JP2011526619A5 - - Google Patents

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JP2011526619A5
JP2011526619A5 JP2011515712A JP2011515712A JP2011526619A5 JP 2011526619 A5 JP2011526619 A5 JP 2011526619A5 JP 2011515712 A JP2011515712 A JP 2011515712A JP 2011515712 A JP2011515712 A JP 2011515712A JP 2011526619 A5 JP2011526619 A5 JP 2011526619A5
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JP
Japan
Prior art keywords
delivery system
drug delivery
rnai
polymer matrix
rnai agent
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JP2011515712A
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English (en)
Japanese (ja)
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JP2011526619A (ja
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Priority claimed from PCT/IB2009/052778 external-priority patent/WO2010001325A2/en
Publication of JP2011526619A publication Critical patent/JP2011526619A/ja
Publication of JP2011526619A5 publication Critical patent/JP2011526619A5/ja
Pending legal-status Critical Current

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JP2011515712A 2008-06-30 2009-06-28 局所ドラッグデリバリーシステム、その方法、および、その組成物 Pending JP2011526619A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12947708P 2008-06-30 2008-06-30
US61/129,477 2008-06-30
PCT/IB2009/052778 WO2010001325A2 (en) 2008-06-30 2009-06-28 Methods, compositions and systems for local delivery of drugs

Publications (2)

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JP2011526619A JP2011526619A (ja) 2011-10-13
JP2011526619A5 true JP2011526619A5 (https=) 2012-08-30

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JP2011515712A Pending JP2011526619A (ja) 2008-06-30 2009-06-28 局所ドラッグデリバリーシステム、その方法、および、その組成物

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US (1) US8999945B2 (https=)
EP (1) EP2323630B1 (https=)
JP (1) JP2011526619A (https=)
CN (1) CN102137658A (https=)
AU (1) AU2009265170A1 (https=)
BR (1) BRPI0910198A2 (https=)
IL (1) IL210185A0 (https=)
WO (1) WO2010001325A2 (https=)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2416762A2 (en) * 2009-04-08 2012-02-15 SurModics, Inc. Controlled release devices and methods for delivery of nucleic acids
EP2437684B1 (en) 2009-06-03 2022-06-15 ForSight Vision5, Inc. Anterior segment drug delivery
EP2525778B1 (en) * 2010-01-19 2018-08-01 Polypid Ltd. Sustained-release nucleic acid matrix compositions
WO2013011511A1 (en) 2011-07-18 2013-01-24 Mor Research Applications Ltd. A device for adjusting the intraocular pressure
JP5989780B2 (ja) 2011-09-14 2016-09-07 フォーサイト・ビジョン5・インコーポレイテッドForsight Vision5,Inc. 眼挿入装置および方法
EP2725103A3 (en) 2011-11-14 2016-01-06 Silenseed Ltd Methods and compositions for treating prostate cancer
US20130122096A1 (en) 2011-11-14 2013-05-16 Silenseed Ltd. Compositions for drug delivery and methods of manufacturing and using same
WO2013086419A1 (en) * 2011-12-09 2013-06-13 California Institute Of Technology Polymer scaffolds and their use in the treatment of vision loss
CN102525935A (zh) * 2012-01-18 2012-07-04 上海交通大学医学院 一种纳米药物载体脑内递送方法
US8889642B2 (en) * 2012-04-19 2014-11-18 Silenseed Ltd. Methods and compositions for RNAi-based cancer treatment
NL2009145C2 (en) * 2012-07-06 2014-01-07 Xeltis B V Implant.
