10 | 徐放性薬剤キャリア組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015002177A Ceased JP2015129128A (ja) | 2008-07-14 | 2015-01-08 | 徐放性薬剤キャリア組成物 |
| JP2016023906A Active JP6053083B2 (ja) | 2008-07-14 | 2016-02-10 | 徐放性薬剤キャリア組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US8877242B2 (enExample) |
| EP (1) | EP2299953B1 (enExample) |
| JP (3) | JP5681626B2 (enExample) |
| CN (2) | CN104274866B (enExample) |
| AU (1) | AU2009272280B2 (enExample) |
| CA (1) | CA2730340C (enExample) |
| DK (1) | DK2299953T3 (enExample) |
| ES (1) | ES2630805T3 (enExample) |
| PL (1) | PL2299953T3 (enExample) |
| WO (1) | WO2010007623A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2767973C (en) | 2009-07-14 | 2019-06-18 | Polypid Ltd. | Lipid-based sustained-release drug carrier matrix |
| WO2011089595A2 (en) | 2010-01-19 | 2011-07-28 | Polypid Ltd. | Sustained-release nucleic acid matrix compositions |
| US9119793B1 (en) | 2011-06-28 | 2015-09-01 | Medicis Pharmaceutical Corporation | Gastroretentive dosage forms for doxycycline |
| CN103717206A (zh) * | 2011-07-27 | 2014-04-09 | 波利皮得有限公司 | 用于肽分子和多肽分子的受控释放的基质组合物 |
| CN102362861B (zh) * | 2011-11-04 | 2014-03-26 | 无锡中科光远生物材料有限公司 | 一种空心核壳结构复合纳米粒子及其制备方法 |
| US20130288951A1 (en) * | 2012-04-27 | 2013-10-31 | Biomet Manufacturing Corp. | Compositions and methods for coating implant surfaces to inhibit surgical infections |
| EA201492145A1 (ru) * | 2012-05-18 | 2015-03-31 | Ой Филана Лтд. | Препарат пролонгированного действия на основе доцетаксела для лечения рака |
| CA2880130C (en) * | 2012-08-02 | 2019-09-24 | Polypid Ltd. | Compositions and methods for the treatment of bone voids and open fractures |
| US10842802B2 (en) | 2013-03-15 | 2020-11-24 | Medicis Pharmaceutical Corporation | Controlled release pharmaceutical dosage forms |
| US20160317560A1 (en) * | 2013-11-07 | 2016-11-03 | The University Of North Carolina At Chapel Hill | Particles containing phospholipids or bioactive fatty acids and uses thereof |
| US20160340659A1 (en) | 2014-01-30 | 2016-11-24 | Yissum Research And Development Company Of The Hebrew University Of Jerusalem Ltd. | Actin binding peptides and compositions comprising same for inhibiting angiogenesis and treating medical conditions associated with same |
| AU2015280417B2 (en) | 2014-06-24 | 2020-01-30 | The Trustees Of Princeton University | Process for encapsulating soluble biologics, therapeutics, and imaging agents |
| TW201618783A (zh) | 2014-08-07 | 2016-06-01 | 艾森塔製藥公司 | 以布魯頓(Bruton)氏酪胺酸激酶(BTK)佔據和BTK再合成速率為基礎之治療癌症、免疫和自體免疫疾病及發炎性疾病之方法 |
| KR102466337B1 (ko) * | 2014-10-02 | 2022-11-14 | 폴리피드 엘티디. | 임플란트 주위염의 치료 방법 |
| DK3200748T3 (da) | 2014-10-02 | 2021-12-13 | Polypid Ltd | Sammensætninger og fremgangsmåder til behandling og profylakse af infektioner på operationssted |
| WO2016168718A1 (en) * | 2015-04-17 | 2016-10-20 | Massachusetts Eye And Ear Infirmary | Prosthetic devices for semicircular canal defects |
| WO2017010685A1 (ko) | 2015-07-10 | 2017-01-19 | 고려대학교 산학협력단 | 의료용 상처치유 촉진기 및 골수염 치료 장치 |
| KR101773287B1 (ko) * | 2016-03-10 | 2017-08-31 | 고려대학교 산학협력단 | 골수염 치료 장치 |
| US11103461B2 (en) | 2015-12-22 | 2021-08-31 | The Trustees Of Princeton University | Process for encapsulating soluble biologics, therapeutics, and imaging agents |
| US20200000976A1 (en) * | 2016-12-16 | 2020-01-02 | Field Orthopaedics Pty Ltd | A medical implant and a method of coating a medical implant |
| WO2019055539A1 (en) | 2017-09-12 | 2019-03-21 | Prudhomme Robert K | CELLULOSIC POLYMER NANOPARTICLES AND METHODS OF FORMING THE SAME |
| JP2021501753A (ja) | 2017-11-03 | 2021-01-21 | ザ・トラスティーズ・オブ・プリンストン・ユニバーシティＴｈｅ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｐｒｉｎｃｅｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ | 徐放性ナノキャリア製剤を形成するための疎水性イオン対化およびフラッシュナノ沈殿 |
| WO2020018890A1 (en) | 2018-07-19 | 2020-01-23 | Prudhomme Robert K | Triblock copolymer stabilizers for the formation of nanoparticles encapsulating soluble biologics, therapeutics, and imaging agents |
| US11731099B2 (en) | 2018-07-20 | 2023-08-22 | The Trustees Of Princeton University | Method for controlling encapsulation efficiency and burst release of water soluble molecules from nanoparticles and microparticles produced by inverse flash nanoprecipitation |
| US20200147032A1 (en) | 2018-11-14 | 2020-05-14 | Robert K. Prud'homme | Dihydromyricetin hot melt extrusion formulations and methods for forming them |
| WO2021026289A1 (en) | 2019-08-08 | 2021-02-11 | Avidence Therapeutics, Inc. | Microsphere-Based Injectible Celecoxib Formulation |
| TWI754876B (zh) * | 2019-12-31 | 2022-02-11 | 財團法人工業技術研究院 | 含藥多層薄膜與其形成方法 |
| CN116635006A (zh) * | 2020-12-21 | 2023-08-22 | 波利皮得有限公司 | 用于治疗实体瘤的组合物和方法 |
| KR20230124561A (ko) * | 2020-12-21 | 2023-08-25 | 폴리피드 엘티디. | 고형 종양 치료를 위한 조성물 및 방법 |
| KR102442807B1 (ko) | 2021-01-29 | 2022-09-15 | 주식회사 티온랩테라퓨틱스 | 초기 방출 제어된 데포 조성물 및 이의 제조방법 |
| US12521349B2 (en) | 2021-01-29 | 2026-01-13 | Tionlab Therapeutics | Initial burst release controlled depot composition and a method thereof |
| KR20230115591A (ko) | 2022-01-27 | 2023-08-03 | 주식회사 티온랩테라퓨틱스 | 초기 방출 제어된 지질 융합 데포 조성물 및 이의 제조방법 |
| WO2025150966A1 (ko) | 2024-01-12 | 2025-07-17 | 주식회사 티온랩테라퓨틱스 | 소르비탄 포화지방산을 포함하는 서방성 지질 전구 제제 및 이의 제조방법 |
| KR20250118174A (ko) | 2024-01-29 | 2025-08-05 | 주식회사 티온랩테라퓨틱스 | 세마글루타이드의 개선된 의료 요법 제공을 위한 비만 및 당뇨 치료용로써, 소수성 이온 페어링 겔레이션을 통한 초기 방출이 제어된 데포 조성물 및 이의 제조방법 |
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