JP2011523643A5 - - Google Patents
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- JP2011523643A5 JP2011523643A5 JP2011510067A JP2011510067A JP2011523643A5 JP 2011523643 A5 JP2011523643 A5 JP 2011523643A5 JP 2011510067 A JP2011510067 A JP 2011510067A JP 2011510067 A JP2011510067 A JP 2011510067A JP 2011523643 A5 JP2011523643 A5 JP 2011523643A5
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- JP
- Japan
- Prior art keywords
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- pharmaceutically acceptable
- acceptable salt
- item
- following formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002502 liposome Substances 0.000 claims description 26
- 229910052760 oxygen Inorganic materials 0.000 claims description 18
- 229910052717 sulfur Inorganic materials 0.000 claims description 18
- 125000004432 carbon atom Chemical group C* 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 9
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- 125000006850 spacer group Chemical group 0.000 claims description 8
- -1 N-methyl-piperazino Chemical group 0.000 claims description 6
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 5
- 125000005647 linker group Chemical group 0.000 claims description 4
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000002947 alkylene group Chemical group 0.000 claims 6
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 description 26
- 125000005843 halogen group Chemical group 0.000 description 26
- 239000002105 nanoparticle Substances 0.000 description 23
- 125000000623 heterocyclic group Chemical group 0.000 description 20
- 229910052757 nitrogen Inorganic materials 0.000 description 19
- 239000003118 drug derivative Substances 0.000 description 18
- 125000005842 heteroatom Chemical group 0.000 description 16
- 125000000753 cycloalkyl group Chemical group 0.000 description 13
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 description 10
- 125000005865 C2-C10alkynyl group Chemical group 0.000 description 10
- 125000003118 aryl group Chemical group 0.000 description 10
- 125000001072 heteroaryl group Chemical group 0.000 description 10
- 229910052739 hydrogen Inorganic materials 0.000 description 10
- 238000000034 method Methods 0.000 description 10
- 125000004122 cyclic group Chemical group 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- 125000004433 nitrogen atom Chemical group N* 0.000 description 7
- 239000012528 membrane Substances 0.000 description 6
- 229910052710 silicon Inorganic materials 0.000 description 6
- 125000000739 C2-C30 alkenyl group Chemical group 0.000 description 4
- 125000000304 alkynyl group Chemical group 0.000 description 4
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 4
- 230000002378 acidificating effect Effects 0.000 description 3
- 125000005103 alkyl silyl group Chemical group 0.000 description 3
- BUZRUIZTMOKRPB-UHFFFAOYSA-N carboxycarbamic acid Chemical compound OC(=O)NC(O)=O BUZRUIZTMOKRPB-UHFFFAOYSA-N 0.000 description 3
- 125000005347 halocycloalkyl group Chemical group 0.000 description 3
- 125000004404 heteroalkyl group Chemical group 0.000 description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 3
- 125000004193 piperazinyl group Chemical group 0.000 description 3
- 230000007928 solubilization Effects 0.000 description 3
- 238000005063 solubilization Methods 0.000 description 3
- 125000001424 substituent group Chemical group 0.000 description 3
- 125000005346 substituted cycloalkyl group Chemical group 0.000 description 3
