JP2011523643A5 - - Google Patents
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- JP2011523643A5 JP2011523643A5 JP2011510067A JP2011510067A JP2011523643A5 JP 2011523643 A5 JP2011523643 A5 JP 2011523643A5 JP 2011510067 A JP2011510067 A JP 2011510067A JP 2011510067 A JP2011510067 A JP 2011510067A JP 2011523643 A5 JP2011523643 A5 JP 2011523643A5
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- JP
- Japan
- Prior art keywords
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- pharmaceutically acceptable
- acceptable salt
- item
- following formula
- Prior art date
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- 239000002502 liposome Substances 0.000 claims description 26
- 229910052760 oxygen Inorganic materials 0.000 claims description 18
- 229910052717 sulfur Inorganic materials 0.000 claims description 18
- 125000004432 carbon atom Chemical group C* 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 9
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- 125000006850 spacer group Chemical group 0.000 claims description 8
- -1 N-methyl-piperazino Chemical group 0.000 claims description 6
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 5
- 125000005647 linker group Chemical group 0.000 claims description 4
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000002947 alkylene group Chemical group 0.000 claims 6
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 description 26
- 125000005843 halogen group Chemical group 0.000 description 26
- 239000002105 nanoparticle Substances 0.000 description 23
- 125000000623 heterocyclic group Chemical group 0.000 description 20
- 229910052757 nitrogen Inorganic materials 0.000 description 19
- 239000003118 drug derivative Substances 0.000 description 18
- 125000005842 heteroatom Chemical group 0.000 description 16
- 125000000753 cycloalkyl group Chemical group 0.000 description 13
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 description 10
- 125000005865 C2-C10alkynyl group Chemical group 0.000 description 10
- 125000003118 aryl group Chemical group 0.000 description 10
- 125000001072 heteroaryl group Chemical group 0.000 description 10
- 229910052739 hydrogen Inorganic materials 0.000 description 10
- 238000000034 method Methods 0.000 description 10
- 125000004122 cyclic group Chemical group 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- 125000004433 nitrogen atom Chemical group N* 0.000 description 7
- 239000012528 membrane Substances 0.000 description 6
- 229910052710 silicon Inorganic materials 0.000 description 6
- 125000000739 C2-C30 alkenyl group Chemical group 0.000 description 4
- 125000000304 alkynyl group Chemical group 0.000 description 4
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 4
- 230000002378 acidificating effect Effects 0.000 description 3
- 125000005103 alkyl silyl group Chemical group 0.000 description 3
- BUZRUIZTMOKRPB-UHFFFAOYSA-N carboxycarbamic acid Chemical compound OC(=O)NC(O)=O BUZRUIZTMOKRPB-UHFFFAOYSA-N 0.000 description 3
- 125000005347 halocycloalkyl group Chemical group 0.000 description 3
- 125000004404 heteroalkyl group Chemical group 0.000 description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 3
- 125000004193 piperazinyl group Chemical group 0.000 description 3
- 230000007928 solubilization Effects 0.000 description 3
- 238000005063 solubilization Methods 0.000 description 3
- 125000001424 substituent group Chemical group 0.000 description 3
- 125000005346 substituted cycloalkyl group Chemical group 0.000 description 3
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 230000001268 conjugating effect Effects 0.000 description 2
- 125000006165 cyclic alkyl group Chemical group 0.000 description 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000003381 solubilizing effect Effects 0.000 description 2
- LWXIHPKOLTXDET-BYPYZUCNSA-N (2s)-2-(2-aminoethylamino)propanoic acid Chemical group OC(=O)[C@H](C)NCCN LWXIHPKOLTXDET-BYPYZUCNSA-N 0.000 description 1
