JP2011527984A5 - - Google Patents
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- Publication number
- JP2011527984A5 JP2011527984A5 JP2010549125A JP2010549125A JP2011527984A5 JP 2011527984 A5 JP2011527984 A5 JP 2011527984A5 JP 2010549125 A JP2010549125 A JP 2010549125A JP 2010549125 A JP2010549125 A JP 2010549125A JP 2011527984 A5 JP2011527984 A5 JP 2011527984A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- glucoside
- kaempferol
- quercetin
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- JPUKWEQWGBDDQB-QSOFNFLRSA-N Astragalin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=CC(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O JPUKWEQWGBDDQB-QSOFNFLRSA-N 0.000 claims 6
- FNTJVYCFNVUBOL-VFKUPZNOSA-N Kaempferol 3-glucuronide Natural products O=C(O)[C@@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@H](OC2=C(c3ccc(O)cc3)Oc3c(c(O)cc(O)c3)C2=O)O1 FNTJVYCFNVUBOL-VFKUPZNOSA-N 0.000 claims 4
- OVSQVDMCBVZWGM-IDRAQACASA-N Hirsutrin Natural products O([C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1)C1=C(c2cc(O)c(O)cc2)Oc2c(c(O)cc(O)c2)C1=O OVSQVDMCBVZWGM-IDRAQACASA-N 0.000 claims 3
- OVSQVDMCBVZWGM-QSOFNFLRSA-N Isoquercetin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-QSOFNFLRSA-N 0.000 claims 3
- 201000010238 heart disease Diseases 0.000 claims 3
- DUBCCGAQYVUYEU-VFKUPZNOSA-N Miquelianin Natural products O=C(O)[C@@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@H](OC2=C(c3cc(O)c(O)cc3)Oc3c(c(O)cc(O)c3)C2=O)O1 DUBCCGAQYVUYEU-VFKUPZNOSA-N 0.000 claims 2
- 208000003067 Myocardial Ischemia Diseases 0.000 claims 2
- 230000002757 inflammatory Effects 0.000 claims 2
- DUBCCGAQYVUYEU-ZUGPOPFOSA-N miquelianin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O DUBCCGAQYVUYEU-ZUGPOPFOSA-N 0.000 claims 2
- 206010007554 Cardiac failure Diseases 0.000 claims 1
- 206010019280 Heart failure Diseases 0.000 claims 1
- 208000010125 Myocardial Infarction Diseases 0.000 claims 1
- 241001593968 Vitis palmata Species 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Claims (8)
- 虚血性心疾患又は炎症性心疾患を予防するための医薬組成物であって、
クエルセチン−３−Ｏ−β−Ｄ−グルクロニド及び／又はケンペロール−３−Ｏ−β−Ｄ−グルクロニドを含む医薬組成物。 - クエルセチン−３−Ｏ−β−Ｄ−グルクロニド及び／又はケンペロール−３−Ｏ−β−Ｄ−グルクロニドが、経血管投与される、請求項１に記載の医薬組成物。
- 虚血性心疾患又は炎症性心疾患を予防するための医薬組成物であって、
クエルセチン−３−Ｏ−β−Ｄ−グルコシド及び／又はケンペロール−３−Ｏ−β−Ｄ−グルコシドを含み、
クエルセチン−３−Ｏ−β−Ｄ−グルコシド及び／又はケンペロール−３−Ｏ−β−Ｄ−グルコシドが、経口投与される、医薬組成物。 - クエルセチン−３−Ｏ−β−Ｄ−グルコシド及び／又はケンペロール−３−Ｏ−β−Ｄ−グルコシドが、それら単独で使用される、請求項３に記載の医薬組成物。
- クエルセチン−３−Ｏ−β−Ｄ−グルコシド及び／又はケンペロール−３−Ｏ−β−Ｄ−グルコシドが、組成物の一部である、請求項３に記載の医薬組成物。
- 赤ブドウ葉抽出物である、請求項５に記載の医薬組成物。
- 使用される抽出物が、ＡＳ１９５として市販されているものである、請求項６に記載の医薬組成物。
- 心疾患が、心筋梗塞及び心不全から選択される、請求項１〜７のいずれかに記載の医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008012909A DE102008012909A1 (de) | 2008-03-06 | 2008-03-06 | Verwendung von Flavonoidverbindungen für die Prophylaxe und Therapie ischämischer oder entzündlicher Herz- und Kreislauferkrankungen |
