CA2717012A1 - Use of flavonoide compounds for the propyhylaxis and therapy of ischaemic or inflammatory heart and cardiovascular diseases - Google Patents

Use of flavonoide compounds for the propyhylaxis and therapy of ischaemic or inflammatory heart and cardiovascular diseases Download PDF

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Publication number
CA2717012A1
CA2717012A1 CA2717012A CA2717012A CA2717012A1 CA 2717012 A1 CA2717012 A1 CA 2717012A1 CA 2717012 A CA2717012 A CA 2717012A CA 2717012 A CA2717012 A CA 2717012A CA 2717012 A1 CA2717012 A1 CA 2717012A1
Authority
CA
Canada
Prior art keywords
glucuronide
beta
quercetin
heart
kaempferol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2717012A
Other languages
English (en)
French (fr)
Inventor
Anke Esperester
Stephan Nees
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of CA2717012A1 publication Critical patent/CA2717012A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
CA2717012A 2008-03-06 2009-03-03 Use of flavonoide compounds for the propyhylaxis and therapy of ischaemic or inflammatory heart and cardiovascular diseases Abandoned CA2717012A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102008012909.7 2008-03-06
DE102008012909A DE102008012909A1 (de) 2008-03-06 2008-03-06 Verwendung von Flavonoidverbindungen für die Prophylaxe und Therapie ischämischer oder entzündlicher Herz- und Kreislauferkrankungen
PCT/EP2009/052502 WO2009109573A1 (de) 2008-03-06 2009-03-03 Verwendung von flavonoidverbindungen für die propyhylaxe und therapie ischämischer oder entzündlicher herz- und kreislauferkrankungen

Publications (1)

Publication Number Publication Date
CA2717012A1 true CA2717012A1 (en) 2009-09-11

Family

ID=40600026

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2717012A Abandoned CA2717012A1 (en) 2008-03-06 2009-03-03 Use of flavonoide compounds for the propyhylaxis and therapy of ischaemic or inflammatory heart and cardiovascular diseases

Country Status (6)

Country Link
US (2) US20110053874A1 (https=)
EP (1) EP2268277A1 (https=)
JP (1) JP2011527984A (https=)
CA (1) CA2717012A1 (https=)
DE (1) DE102008012909A1 (https=)
WO (1) WO2009109573A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009027382A2 (de) * 2007-08-31 2009-03-05 Boehringer Ingelheim International Gmbh Sprühfähige zusammensetzung enthaltend extrakt aus rotem weinlaub
DE102008012908A1 (de) * 2008-03-06 2009-09-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Methode zum anti-inflammatorischen und anti-ödematösen Schutz von explantiertem biologischen Material bis zu seiner Transplantation in Patienten
BR112015008156A2 (pt) 2012-10-11 2017-07-04 Armaron Bio Pty Ltd novos compostos flavonóides e suas respectivas utilizações
CN113398114B (zh) * 2021-05-28 2022-11-01 浙江大学智能创新药物研究院 3,7,8,4′-四羟基黄酮在制备抗心血管疾病药物中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69918852T2 (de) * 1998-10-29 2005-07-21 Merck Patent Gmbh Zusammensetzung enthaltend eine mischung von bioflavonoiden
JP2001122791A (ja) 1999-10-20 2001-05-08 Boehringer Ingelheim Internatl Gmbh 下肢の慢性静脈不全の軽減および予防のための赤色ブドウ樹葉の水性抽出物よりなる食事補強剤
CN1450905A (zh) * 2000-05-25 2003-10-22 法马顿股份有限公司 增强细胞保护的方法
CN1197567C (zh) * 2002-10-21 2005-04-20 中国人民解放军第二军医大学 山奈酚衍生物用于制备防治脑血管疾病药物的用途
AU2003298180B2 (en) 2002-12-31 2010-01-21 Boehringer Ingelheim International Gmbh Film coated tablet comprising an extract of red vine leaves

Also Published As

Publication number Publication date
JP2011527984A (ja) 2011-11-10
US20110053874A1 (en) 2011-03-03
US20130109641A1 (en) 2013-05-02
DE102008012909A1 (de) 2009-09-10
WO2009109573A1 (de) 2009-09-11
EP2268277A1 (de) 2011-01-05

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20140304