JP2011517288A - 組織部位における創傷を治療するシステムおよび方法 - Google Patents
組織部位における創傷を治療するシステムおよび方法 Download PDFInfo
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- JP2011517288A JP2011517288A JP2010548912A JP2010548912A JP2011517288A JP 2011517288 A JP2011517288 A JP 2011517288A JP 2010548912 A JP2010548912 A JP 2010548912A JP 2010548912 A JP2010548912 A JP 2010548912A JP 2011517288 A JP2011517288 A JP 2011517288A
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- drape
- tissue site
- adhesive layer
- adhesive
- release
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00795—Plasters special helping devices
- A61F2013/00842—Plasters special helping devices for tearing off dressing of desired size
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/11—Methods of delaminating, per se; i.e., separating at bonding face
- Y10T156/1153—Temperature change for delamination [e.g., heating during delaminating, etc.]
- Y10T156/1158—Electromagnetic radiation applied to work for delamination [e.g., microwave, uv, ir, etc.]
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/19—Delaminating means
- Y10T156/1911—Heating or cooling delaminating means [e.g., melting means, freezing means, etc.]
- Y10T156/1917—Electromagnetic radiation delaminating means [e.g., microwave, uv, ir, etc.]
Abstract
【選択図】図1B
Description
ドレープ125は通常、組織部位105の上を覆っていると理解される。ドレープ125は、システムの1またはそれ以上の要素を組織部位105に固定するように機能してもよい。例えば、ドレープ125は、任意のマニホールドを組織部位105に固定してもよい。ドレープ125は、好適には滅菌可能である。ドレープ125は、ポリマのような生体適合性の薄いフィルム材料を具えてもよい。ドレープ125は、織布または不織布材料を具えてもよい。ドレープ125は、弾性または非弾性材料を具えてもよい。ドレープ125は、フレキシブルまたは柔軟性がない材料を具えてもよい。柔軟性がない材料でできたドレープ125は、特定の組織部位105用に成形してもよい。好適には、ドレープ125は、皮膚のような順応性を有する軟質で、フレキシブルな材料である。ドレープ125は、不透過性、半透過性、または透過性の材料を具えてもよい。透過特性は、所望の水分および気体(例えば、酸素)の透過率に応じて選択してもよい。いくつかの実施形態では、ドレープ125は、水分に対して比較的に不透過性であり、酸素に対して比較的に透過性の材料を具える。ドレープ125は、例えば、通気性を制御するために材料でコーティングしてもよい。ドレープ125は、閉塞または非閉塞材料を具えてもよい。閉塞被覆材は、組織部位105に供給する治療薬の吸収率を増やすためには望ましい。
システムは接着層477を具えてもよい。接着層477は、ドレープ125のようなシステムの1またはそれ以上の要素を組織部位105に固定するように機能してもよい。接着層477は、好適には、ドレープ125の接着面のようなドレープ125上に配置される。接着層477は、組織部位105と結合するように構成されてもよい。接着層477は、単一または複数の層内に、組織部位105のような面に付着可能な任意の材料を具えてもよい。いくつかの実施形態では、接着層477を介してドレープ125が組織部位105に接着する。一実施例では、組織部位105に利用する前に、接着層477をドレープ125の接着面に予め適用してもよい。
離型物質182を含む離型剤482は、組織部位105からのドレープ125の除去を容易にできる。離型剤482は、ドレープ125と組織部位105との間の接着特性に物理的または化学的影響を与えることができる。離型剤は、接着層477内、その上、またはその近位に活性しないか、不活性形な状態で存在してもよい。例えば、離型剤482を;無作為またはパターン化された範囲を有する接着剤の面上の;無作為またはパターン化された範囲を有するドレープ125に結合する;またはこれらまたは他の位置に配置された微細構造内に含まれた、接着剤と混合してもよい。離型剤482が放出または活性化すると、接着層477内、または接着層477と組織部位105との間のインタフェースに沿って拡散することができ、そこに固定されたドレープ125の除去が容易となる。示差走査熱量測定(DSC)、流量計、機械的引張り試験装置のような技術を、接着層477内または接着層477上の離型剤の量を最適化するのに用いてもよい。
