JP2011521054A5 - - Google Patents
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- JP2011521054A5 JP2011521054A5 JP2011509670A JP2011509670A JP2011521054A5 JP 2011521054 A5 JP2011521054 A5 JP 2011521054A5 JP 2011509670 A JP2011509670 A JP 2011509670A JP 2011509670 A JP2011509670 A JP 2011509670A JP 2011521054 A5 JP2011521054 A5 JP 2011521054A5
- Authority
- JP
- Japan
- Prior art keywords
- copolymer
- group
- alkyl
- normal physiological
- block
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001577 copolymer Polymers 0.000 claims 21
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 7
- 239000000470 constituent Substances 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000002091 cationic group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000007935 neutral effect Effects 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 230000005588 protonation Effects 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000000129 anionic group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 229920000359 diblock copolymer Polymers 0.000 claims 1
- 230000014509 gene expression Effects 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
Applications Claiming Priority (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5290808P | 2008-05-13 | 2008-05-13 | |
| US5291408P | 2008-05-13 | 2008-05-13 | |
| US61/052,908 | 2008-05-13 | ||
| US61/052,914 | 2008-05-13 | ||
| US9129408P | 2008-08-22 | 2008-08-22 | |
| US61/091,294 | 2008-08-22 | ||
| US11205408P | 2008-11-06 | 2008-11-06 | |
| US11204808P | 2008-11-06 | 2008-11-06 | |
| US61/112,054 | 2008-11-06 | ||
| US61/112,048 | 2008-11-06 | ||
| US12076908P | 2008-12-08 | 2008-12-08 | |
| US61/120,769 | 2008-12-08 | ||
| US14077408P | 2008-12-24 | 2008-12-24 | |
| US14077908P | 2008-12-24 | 2008-12-24 | |
| US61/140,774 | 2008-12-24 | ||
| US61/140,779 | 2008-12-24 | ||
| US17137709P | 2009-04-21 | 2009-04-21 | |
| US61/171,377 | 2009-04-21 | ||
| PCT/US2009/043847 WO2009140427A2 (en) | 2008-05-13 | 2009-05-13 | Diblock copolymers and polynucleotide complexes thereof for delivery into cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015200236A Division JP6239565B2 (ja) | 2008-05-13 | 2015-10-08 | 細胞内に送達するためのジブロックコポリマーおよびそのポリヌクレオチド複合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011521054A JP2011521054A (ja) | 2011-07-21 |
| JP2011521054A5 true JP2011521054A5 (https=) | 2012-07-05 |
| JP5911723B2 JP5911723B2 (ja) | 2016-04-27 |
Family
ID=41319323
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011509670A Expired - Fee Related JP5911723B2 (ja) | 2008-05-13 | 2009-05-13 | 細胞内に送達するためのジブロックコポリマーおよびそのポリヌクレオチド複合体 |
| JP2015200236A Active JP6239565B2 (ja) | 2008-05-13 | 2015-10-08 | 細胞内に送達するためのジブロックコポリマーおよびそのポリヌクレオチド複合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015200236A Active JP6239565B2 (ja) | 2008-05-13 | 2015-10-08 | 細胞内に送達するためのジブロックコポリマーおよびそのポリヌクレオチド複合体 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9476063B2 (https=) |
| EP (2) | EP2281011B1 (https=) |
| JP (2) | JP5911723B2 (https=) |
| KR (1) | KR101661636B1 (https=) |
| CN (2) | CN103342789B (https=) |
| AU (1) | AU2009246327B8 (https=) |
| BR (1) | BRPI0912159B8 (https=) |
| CA (3) | CA3065577C (https=) |
| ES (1) | ES2404131T3 (https=) |