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 230000001268 conjugating effect Effects 0.000 description 2
- 125000006165 cyclic alkyl group Chemical group 0.000 description 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000003381 solubilizing effect Effects 0.000 description 2
- LWXIHPKOLTXDET-BYPYZUCNSA-N (2s)-2-(2-aminoethylamino)propanoic acid Chemical group OC(=O)[C@H](C)NCCN LWXIHPKOLTXDET-BYPYZUCNSA-N 0.000 description 1
- OHENVLLVUMQCNT-UHFFFAOYSA-N 2-(aminomethylamino)acetic acid Chemical group NCNCC(O)=O OHENVLLVUMQCNT-UHFFFAOYSA-N 0.000 description 1
- QZDZEQOMUGMANT-HGRCFPFLSA-N CC(C)(C)OC(N[C@H]([C@H](C(O[C@@H](C1)C(C)=C([C@H](C(C(C)([C@H](C[C@H]2OC[C@]22OC(C)=O)O)[C@@H]2[C@@]2(C3)OC(c4ccccc4)=O)=O)O)C3(C)[C@@]12O)=O)OC(CCCN1CCN(C)CC1)=O)c1ccccc1)=O Chemical compound CC(C)(C)OC(N[C@H]([C@H](C(O[C@@H](C1)C(C)=C([C@H](C(C(C)([C@H](C[C@H]2OC[C@]22OC(C)=O)O)[C@@H]2[C@@]2(C3)OC(c4ccccc4)=O)=O)O)C3(C)[C@@]12O)=O)OC(CCCN1CCN(C)CC1)=O)c1ccccc1)=O QZDZEQOMUGMANT-HGRCFPFLSA-N 0.000 description 1
- UQULALZGMRBUMD-FSBDEDPYSA-N CC(C)(C)OC(N[C@H]([C@H](C(O[C@@H](C1)C(C)=C([C@H](C([C@](C)([C@H](C[C@H]2OC3)O)[C@H]([C@@H]4OC(c5ccccc5)=O)[C@@]23OC(C)=O)=O)O)C(C)(C)[C@@]14O)=O)OC(CCN1CCCCC1)=O)c1ccccc1)=O Chemical compound CC(C)(C)OC(N[C@H]([C@H](C(O[C@@H](C1)C(C)=C([C@H](C([C@](C)([C@H](C[C@H]2OC3)O)[C@H]([C@@H]4OC(c5ccccc5)=O)[C@@]23OC(C)=O)=O)O)C(C)(C)[C@@]14O)=O)OC(CCN1CCCCC1)=O)c1ccccc1)=O UQULALZGMRBUMD-FSBDEDPYSA-N 0.000 description 1
- ORTQFODLPLMDGP-DNCPDDFDSA-N CC(C)(C)OC(N[C@H]([C@H](C(O[C@@H](C1)C(C)=C([C@H](C([C@](C)([C@H](C[C@H]2OC3)O)[C@H]([C@@H]4OC(c5ccccc5)=O)[C@@]23OC(C)=O)=O)O)C(C)(C)[C@@]14O)=O)OC(CN1CCOCC1)=O)c1ccccc1)=O Chemical compound CC(C)(C)OC(N[C@H]([C@H](C(O[C@@H](C1)C(C)=C([C@H](C([C@](C)([C@H](C[C@H]2OC3)O)[C@H]([C@@H]4OC(c5ccccc5)=O)[C@@]23OC(C)=O)=O)O)C(C)(C)[C@@]14O)=O)OC(CN1CCOCC1)=O)c1ccccc1)=O ORTQFODLPLMDGP-DNCPDDFDSA-N 0.000 description 1
- 241001481833 Coryphaena hippurus Species 0.000 description 1
- 239000005517 L01XE01 - Imatinib Substances 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- GPTXWRGISTZRIO-UHFFFAOYSA-N chlorquinaldol Chemical compound ClC1=CC(Cl)=C(O)C2=NC(C)=CC=C21 GPTXWRGISTZRIO-UHFFFAOYSA-N 0.000 description 1
- 229940126214 compound 3 Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- YLMAHDNUQAMNNX-UHFFFAOYSA-N imatinib methanesulfonate Chemical compound CS(O)(=O)=O.C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 YLMAHDNUQAMNNX-UHFFFAOYSA-N 0.000 description 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 1
- 229960004768 irinotecan Drugs 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5592908P | 2008-05-23 | 2008-05-23 | |
| US61/055,929 | 2008-05-23 | ||
| PCT/IB2009/006532 WO2009141738A2 (en) | 2008-05-23 | 2009-05-26 | Modified drugs for use in liposomal nanoparticles |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014043564A Division JP5744267B2 (ja) | 2008-05-23 | 2014-03-06 | リポソームナノ粒子中で使用するための修飾薬物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011523643A JP2011523643A (ja) | 2011-08-18 |
| JP2011523643A5 true JP2011523643A5 (OSRAM) | 2012-07-19 |
| JP5542804B2 JP5542804B2 (ja) | 2014-07-09 |
Family
ID=41340622