いくつかの実施形態では、離型剤は離型物質182を具える。離型物質182は、接着層477内に活性せずに分散していてもよい。離型物質182は、接着層477と組織部位105との間のインタフェースに位置してもよい。離型物質182は、接着層477内の任意の位置、さらには接着層477とドレープ125との間のインタフェースのような接着層477の外面に配置されうることを意図している。いくかの実施形態では、離型物質182は微細構造を具えてもよい。例えば、離型物質182は微細構造を形成してもよい。他の実施例では、離型物質182は微細構造内に封入されてもよい。適切な微細構造は、以下に記載するようなものであってもよい。いくつかの実施形態では、離型物質182は、接着層の接着剤の成分であってもよい。離型剤が、接着と化学的に干渉する、接着を弱める、または破壊するように機能する場合、通常は結合物質295を具える。
微細構造は、離型剤の送達媒体として機能してもよい。一実施形態では、システムは、接着層477に結合する複数の微細構造を具える。離型物質182を微細構造材料内に封入してもよく、ドレープ125の保管および適用時に微細構造が不活性な状態で残っている場合は、ドレープ125内またはその上に組み込んでもよい。微細構造は、外部刺激184が加わると放出される1またはそれ以上の離型物質182を含んでもよい。外部刺激184によって誘発されたこのような放出は、組織部位105からのドレープ125の除去を容易にできる。例えば、微細構造は、外部刺激184によって弱化、不安定化、または切断される材料を具えてもよく、これにより微細構造に含まれる離型物質182の放出が可能となる。
いくつかの実施形態では、離型剤482は結合物質295を具える。結合物質295は、離型物質182または接着剤といった他の要素との接着、または他の要素との結合が可能な1またはそれ以上の分子である。結合物質295の接着は、共有結合またはイオン結合であってもよい。結合物質295が分解すると、通常は接着剤ボンドの分解によって、組織部位からのドレープの除去を容易にすることができる。
様々な実施形態では、外部刺激184が加わることで、システムにおけるドレープ125の除去が容易となる。実施する特定の実施形態に応じて、様々な外部刺激184を用いてもよい。外部刺激184の非制限的な実施例は、電磁気(例えば、可視紫外線、または可視赤外線)、磁気、音声、pH、圧力(例えば、正大気圧、陰大気圧、せん断力、直接力)、熱、水分、または物質を含む。外部刺激184はさらに、接着層477内の離型物質182または結合物質295と反応可能な物質、化合物、液体、または気体であってもよく、これにより離型物質182が放出される。
以下の非制限的な実施例を、さらに本発明を説明する目的で提供している。以下の実施例において開示している技術は、本発明の実施において発明者が優れた機能を発見してきたアプローチを示しており、従って、その実施に対する実施例の方式を構成すると考えられることを、当該技術分野の当業者は理解すべきである。しかしながら、当該技術分野の当業者は、現在の開示に照らし合わせて、多くの変更が開示されている特定の実施形態についてなされ、本発明の精神および範囲を逸脱することなく同様または類似した結果を得ることが可能であると理解すべきである。
Claims (29)
- 組織部位における創傷を治療するシステムにおいて:
前記組織部位における前記創傷を覆うように構成されたドレープと;
前記ドレープの少なくとも一部に貼り付けられる一面と、前記組織部位と接着するように構成された反対側の面とを有する接着剤と;
前記接着剤内に含まれ、前記組織部位への前記接着剤の接着を弱める外部刺激に反応する離型剤と;を具えており、
前記接着剤の接着の弱化が前記組織部位からの前記ドレープの除去を容易にすることを特徴とするシステム。 - 請求項1に記載のシステムにおいて、前記離型剤が、離型物質および結合物質の少なくとも一方を含むことを特徴とするシステム。
- 請求項1に記載のシステムにおいて、前記外部刺激が、電磁エネルギ;磁場;音声;pHレベル;圧力;熱エネルギ;および水分のうちの少なくとも1つを含むことを特徴とするシステム。
- 請求項1に記載のシステムがさらに接着支持層を具えており、当該接着支持層が接着層と着脱可能に結合することを特徴とするシステム。
- 請求項1に記載のシステムにおいて、前記組織部位から前記ドレープを除去するのに必要な力の量が、前記離型剤なしで前記ドレープを除去するのに必要な力の量の少なくとも約20%減少することを特徴とするシステム。
- 請求項2に記載のシステムにおいて、前記離型物質が:サブアンビエントTg材料;感光性樹脂;天然油;合成油;界面活性剤;シリコーン粒子;パラフィン粒子;フッ化炭素粒子;テルペン;溶媒;脂質;熱分解性接着剤;Gecko模倣体;超音波分解性化合物;熱可逆性接着剤;イガイ接着性タンパク質;ポリマブラシ;溶媒誘起スイッチング;MEMS装置;またはシリコーンゲルのうちの少なくとも1つを含むことを特徴とするシステム。