| DE102008012909.7 | 2008-03-06 | ||
| PCT/EP2009/052502 WO2009109573A1 (de) | 2008-03-06 | 2009-03-03 | Verwendung von flavonoidverbindungen für die propyhylaxe und therapie ischämischer oder entzündlicher herz- und kreislauferkrankungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011527984A JP2011527984A (ja) | 2011-11-10 |
| JP2011527984A5 true JP2011527984A5 (ja) | 2012-04-26 |
Family
ID=40600026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010549125A Pending JP2011527984A (ja) | 2008-03-06 | 2009-03-03 | 虚血性又は炎症性の心疾患及び心臓血管疾患の予防と治療のためのフラボノイド化合物の使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20110053874A1 (ja) |
| EP (1) | EP2268277A1 (ja) |
| JP (1) | JP2011527984A (ja) |
| CA (1) | CA2717012A1 (ja) |
| DE (1) | DE102008012909A1 (ja) |
| WO (1) | WO2009109573A1 (ja) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2482864C2 (ru) * | 2007-08-31 | 2013-05-27 | Бёрингер Ингельхайм Интернациональ Гмбх | Пригодная для распыления композиция, содержащая экстракт из листьев красного винограда |
| DE102008012908A1 (de) * | 2008-03-06 | 2009-09-10 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Methode zum anti-inflammatorischen und anti-ödematösen Schutz von explantiertem biologischen Material bis zu seiner Transplantation in Patienten |
| SG11201502758SA (en) | 2012-10-11 | 2015-05-28 | Armaron Bio Pty Ltd | Novel flavonoid compounds and uses thereof |
| CN113398114B (zh) * | 2021-05-28 | 2022-11-01 | 浙江大学智能创新药物研究院 | 3,7,8,4′-四羟基黄酮在制备抗心血管疾病药物中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2348395C (en) * | 1998-10-29 | 2009-12-22 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Compositions comprising a mixture of bioflavonols |
| JP2001122791A (ja) | 1999-10-20 | 2001-05-08 | Boehringer Ingelheim Internatl Gmbh | 下肢の慢性静脈不全の軽減および予防のための赤色ブドウ樹葉の水性抽出物よりなる食事補強剤 |
| EP1317272B1 (en) * | 2000-05-25 | 2006-04-12 | Boehringer Ingelheim International GmbH | Composition for improving the cell protection comprising a lipophilic antioxidant an a hydrophilic antioxidant |
| CN1197567C (zh) * | 2002-10-21 | 2005-04-20 | 中国人民解放军第二军医大学 | 山奈酚衍生物用于制备防治脑血管疾病药物的用途 |
| BRPI0317883B8 (pt) | 2002-12-31 | 2021-05-25 | Boehringer Ingelheim Int | comprimido revestido com filme compreendendo um extrato de folhas de vinha vermelha |
-
2008
- 2008-03-06 DE DE102008012909A patent/DE102008012909A1/de not_active Withdrawn
-
2009
- 2009-03-03 WO PCT/EP2009/052502 patent/WO2009109573A1/de active Application Filing
- 2009-03-03 EP EP09718237A patent/EP2268277A1/de not_active Withdrawn
- 2009-03-03 US US12/919,561 patent/US20110053874A1/en not_active Abandoned
- 2009-03-03 CA CA2717012A patent/CA2717012A1/en not_active Abandoned
- 2009-03-03 JP JP2010549125A patent/JP2011527984A/ja active Pending
-
2012
- 2012-12-11 US US13/710,799 patent/US20130109641A1/en not_active Abandoned
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