JP2011526909A5 - - Google Patents
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- Publication number
- JP2011526909A5 JP2011526909A5 JP2011516753A JP2011516753A JP2011526909A5 JP 2011526909 A5 JP2011526909 A5 JP 2011526909A5 JP 2011516753 A JP2011516753 A JP 2011516753A JP 2011516753 A JP2011516753 A JP 2011516753A JP 2011526909 A5 JP2011526909 A5 JP 2011526909A5
- Authority
- JP
- Japan
- Prior art keywords
- oxo
- solid
- azepan
- imidazo
- difluorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000007787 solid Substances 0.000 claims 26
- -1 2,3-difluorophenyl Chemical group 0.000 claims 20
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 239000000825 pharmaceutical preparation Substances 0.000 claims 10
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims 9
- 229910052700 potassium Inorganic materials 0.000 claims 6
- 239000011591 potassium Substances 0.000 claims 6
- 239000008280 blood Substances 0.000 claims 5
- 210000004369 blood Anatomy 0.000 claims 5
- CGDZXLJGHVKVIE-DNVCBOLYSA-N n-[(3r,6s)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-3h-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide Chemical compound FC1=CC=CC([C@H]2CN(CC(F)(F)F)C(=O)[C@H](NC(=O)N3CCC(CC3)N3C(NC4=NC=CC=C43)=O)CC2)=C1F CGDZXLJGHVKVIE-DNVCBOLYSA-N 0.000 claims 4
- OKTJSMMVPCPJKN-OUBTZVSYSA-N Carbon-13 Chemical compound [13C] OKTJSMMVPCPJKN-OUBTZVSYSA-N 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- 238000001237 Raman spectrum Methods 0.000 claims 3
- 230000001747 exhibiting effect Effects 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 239000002736 nonionic surfactant Substances 0.000 claims 2
- 239000008180 pharmaceutical surfactant Substances 0.000 claims 2
- KWYUFKZDYYNOTN-UHFFFAOYSA-M potassium hydroxide Inorganic materials [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims 2
- 239000007909 solid dosage form Substances 0.000 claims 2
- 230000003595 spectral effect Effects 0.000 claims 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- MYJUJZURQORXNY-UHFFFAOYSA-N [K].N1(CCCCC1)C(=O)N Chemical compound [K].N1(CCCCC1)C(=O)N MYJUJZURQORXNY-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 229920001400 block copolymer Polymers 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 claims 1
- JSPCTNUQYWIIOT-UHFFFAOYSA-N piperidine-1-carboxamide Chemical compound NC(=O)N1CCCCC1 JSPCTNUQYWIIOT-UHFFFAOYSA-N 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- 235000011118 potassium hydroxide Nutrition 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13354208P | 2008-06-30 | 2008-06-30 | |
| US61/133,542 | 2008-06-30 | ||
| PCT/US2009/049009 WO2010002763A1 (en) | 2008-06-30 | 2009-06-29 | Solid dosage formulations of telcagepant potassium |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011155043A Division JP2011246478A (ja) | 2008-06-30 | 2011-07-13 | テルカゲパントカリウムの固形投与製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011526909A JP2011526909A (ja) | 2011-10-20 |
| JP2011526909A5 true JP2011526909A5 (https=) | 2011-12-01 |
Family
ID=41057505
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011516753A Withdrawn JP2011526909A (ja) | 2008-06-30 | 2009-06-29 | テルカゲパントカリウムの固形投与製剤 |
| JP2011155043A Withdrawn JP2011246478A (ja) | 2008-06-30 | 2011-07-13 | テルカゲパントカリウムの固形投与製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011155043A Withdrawn JP2011246478A (ja) | 2008-06-30 | 2011-07-13 | テルカゲパントカリウムの固形投与製剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20100009967A1 (https=) |
| EP (1) | EP2303238A1 (https=) |
| JP (2) | JP2011526909A (https=) |
| KR (1) | KR20110025926A (https=) |
| CN (1) | CN102076330A (https=) |
| AR (1) | AR072395A1 (https=) |
| AU (1) | AU2009267145A1 (https=) |
| CA (1) | CA2728547A1 (https=) |
| CR (1) | CR20110038A (https=) |
| DO (1) | DOP2010000409A (https=) |
| IL (1) | IL209833A0 (https=) |
| MX (1) | MX2010014524A (https=) |
| RU (1) | RU2011103170A (https=) |
| SV (1) | SV2010003774A (https=) |
| TW (1) | TW201004954A (https=) |
| WO (1) | WO2010002763A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009055733A1 (en) * | 2007-10-25 | 2009-04-30 | Proteus Biomedical, Inc. | Fluid transfer port information system |
| CA2722536A1 (en) * | 2008-02-05 | 2009-08-13 | Merck & Co., Inc. | Prodrugs of cgrp receptor antagonist |
| WO2017001434A1 (en) * | 2015-06-29 | 2017-01-05 | Galderma Research & Development | Cgrp receptor antagonist compounds for topical treatment of skin disorders |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
| IL131651A0 (en) * | 1997-03-13 | 2001-01-28 | Hexal Ag | A pharmaceutical formulation containing benzimidazoles with amino acid/caclodextrin combinations and a process for producing the same |
| US6174548B1 (en) * | 1998-08-28 | 2001-01-16 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
| JO2355B1 (en) * | 2003-04-15 | 2006-12-12 | ميرك شارب اند دوم كوربوريشن | Hereditary calcitonin polypeptide receptor antagonists |
| WO2007120592A1 (en) * | 2006-04-10 | 2007-10-25 | Merck & Co., Inc. | Cgrp antagonist salt |
| WO2008030524A2 (en) * | 2006-09-08 | 2008-03-13 | Merck & Co., Inc. | Liquid pharmaceutical formulations for oral administration of a cgrp antagonist |
-
2009
- 2009-06-29 CA CA2728547A patent/CA2728547A1/en not_active Abandoned
- 2009-06-29 RU RU2011103170/15A patent/RU2011103170A/ru not_active Application Discontinuation
- 2009-06-29 MX MX2010014524A patent/MX2010014524A/es not_active Application Discontinuation
- 2009-06-29 EP EP09774214A patent/EP2303238A1/en not_active Withdrawn
- 2009-06-29 TW TW098121909A patent/TW201004954A/zh unknown
- 2009-06-29 WO PCT/US2009/049009 patent/WO2010002763A1/en not_active Ceased
- 2009-06-29 CN CN2009801252261A patent/CN102076330A/zh active Pending
- 2009-06-29 AU AU2009267145A patent/AU2009267145A1/en not_active Abandoned
- 2009-06-29 KR KR1020107029334A patent/KR20110025926A/ko not_active Withdrawn
- 2009-06-29 US US12/493,311 patent/US20100009967A1/en not_active Abandoned
- 2009-06-29 JP JP2011516753A patent/JP2011526909A/ja not_active Withdrawn
- 2009-06-29 AR ARP090102404A patent/AR072395A1/es unknown
-
2010
- 2010-12-07 IL IL209833A patent/IL209833A0/en unknown
- 2010-12-21 SV SV2010003774A patent/SV2010003774A/es not_active Application Discontinuation
- 2010-12-30 DO DO2010000409A patent/DOP2010000409A/es unknown
-
2011
- 2011-01-21 CR CR20110038A patent/CR20110038A/es not_active Application Discontinuation
- 2011-07-13 JP JP2011155043A patent/JP2011246478A/ja not_active Withdrawn
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