CN102861341B (zh) * 2012-09-29 2015-06-17 张建祥 一种能高效负载核酸类药物的复合纳米载体及其制备方法
RU2652063C2 (ru) 2012-10-26 2018-04-24 Форсайт Вижн5, Инк. Офтальмологическая система для замедленного высвобождения лекарственного средства в глазу
WO2014076703A1 (en) * 2012-11-14 2014-05-22 Silenseed Ltd. Methods and compositions for treating cancer
EP3031921B1 (en) 2012-12-12 2025-03-12 The Broad Institute, Inc. Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
US10102441B2 (en) * 2013-02-07 2018-10-16 Vanderbilt University Methods for automatic segmentation of inner ear anatomy in post-implantation CT and applications of same
US9784730B2 (en) 2013-03-21 2017-10-10 University Of Washington Through Its Center For Commercialization Nanoparticle for targeting brain tumors and delivery of O6-benzylguanine
CN104394898B (zh) * 2013-05-02 2017-10-13 卡迪奥诺沃姆有限公司 球囊表面涂层
RU2716420C2 (ru) 2013-06-17 2020-03-11 Те Брод Инститьют Инк. Доставка и применение систем crispr-cas, векторов и композиций для целенаправленного воздействия и терапии в печени
MX374532B (es) 2013-06-17 2025-03-06 Broad Inst Inc Suministro, uso y aplicaciones terapéuticas de los sistemas y composiciones crispr-cas, para actuar sobre trastornos y enfermedades utilizando componentes víricos.
CN105683379A (zh) 2013-06-17 2016-06-15 布罗德研究所有限公司 用于对有丝分裂后细胞的疾病和障碍进行靶向和建模的系统、方法和组合物的递送、工程化和优化
CN103394127A (zh) * 2013-08-02 2013-11-20 苏州市马尔泰新材料有限公司 一种含有中西医药的阴道模具材料
CN103394128A (zh) * 2013-08-02 2013-11-20 苏州市马尔泰新材料有限公司 一种含有川芎的模具材料
JP6793547B2 (ja) 2013-12-12 2020-12-02 ザ・ブロード・インスティテュート・インコーポレイテッド 最適化機能CRISPR−Cas系による配列操作のための系、方法および組成物
JP6712948B2 (ja) 2013-12-12 2020-06-24 ザ・ブロード・インスティテュート・インコーポレイテッド 組成物、及びヌクレオチドリピート障害におけるcrispr−cas系の使用方法
SG10201804975PA (en) 2013-12-12 2018-07-30 Broad Inst Inc Delivery, Use and Therapeutic Applications of the Crispr-Cas Systems and Compositions for HBV and Viral Diseases and Disorders
EP3080259B1 (en) 2013-12-12 2023-02-01 The Broad Institute, Inc. Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
JP7103750B2 (ja) 2013-12-12 2022-07-20 ザ・ブロード・インスティテュート・インコーポレイテッド ゲノム編集のためのCRISPR-Cas系及び組成物の送達、使用及び治療適用
JP2017507946A (ja) * 2014-02-26 2017-03-23 エスリス ゲーエムベーハーethris GmbH Rnaを胃腸内投与するための組成物
CN104027848B (zh) * 2014-06-24 2015-10-14 中国人民解放军第四军医大学 一种用于牙周组织的生物支架材料及其制备方法
WO2016009428A1 (en) * 2014-07-14 2016-01-21 Silenseed Ltd. Rna interference compositions targeting heat shock protein 90 and methods of use thereof
WO2016028682A1 (en) 2014-08-17 2016-02-25 The Broad Institute Inc. Genome editing using cas9 nickases
US10912933B2 (en) 2014-08-19 2021-02-09 The Regents Of The University Of California Implants for localized drug delivery and methods of use thereof
WO2016049258A2 (en) 2014-09-25 2016-03-31 The Broad Institute Inc. Functional screening with optimized functional crispr-cas systems
US11033659B2 (en) 2014-09-29 2021-06-15 Board Of Regents Of The University Of Nebraska Nanofiber structures and methods of synthesis and use thereof
US20180072815A1 (en) 2014-10-23 2018-03-15 Singh Biotechnology, Llc Single Domain Antibodies Directed Against Intracellular Antigens
US20160115247A1 (en) * 2014-10-23 2016-04-28 Singh Biotechnology, Llc Single domain antibodies directed against intracellular antigens
WO2016094872A1 (en) 2014-12-12 2016-06-16 The Broad Institute Inc. Dead guides for crispr transcription factors
WO2016094874A1 (en) 2014-12-12 2016-06-16 The Broad Institute Inc. Escorted and functionalized guides for crispr-cas systems
