CN102014967A - 芘携带肽穿过血脑屏障的用途 - Google Patents

芘携带肽穿过血脑屏障的用途 Download PDF

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Publication number
CN102014967A
CN102014967A CN2009801166660A CN200980116666A CN102014967A CN 102014967 A CN102014967 A CN 102014967A CN 2009801166660 A CN2009801166660 A CN 2009801166660A CN 200980116666 A CN200980116666 A CN 200980116666A CN 102014967 A CN102014967 A CN 102014967A
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CN
China
Prior art keywords
peptide
pyrene
conjugate
seq
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801166660A
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English (en)
Chinese (zh)
Inventor
雷内·韦格尔津
安德鲁·纽伯格
D·罗克珊·杜安
艾伦·鲁道夫
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Adlyfe Inc
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Adlyfe Inc
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Publication date
Application filed by Adlyfe Inc filed Critical Adlyfe Inc
Publication of CN102014967A publication Critical patent/CN102014967A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
CN2009801166660A 2008-03-21 2009-01-30 芘携带肽穿过血脑屏障的用途 Pending CN102014967A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3863408P 2008-03-21 2008-03-21
US61/038,634 2008-03-21
PCT/US2009/000613 WO2009117041A2 (en) 2008-03-21 2009-01-30 Use of pyrene to carry peptides across the blood brain barrier

Publications (1)

Publication Number Publication Date
CN102014967A true CN102014967A (zh) 2011-04-13

Family

ID=40974375

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801166660A Pending CN102014967A (zh) 2008-03-21 2009-01-30 芘携带肽穿过血脑屏障的用途

Country Status (8)

Country Link
US (1) US20090238754A1 (enExample)
EP (1) EP2268314A2 (enExample)
JP (1) JP2011517666A (enExample)
CN (1) CN102014967A (enExample)
AU (1) AU2009226161A1 (enExample)
CA (1) CA2718860A1 (enExample)
MX (1) MX2010010266A (enExample)
WO (1) WO2009117041A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110759974A (zh) * 2018-07-25 2020-02-07 中国医学科学院药物研究所 一种磷脂-聚乙二醇-狂犬病毒衍生肽聚合物，其制备方法及应用

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002320045B2 (en) 2001-05-31 2008-05-08 Adlyfe, Inc. Misfolded protein sensor method
US20050026165A1 (en) 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
JP5097206B2 (ja) * 2006-07-28 2012-12-12 エイディーライフ インコーポレイティッド 診断および治療のためのペプチドプローブ
US20090274621A1 (en) * 2008-03-21 2009-11-05 Adlyfe, Inc Use of pyrene to carry non-peptide agents across the blood brain barrier
CN102365295A (zh) * 2009-01-30 2012-02-29 阿德利夫股份有限公司 构象动力肽
WO2013025261A2 (en) * 2011-04-06 2013-02-21 Georgia Tech Research Corporation Fluorogenic peptide probes and assays
EP2712425A2 (en) 2011-04-27 2014-04-02 Adlyfe, Inc. Ocular detection of amyloid proteins
JP6144673B2 (ja) 2011-06-03 2017-06-07 オフィディオン インコーポレイティド 血液脳関門を通過して輸送するための組成物及び方法
PL230602B1 (pl) 2013-04-04 2018-11-30 Centrum Badan Molekularnych I Makromolekularnych Polskiej Akademii Nauk Kwas (E)-3-arylo-3-oksoprop-1-enylo-2-fosfonowy i jego pochodne, sposob ich wytwarzania oraz ich zastosowanie
PL223918B1 (pl) 2013-05-28 2016-11-30 Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk 3-Arylo-2-fosforylo podstawione 1-indanony i sposób ich wytwarzania
WO2018226992A1 (en) 2017-06-07 2018-12-13 Adrx, Inc. Tau aggregation inhibitors
CA3073062A1 (en) 2017-08-18 2019-02-21 Adrx, Inc. Tau aggregation peptide inhibitors
US10568907B1 (en) 2018-10-09 2020-02-25 Carol J. Buck Methods of treating basal cell carcinoma and glioblastoma
US10369170B1 (en) 2018-10-09 2019-08-06 Carol J. Buck Methods of treating basal cell carcinoma and glioblastoma
AU2020398216A1 (en) 2019-12-04 2022-06-30 The Board Of Trustees Of The Leland Stanford Junior University Enhancing blood-brain barrier drug transport by targeting endogenous regulators