- 請求項2に記載のシステムにおいて、前記離型物質が:ビタミンE;グリセリン;グリセロール;オリーブ油;サフラワー油;ごま油;ティーツリー油;ステアリン酸;ステアリン酸グリセリル;パルミチン酸レチニル;アラントイン;大豆エステル;リモネン;DMSO;IPA;酢酸エチル;ポリエチレングリコール;酢酸テトラヒドロフルフリル;トリラウリン;ポリビニルシロキサンのマイクロスケールピラー;カーボンナノチューブ;被覆PDMSの微細パターン;波形PDMSフィルム;アルコキシル化アクリラート;PS;PVP;MEMS装置;窒素;ヘリウム;水素;二酸化炭素;酸素;活性酸素;二酸化炭素;酒石酸;炭酸水素;塩化カルシウム;クエン酸;クロロフルオロカーボン;または炭化水素のうちの少なくとも1つを含むことを特徴とするシステム。
- 請求項2に記載のシステムにおいて、前記離型物質が接着層内の少なくとも2つの物質間の反応によって生成された複数の気体粒子を含んでおり、前記外部刺激が加わると前記反応が起こることを特徴とするシステム。
- 請求項8に記載のシステムにおいて、前記複数の気体粒子が前記外部刺激に曝されて放出された場合、前記接着層内の多孔率が増加して、前記組織部位から前記ドレープを除去するのに十分な力の量を減少させることを特徴とするシステム。
- 請求項2に記載のシステムにおいて、前記離型物質が複数の油粒子を具えており、当該油粒子が前記外部刺激に曝されて放出された場合、(i)接着層と前記ドレープまたは前記組織部位との間、あるいは(ii)前記結合物質と前記ドレープ、前記接着層、または前記組織部位との間の接着を弱め;
弱まった前記接着が前記組織部位から前記ドレープを除去するのに十分な力の量を減少させることを特徴とするシステム。 - 請求項1に記載のシステムがさらに、前記離型剤を含んで前記外部刺激に反応して前記離型剤の少なくとも一部を放出する複数の微細構造を具えることを特徴とするシステム。
- 請求項11に記載のシステムにおいて、前記複数の微細構造が:重合体送達システム、微小球、高分子ハイドロゲル、リポソーム、またはミセルのうちの少なくとも1つを含むことを特徴とするシステム。
- 請求項11に記載のシステムにおいて、前記複数の微細構造が:多糖類;N−アセチル−グルコサミン;シリコーン;ラテックス;ポリ−ラクチド−co−グリコリド;ポリエチレン−co−酢酸ビニル;ポリ酸無水物;ポリビニルアルコール;ポリホスファゼン;PLA;PLGA;DPPCで被覆したPLGA、DPPC、DSPC、またはEVAc;ゼラチン;アルブミン;キトサン;デキストラン;サイクロデキストラン;DL−PLG SDLMs;PEG;ヒアルロン酸ナトリウム;ジケトピペラジン誘導体;リン酸カルシウム−PEG粒子;オリゴ糖誘導体;リン脂質;ドデシル硫酸ナトリウム;ドデシルマルトシド;コラーゲン;フィブリン;アルギン酸;ポリアクリル酸アルキルポリマ;カゼイン;レシチン;ホスファチジルコリン;ホスファチジルエタノールアミン;スフィンゴミエリン;ホスファチジルセリン;ホスファチジルグリセロール;ホスファチジルイノシトール;セラミック;ガラス;あるいはそれらのポリマの組み合わせのうちの少なくとも1つを含むことを特徴とするシステム。
- 請求項2に記載のシステムにおいて、前記結合物質が:ベンゾイン誘導体;光分解性リンカ;光可逆性ポリマ;熱反応性ポリマ;形状記憶ポリマ;pH感受性ポリマ;分析物感受性ポリマ;または光架橋剤のうちの少なくとも1つを含むことを特徴とするシステム。
- 請求項2に記載のシステムにおいて、前記結合物質が:ジメトキシベンゾイン;ジメチルプロピオン酸;酢酸3,5−ジメトキシベンジル;4−(2−クロロプロピオニル)フェニル酢酸;ポリ(N−イソプロピルアクリルアミド);ポリ(エチレンオキシド);ポリ(プロピレンオキシド);ポリ(N,N’−メチレンビスアクリルアミド);オリゴ(ε−カプラクトン)ジメチルアクリレート;ポリ(メタクリル酸);リン脂質;シリコンベースのポリサイラミンゲル;ジシアリルラクト−N−テトラオース;歯科用複合物のうちの少なくとも1つを含むことを特徴とするシステム。
- 請求項2に記載のシステムにおいて、前記ドレープが接着層に結合し、前記接着層が前記結合物質に結合し、前記結合物質が前記組織部位に結合するように構成されることを特徴とするシステム。
- 請求項2に記載のシステムにおいて、前記ドレープが前記結合物質に結合し;前記結合物質が接着層に結合し、前記接着層が前記組織部位に結合するように構成されることを特徴とするシステム。
- 請求項2に記載のシステムにおいて、接着層が第1の接着層と第2の接着層とを具えており;前記ドレープが前記第1の接着層に結合し;前記第1の接着層が前記結合物質に結合し;前記結合物質が前記第2の接着層に結合し;前記第2の接着層が前記組織部位に結合するように構成されることを特徴とするシステム。
- 請求項11に記載のシステムにおいて、前記微細構造が前記結合物質に結合し、前記結合物質が接着層に結合することを特徴とするシステム。
- 請求項2に記載のシステムにおいて、前記結合物質が、静電力を介して前記ドレープに結合することを特徴とするシステム。
- 請求項2に記載のシステムにおいて、前記結合物質が、静電力を介して接着層に結合することを特徴とするシステム。
- 請求項11に記載のシステムにおいて、前記結合物質が、静電力を介して前記複数の微細構造に結合することを特徴とするシステム。
- 請求項2に記載のシステムにおいて、前記結合物質が、静電力を介して前記組織部位に結合するように適合可能であることを特徴とするシステム。
- 請求項1に記載のシステム、または一緒か別個に梱包されて前記組織部位に適用する前に組み合わせるように構成された各要素を具えることを特徴とするキット。