EP3889260A1 (en) 2014-12-12 2021-10-06 The Broad Institute, Inc. Protected guide rnas (pgrnas)
WO2016094880A1 (en) 2014-12-12 2016-06-16 The Broad Institute Inc. Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs)
EP3234192B1 (en) 2014-12-19 2021-07-14 The Broad Institute, Inc. Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing
WO2016106236A1 (en) 2014-12-23 2016-06-30 The Broad Institute Inc. Rna-targeting system
CA2970370A1 (en) 2014-12-24 2016-06-30 Massachusetts Institute Of Technology Crispr having or associated with destabilization domains
US20160296532A1 (en) 2015-04-13 2016-10-13 Forsight Vision5, Inc. Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent
AU2016279077A1 (en) 2015-06-18 2019-03-28 Omar O. Abudayyeh Novel CRISPR enzymes and systems
US9790490B2 (en) 2015-06-18 2017-10-17 The Broad Institute Inc. CRISPR enzymes and systems
WO2016205749A1 (en) 2015-06-18 2016-12-22 The Broad Institute Inc. Novel crispr enzymes and systems
TWI906646B (zh) 2015-06-18 2025-12-01 美商博得學院股份有限公司 降低脫靶效應的crispr酶突變
WO2017031370A1 (en) 2015-08-18 2017-02-23 The Broad Institute, Inc. Methods and compositions for altering function and structure of chromatin loops and/or domains
US12241053B2 (en) 2015-10-09 2025-03-04 The Brigham And Women's Hospital, Inc. Modulation of novel immune checkpoint targets
CN116814590A (zh) 2015-10-22 2023-09-29 布罗德研究所有限公司 Vi-b型crispr酶和系统
EP3368687B1 (en) 2015-10-27 2021-09-29 The Broad Institute, Inc. Compositions and methods for targeting cancer-specific sequence variations
WO2017075451A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
WO2017075465A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
WO2017075478A2 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by use of immune cell gene signatures
US12110490B2 (en) 2015-12-18 2024-10-08 The Broad Institute, Inc. CRISPR enzymes and systems
US10342899B2 (en) 2015-12-19 2019-07-09 Cardiac Pacemakers, Inc. Biologically inert coating for implantable medical devices
US11180759B2 (en) 2016-01-19 2021-11-23 The University Of North Carolina At Chapel Hill Methods and compositions using RNA interference and antisense oligonucleotides for inhibition of KRAS
WO2017127473A1 (en) * 2016-01-19 2017-07-27 The University Of North Carolina At Chapel Hill Methods and compositions using rna interference for inhibition of kras
EP3445853A1 (en) 2016-04-19 2019-02-27 The Broad Institute, Inc. Cpf1 complexes with reduced indel activity
AU2017257274B2 (en) 2016-04-19 2023-07-13 Massachusetts Institute Of Technology Novel CRISPR enzymes and systems
KR20260004568A (ko) 2016-04-19 2026-01-08 더 브로드 인스티튜트, 인코퍼레이티드 신규한 crispr 효소 및 시스템
US12031235B2 (en) 2016-04-28 2024-07-09 Amogreentech Co., Ltd. Nanofiber composite membrane for guided bone regeneration, and manufacturing method therefor
EP3471787B1 (en) 2016-06-16 2021-08-18 Cardiac Pacemakers, Inc. Hydrophilization and antifouling of enhanced metal surfaces
CN109642231A (zh) 2016-06-17 2019-04-16 博德研究所 Vi型crispr直向同源物和系统
US12595478B2 (en) 2016-06-29 2026-04-07 The Broad Institute, Inc. Crispr-Cas systems having destabilization domain
WO2018017929A1 (en) * 2016-07-21 2018-01-25 Board Of Regents Of The University Of Nebraska Ring and tubular structures and methods of synthesis and use thereof
US10842912B2 (en) 2016-08-09 2020-11-24 Cardiac Pacemakers, Inc. Functionalized PEG for implantable medical devices
WO2018035387A1 (en) 2016-08-17 2018-02-22 The Broad Institute, Inc. Novel crispr enzymes and systems