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011510067A Expired - Fee Related JP5542804B2 (ja) | 2008-05-23 | 2009-05-26 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2014043564A Expired - Fee Related JP5744267B2 (ja) | 2008-05-23 | 2014-03-06 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2014146559A Expired - Fee Related JP5992019B2 (ja) | 2008-05-23 | 2014-07-17 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2016159491A Expired - Fee Related JP6437968B2 (ja) | 2008-05-23 | 2016-08-16 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2018214441A Pending JP2019048851A (ja) | 2008-05-23 | 2018-11-15 | リポソームナノ粒子中で使用するための修飾薬物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014043564A Expired - Fee Related JP5744267B2 (ja) | 2008-05-23 | 2014-03-06 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2014146559A Expired - Fee Related JP5992019B2 (ja) | 2008-05-23 | 2014-07-17 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2016159491A Expired - Fee Related JP6437968B2 (ja) | 2008-05-23 | 2016-08-16 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2018214441A Pending JP2019048851A (ja) | 2008-05-23 | 2018-11-15 | リポソームナノ粒子中で使用するための修飾薬物 |
Country Status (9)
| Country | Link |
|---|---|
| US (7) | US8790691B2 (OSRAM) |
| EP (2) | EP3415151A1 (OSRAM) |
| JP (5) | JP5542804B2 (OSRAM) |
| KR (5) | KR101975843B1 (OSRAM) |
| CN (2) | CN104622809B (OSRAM) |
| CA (3) | CA2725535C (OSRAM) |
| ES (1) | ES2694481T3 (OSRAM) |
| IL (2) | IL209419A (OSRAM) |
| WO (1) | WO2009141738A2 (OSRAM) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101975843B1 (ko) * | 2008-05-23 | 2019-05-09 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 리포좀 나노입자에 사용하기 위한 변형된 약물 |
| CN102018672B (zh) * | 2010-11-29 | 2013-09-18 | 广州朗圣药业有限公司 | 一种水溶性药物的脂质体冻干组合物及其制备方法 |
| CN102617517B (zh) * | 2011-01-27 | 2015-11-18 | 李勤耕 | 一类新的7,10-o,o-二甲多西紫杉醇衍生物及其应用 |
| EP2667848A1 (en) | 2011-01-28 | 2013-12-04 | Koninklijke Philips N.V. | Carriers for the local release of hydrophilic prodrugs |
| WO2012166949A1 (en) * | 2011-05-31 | 2012-12-06 | Regents Of The University Of Minnesota | Silicate prodrugs and nanoparticles |
| WO2014058744A2 (en) | 2012-10-09 | 2014-04-17 | California Institute Of Technology | In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes |
| WO2014058729A1 (en) * | 2012-10-09 | 2014-04-17 | California Institute Of Technology | In vivo and in vitro carbene insertion and nitrene transfer reactions catalyzed by heme enzymes |
| JP6294456B2 (ja) * | 2013-03-13 | 2018-03-14 | マリンクロッド エルエルシー | 修飾されたドセタキセルリポソーム製剤 |
| GB201315321D0 (en) * | 2013-08-28 | 2013-10-09 | Koninklijke Nederlandse Akademie Van Wetenschappen | Transduction Buffer |
| WO2015043792A1 (en) | 2013-09-30 | 2015-04-02 | Danmarks Tekniske Universitet | Silicone chain extender |
| US9399762B2 (en) | 2014-02-18 | 2016-07-26 | California Institute Of Technology | Methods and systems for sulfimidation or sulfoximidation of organic molecules |
| CN105085437B (zh) * | 2014-05-23 | 2018-07-03 | 上海交通大学 | 3-(1-叔丁氧羰酰哌嗪-4-yl)丙酸的两亲性衍生物及其用途 |
| CN104368011B (zh) * | 2014-11-27 | 2017-05-10 | 东南大学 | 一种药物甜菜碱缀合物、其药物组合物及应用 |
| EP3258913A1 (en) * | 2015-02-17 | 2017-12-27 | Mallinckrodt Nuclear Medicine LLC | Modified docetaxel liposome formulations and uses thereof |
| TWI678213B (zh) * | 2015-07-22 | 2019-12-01 | 美商史倍壯製藥公司 | 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物 |
| US20180344644A1 (en) * | 2015-09-21 | 2018-12-06 | Mallinckrodt Llc | Improved stability of liposome formulations and uses thereof |
| GB201521101D0 (en) | 2015-11-30 | 2016-01-13 | Koninklijke Nederlandse Akademie Van Wetenschappen | Transduction buffer |
| ES2954596T3 (es) * | 2015-12-23 | 2023-11-23 | Univ British Columbia | Profármacos unidos a lípidos |
| WO2018160794A1 (en) | 2017-03-01 | 2018-09-07 | Merrimack Pharmaceuticals, Inc. | Epha2-targeted docetaxel -generating liposomes in combination with an agent that impedes regulatory t cell activity for treating cancer |
