ES2630805T3 - Composición de vehículo de fármaco de liberación sostenida - Google Patents

Composición de vehículo de fármaco de liberación sostenida Download PDF

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Publication number
ES2630805T3
ES2630805T3 ES09797631.0T ES09797631T ES2630805T3 ES 2630805 T3 ES2630805 T3 ES 2630805T3 ES 09797631 T ES09797631 T ES 09797631T ES 2630805 T3 ES2630805 T3 ES 2630805T3
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Spain
Prior art keywords
another embodiment
matrix
bone
matrix composition
fatty acid
Prior art date
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Application number
ES09797631.0T
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English (en)
Spanish (es)
Inventor
Noam Emanuel
Moshe Neuman
Shlomo Barak
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Polypid Ltd
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Polypid Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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    • A61K31/65—Tetracyclines
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
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    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/04—Coatings containing a composite material such as inorganic/organic, i.e. material comprising different phases

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Polymers & Plastics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES09797631.0T 2008-07-14 2009-07-14 Composición de vehículo de fármaco de liberación sostenida Active ES2630805T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8028908P 2008-07-14 2008-07-14
US80289P 2008-07-14
US15478509P 2009-02-24 2009-02-24
US154785P 2009-02-24
PCT/IL2009/000701 WO2010007623A1 (en) 2008-07-14 2009-07-14 Sustained-release drug carrier composition

Publications (1)

Publication Number Publication Date
ES2630805T3 true ES2630805T3 (es) 2017-08-24

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ES09797631.0T Active ES2630805T3 (es) 2008-07-14 2009-07-14 Composición de vehículo de fármaco de liberación sostenida

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US (6) US8877242B2 (enExample)
EP (1) EP2299953B1 (enExample)
JP (3) JP5681626B2 (enExample)
CN (2) CN102159163B (enExample)
AU (1) AU2009272280B2 (enExample)
CA (1) CA2730340C (enExample)
DK (1) DK2299953T3 (enExample)
ES (1) ES2630805T3 (enExample)
PL (1) PL2299953T3 (enExample)
WO (1) WO2010007623A1 (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010272167B2 (en) 2009-07-14 2016-11-17 Polypid Ltd. Sustained-release drug carrier composition
JP5860409B2 (ja) 2010-01-19 2016-02-16 ポリピッド リミテッド 徐放性核酸マトリックス組成物
US9119793B1 (en) 2011-06-28 2015-09-01 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for doxycycline
CN103717206A (zh) * 2011-07-27 2014-04-09 波利皮得有限公司 用于肽分子和多肽分子的受控释放的基质组合物
CN102362861B (zh) * 2011-11-04 2014-03-26 无锡中科光远生物材料有限公司 一种空心核壳结构复合纳米粒子及其制备方法
US20130288951A1 (en) * 2012-04-27 2013-10-31 Biomet Manufacturing Corp. Compositions and methods for coating implant surfaces to inhibit surgical infections
WO2013171382A1 (en) * 2012-05-18 2013-11-21 Oy Filana Ltd Docetaxel-based prolonged-release cancer treatment drug
EA027543B1 (ru) * 2012-08-02 2017-08-31 Полипид Лтд. Композиции и способы для лечения участков отсутствующей костной ткани и открытых переломов
