JP2011517666A - 血液脳関門を横断してペプチドを運搬するためのピレンの使用 - Google Patents

血液脳関門を横断してペプチドを運搬するためのピレンの使用 Download PDF

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JP2011517666A
JP2011517666A JP2011500764A JP2011500764A JP2011517666A JP 2011517666 A JP2011517666 A JP 2011517666A JP 2011500764 A JP2011500764 A JP 2011500764A JP 2011500764 A JP2011500764 A JP 2011500764A JP 2011517666 A JP2011517666 A JP 2011517666A
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peptide
pyrene
agent
conjugate
seq
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JP2011517666A5 (enExample
Inventor
レネー ヴェグジン
アンドリュー ニューボーグ
ディー． ロクサンヌ ダンカン
アラン ルドルフ
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エイディーライフ インコーポレイティッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
JP2011500764A 2008-03-21 2009-01-30 血液脳関門を横断してペプチドを運搬するためのピレンの使用 Pending JP2011517666A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3863408P 2008-03-21 2008-03-21
US61/038,634 2008-03-21
PCT/US2009/000613 WO2009117041A2 (en) 2008-03-21 2009-01-30 Use of pyrene to carry peptides across the blood brain barrier

Publications (2)

Publication Number Publication Date
JP2011517666A true JP2011517666A (ja) 2011-06-16
JP2011517666A5 JP2011517666A5 (enExample) 2013-04-11

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ID=40974375

Family Applications (1)

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JP2011500764A Pending JP2011517666A (ja) 2008-03-21 2009-01-30 血液脳関門を横断してペプチドを運搬するためのピレンの使用

Country Status (8)

Country Link
US (1) US20090238754A1 (enExample)
EP (1) EP2268314A2 (enExample)
JP (1) JP2011517666A (enExample)
CN (1) CN102014967A (enExample)
AU (1) AU2009226161A1 (enExample)
CA (1) CA2718860A1 (enExample)
MX (1) MX2010010266A (enExample)
WO (1) WO2009117041A2 (enExample)

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EP1395833B1 (en) 2001-05-31 2013-02-27 Adlyfe, Inc. Misfolded protein sensor method
US20050026165A1 (en) 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
EP2156181B1 (en) * 2006-07-28 2015-11-04 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics
US20090274621A1 (en) * 2008-03-21 2009-11-05 Adlyfe, Inc Use of pyrene to carry non-peptide agents across the blood brain barrier
MX2011007916A (es) * 2009-01-30 2011-11-18 Adlyfe Inc Péptidos conformacionalmente dinámicos.
US20140328762A1 (en) * 2011-04-06 2014-11-06 Yiyi Zhang Fluorogenic Peptide Probes and Assays
EP2712425A2 (en) 2011-04-27 2014-04-02 Adlyfe, Inc. Ocular detection of amyloid proteins
JP6144673B2 (ja) 2011-06-03 2017-06-07 オフィディオン インコーポレイティド 血液脳関門を通過して輸送するための組成物及び方法
PL230602B1 (pl) 2013-04-04 2018-11-30 Centrum Badan Molekularnych I Makromolekularnych Polskiej Akademii Nauk Kwas (E)-3-arylo-3-oksoprop-1-enylo-2-fosfonowy i jego pochodne, sposob ich wytwarzania oraz ich zastosowanie
PL223918B1 (pl) 2013-05-28 2016-11-30 Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk 3-Arylo-2-fosforylo podstawione 1-indanony i sposób ich wytwarzania
EP3634978A1 (en) 2017-06-07 2020-04-15 Adrx, Inc. Tau aggregation inhibitors
EP3668886A2 (en) 2017-08-18 2020-06-24 Adrx, Inc. Tau aggregation peptide inhibitors
CN110759974B (zh) * 2018-07-25 2021-11-09 中国医学科学院药物研究所 一种磷脂-聚乙二醇-狂犬病毒衍生肽聚合物，其制备方法及应用
US10369170B1 (en) 2018-10-09 2019-08-06 Carol J. Buck Methods of treating basal cell carcinoma and glioblastoma
US10568907B1 (en) 2018-10-09 2020-02-25 Carol J. Buck Methods of treating basal cell carcinoma and glioblastoma
IL293545A (en) 2019-12-04 2022-08-01 Univ Leland Stanford Junior Enhancing blood-brain barrier drug transport by targeting endogenous regulators

Citations (7)

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JP2001515044A (ja) * 1997-08-14 2001-09-18 ザ・レジェンツ・オブ・ザ・ユニバーシティー・オブ・カリフォルニア 蛍光アミロイドＡβペプチドとその使用
JP2005501508A (ja) * 2001-01-10 2005-01-20 アメリカ合衆国 ｓＦＲＰおよびｓＦＲＰと相互作用するペプチドモチーフならびにそれらの使用法
WO2005035549A2 (en) * 2003-10-14 2005-04-21 Kernel Biopharma Inc. Amiphiphylic peptide-pna conjugates for the delivery of pna through the blood brain barrier
WO2005076732A2 (en) * 2004-02-17 2005-08-25 Kernel Biopharma Inc. Peptide-pna chimera targeting inducible nitric oxide synthase
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
WO2006109485A1 (ja) * 2005-03-31 2006-10-19 The Noguchi Institute 質量分析法
WO2008013859A2 (en) * 2006-07-28 2008-01-31 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics

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US5604198A (en) * 1994-05-12 1997-02-18 Poduslo; Joseph F. Method to enhance permeability of the blood/brain blood/nerve barriers to therapeutic agents
US5670477A (en) * 1995-04-20 1997-09-23 Joseph F. Poduslo Method to enhance permeability of the blood/brain blood/nerve bariers to therapeutic agents
US6761888B1 (en) * 2000-05-26 2004-07-13 Neuralab Limited Passive immunization treatment of Alzheimer's disease
US20030162698A1 (en) * 1999-01-27 2003-08-28 Alphonse Galdes Methods and compositions for treating dopaminergic and gaba-nergic disorders
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US20090274621A1 (en) * 2008-03-21 2009-11-05 Adlyfe, Inc Use of pyrene to carry non-peptide agents across the blood brain barrier

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JP2001515044A (ja) * 1997-08-14 2001-09-18 ザ・レジェンツ・オブ・ザ・ユニバーシティー・オブ・カリフォルニア 蛍光アミロイドＡβペプチドとその使用
JP2005501508A (ja) * 2001-01-10 2005-01-20 アメリカ合衆国 ｓＦＲＰおよびｓＦＲＰと相互作用するペプチドモチーフならびにそれらの使用法
WO2005035549A2 (en) * 2003-10-14 2005-04-21 Kernel Biopharma Inc. Amiphiphylic peptide-pna conjugates for the delivery of pna through the blood brain barrier
WO2005076732A2 (en) * 2004-02-17 2005-08-25 Kernel Biopharma Inc. Peptide-pna chimera targeting inducible nitric oxide synthase
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
WO2006109485A1 (ja) * 2005-03-31 2006-10-19 The Noguchi Institute 質量分析法
WO2008013859A2 (en) * 2006-07-28 2008-01-31 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics

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Also Published As

Publication number Publication date
CN102014967A (zh) 2011-04-13
CA2718860A1 (en) 2009-09-24
WO2009117041A3 (en) 2010-01-07
US20090238754A1 (en) 2009-09-24
MX2010010266A (es) 2010-12-14
EP2268314A2 (en) 2011-01-05
AU2009226161A1 (en) 2009-09-24
WO2009117041A2 (en) 2009-09-24

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