| CN109422759B (zh) * | 2017-08-22 | 2021-05-04 | 复旦大学 | 小分子修饰的紫杉烷类水溶性前药及其药用用途 |
| CN111004195B (zh) * | 2019-12-03 | 2022-01-28 | 沈阳药科大学 | 卡巴他赛弱碱性衍生物及其制剂 |
| JP2025537677A (ja) * | 2022-07-07 | 2025-11-20 | ナノスター・ファーマシューティカルズ・リミテッド | 多重層ベシクル薬物製剤 |
| CN117024381B (zh) * | 2023-08-14 | 2025-08-12 | 沈阳药科大学 | 卡巴他赛衍生物及其脂质体制剂 |
| CN118324842B (zh) * | 2024-04-10 | 2025-05-02 | 沈阳药科大学 | 地塞米松弱碱性衍生物及其制剂的制备及应用 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2979518A (en) * | 1956-08-14 | 1961-04-11 | Organon | New steroid alaninates |
| GB1272841A (en) * | 1969-01-23 | 1972-05-03 | Leo Ab | New corticoid steroid compounds of cytostatic interest |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4443440A (en) * | 1982-08-30 | 1984-04-17 | The Upjohn Company | Amine containing ester prodrugs of corticosteroids |
| US4501728A (en) * | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| DE3587342T2 (de) * | 1984-10-04 | 1993-12-02 | Sandoz Ag | Cyclosporine. |
| US4975282A (en) * | 1985-06-26 | 1990-12-04 | The Liposome Company, Inc. | Multilamellar liposomes having improved trapping efficiencies |
| US4737323A (en) * | 1986-02-13 | 1988-04-12 | Liposome Technology, Inc. | Liposome extrusion method |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| JPH01117885A (ja) * | 1987-10-30 | 1989-05-10 | Dai Ichi Seiyaku Co Ltd | 新規ボドフィロトキシン誘導体及びその製造法 |
| ZA886810B (en) * | 1987-12-18 | 1989-08-30 | Bristol Myers Co | Epipodophyllotoxin glucoside 4'-acyl derivatives |
| US4942184A (en) * | 1988-03-07 | 1990-07-17 | The United States Of America As Represented By The Department Of Health And Human Services | Water soluble, antineoplastic derivatives of taxol |
| IL91664A (en) | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
| US4960790A (en) * | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
| US5457111A (en) * | 1991-09-05 | 1995-10-10 | Abbott Laboratories | Macrocyclic immunomodulators |
| US5534632A (en) * | 1991-09-05 | 1996-07-09 | Abbott Laboratories | Macrocyclic carbamate immunomodulators |
| US5563172A (en) * | 1991-09-05 | 1996-10-08 | Abbott Laboratories | Macrocyclic amide and urea immunomodulators |
| JPH069600A (ja) | 1992-05-06 | 1994-01-18 | Bristol Myers Squibb Co | タクソールのベンゾエート誘導体 |
| US5547981A (en) * | 1993-03-09 | 1996-08-20 | Enzon, Inc. | Taxol-7-carbazates |
| US5475011A (en) * | 1993-03-26 | 1995-12-12 | The Research Foundation Of State University Of New York | Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment |
| EP0727992A4 (en) * | 1993-10-20 | 2001-01-31 | Enzon Inc | SUBSTITUTED TAXOID SUBSTANCES IN 2 'AND / OR 7' POSITION |
| US5489589A (en) * | 1994-12-07 | 1996-02-06 | Bristol-Myers Squibb Company | Amino acid derivatives of paclitaxel |
| JPH09110865A (ja) * | 1995-08-15 | 1997-04-28 | Masao Oguro | タキソール誘導体 |
| US6107332A (en) | 1995-09-12 | 2000-08-22 | The Liposome Company, Inc. | Hydrolysis-promoting hydrophobic taxane derivatives |
| ES2208946T3 (es) * | 1996-08-23 | 2004-06-16 | Sequus Pharmaceuticals, Inc. | Liposomas que contienen un compuesto de cisplatino. |
| GB9814527D0 (en) * | 1998-07-03 | 1998-09-02 | Cyclacel Ltd | Delivery system |
| US6365179B1 (en) * | 1999-04-23 | 2002-04-02 | Alza Corporation | Conjugate having a cleavable linkage for use in a liposome |
| FR2810321B1 (fr) * | 2000-06-20 | 2002-07-26 | Adir | Nouveaux derives de podophyllotoxine carbamate et thiocarbamate, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN1284523C (zh) * | 2000-10-04 | 2006-11-15 | 协和发酵工业株式会社 | 由脂质膜被覆微粒的方法 |