US10842802B2 (en) 2013-03-15 2020-11-24 Medicis Pharmaceutical Corporation Controlled release pharmaceutical dosage forms
WO2015069870A1 (en) * 2013-11-07 2015-05-14 The University Of North Carolina At Chapel Hill Particles containing phospholipids or bioactive fatty acid
WO2015114633A1 (en) 2014-01-30 2015-08-06 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Ltd. Actin binding peptides and compositions comprising same for inhibiting angiogenes is and treating medical conditions associated with same
EP4299058A3 (en) 2014-06-24 2024-03-27 The Trustees of Princeton University Process for encapsulating soluble biologics, therapeutics, and imaging agents
WO2016020901A1 (en) 2014-08-07 2016-02-11 Acerta Pharma B.V. Methods of treating cancers, immune and autoimmune diseases, and inflammatory diseases based on btk occupancy and btk resynthesis rate
JP2017531461A (ja) * 2014-10-02 2017-10-26 ポリピッド リミテッド インプラント周囲炎の治療法
CN106999356A (zh) 2014-10-02 2017-08-01 波利皮得有限公司 用于治疗和预防手术部位感染的组合物和方法
US10695168B2 (en) * 2015-04-17 2020-06-30 Massachusetts Eye And Ear Infirmary Prosthetic devices for semicircular canal defects
KR101773287B1 (ko) * 2016-03-10 2017-08-31 고려대학교 산학협력단 골수염 치료 장치
US11617896B2 (en) 2015-07-10 2023-04-04 Korea University Research And Business Foundation Medical wound healing accelerator and osteomyelitis treatment device
AU2016378743A1 (en) 2015-12-22 2018-08-02 The Trustees Of Princeton University Process for encapsulating soluble biologics, therapeutics, and imaging agents
WO2018107243A1 (en) * 2016-12-16 2018-06-21 Field Orthopaedics Pty Ltd A medical implant and a method of coating a medical implant
WO2019055539A1 (en) 2017-09-12 2019-03-21 Prudhomme Robert K CELLULOSIC POLYMER NANOPARTICLES AND METHODS OF FORMING THE SAME
JP2021501753A (ja) 2017-11-03 2021-01-21 ザ・トラスティーズ・オブ・プリンストン・ユニバーシティＴｈｅ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｐｒｉｎｃｅｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ 徐放性ナノキャリア製剤を形成するための疎水性イオン対化およびフラッシュナノ沈殿
US12186436B2 (en) 2018-07-19 2025-01-07 The Trustees Of Princeton University Triblock copolymer stabilizers for the formation of nanoparticles encapsulating soluble biologics, therapeutics, and imaging agents
US11731099B2 (en) 2018-07-20 2023-08-22 The Trustees Of Princeton University Method for controlling encapsulation efficiency and burst release of water soluble molecules from nanoparticles and microparticles produced by inverse flash nanoprecipitation
US20200147032A1 (en) 2018-11-14 2020-05-14 Robert K. Prud'homme Dihydromyricetin hot melt extrusion formulations and methods for forming them
JP7395210B2 (ja) * 2019-08-08 2023-12-11 アヴィデンス セラピューティクス， インコーポレイテッド ミクロスフェアに基づく注射用セレコキシブ製剤
TWI754876B (zh) * 2019-12-31 2022-02-11 財團法人工業技術研究院 含藥多層薄膜與其形成方法
EP4262783A1 (en) * 2020-12-21 2023-10-25 Polypid Ltd. Compositions and methods for the treatment of solid tumors
US20220296524A1 (en) 2021-01-29 2022-09-22 Tionlab Therapeutics Initial burst release controlled depot composition and a method thereof
KR102442807B1 (ko) 2021-01-29 2022-09-15 주식회사 티온랩테라퓨틱스 초기 방출 제어된 데포 조성물 및 이의 제조방법
KR20230115591A (ko) 2022-01-27 2023-08-03 주식회사 티온랩테라퓨틱스 초기 방출 제어된 지질 융합 데포 조성물 및 이의 제조방법
KR20250110749A (ko) 2024-01-12 2025-07-21 주식회사 티온랩테라퓨틱스 소르비탄 포화지방산을 포함하는 서방성 지질 전구 제제 및 이의 제조방법
KR20250118174A (ko) 2024-01-29 2025-08-05 주식회사 티온랩테라퓨틱스 세마글루타이드의 개선된 의료 요법 제공을 위한 비만 및 당뇨 치료용로써, 소수성 이온 페어링 겔레이션을 통한 초기 방출이 제어된 데포 조성물 및 이의 제조방법