| IL (1) | IL209238A (https=) |
| MX (1) | MX2010012238A (https=) |
| WO (1) | WO2009140427A2 (https=) |
| ZA (1) | ZA201008729B (https=) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103342789B (zh) | 2008-05-13 | 2016-11-23 | 华盛顿大学 | 用于向细胞内递送的二嵌段共聚物和其多核苷酸复合物 |
| WO2009140421A2 (en) | 2008-05-13 | 2009-11-19 | University Of Washington | Polymeric carrier |
| KR101764427B1 (ko) | 2008-05-13 | 2017-08-02 | 유니버시티 오브 워싱톤 | 미셀성 어셈블리 |
| WO2010021770A1 (en) | 2008-08-22 | 2010-02-25 | University Of Washington | Heterogeneous polymeric micelles for intracellular delivery |
| EP2352522A4 (en) | 2008-11-06 | 2014-03-05 | Univ Washington | BISPECIFIC AUXILIARIES FOR INTRA-CELLULAR RELEASE |
| EP2364330B1 (en) * | 2008-11-06 | 2015-03-25 | University Of Washington | Multiblock copolymers |
| US9593169B2 (en) | 2008-12-08 | 2017-03-14 | University Of Washington | Omega-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization |
| WO2011060281A1 (en) * | 2009-11-13 | 2011-05-19 | University Of Washington Through Its Center For Commercialization | Hydrophobic block conjugated therapeutic agents |
| WO2011062965A2 (en) | 2009-11-18 | 2011-05-26 | University Of Washington Through Its Center For Commercialization | Targeting monomers and polymers having targeting blocks |
| US8349308B2 (en) | 2010-03-26 | 2013-01-08 | Mersana Therapeutics, Inc. | Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| RU2013120302A (ru) | 2010-10-01 | 2014-11-20 | Модерна Терапьютикс, Инк. | Сконструированные нуклеиновые кислоты и способы их применения |
| EP2691101A2 (en) | 2011-03-31 | 2014-02-05 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| WO2013032829A1 (en) | 2011-08-26 | 2013-03-07 | Arrowhead Research Corporation | Poly(vinyl ester) polymers for in vivo nucleic acid delivery |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| MX361938B (es) * | 2011-09-13 | 2018-12-19 | Monsanto Technology Llc | Métodos y composiciones para el control de malezas. |
| RU2648950C2 (ru) | 2011-10-03 | 2018-04-02 | Модерна Терапьютикс, Инк. | Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение |
| CN104114572A (zh) | 2011-12-16 | 2014-10-22 | 现代治疗公司 | 经修饰的核苷、核苷酸和核酸组合物 |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| AU2013243948A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins associated with human disease |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| JP2015515530A (ja) * | 2012-04-18 | 2015-05-28 | アローヘッド リサーチ コーポレイション | インビボ核酸送達のためのポリ（アクリラート）ポリマー |
| US9808480B2 (en) | 2012-04-27 | 2017-11-07 | Nanocarrier Co., Ltd. | Unit structure-type pharmaceutical composition for nucleic acid delivery |
| MX360866B (es) | 2012-05-24 | 2018-11-09 | A B Seeds Ltd | Composiciones y métodos para silenciar la expresión genética. |
| US10046086B2 (en) | 2012-09-21 | 2018-08-14 | Vanderbilt University | Poly(thioketal-urethane) scaffolds and methods of use |
| WO2014047524A1 (en) | 2012-09-21 | 2014-03-27 | Vanderbilt University | Poly(thioketal-urethane) scaffolds and methods of use |
| WO2014081507A1 (en) | 2012-11-26 | 2014-05-30 | Moderna Therapeutics, Inc. | Terminally modified rna |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| EP3027221A1 (en) * | 2013-07-30 | 2016-06-08 | PhaseRx, Inc. | Block copolymers and their conjugates or complexes with oligonucleotides |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| JP2016538829A (ja) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 低密度リポタンパク質受容体をコードするポリヌクレオチド |