- OHENVLLVUMQCNT-UHFFFAOYSA-N 2-(aminomethylamino)acetic acid Chemical group NCNCC(O)=O OHENVLLVUMQCNT-UHFFFAOYSA-N 0.000 description 1
- QZDZEQOMUGMANT-HGRCFPFLSA-N CC(C)(C)OC(N[C@H]([C@H](C(O[C@@H](C1)C(C)=C([C@H](C(C(C)([C@H](C[C@H]2OC[C@]22OC(C)=O)O)[C@@H]2[C@@]2(C3)OC(c4ccccc4)=O)=O)O)C3(C)[C@@]12O)=O)OC(CCCN1CCN(C)CC1)=O)c1ccccc1)=O Chemical compound CC(C)(C)OC(N[C@H]([C@H](C(O[C@@H](C1)C(C)=C([C@H](C(C(C)([C@H](C[C@H]2OC[C@]22OC(C)=O)O)[C@@H]2[C@@]2(C3)OC(c4ccccc4)=O)=O)O)C3(C)[C@@]12O)=O)OC(CCCN1CCN(C)CC1)=O)c1ccccc1)=O QZDZEQOMUGMANT-HGRCFPFLSA-N 0.000 description 1
- UQULALZGMRBUMD-FSBDEDPYSA-N CC(C)(C)OC(N[C@H]([C@H](C(O[C@@H](C1)C(C)=C([C@H](C([C@](C)([C@H](C[C@H]2OC3)O)[C@H]([C@@H]4OC(c5ccccc5)=O)[C@@]23OC(C)=O)=O)O)C(C)(C)[C@@]14O)=O)OC(CCN1CCCCC1)=O)c1ccccc1)=O Chemical compound CC(C)(C)OC(N[C@H]([C@H](C(O[C@@H](C1)C(C)=C([C@H](C([C@](C)([C@H](C[C@H]2OC3)O)[C@H]([C@@H]4OC(c5ccccc5)=O)[C@@]23OC(C)=O)=O)O)C(C)(C)[C@@]14O)=O)OC(CCN1CCCCC1)=O)c1ccccc1)=O UQULALZGMRBUMD-FSBDEDPYSA-N 0.000 description 1
- ORTQFODLPLMDGP-DNCPDDFDSA-N CC(C)(C)OC(N[C@H]([C@H](C(O[C@@H](C1)C(C)=C([C@H](C([C@](C)([C@H](C[C@H]2OC3)O)[C@H]([C@@H]4OC(c5ccccc5)=O)[C@@]23OC(C)=O)=O)O)C(C)(C)[C@@]14O)=O)OC(CN1CCOCC1)=O)c1ccccc1)=O Chemical compound CC(C)(C)OC(N[C@H]([C@H](C(O[C@@H](C1)C(C)=C([C@H](C([C@](C)([C@H](C[C@H]2OC3)O)[C@H]([C@@H]4OC(c5ccccc5)=O)[C@@]23OC(C)=O)=O)O)C(C)(C)[C@@]14O)=O)OC(CN1CCOCC1)=O)c1ccccc1)=O ORTQFODLPLMDGP-DNCPDDFDSA-N 0.000 description 1
- 241001481833 Coryphaena hippurus Species 0.000 description 1
- 239000005517 L01XE01 - Imatinib Substances 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- GPTXWRGISTZRIO-UHFFFAOYSA-N chlorquinaldol Chemical compound ClC1=CC(Cl)=C(O)C2=NC(C)=CC=C21 GPTXWRGISTZRIO-UHFFFAOYSA-N 0.000 description 1
- 229940126214 compound 3 Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- YLMAHDNUQAMNNX-UHFFFAOYSA-N imatinib methanesulfonate Chemical compound CS(O)(=O)=O.C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 YLMAHDNUQAMNNX-UHFFFAOYSA-N 0.000 description 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 1
- 229960004768 irinotecan Drugs 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5592908P | 2008-05-23 | 2008-05-23 | |
| US61/055,929 | 2008-05-23 | ||
| PCT/IB2009/006532 WO2009141738A2 (en) | 2008-05-23 | 2009-05-26 | Modified drugs for use in liposomal nanoparticles |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014043564A Division JP5744267B2 (ja) | 2008-05-23 | 2014-03-06 | リポソームナノ粒子中で使用するための修飾薬物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011523643A JP2011523643A (ja) | 2011-08-18 |
| JP2011523643A5 true JP2011523643A5 (cg-RX-API-DMAC7.html) | 2012-07-19 |
| JP5542804B2 JP5542804B2 (ja) | 2014-07-09 |
Family
ID=41340622
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011510067A Expired - Fee Related JP5542804B2 (ja) | 2008-05-23 | 2009-05-26 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2014043564A Expired - Fee Related JP5744267B2 (ja) | 2008-05-23 | 2014-03-06 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2014146559A Expired - Fee Related JP5992019B2 (ja) | 2008-05-23 | 2014-07-17 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2016159491A Expired - Fee Related JP6437968B2 (ja) | 2008-05-23 | 2016-08-16 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2018214441A Pending JP2019048851A (ja) | 2008-05-23 | 2018-11-15 | リポソームナノ粒子中で使用するための修飾薬物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014043564A Expired - Fee Related JP5744267B2 (ja) | 2008-05-23 | 2014-03-06 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2014146559A Expired - Fee Related JP5992019B2 (ja) | 2008-05-23 | 2014-07-17 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2016159491A Expired - Fee Related JP6437968B2 (ja) | 2008-05-23 | 2016-08-16 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2018214441A Pending JP2019048851A (ja) | 2008-05-23 | 2018-11-15 | リポソームナノ粒子中で使用するための修飾薬物 |
Country Status (9)