EP4485466A3 (en) 2016-08-17 2025-04-02 The Broad Institute Inc. Novel crispr enzymes and systems
WO2018049025A2 (en) 2016-09-07 2018-03-15 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses
CA3038304A1 (en) 2016-09-28 2018-04-05 Board Of Regents Of The University Of Nebraska Nanofiber structures and methods of use thereof
US12499971B2 (en) 2016-09-28 2025-12-16 The Broad Institute, Inc. Systematic screening and mapping of regulatory elements in non-coding genomic regions, methods, compositions, and applications thereof
US12447213B2 (en) 2016-10-07 2025-10-21 The Broad Institute, Inc. Modulation of novel immune checkpoint targets
KR101949507B1 (ko) * 2016-11-09 2019-02-18 주식회사 삼양바이오팜 Kras를 표적으로 하는 핵산 함유 약제학적 조성물 및 그 제조방법
JP2020511141A (ja) 2017-03-15 2020-04-16 ザ・ブロード・インスティテュート・インコーポレイテッド 新規Cas13bオルソログCRISPR酵素及び系
AU2018251801B2 (en) 2017-04-12 2024-11-07 Massachusetts Institute Of Technology Novel type VI CRISPR orthologs and systems
US11591601B2 (en) 2017-05-05 2023-02-28 The Broad Institute, Inc. Methods for identification and modification of lncRNA associated with target genotypes and phenotypes
CN110691586A (zh) 2017-05-24 2020-01-14 思兰斯德有限责任公司 用于癌症免疫疗法的组合物和方法
WO2018227078A1 (en) 2017-06-09 2018-12-13 Board Of Regents Of The University Of Nebraska Nanofiber structures and methods of use thereof
CN110168093B (zh) * 2017-09-12 2023-08-15 中科蓝华(广州)生物医药技术有限公司 一种转染细胞内寄生虫的试剂盒及其应用
EP3684726A4 (en) 2017-09-19 2021-06-30 Board of Regents of the University of Nebraska NANOFIBER STRUCTURES AND METHODS OF USING THEM
WO2019058333A2 (en) * 2017-09-22 2019-03-28 Cochlear Limited BIOACTIVE AGENT DISTRIBUTION
WO2019071054A1 (en) 2017-10-04 2019-04-11 The Broad Institute, Inc. METHODS AND COMPOSITIONS FOR MODIFYING THE FUNCTION AND STRUCTURE OF BUCKLES AND / OR CHROMATIN DOMAINS
EP3710039A4 (en) 2017-11-13 2021-08-04 The Broad Institute, Inc. METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER BY TARGETING THE CLEC2D-KLRB1 PATH
US10968257B2 (en) 2018-04-03 2021-04-06 The Broad Institute, Inc. Target recognition motifs and uses thereof
MX2020014243A (es) 2018-06-19 2021-05-12 Biontech Us Inc Neoantigenos y usos de los mismos.
US12421507B2 (en) 2018-08-20 2025-09-23 The Broad Institute, Inc. Methods and compositions for optochemical control of CRISPR-CAS9
US12383652B2 (en) 2018-12-14 2025-08-12 Board Of Regents Of The University Of Nebraska Nanofiber structures and methods of manufacture and use thereof
US12534714B2 (en) 2019-03-18 2026-01-27 The Broad Institute, Inc. Type VII CRISPR proteins and systems
EP3969589A1 (en) * 2019-05-17 2022-03-23 Silenseed Ltd. Compositions and methods for reducing perineural invasion and pain
JP7295559B2 (ja) * 2019-06-03 2023-06-21 国立大学法人 奈良先端科学技術大学院大学 キトサン系複合体組成物及びキトサン系複合体の製造方法
US11338119B2 (en) 2020-03-20 2022-05-24 The Regents Of The University Of California Implantable drug delivery devices for localized drug delivery
CN115515657A (zh) 2020-03-20 2022-12-23 加利福尼亚大学董事会 用于局部药物递送的可植入药物递送设备
US11344526B2 (en) 2020-03-20 2022-05-31 The Regents Of The University Of California Implantable drug delivery devices for localized drug delivery
US11173291B2 (en) 2020-03-20 2021-11-16 The Regents Of The University Of California Implantable drug delivery devices for localized drug delivery
WO2022067197A1 (en) * 2020-09-28 2022-03-31 The Regents Of The University Of California Drug implants containing apalutamide and methods of use thereof