| JP6564369B2 (ja) | 2013-12-09 | 2019-08-21 | デュレクト コーポレイション | 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法 |
| RS60902B1 (sr) | 2014-03-09 | 2020-11-30 | Univ Pennsylvania | Kompozicije korisne u lečenju nedostatka ornitinske transkarbamilaze (otc) |
| US9993563B2 (en) * | 2014-03-28 | 2018-06-12 | Aposense Ltd. | Compounds and methods for trans-membrane delivery of molecules |
| CA2944141C (en) * | 2014-03-28 | 2023-03-28 | Aposense Ltd. | Compounds and methods for trans-membrane delivery of molecules |
| US11318206B2 (en) | 2014-03-28 | 2022-05-03 | Aposense Ltd | Compounds and methods for trans-membrane delivery of molecules |
| US10695288B2 (en) | 2014-11-19 | 2020-06-30 | Vanderbilt University | Reactive oxygen species (ROS)-responsive compositions and methods thereof |
| US11219634B2 (en) | 2015-01-21 | 2022-01-11 | Genevant Sciences Gmbh | Methods, compositions, and systems for delivering therapeutic and diagnostic agents into cells |
| US10676726B2 (en) | 2015-02-09 | 2020-06-09 | Duke University | Compositions and methods for epigenome editing |
| EP3288594B1 (en) | 2015-04-27 | 2022-06-29 | The Trustees of The University of Pennsylvania | Dual aav vector system for crispr/cas9 mediated correction of human disease |
| WO2017015637A1 (en) | 2015-07-22 | 2017-01-26 | Duke University | High-throughput screening of regulatory element function with epigenome editing technologies |
| EP3341727B1 (en) | 2015-08-25 | 2022-08-10 | Duke University | Compositions and methods of improving specificity in genomic engineering using rna-guided endonucleases |
| EP4089175A1 (en) | 2015-10-13 | 2022-11-16 | Duke University | Genome engineering with type i crispr systems in eukaryotic cells |
| US10947338B2 (en) * | 2016-03-29 | 2021-03-16 | Lg Chem, Ltd. | Block polymer and polymer electrolyte membrane comprising same |
| US20190127713A1 (en) | 2016-04-13 | 2019-05-02 | Duke University | Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use |
| WO2018017754A1 (en) | 2016-07-19 | 2018-01-25 | Duke University | Therapeutic applications of cpf1-based genome editing |
| KR102350647B1 (ko) | 2016-09-02 | 2022-01-14 | 다이서나 파마수이티컬, 인크. | 4'-포스페이트 유사체 및 이를 포함하는 올리고뉴클레오타이드 |
| WO2018126084A1 (en) | 2016-12-30 | 2018-07-05 | Phaserx, Inc. | Branched peg molecules and related compositions and methods |
| IL267919B2 (en) | 2017-01-09 | 2024-03-01 | Aposense Ltd | Compounds and methods for transmembrane transfer of molecules |
| US11786607B2 (en) | 2017-06-15 | 2023-10-17 | Modernatx, Inc. | RNA formulations |
| EP3677268A4 (en) | 2017-08-31 | 2021-04-21 | The University Of Tokyo | UNIFORM POLYIONAL COMPLEX LOADED WITH NUCLEIC ACID |
| WO2019046809A1 (en) | 2017-08-31 | 2019-03-07 | Modernatx, Inc. | METHODS OF MANUFACTURING LIPID NANOPARTICLES |
| IL275773B2 (en) | 2018-01-01 | 2025-07-01 | Aposense Ltd | Compounds and methods for trans-membrane delivery of molecules |
| CN113271926A (zh) | 2018-09-20 | 2021-08-17 | 摩登纳特斯有限公司 | 脂质纳米颗粒的制备及其施用方法 |
