JP2011527984A5 - - Google Patents

Info

Publication number

JP2011527984A5

JP2011527984A5 JP2010549125A JP2010549125A JP2011527984A5 JP 2011527984 A5 JP2011527984 A5 JP 2011527984A5 JP 2010549125 A JP2010549125 A JP 2010549125A JP 2010549125 A JP2010549125 A JP 2010549125A JP 2011527984 A5 JP2011527984 A5 JP 2011527984A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

glucoside

kaempferol

quercetin

composition according

Prior art date

2009-03-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000008194 pharmaceutical composition Substances 0.000 claims 10
• MQVRGDZCYDEQML-UHFFFAOYSA-N Astragalin Natural products C1=CC(OC)=CC=C1C1=C(OC2C(C(O)C(O)C(CO)O2)O)C(=O)C2=C(O)C=C(O)C=C2O1 MQVRGDZCYDEQML-UHFFFAOYSA-N 0.000 claims 3
• OVSQVDMCBVZWGM-IDRAQACASA-N Hirsutrin Natural products O([C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1)C1=C(c2cc(O)c(O)cc2)Oc2c(c(O)cc(O)c2)C1=O OVSQVDMCBVZWGM-IDRAQACASA-N 0.000 claims 3
• FVQOMEDMFUMIMO-UHFFFAOYSA-N Hyperosid Natural products OC1C(O)C(O)C(CO)OC1OC1C(=O)C2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 FVQOMEDMFUMIMO-UHFFFAOYSA-N 0.000 claims 3
• 208000019622 heart disease Diseases 0.000 claims 3
• JPUKWEQWGBDDQB-QSOFNFLRSA-N kaempferol 3-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=CC(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O JPUKWEQWGBDDQB-QSOFNFLRSA-N 0.000 claims 3
• ZDQHCVFHPTWFMA-UHFFFAOYSA-N kaempferol 3-O-beta-D-glucoside Natural products OCC1OC(OC2=C(Oc3cc(O)cc(O)c3C2)c4ccc(O)c(O)c4)C(O)C(O)C1O ZDQHCVFHPTWFMA-UHFFFAOYSA-N 0.000 claims 3
• OVSQVDMCBVZWGM-QSOFNFLRSA-N quercetin 3-O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-QSOFNFLRSA-N 0.000 claims 3
• FNTJVYCFNVUBOL-VFKUPZNOSA-N Kaempferol 3-glucuronide Natural products O=C(O)[C@@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@H](OC2=C(c3ccc(O)cc3)Oc3c(c(O)cc(O)c3)C2=O)O1 FNTJVYCFNVUBOL-VFKUPZNOSA-N 0.000 claims 2
• DUBCCGAQYVUYEU-VFKUPZNOSA-N Miquelianin Natural products O=C(O)[C@@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@H](OC2=C(c3cc(O)c(O)cc3)Oc3c(c(O)cc(O)c3)C2=O)O1 DUBCCGAQYVUYEU-VFKUPZNOSA-N 0.000 claims 2
• DUBCCGAQYVUYEU-UHFFFAOYSA-N Querciturone Natural products O1C(C(O)=O)C(O)C(O)C(O)C1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O DUBCCGAQYVUYEU-UHFFFAOYSA-N 0.000 claims 2
• 230000002757 inflammatory effect Effects 0.000 claims 2
• FNTJVYCFNVUBOL-ZUGPOPFOSA-N kaempferol 3-O-glucuronide Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC1=C(C=2C=CC(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O FNTJVYCFNVUBOL-ZUGPOPFOSA-N 0.000 claims 2
• DUBCCGAQYVUYEU-ZUGPOPFOSA-N miquelianin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O DUBCCGAQYVUYEU-ZUGPOPFOSA-N 0.000 claims 2
• 208000031225 myocardial ischemia Diseases 0.000 claims 2
• LOJXBHNAFUDMIQ-UHFFFAOYSA-N quercetin-3-alpha-glucuronide Natural products OC1OC(C(O)C(O)C1O)C(=O)Oc1c(oc2cc(O)cc(O)c2c1=O)-c1ccc(O)c(O)c1 LOJXBHNAFUDMIQ-UHFFFAOYSA-N 0.000 claims 2
• 206010019280 Heart failures Diseases 0.000 claims 1
• 241001593968 Vitis palmata Species 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 208000010125 myocardial infarction Diseases 0.000 claims 1