IT202100021779A1 (it) 2021-08-11 2023-02-11 Plasfer S R L Piastrine trasfettate con sirna e loro usi terapeutici
TR2021017752A2 (tr) 2021-11-15 2021-12-21 S D Ue Idari Ve Maliis Dai Bas Genelsekreterlik Transdermal- i̇laç salim özelli̇kli̇ yeni̇li̇kçi̇ nanoli̇fli̇ medi̇kal teksti̇l malzemesi̇ üreti̇m yöntemi̇
CN114381421B (zh) * 2022-02-09 2023-08-15 河北医科大学 溶菌酶诱导的小鼠血管平滑肌细胞炎症模型及其建立方法和应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687808A (en) 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
US5801154A (en) * 1993-10-18 1998-09-01 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of multidrug resistance-associated protein
JPH09124490A (ja) * 1995-10-27 1997-05-13 Eisai Co Ltd ヌクレオチド含有製剤
US6303374B1 (en) 2000-01-18 2001-10-16 Isis Pharmaceuticals Inc. Antisense modulation of caspase 3 expression
US6852709B2 (en) 2000-05-31 2005-02-08 Johns Hopkins University Biologically useful polyphosphates
US6998115B2 (en) 2000-10-10 2006-02-14 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
US7427394B2 (en) 2000-10-10 2008-09-23 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
US6514193B2 (en) * 2000-11-16 2003-02-04 Microspherix Llc Method of administering a therapeutically active substance
US6812217B2 (en) * 2000-12-04 2004-11-02 Medtronic, Inc. Medical device and methods of use
US20040121348A1 (en) * 2001-10-26 2004-06-24 Ribopharma Ag Compositions and methods for treating pancreatic cancer
US20040063654A1 (en) * 2001-11-02 2004-04-01 Davis Mark E. Methods and compositions for therapeutic use of RNA interference
US20060160759A1 (en) * 2002-09-28 2006-07-20 Jianzhu Chen Influenza therapeutic
US20070207211A1 (en) * 2003-04-10 2007-09-06 Pr Pharmaceuticals, Inc. Emulsion-based microparticles and methods for the production thereof
US20060228404A1 (en) * 2004-03-04 2006-10-12 Anderson Daniel G Compositions and methods for treatment of hypertrophic tissues
EP1604697A1 (en) * 2004-06-09 2005-12-14 J.A.C.C. GmbH Implantable device
CA2583826A1 (en) * 2004-10-22 2006-05-04 Benitec, Inc. Therapeutic rnai agents for treating psoriasis
EP1679065A1 (en) * 2005-01-07 2006-07-12 OctoPlus Sciences B.V. Controlled release compositions for interferon based on PEGT/PBT block copolymers
US20100310670A1 (en) * 2005-09-02 2010-12-09 Takeda Pharmaceutical Company Limited Sustained-release microsphere containing short chain deoxyribonucleic acid or short chain ribonucleic acid and method of producing the same
JP5460054B2 (ja) * 2005-11-23 2014-04-02 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム 腫瘍形成性ras特異的細胞障害性化合物およびその使用法
US8138160B2 (en) 2006-08-03 2012-03-20 Warsaw Orthopedic, Inc. Reagents, methods and systems to suppress pro-inflammatory cytokines
US8936794B2 (en) * 2006-08-25 2015-01-20 The Regents Of The University Of Michigan Conducting polymer nanotube actuators for precisely controlled release of medicine and bioactive molecules
US8039010B2 (en) 2006-11-03 2011-10-18 Allergan, Inc. Sustained release intraocular drug delivery systems comprising a water soluble therapeutic agent and a release modifier
WO2008073856A2 (en) 2006-12-08 2008-06-19 Massachusetts Institute Of Technology Delivery of nanoparticles and/or agents to cells
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
US20090149569A1 (en) * 2007-07-19 2009-06-11 Shastri V Prasad Surface engineering of tissue graft materials for enhanced porosity and cell adhesion

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