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4522803A (en) * 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US4882167A (en) * 1983-05-31 1989-11-21 Jang Choong Gook Dry direct compression compositions for controlled release dosage forms
US4578384A (en) * 1984-02-15 1986-03-25 The United States Of America As Represented By The Secretary Of The Army Polylactic-polyglycolic acids combined with an acidic phospholipid-lysozyme complex for healing osseous tissue
US4522863A (en) 1984-06-21 1985-06-11 Kimberly-Clark Corporation Soft nonwoven laminate bonded by adhesive on reinforcing scrim
JPS6163613A (ja) 1984-09-04 1986-04-01 Mitsui Toatsu Chem Inc 顆粒状に調整された徐放性製剤
US5043166A (en) * 1987-01-09 1991-08-27 Hadasit Medical Research, Inc. Liposome/anthraquinone drug composition and method
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
EP0502119B1 (en) 1989-11-13 1996-01-31 Scios Nova, Inc. Lipospheres for controlled delivery of substances
US6120805A (en) * 1990-04-06 2000-09-19 Rhone-Poulenc Rorer Sa Microspheres, process for their preparation and their use
JPH046115A (ja) 1990-04-25 1992-01-10 Olympus Optical Co Ltd 光学素子成形用型
DK166600B1 (da) 1991-01-17 1993-06-21 Therkel Bisgaard Vaerktoejssaet til brug ved suturering i dybe operationsaabninger eller legemshulrum
US5922340A (en) * 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US6180134B1 (en) * 1993-03-23 2001-01-30 Sequus Pharmaceuticals, Inc. Enhanced ciruclation effector composition and method
CA2190121A1 (en) 1994-03-15 1995-09-21 Edith Mathiowitz Polymeric gene delivery system
US6156337A (en) * 1994-07-08 2000-12-05 Opperbas Holding B.V. Method for high loading of vesicles with biopolymeric substances
US6333021B1 (en) * 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
US6040295A (en) 1995-01-13 2000-03-21 Genemedicine, Inc. Formulated nucleic acid compositions and methods of administering the same for gene therapy
US5919480A (en) * 1996-06-24 1999-07-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposomal influenza vaccine composition and method
JPH108035A (ja) 1996-06-25 1998-01-13 Akebono Brake Ind Co Ltd 非石綿系摩擦材
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
AU3981097A (en) 1996-08-21 1998-03-06 Alkermes Controlled Therapeutics, Inc. Controlled release microparticles with a hydrophobic material
AU736056B2 (en) * 1996-09-11 2001-07-26 Imarx Pharmaceutical Corp. Improved methods for diagnostic imaging using a contrast agent and a vasodilator
US6048551A (en) * 1997-03-27 2000-04-11 Hilfinger; John M. Microsphere encapsulation of gene transfer vectors
JP2000511941A (ja) * 1997-07-02 2000-09-12 ユーロ−セルティーク エス．エイ． 関節間隙および身体間隙における持効性麻酔
US6287587B2 (en) 1997-07-15 2001-09-11 Takeda Chemical Industries, Ltd. Process for producing sustained-release preparation by in-water drying
US6787132B1 (en) * 1997-12-04 2004-09-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Combined chemo-immunotherapy with liposomal drugs and cytokines
PT1079805E (pt) 1998-04-27 2005-03-31 Opperbas Holding Bv Composicao farmaceutica compreendendo factor viii e lipossomas neutros
US6423345B2 (en) * 1998-04-30 2002-07-23 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
EP1098610B1 (en) * 1998-07-17 2009-04-15 Pacira Pharmaceuticals, Inc. Biodegradable compositions for the controlled release of encapsulated substances
US6162462A (en) * 1998-08-12 2000-12-19 New York University Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient
US6153217A (en) * 1999-01-22 2000-11-28 Biodelivery Sciences, Inc. Nanocochleate formulations, process of preparation and method of delivery of pharmaceutical agents
US6083482A (en) * 1999-05-11 2000-07-04 Icn Pharmaceuticals, Inc. Conformationally locked nucleosides and oligonucleotides
AU5624500A (en) 1999-06-18 2001-01-09 Collaborative Group, Ltd., The Hyaluronic acid microspheres for sustained gene transfer
DE10001172A1 (de) * 2000-01-13 2001-07-26 Max Planck Gesellschaft Templatieren von Feststoffpartikeln mit Polymermultischichten
US6267587B1 (en) * 2000-07-06 2001-07-31 Johnson & Johnson Vision Care, Inc. Thermal curing oven and thermal curing process
US6967028B2 (en) * 2000-07-31 2005-11-22 Mainelab Prolonged release microspheres for injectable administration
AU2001296494A1 (en) * 2000-10-02 2002-04-15 Arizeke Pharmaceuticals, Inc. Compositions and methods for the transport of biologically active agents across cellular barriers
US7749539B2 (en) * 2000-11-30 2010-07-06 Efrat Biopolymers Ltd. Polymeric formulations for drug delivery
FI20010540A0 (fi) * 2001-03-16 2001-03-16 Yli Urpo Antti Komposiitti pehmyt- ja kovakudosvammojen korjaamiseksi ja mainitun komposiitin käyttö
JP2005509604A (ja) * 2001-09-28 2005-04-14 マクニール−ピーピーシー・インコーポレイテッド 菓子組成物を含む剤形