| WO2020092633A1 (en) * | 2018-10-30 | 2020-05-07 | Vanderbilt University | Graft copolymers, methods of forming graft copolymers, and methods of use thereof |
| JP7389055B2 (ja) * | 2019-01-09 | 2023-11-29 | デンカ株式会社 | トリブロック共重合体及びトリブロック共重合体の製造方法 |
| WO2020205473A1 (en) | 2019-03-29 | 2020-10-08 | Decerna Pharmaceuticals, Inc. | Compositions and methods for the treatment of kras associated diseases or disorders |
| WO2020226960A1 (en) | 2019-05-03 | 2020-11-12 | Dicerna Pharmaceuticals, Inc. | Double-stranded nucleic acid inhibitor molecules with shortened sense strands |
| BR112022013821A2 (pt) | 2020-01-15 | 2022-09-13 | Dicerna Pharmaceuticals Inc | Ácidos nucleicos de 4?-o-metileno fosfonato e seus análogos |
| KR20230004841A (ko) * | 2020-04-30 | 2023-01-06 | 다우 글로벌 테크놀로지스 엘엘씨 | Raft 중합에 의해 올레핀-아크릴레이트 블록 공중합체를 제조하는 방법 |
| IL300283A (en) | 2020-08-04 | 2023-04-01 | Dicerna Pharmaceuticals Inc | Systemic administration of oligonucleotides |
| CN113087017A (zh) * | 2021-04-06 | 2021-07-09 | 中国科学院理化技术研究所 | 一种偏钒酸钠纳米球及其制备方法和应用 |
| IL317874A (en) | 2022-06-24 | 2025-02-01 | Tune Therapeutics Inc | Compounds, systems and methods for reducing low density lipoproteins through targeted gene suppression |
| WO2025072751A1 (en) | 2023-09-29 | 2025-04-03 | Battelle Memorial Institute | Polymer nanoparticle compositions for in vivo expression of polypeptides |
| WO2025072893A1 (en) | 2023-09-29 | 2025-04-03 | Battelle Memorial Institute | Polymer nanoparticle compositions for non-viral gene delivery |
| WO2025250979A1 (en) | 2024-05-31 | 2025-12-04 | Battelle Memorial Institute | Polymer nanoparticle compositions for non-viral gene delivery |
| US20260090998A1 (en) | 2024-10-02 | 2026-04-02 | Battelle Memorial Institute | Methods of using polymer nanoparticle compositions for treating a disease |
Family Cites Families (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5057313A (en) * | 1986-02-25 | 1991-10-15 | The Center For Molecular Medicine And Immunology | Diagnostic and therapeutic antibody conjugates |
| US4699784A (en) * | 1986-02-25 | 1987-10-13 | Center For Molecular Medicine & Immunology | Tumoricidal methotrexate-antibody conjugate |
| US4877603A (en) | 1987-12-18 | 1989-10-31 | The Procter & Gamble Company | Oral compositions |
| US6359054B1 (en) * | 1994-11-18 | 2002-03-19 | Supratek Pharma Inc. | Polynucleotide compositions for intramuscular administration |
| FR2767829B1 (fr) | 1997-09-01 | 1999-12-03 | Georges Sturtz | Composes phosphonates ou gem-bisphosphonates acryliques ou methacryliques |
| US6210717B1 (en) | 1997-12-12 | 2001-04-03 | Samyang Corporation | Biodegradable mixed polymeric micelles for gene delivery |
| US6410057B1 (en) * | 1997-12-12 | 2002-06-25 | Samyang Corporation | Biodegradable mixed polymeric micelles for drug delivery |
| US6383811B2 (en) * | 1997-12-30 | 2002-05-07 | Mirus Corporation | Polyampholytes for delivering polyions to a cell |
| ATE443528T1 (de) * | 1998-01-05 | 2009-10-15 | Univ Washington | Erhöhter transport unter benutzung membranzerstörender stoffe |
| US6306994B1 (en) * | 1999-05-14 | 2001-10-23 | E. I. Du Pont De Nemours And Company | Inks with enhanced substrate binding characteristics |
| US8137695B2 (en) | 2006-08-18 | 2012-03-20 | Arrowhead Madison Inc. | Polyconjugates for in vivo delivery of polynucleotides |