| US6855720B2 (en) * | 2001-03-01 | 2005-02-15 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
| US6403604B1 (en) * | 2001-03-01 | 2002-06-11 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
| JP2005500988A (ja) * | 2001-03-23 | 2005-01-13 | ルイトポルド・ファーマシューティカルズ・インコーポレーテッド | 脂肪族アミン薬物複合体 |
| CA2442539C (en) * | 2001-03-27 | 2011-11-08 | Phares Pharmaceutical Research N.V. | Method and composition for solubilising a biologically active compound with low water solubility |
| GB0111279D0 (en) * | 2001-05-10 | 2001-06-27 | Nycomed Imaging As | Radiolabelled liposomes |
| ITMI20020148A1 (it) * | 2002-01-29 | 2003-07-29 | Nicox Sa | Nuovi corticosteroidi |
| US20050152962A1 (en) * | 2002-06-12 | 2005-07-14 | Metselaar Josbert M. | Composition for treatment of inflammatory disorders |
| EP1585504A4 (en) * | 2002-11-06 | 2009-07-15 | Azaya Therapeutics Inc | Protein stabilized liposomal formulations of pharmaceutical active ingredients |
| US7342114B2 (en) * | 2003-07-01 | 2008-03-11 | California Pacific Medical Center | Podophyllotoxin derivatives |
| US8173840B2 (en) * | 2003-07-29 | 2012-05-08 | Signature R&D Holdings, Llc | Compounds with high therapeutic index |
| US20050095283A1 (en) | 2003-09-16 | 2005-05-05 | Aphios Corporation | Compositions and methods for topically treating diseases |
| EP1689439A2 (en) * | 2003-09-22 | 2006-08-16 | Acidophil LLC | Small molecule compositions and methods for increasing drug efficiency using compositions thereof |
| EP1537858A1 (en) * | 2003-12-04 | 2005-06-08 | Vectron Therapeutics AG | Drug delivery vehicles and uses thereof |
| EP1706148A2 (en) * | 2004-01-14 | 2006-10-04 | Gilead Sciences, Inc. | Lipid-based dispersions useful for drug delivery |
| CA2821167C (en) * | 2004-05-03 | 2016-06-28 | Merrimack Pharmaceuticals, Inc. | Drug delivery liposomes containing anionic polyols or anionic sugars |
| WO2006027787A1 (en) * | 2004-09-09 | 2006-03-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposomal compositions of glucocorticoid and glucocorticoid derivatives |
| MX2007005234A (es) * | 2004-10-29 | 2008-03-10 | Neopharm Inc | Proceso de fabricacion para preparaciones liposomales. |
| JP4504845B2 (ja) * | 2005-03-11 | 2010-07-14 | テスコ・エコライティング株式会社 | 照明器具用下部反射板の取り付け具 |
| EP1896007B1 (en) * | 2005-05-04 | 2014-03-19 | Medigene AG | Method of administering a cationic liposomal preparation comprising paclitexel |
| CA2608631C (en) * | 2005-06-09 | 2014-07-29 | Biolipox Ab | Method and composition for treating inflammatory disorders |
| US8653238B2 (en) * | 2006-02-27 | 2014-02-18 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for transport of molecules with enhanced release properties across biological barriers |
| TW201509433A (zh) * | 2006-12-13 | 2015-03-16 | Cerulean Pharma Inc | 用於醫物傳遞之以環糊精為基之聚合物 |
| CN101029034B (zh) | 2007-03-30 | 2010-05-26 | 浙江大学 | 多烯紫杉醇水溶性衍生物及制备方法和用途 |
| KR101975843B1 (ko) * | 2008-05-23 | 2019-05-09 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 리포좀 나노입자에 사용하기 위한 변형된 약물 |
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2009
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- 2009-05-26 EP EP18185021.5A patent/EP3415151A1/en not_active Withdrawn
- 2009-05-26 KR KR1020197012513A patent/KR20190049930A/ko not_active Ceased
- 2009-05-26 US US12/993,482 patent/US8790691B2/en not_active Expired - Fee Related
- 2009-05-26 KR KR1020167025450A patent/KR101830018B1/ko not_active Expired - Fee Related
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