| Country | Link |
|---|---|
| US (7) | US8790691B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3415151A1 (cg-RX-API-DMAC7.html) |
| JP (5) | JP5542804B2 (cg-RX-API-DMAC7.html) |
| KR (5) | KR20190049930A (cg-RX-API-DMAC7.html) |
| CN (2) | CN102105135B (cg-RX-API-DMAC7.html) |
| CA (3) | CA2725535C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2694481T3 (cg-RX-API-DMAC7.html) |
| IL (2) | IL209419A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009141738A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190049930A (ko) * | 2008-05-23 | 2019-05-09 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 리포좀 나노입자에 사용하기 위한 변형된 약물 |
| CN102018672B (zh) * | 2010-11-29 | 2013-09-18 | 广州朗圣药业有限公司 | 一种水溶性药物的脂质体冻干组合物及其制备方法 |
| CN102617517B (zh) * | 2011-01-27 | 2015-11-18 | 李勤耕 | 一类新的7,10-o,o-二甲多西紫杉醇衍生物及其应用 |
| CN103338747A (zh) * | 2011-01-28 | 2013-10-02 | 皇家飞利浦电子股份有限公司 | 用于局部释放亲水性前药的载体 |
| US9375484B2 (en) | 2011-05-31 | 2016-06-28 | Regents Of The University Of Minnesota | Taxane silicate prodrugs and nanoparticles |
| WO2014058729A1 (en) * | 2012-10-09 | 2014-04-17 | California Institute Of Technology | In vivo and in vitro carbene insertion and nitrene transfer reactions catalyzed by heme enzymes |
| JP2015534464A (ja) | 2012-10-09 | 2015-12-03 | カリフォルニア インスティチュート オブ テクノロジー | ヘム酵素によって触媒されるインビボおよびインビトロオレフィンシクロプロパン化 |
| CN105188675A (zh) * | 2013-03-13 | 2015-12-23 | 马林克罗特有限公司 | 经修饰多西他赛脂质体制剂 |
| GB201315321D0 (en) * | 2013-08-28 | 2013-10-09 | Koninklijke Nederlandse Akademie Van Wetenschappen | Transduction Buffer |
| EP3052508A1 (en) | 2013-09-30 | 2016-08-10 | Danmarks Tekniske Universitet | Silicone chain extender |
| US9399762B2 (en) | 2014-02-18 | 2016-07-26 | California Institute Of Technology | Methods and systems for sulfimidation or sulfoximidation of organic molecules |
| CN105085437B (zh) * | 2014-05-23 | 2018-07-03 | 上海交通大学 | 3-(1-叔丁氧羰酰哌嗪-4-yl)丙酸的两亲性衍生物及其用途 |
| CN104368011B (zh) * | 2014-11-27 | 2017-05-10 | 东南大学 | 一种药物甜菜碱缀合物、其药物组合物及应用 |
| WO2016134066A1 (en) * | 2015-02-17 | 2016-08-25 | Mallinckrodt Llc | Modified docetaxel liposome formulations and uses thereof |
| TWI678213B (zh) * | 2015-07-22 | 2019-12-01 | 美商史倍壯製藥公司 | 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物 |
| EP3352733A1 (en) | 2015-09-21 | 2018-08-01 | Mallinckrodt LLC | Improved stability of liposome formulations and uses thereof |
| GB201521101D0 (en) | 2015-11-30 | 2016-01-13 | Koninklijke Nederlandse Akademie Van Wetenschappen | Transduction buffer |
| AU2016379454B2 (en) * | 2015-12-23 | 2021-01-28 | The University Of British Columbia | Lipid-linked prodrugs |
| WO2018160794A1 (en) | 2017-03-01 | 2018-09-07 | Merrimack Pharmaceuticals, Inc. | Epha2-targeted docetaxel -generating liposomes in combination with an agent that impedes regulatory t cell activity for treating cancer |
| CN109422759B (zh) * | 2017-08-22 | 2021-05-04 | 复旦大学 | 小分子修饰的紫杉烷类水溶性前药及其药用用途 |
| CN111004195B (zh) * | 2019-12-03 | 2022-01-28 | 沈阳药科大学 | 卡巴他赛弱碱性衍生物及其制剂 |
| JP2025537677A (ja) * | 2022-07-07 | 2025-11-20 | ナノスター・ファーマシューティカルズ・リミテッド | 多重層ベシクル薬物製剤 |
| CN117024381B (zh) * | 2023-08-14 | 2025-08-12 | 沈阳药科大学 | 卡巴他赛衍生物及其脂质体制剂 |
| CN118324842B (zh) * | 2024-04-10 | 2025-05-02 | 沈阳药科大学 | 地塞米松弱碱性衍生物及其制剂的制备及应用 |
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| JP2009528292A (ja) * | 2006-02-27 | 2009-08-06 | ザ ボード オブ トラスティーズ オブ レランド スタンフォード ジュニア ユニバーシティ | 生物学的障壁を越える増強された放出特性を有する分子の輸送のための組成物および方法 |
| TWI528976B (zh) * | 2006-12-13 | 2016-04-11 | 斯茹林製藥公司 | 用於醫物傳遞之以環糊精為基之聚合物 |
| CN101029034B (zh) | 2007-03-30 | 2010-05-26 | 浙江大学 | 多烯紫杉醇水溶性衍生物及制备方法和用途 |
| KR20190049930A (ko) * | 2008-05-23 | 2019-05-09 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 리포좀 나노입자에 사용하기 위한 변형된 약물 |
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2009
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- 2009-05-26 EP EP09750195.1A patent/EP2282724B1/en not_active Not-in-force
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