| US7098032B2 (en) * | 2001-01-02 | 2006-08-29 | Mirus Bio Corporation | Compositions and methods for drug delivery using pH sensitive molecules |
| US7033607B2 (en) * | 1999-12-31 | 2006-04-25 | Mirus Bio Corporation | pH-titratable polyampholytes for delivering polyions to a cell |
| US7737108B1 (en) * | 2000-01-07 | 2010-06-15 | University Of Washington | Enhanced transport using membrane disruptive agents |
| US20030134420A1 (en) * | 2000-02-18 | 2003-07-17 | Lollo Charles Peter | Methods and compositions for gene delivery |
| EP1286643A2 (en) | 2000-05-17 | 2003-03-05 | Labopharm Inc. | Drug containing polymeric micelles |
| US6852816B2 (en) | 2000-10-06 | 2005-02-08 | Biocompatibles Uk Limited | Zwitterionic polymers |
| SE517421C2 (sv) * | 2000-10-06 | 2002-06-04 | Bioglan Ab | Mikropartiklar, lämpade för parenteral administration, väsentligen bestående av stärkelse med minst 85 % amylopektin och med reducerad molekylvikt, samt framställning därav |
| WO2003087188A1 (en) | 2001-04-26 | 2003-10-23 | Nanosphere, Inc. | Oligonucleotide-modified romp polymers and co-polymers |
| US6939564B2 (en) * | 2001-06-08 | 2005-09-06 | Labopharm, Inc. | Water-soluble stabilized self-assembled polyelectrolytes |
| US7094810B2 (en) * | 2001-06-08 | 2006-08-22 | Labopharm, Inc. | pH-sensitive block copolymers for pharmaceutical compositions |
| US6780428B2 (en) * | 2001-06-08 | 2004-08-24 | Labopharm, Inc. | Unimolecular polymeric micelles with an ionizable inner core |
| US20030191081A1 (en) * | 2001-12-28 | 2003-10-09 | Pierre Lemieux | Pharmaceutical compositions and methods of use thereof comprising polyanionic polymers and amphiphilic block copolymers to improve gene expression |
| US20050220880A1 (en) * | 2002-03-07 | 2005-10-06 | Lewis Andrew L | Drug carriers comprising amphiphilic block copolymers |
| US7229973B2 (en) | 2002-05-19 | 2007-06-12 | You Han Bae | pH-sensitive polymeric micelles for drug delivery |
| EP1400555A1 (en) | 2002-09-17 | 2004-03-24 | Kawamura Institute Of Chemical Research | Water-soluble block copolymer and production method therefor |
| JP2006505686A (ja) | 2002-11-07 | 2006-02-16 | ロディア・シミ | 両性又は双極性イオン性部分を含む制御された構造のコポリマー |
| AU2003293082A1 (en) * | 2002-11-27 | 2004-06-23 | Tufts University | Antioxidant-functionalized polymers |
| ATE461961T1 (de) * | 2002-12-30 | 2010-04-15 | Nektar Therapeutics | Mehrarmige polypeptid-poly(ethylenglykol)- blockcopolymere als arzneistoffzufuhrvehikel |
| US7871818B2 (en) * | 2003-01-31 | 2011-01-18 | Roche Madison Inc. | Membrane active polymers |
| US7217776B1 (en) * | 2003-02-14 | 2007-05-15 | Iowa State University Research Foundation | pH-sensitive methacrylic copolymer gels and the production thereof |
| US20040162235A1 (en) * | 2003-02-18 | 2004-08-19 | Trubetskoy Vladimir S. | Delivery of siRNA to cells using polyampholytes |
| JP4535229B2 (ja) * | 2003-05-08 | 2010-09-01 | 国立大学法人 東京大学 | ポリエチレングリコール−ポリカチオンブロック共重合体 |
| FR2868784B1 (fr) * | 2004-04-09 | 2006-05-26 | Oreal | Copolymere sequence, composition le comprenant et procede de traitement cosmetique |
| US7632905B2 (en) | 2004-04-09 | 2009-12-15 | L'oreal S.A. | Block copolymer, composition comprising it and cosmetic treatment process |