- 請求項24に記載のキットにおいて:被覆材、ドレープ、マニホールド、接着剤、裏面接着剤、粘着テープ、離型剤、離型物質、結合物質、微細構造、外部刺激剤、外部刺激源、外部エネルギ源、殺菌スワブ、および皮膚用医薬スワブからなるグループから選択された少なくとも1つの要素を具えることを特徴とするキット。
- 請求項24に記載のキットにおいて、前記システムまたはその要素の適用または除去についての説明書を具えることを特徴とするキット。
- 組織部位からのドレープ除去を容易にする方法において、当該方法が:
請求項1に記載のシステムを組織部位に付着させるステップと;
前記組織部位から前記システムを除去するのに十分な力の量が減少するように、前記離型剤を放出するの十分な有効量の外部刺激に前記システムを曝すステップと、を具えることを特徴とする方法。 - 請求項27に記載の方法がさらに、前記組織部位から少なくとも前記ドレープを除去する更なるステップを具えることを特徴とする方法。
- 請求項27に記載の方法がさらに、前記組織部位から少なくとも前記ドレープと接着層のかなりの部分を除去する更なるステップを具えることを特徴とする方法。
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- 2009-02-27 US US12/394,618 patent/US8450554B2/en active Active
- 2009-02-27 TW TW098106621A patent/TW200946146A/zh unknown
- 2009-02-27 BR BRPI0906016-2A patent/BRPI0906016A2/pt not_active IP Right Cessation
- 2009-02-27 EP EP18166382.4A patent/EP3415171B1/en active Active
- 2009-02-27 KR KR1020107020696A patent/KR20100126392A/ko not_active Application Discontinuation
- 2009-02-27 RU RU2010133486/15A patent/RU2010133486A/ru not_active Application Discontinuation
- 2009-02-27 AU AU2009219126A patent/AU2009219126B2/en not_active Ceased
- 2009-02-27 CA CA2711108A patent/CA2711108C/en not_active Expired - Fee Related
- 2009-02-27 WO PCT/US2009/035524 patent/WO2009108884A2/en active Application Filing
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JP7023075B2 (ja) | 2011-12-16 | 2022-02-21 | スリーエム イノベイティブ プロパティズ カンパニー | 切り替え可能ドレープを用いるシーリングシステムおよび方法 |
JP2015519961A (ja) * | 2012-06-08 | 2015-07-16 | ゴットリープ ビンダー ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンデイトゲゼルシャフト | 個体を治療するための医療製品 |
WO2018003680A1 (ja) * | 2016-06-27 | 2018-01-04 | 学校法人日本大学 | 充填液、バルーン送達装置、医療用超音波装置、医療システム、管状器官閉塞術、及び管状器官閉塞解除術 |
Also Published As
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CA2711108C (en) | 2016-11-22 |
AU2009219126A1 (en) | 2009-09-03 |
ZA201006081B (en) | 2011-05-25 |
EP2244748A2 (en) | 2010-11-03 |
EP3415171B1 (en) | 2022-12-14 |
JP5243560B2 (ja) | 2013-07-24 |
AU2009219126B2 (en) | 2014-07-31 |
WO2009108884A3 (en) | 2009-10-22 |
US8450554B2 (en) | 2013-05-28 |
CN101925369A (zh) | 2010-12-22 |
BRPI0906016A2 (pt) | 2015-06-30 |
CA2711108A1 (en) | 2009-09-03 |
IL207522A0 (en) | 2010-12-30 |
WO2009108884A2 (en) | 2009-09-03 |
US20090216170A1 (en) | 2009-08-27 |
EP2244748B1 (en) | 2018-04-11 |
RU2010133486A (ru) | 2012-04-10 |
EP3415171A1 (en) | 2018-12-19 |
KR20100126392A (ko) | 2010-12-01 |
TW200946146A (en) | 2009-11-16 |
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