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4822733A (en) * 1985-05-28 1989-04-18 Amoco Corporation Lifetime-resolved assay procedures
US5260308A (en) * 1991-11-06 1993-11-09 Mayo Foundation For Medical Education And Research Method to increase permeability of the blood-nerve/brain barriers to proteins
US5604198A (en) * 1994-05-12 1997-02-18 Poduslo; Joseph F. Method to enhance permeability of the blood/brain blood/nerve barriers to therapeutic agents
US5670477A (en) * 1995-04-20 1997-09-23 Joseph F. Poduslo Method to enhance permeability of the blood/brain blood/nerve bariers to therapeutic agents
JP2001515044A (ja) * 1997-08-14 2001-09-18 ザ・レジェンツ・オブ・ザ・ユニバーシティー・オブ・カリフォルニア 蛍光アミロイドＡβペプチドとその使用
US6761888B1 (en) * 2000-05-26 2004-07-13 Neuralab Limited Passive immunization treatment of Alzheimer's disease
US20030162698A1 (en) * 1999-01-27 2003-08-28 Alphonse Galdes Methods and compositions for treating dopaminergic and gaba-nergic disorders
WO2001074374A1 (en) * 2000-04-04 2001-10-11 Mayo Foundation For Medical Education And Research Methods for detecting plaques in vivo
US7311893B2 (en) * 2000-07-25 2007-12-25 Neurochem (International) Limited Amyloid targeting imaging agents and uses thereof
US7470420B2 (en) * 2000-12-05 2008-12-30 The Regents Of The University Of California Optical determination of glucose utilizing boronic acid adducts
JP4029041B2 (ja) * 2001-01-10 2008-01-09 アメリカ合衆国 ｓＦＲＰおよびｓＦＲＰと相互作用するペプチドモチーフならびにそれらの使用法
GB0106953D0 (en) * 2001-03-20 2001-05-09 Univ Aberdeen Neufofibrillary labels
WO2002094191A2 (en) * 2001-05-23 2002-11-28 New York University Detection of alzheimer's amyloid by magnetic resonance imaging
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
US7851593B2 (en) * 2002-01-04 2010-12-14 Becton, Dickinson And Company Binding proteins as biosensors
CN1688299A (zh) * 2002-01-29 2005-10-26 普罗特米克斯公司 抑制细胞毒性蛋白构象异构体
WO2005004794A2 (en) * 2003-06-09 2005-01-20 Alnylam Pharmaceuticals Inc. Method of treating neurodegenerative disease
US20050009109A1 (en) * 2003-07-08 2005-01-13 Stanford University Fluorophore compounds and their use in biological systems
WO2005035549A2 (en) * 2003-10-14 2005-04-21 Kernel Biopharma Inc. Amiphiphylic peptide-pna conjugates for the delivery of pna through the blood brain barrier
US20080038349A1 (en) * 2004-02-17 2008-02-14 Lamensdorf Itschak Peptide-Pna Chimera Targeting Inducible Nitric Oxide Synthetase
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
EP1853915B1 (en) * 2005-02-15 2011-10-12 Adlyfe, Inc. Method for detecting misfolded proteins and prions
JP4295338B2 (ja) * 2005-03-31 2009-07-15 財団法人野口研究所 質量分析法
US7388747B2 (en) * 2006-04-07 2008-06-17 Inventec Corporation Heat plate fixing structure
JP5097206B2 (ja) * 2006-07-28 2012-12-12 エイディーライフ インコーポレイティッド 診断および治療のためのペプチドプローブ
US20090274621A1 (en) * 2008-03-21 2009-11-05 Adlyfe, Inc Use of pyrene to carry non-peptide agents across the blood brain barrier

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110759974A (zh) * 2018-07-25 2020-02-07 中国医学科学院药物研究所 一种磷脂-聚乙二醇-狂犬病毒衍生肽聚合物，其制备方法及应用
CN110759974B (zh) * 2018-07-25 2021-11-09 中国医学科学院药物研究所 一种磷脂-聚乙二醇-狂犬病毒衍生肽聚合物，其制备方法及应用

Also Published As

Publication number Publication date
AU2009226161A1 (en) 2009-09-24
EP2268314A2 (en) 2011-01-05
MX2010010266A (es) 2010-12-14
WO2009117041A2 (en) 2009-09-24
WO2009117041A3 (en) 2010-01-07
CA2718860A1 (en) 2009-09-24
US20090238754A1 (en) 2009-09-24
JP2011517666A (ja) 2011-06-16

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Application publication date: 20110413