| US20080274454A1 (en) | 2004-04-07 | 2008-11-06 | Mirkin Chad A | Reversible and Chemically Programmable Micelle Assembly With Dna Block-Copolymer Amphiphiles |
| US8821859B2 (en) * | 2004-05-19 | 2014-09-02 | Agency For Science, Technology And Research | Methods and articles for the delivery of therapeutic agents |
| GB0418123D0 (en) | 2004-08-13 | 2004-09-15 | Asahi Chemical Ind | Polymers useful as medical materials |
| US20060134221A1 (en) * | 2004-12-03 | 2006-06-22 | Vical Incorporated | Methods for producing block copolymer/amphiphilic particles |
| US20060165810A1 (en) * | 2004-12-28 | 2006-07-27 | The Trustees Of The University Of Pennsylvania | Controlled release from block co-polymer worm micelles |
| US20060171980A1 (en) * | 2005-02-01 | 2006-08-03 | Helmus Michael N | Implantable or insertable medical devices having optimal surface energy |
| EP1863859A4 (en) * | 2005-03-31 | 2009-04-22 | Ap Pharma Inc | PEG-POLYACETAL AND PEG-POLYACETAL-POE-PFROPOPOPOLYMERS AND PHARMACEUTICAL COMPOSITIONS |
| EP1868664A2 (en) * | 2005-04-15 | 2007-12-26 | Interface Biologics Inc. | Methods and compositions for the delivery of biologically active agents |
| US9139850B2 (en) * | 2005-05-19 | 2015-09-22 | L'oreal | Vectorization of dsRNA by cationic particles and topical use |
| EP1891141B1 (en) | 2005-05-31 | 2016-11-16 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Triblock copolymers for cytoplasmic delivery of gene-based drugs |
| FR2890859B1 (fr) * | 2005-09-21 | 2012-12-21 | Oreal | Oligonucleotide d'arn double brin inhibant l'expression de la tyrosinase |
| WO2007109584A1 (en) | 2006-03-16 | 2007-09-27 | University Of Washington | Temperature-and ph-responsive polymer compositions |
| US8367113B2 (en) * | 2006-05-15 | 2013-02-05 | Massachusetts Institute Of Technology | Polymers for functional particles |
| CN101501108A (zh) | 2006-07-05 | 2009-08-05 | 新加坡科技研究局 | 用于药物递送的胶束 |
| WO2008085556A2 (en) | 2006-09-12 | 2008-07-17 | University Of South Florida | Surfactant-free nanoparticles for drug delivery |
| US20080081075A1 (en) * | 2006-10-02 | 2008-04-03 | National Tsing Hua University | Multifunctional mixed micelle of graft and block copolymers and preparation thereof |
| WO2008071009A1 (en) | 2006-12-15 | 2008-06-19 | The Governors Of The University Of Alberta | Novel ligand guided block copolymers for targeted drug delivery |
| WO2008088658A2 (en) * | 2007-01-17 | 2008-07-24 | Immunomedics, Inc. | Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites |
| US20080311045A1 (en) * | 2007-06-06 | 2008-12-18 | Biovaluation & Analysis, Inc. | Polymersomes for Use in Acoustically Mediated Intracellular Drug Delivery in vivo |
| WO2008148174A1 (en) | 2007-06-08 | 2008-12-11 | Queensland University Of Technology | Wound repair composition and method |
| WO2008153940A1 (en) | 2007-06-11 | 2008-12-18 | Biocure, Inc. | Vesicles for active macromolecule delivery |
| JP2010532786A (ja) | 2007-07-06 | 2010-10-14 | ノースイースタン ユニバーシティ | Ｒｎａ薬剤の両親媒性接合を含む混合ミセルおよびその使用 |
| US20090036625A1 (en) * | 2007-08-01 | 2009-02-05 | Chung Yuan Christian University | Amphiphilic Polymer, Method for Forming the Same and Application thereof |
| EP2025348A1 (en) | 2007-08-13 | 2009-02-18 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Targeted block copolymer micelles |