TWI226249B (en) * 2001-12-19 2005-01-11 Ind Tech Res Inst Biodegradable composite matrix for enhancing angiogenesis
AU2003215388A1 (en) * 2002-02-22 2003-09-09 Purdue Research Foundation Magnetic nanomaterials and methods for detection of biological materials
EP1509203B1 (en) * 2002-05-15 2016-04-13 California Pacific Medical Center Delivery of nucleic acid-like compounds
US7144430B2 (en) * 2002-07-12 2006-12-05 Motion Control, Inc. Wrist device for use with a prosthetic limb
SE0202619D0 (sv) * 2002-09-05 2002-09-05 Fredrik Nederberg New Polymers and Applications
EP1601326A4 (en) * 2003-02-12 2011-05-11 Ceremed Inc RANDOM ALKYLENE OXIDE COPOLYMERS FOR MEDICAL AND SURGICAL USES
GB0305941D0 (en) * 2003-03-14 2003-04-23 Camurus Ab Composition
AU2004228849B2 (en) * 2003-04-10 2010-05-06 Teijin Limited Biodegradable film having honeycomb structure
US20040247624A1 (en) * 2003-06-05 2004-12-09 Unger Evan Charles Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility
US20060188573A1 (en) * 2003-06-10 2006-08-24 Anna Imberg Composite materials and particles
US20050249697A1 (en) * 2003-09-24 2005-11-10 Uhrich Kathryn E Compositions and methods for the inhibition of bone growth and resorption
JP2005154514A (ja) * 2003-11-21 2005-06-16 Univ Waseda 機能性生分解性材料およびその製造方法
JP4647497B2 (ja) * 2003-11-21 2011-03-09 帝人株式会社 組織再生用基材および細胞との複合体とその製造方法
CA2553426A1 (en) * 2004-01-15 2005-08-04 Alza Corporation Liposome composition for delivery of therapeutic agents
US8277831B2 (en) * 2004-02-17 2012-10-02 Advanced Technologies And Regenerative Medicine, Llc. Drug-enhanced adhesion prevention
US7744644B2 (en) * 2004-03-19 2010-06-29 Boston Scientific Scimed, Inc. Medical articles having regions with polyelectrolyte multilayer coatings for regulating drug release
MXPA06014095A (es) * 2004-06-04 2007-08-07 Camurus Ab Formulaciones de deposito de lipidos.
EP1765367A4 (en) * 2004-06-15 2010-08-11 Therapeutics Inc Encore PHOSPHOLIPID COMPOSITIONS AND METHOD FOR THEIR PREPARATION AND USE
WO2006009825A1 (en) * 2004-06-17 2006-01-26 Virun, Inc. Compositions comprising a mucoadhesive protein and an active principle for mucosal delivery of said agents
KR20070054644A (ko) * 2004-07-26 2007-05-29 액테리온 파마슈티칼 리미티드 미립자 제형으로 흡입된 일로프로스트에 의한 폐고혈압의치료
US20080095849A1 (en) * 2005-04-25 2008-04-24 Amgen Inc. Peptide sustained release compositions and uses thereof
US20070141134A1 (en) * 2005-12-16 2007-06-21 Kosak Matthew K Shielded micelles for polynucleotide delivery
EP1976460A4 (en) * 2006-01-19 2012-06-20 Warsaw Orthopedic Inc INJECTABLE AND FORMABLE BONE REPLACEMENT MATERIALS
US20090318355A1 (en) * 2006-02-15 2009-12-24 Chen Thomas T Compositions and methods for promoting tissue repair and wound healing
CA2648099C (en) * 2006-03-31 2012-05-29 The Brigham And Women's Hospital, Inc System for targeted delivery of therapeutic agents
US8703167B2 (en) * 2006-06-05 2014-04-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug
WO2008108286A1 (ja) 2007-03-02 2008-09-12 Teika Pharmaceutical Co., Ltd. 経皮吸収医薬組成物、医薬組成物貯蔵ユニットおよびこれを利用する経皮吸収製剤
WO2008124634A1 (en) * 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
US20090006311A1 (en) * 2007-06-28 2009-01-01 Yahoo! Inc. Automated system to improve search engine optimization on web pages
WO2009006311A2 (en) 2007-06-29 2009-01-08 Wisconsin Alumni Research Foundation Structuring effect of cholesterol in peg-phospholipid micelles, drug delivery of amphotericin b, and combination antifungals
US20090110713A1 (en) 2007-10-31 2009-04-30 Florencia Lim Biodegradable polymeric materials providing controlled release of hydrophobic drugs from implantable devices
WO2009061515A1 (en) 2007-11-09 2009-05-14 Northeastern University Self-assembling micelle-like nanoparticles for systemic gene delivery
WO2009110939A2 (en) 2007-12-10 2009-09-11 Massachusetts Institute Of Technology Drug delivery system for pharmaceuticals and radiation
TWI373474B (en) 2007-12-31 2012-10-01 Univ Kaohsiung Medical Stem cell transfection method
US8685432B2 (en) * 2008-03-25 2014-04-01 University Of Utah Research Foundation Controlled release tissue graft combination biomaterials
US8128983B2 (en) * 2008-04-11 2012-03-06 Abbott Cardiovascular Systems Inc. Coating comprising poly(ethylene glycol)-poly(lactide-glycolide-caprolactone) interpenetrating network
PL2279254T3 (pl) 2008-04-15 2017-11-30 Protiva Biotherapeutics Inc. Nowe preparaty lipidowe do dostarczania kwasów nukleinowych
AU2010272167B2 (en) 2009-07-14 2016-11-17 Polypid Ltd. Sustained-release drug carrier composition
KR101114771B1 (ko) 2009-09-23 2012-03-05 유영환 석쇠
JP5860409B2 (ja) 2010-01-19 2016-02-16 ポリピッド リミテッド 徐放性核酸マトリックス組成物

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