JP2011525361A5 - - Google Patents
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- Publication number
- JP2011525361A5 JP2011525361A5 JP2011515164A JP2011515164A JP2011525361A5 JP 2011525361 A5 JP2011525361 A5 JP 2011525361A5 JP 2011515164 A JP2011515164 A JP 2011515164A JP 2011515164 A JP2011515164 A JP 2011515164A JP 2011525361 A5 JP2011525361 A5 JP 2011525361A5
- Authority
- JP
- Japan
- Prior art keywords
- spqqgdh
- seq
- wild type
- sequence
- acinetobacter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000589291 Acinetobacter Species 0.000 claims 2
- 230000037431 insertion Effects 0.000 claims 2
- 238000003780 insertion Methods 0.000 claims 2
- MMXZSJMASHPLLR-UHFFFAOYSA-N pyrroloquinoline quinone Chemical compound C12=C(C(O)=O)C=C(C(O)=O)N=C2C(=O)C(=O)C2=C1NC(C(=O)O)=C2 MMXZSJMASHPLLR-UHFFFAOYSA-N 0.000 claims 2
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008030435A DE102008030435A1 (de) | 2008-06-26 | 2008-06-26 | Neuartige Varianten PQQ-abhängiger Glukosehydrogenase mit verbesserter Substratspezifität |
| DE102008030435.2 | 2008-06-26 | ||
| PCT/EP2009/004350 WO2009156083A1 (de) | 2008-06-26 | 2009-06-17 | Neuartige varianten pqq-abhängiger glukosedehydrogenase mit verbesserter substratspezifität |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011525361A JP2011525361A (ja) | 2011-09-22 |
| JP2011525361A5 true JP2011525361A5 (enExample) | 2012-08-02 |
Family
ID=40972803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011515164A Pending JP2011525361A (ja) | 2008-06-26 | 2009-06-17 | 向上した基質特異性を有するpqq−依存的グルコースデヒドロゲナーゼの新規変異体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8580547B2 (enExample) |
| EP (1) | EP2294188A1 (enExample) |
| JP (1) | JP2011525361A (enExample) |
| CN (2) | CN102076846A (enExample) |
| DE (1) | DE102008030435A1 (enExample) |
| WO (1) | WO2009156083A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2655650B1 (en) | 2010-12-20 | 2017-12-20 | LEK Pharmaceuticals d.d. | Enzymatic synthesis of active pharmaceutical ingredient and intermediates thereof |
| EP2465936A1 (en) | 2010-12-20 | 2012-06-20 | LEK Pharmaceuticals d.d. | Enzymatic synthesis of statins and intermediates thereof |
| CN111073866B (zh) | 2015-10-29 | 2024-03-19 | 英科隆生物技术(杭州)有限公司 | PQQ-sGDH突变体、聚核苷酸及其在葡萄糖检测中的应用 |
| CN109085269B (zh) * | 2018-08-15 | 2021-03-09 | 江苏省原子医学研究所 | PQQ与Lys及Arg反应行为研究的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1184472C (zh) | 1999-10-05 | 2005-01-12 | 松下电器产业株式会社 | 葡萄糖传感器 |
| WO2002034919A1 (en) | 2000-10-27 | 2002-05-02 | Roche Diagnostics Gmbh | Variants of soluble pyrroloquinoline quinone-dependent glucose dehydrogenase |
| EP1367120A3 (en) | 2002-05-27 | 2004-06-02 | Toyo Boseki Kabushiki Kaisha | Modified pyrroloquinoline quinone (PQQ) dependent glucose dehydrogenase with superior substrate specificity and stability |
| DE10320259A1 (de) | 2003-05-07 | 2004-11-25 | Bayer Technology Services Gmbh | Neuartige Glukose Dehydrogenase und ihre Herstellung |
| DE602004023736D1 (de) | 2003-09-08 | 2009-12-03 | Toyo Boseki | Pyrrolochinolin-chinon (pqq)-abhängige glucosedehydrogenase-modifikation mit ausgezeichneter substratspezifität |
| JP2007043983A (ja) * | 2005-08-11 | 2007-02-22 | Toyobo Co Ltd | 基質特異性に優れた改変型ピロロキノリンキノン依存性グルコースデヒドロゲナーゼ |
| JP2007000020A (ja) * | 2005-06-21 | 2007-01-11 | Toyobo Co Ltd | 基質特異性に優れたピロロキノリンキノン(pqq)依存性グルコースデヒドロゲナーゼ改変体 |
| WO2006085509A1 (ja) * | 2005-02-08 | 2006-08-17 | Toyo Boseki Kabushiki Kaisha | 基質特異性に優れた改変型ピロロキノリンキノン依存性グルコースデヒドロゲナーゼ |
| JP2006217810A (ja) * | 2005-02-08 | 2006-08-24 | Toyobo Co Ltd | 基質特異性に優れたピロロキノリンキノン(pqq)依存性グルコースデヒドロゲナーゼ改変体 |
-
2008
- 2008-06-26 DE DE102008030435A patent/DE102008030435A1/de not_active Withdrawn
-
2009
- 2009-06-17 WO PCT/EP2009/004350 patent/WO2009156083A1/de not_active Ceased
- 2009-06-17 CN CN200980124063.5A patent/CN102076846A/zh active Pending
- 2009-06-17 EP EP09768932A patent/EP2294188A1/de not_active Withdrawn
- 2009-06-17 CN CN201310472347.1A patent/CN103540572A/zh active Pending
- 2009-06-17 US US12/999,465 patent/US8580547B2/en not_active Expired - Fee Related
- 2009-06-17 JP JP2011515164A patent/JP2011525361A/ja active Pending
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