| US20110142951A1 (en) | 2008-05-13 | 2011-06-16 | University Of Washington | Micelles for intracellular delivery of therapeutic agents |
| WO2009140421A2 (en) | 2008-05-13 | 2009-11-19 | University Of Washington | Polymeric carrier |
| KR101764427B1 (ko) | 2008-05-13 | 2017-08-02 | 유니버시티 오브 워싱톤 | 미셀성 어셈블리 |
| CN103342789B (zh) | 2008-05-13 | 2016-11-23 | 华盛顿大学 | 用于向细胞内递送的二嵌段共聚物和其多核苷酸复合物 |
| US20110129921A1 (en) | 2008-05-13 | 2011-06-02 | University Of Washington | Targeted polymer bioconjugates |
| WO2010021770A1 (en) | 2008-08-22 | 2010-02-25 | University Of Washington | Heterogeneous polymeric micelles for intracellular delivery |
| ES2366758T3 (es) | 2008-10-22 | 2011-10-25 | Clariant Finance (Bvi) Limited | Compuestos de fosfonato olefínicamente insaturados, polímeros fabricados a partir de ellos, y su uso. |
| EP2364330B1 (en) | 2008-11-06 | 2015-03-25 | University Of Washington | Multiblock copolymers |
| US20110281934A1 (en) * | 2008-11-06 | 2011-11-17 | Phaserx, Inc. | Micelles of hydrophilically shielded membrane-destabilizing copolymers |
| EP2352522A4 (en) * | 2008-11-06 | 2014-03-05 | Univ Washington | BISPECIFIC AUXILIARIES FOR INTRA-CELLULAR RELEASE |
| US20100150952A1 (en) * | 2008-11-07 | 2010-06-17 | University Of Washington | pH-RESPONSIVE POLYMER CARRIER COMPOSITIONS FOR CYTOSOLIC PROTEIN DELIVERY |
| US9593169B2 (en) | 2008-12-08 | 2017-03-14 | University Of Washington | Omega-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization |
-
2009
- 2009-05-13 CN CN201310232498.XA patent/CN103342789B/zh not_active Expired - Fee Related
- 2009-05-13 WO PCT/US2009/043847 patent/WO2009140427A2/en not_active Ceased
- 2009-05-13 ES ES09747510T patent/ES2404131T3/es active Active
- 2009-05-13 KR KR1020107027808A patent/KR101661636B1/ko active Active
- 2009-05-13 JP JP2011509670A patent/JP5911723B2/ja not_active Expired - Fee Related
- 2009-05-13 CA CA3065577A patent/CA3065577C/en active Active
- 2009-05-13 CN CN2009801228883A patent/CN102083878B/zh not_active Expired - Fee Related
- 2009-05-13 EP EP09747510A patent/EP2281011B1/en active Active
- 2009-05-13 CA CA2972694A patent/CA2972694C/en active Active
- 2009-05-13 EP EP13156237.3A patent/EP2620161A1/en not_active Withdrawn
- 2009-05-13 BR BRPI0912159A patent/BRPI0912159B8/pt active IP Right Grant
- 2009-05-13 CA CA2724105A patent/CA2724105C/en active Active
- 2009-05-13 MX MX2010012238A patent/MX2010012238A/es active IP Right Grant
- 2009-05-13 US US12/992,517 patent/US9476063B2/en active Active
- 2009-05-13 AU AU2009246327A patent/AU2009246327B8/en active Active
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2010
- 2010-11-10 IL IL209238A patent/IL209238A/en active IP Right Grant
- 2010-12-03 ZA ZA2010/08729A patent/ZA201008729B/en unknown
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2015
- 2015-10-08 JP JP2015200236A patent/JP6239565B2/ja active Active
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2016
- 2016-09-13 US US15/264,392 patent/US9862792B2/en active Active
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2017
- 2017-11-30 US US15/828,078 patent/US20180171056A1/en not_active Abandoned
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