JP2011516417A - Nmdanr2b−サブタイプ選択的アンタゴニストを使用する障害の処置方法 - Google Patents

Nmdanr2b−サブタイプ選択的アンタゴニストを使用する障害の処置方法 Download PDF

Info

Publication number
JP2011516417A
JP2011516417A JP2011501153A JP2011501153A JP2011516417A JP 2011516417 A JP2011516417 A JP 2011516417A JP 2011501153 A JP2011501153 A JP 2011501153A JP 2011501153 A JP2011501153 A JP 2011501153A JP 2011516417 A JP2011516417 A JP 2011516417A
Authority
JP
Japan
Prior art keywords
pain
formula
compound
disease
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011501153A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011516417A5 (https=
Inventor
ジョン・アラン・ケンプ
ティモシー・タスカー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evotec Neurosciences GmbH
Original Assignee
Evotec Neurosciences GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evotec Neurosciences GmbH filed Critical Evotec Neurosciences GmbH
Publication of JP2011516417A publication Critical patent/JP2011516417A/ja
Publication of JP2011516417A5 publication Critical patent/JP2011516417A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2011501153A 2008-03-27 2009-03-26 Nmdanr2b−サブタイプ選択的アンタゴニストを使用する障害の処置方法 Pending JP2011516417A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4008708P 2008-03-27 2008-03-27
US61/040,087 2008-03-27
PCT/EP2009/002241 WO2009118187A1 (en) 2008-03-27 2009-03-26 Methods for treating disorders using nmda nr2b-subtype selective antagonist

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014020051A Division JP2014098018A (ja) 2008-03-27 2014-02-05 Nmdanr2b−サブタイプ選択的アンタゴニストを使用する障害の処置方法

Publications (2)

Publication Number Publication Date
JP2011516417A true JP2011516417A (ja) 2011-05-26
JP2011516417A5 JP2011516417A5 (https=) 2012-01-05

Family

ID=40910288

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2011501153A Pending JP2011516417A (ja) 2008-03-27 2009-03-26 Nmdanr2b−サブタイプ選択的アンタゴニストを使用する障害の処置方法
JP2014020051A Pending JP2014098018A (ja) 2008-03-27 2014-02-05 Nmdanr2b−サブタイプ選択的アンタゴニストを使用する障害の処置方法
JP2015236571A Pending JP2016094430A (ja) 2008-03-27 2015-12-03 Nmdanr2b−サブタイプ選択的アンタゴニストを使用する障害の処置方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2014020051A Pending JP2014098018A (ja) 2008-03-27 2014-02-05 Nmdanr2b−サブタイプ選択的アンタゴニストを使用する障害の処置方法
JP2015236571A Pending JP2016094430A (ja) 2008-03-27 2015-12-03 Nmdanr2b−サブタイプ選択的アンタゴニストを使用する障害の処置方法

Country Status (14)

Country Link
US (1) US20110053951A1 (https=)
EP (1) EP2254580A1 (https=)
JP (3) JP2011516417A (https=)
KR (1) KR20100135847A (https=)
CN (1) CN101977606A (https=)
AU (1) AU2009228660B2 (https=)
BR (1) BRPI0909378A2 (https=)
CA (1) CA2719749A1 (https=)
IL (1) IL207835A0 (https=)
MX (1) MX2010009649A (https=)
NZ (1) NZ588698A (https=)
RU (1) RU2499598C2 (https=)
WO (1) WO2009118187A1 (https=)
ZA (1) ZA201006587B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017525700A (ja) * 2014-08-15 2017-09-07 ヤンセン ファーマシューティカルズ,インコーポレーテッド ピラゾール類
JP2019504854A (ja) * 2016-02-10 2019-02-21 ヤンセン ファーマシューティカ エヌ.ベー. Nr2b選択的nmda調節因子としての置換1,2,3−トリアゾール

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013251079B2 (en) 2012-04-20 2017-03-23 Ucb Pharma S.A. Methods for treating Parkinson's disease
WO2015175806A1 (en) * 2014-05-16 2015-11-19 The Trustees Of The University Of Pennsylvania Applications of automatic anatomy recognition in medical tomographic imagery based on fuzzy anatomy models
WO2016025917A1 (en) * 2014-08-15 2016-02-18 Janssen Pharmaceuticals, Inc. Triazoles as nr2b receptor inhibitors
BR112017025023B1 (pt) 2015-06-01 2024-01-30 Rugen Holdings (Cayman) Limited Compostos heterocíclicos de carbamato de 3,3-difluoropiperidina, seu uso como antagonistas do receptor nmda nr2b e composição farmacêutica que os compreende
HRP20200410T1 (hr) 2015-07-09 2020-08-21 Janssen Pharmaceutica Nv Supstituirani 4-azaindoli i njihova upotreba kao modulatora glun2b receptora
US10487055B2 (en) 2016-06-01 2019-11-26 Rhode Island Board Of Education Diindole compounds useful in treatment of nervous system disorders
TW201819376A (zh) 2016-10-06 2018-06-01 比利時商健生藥品公司 經取代之1H-咪唑並[4,5-b]吡啶-2(3H)-酮及其作為GLUN2B受體調節劑之用途
WO2018098128A1 (en) 2016-11-22 2018-05-31 Rugen Holdings (Cayman) Limited Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders
US10732235B2 (en) * 2018-03-29 2020-08-04 Siemens Healthcare Gmbh Magnetic resonance method and apparatus using atlas-based masking for quantitative susceptibility mapping
WO2019193516A2 (en) 2018-04-04 2019-10-10 Janssen Pharmaceutica Nv Substituted pyridine and pyrimidines and their use as glun2b receptor modulators
KR20220024403A (ko) 2019-06-14 2022-03-03 얀센 파마슈티카 엔.브이. 치환된 피라졸로-피라진 및 이들의 glun2b 수용체 조절제로서의 용도
CN113950357A (zh) 2019-06-14 2022-01-18 詹森药业有限公司 吡嗪氨基甲酸酯及其作为GluN2B受体调节剂的用途
SG11202112405VA (en) 2019-06-14 2021-12-30 Janssen Pharmaceutica Nv Substituted heteroaromatic pyrazolo-pyridines and their use as glun2b receptor modulators
CN113993868A (zh) 2019-06-14 2022-01-28 詹森药业有限公司 取代的吡唑并吡啶酰胺以及它们作为glun2b受体调节剂的用途
MX2021015508A (es) 2019-06-14 2022-01-31 Janssen Pharmaceutica Nv Carbamatos de piridina y su uso como moduladores del receptor glun2b.
AU2020293642A1 (en) 2019-06-14 2022-01-20 Janssen Pharmaceutica Nv Substituted pyrazolo[4,3-b]pyridines and their use as GluN2B receptor modulators
JP7667097B2 (ja) 2019-06-14 2025-04-22 ヤンセン ファーマシューティカ エヌ.ベー. 置換ピラゾロ-ピリジンアミド及びglun2b受容体調節因子としてのその使用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005532326A (ja) * 2002-05-16 2005-10-27 エフ.ホフマン−ラ ロシュ アーゲー Nmdaレセプターブロッカーとしての(イミダゾール−1−イル−メチル)−ピリダジン

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT885004E (pt) * 1996-03-08 2002-08-30 Hoffmann La Roche Utilizacao de derivados de 4-fenil-3,6-di-hidro-2h-piridilo como bloqueadores dos subtipos dos receptores nmda
US5985936A (en) * 1997-12-18 1999-11-16 Forbes Medi-Tech, Inc. Method of preventing and delaying onset of Alzheimer's disease and composition therefor
US6015824A (en) * 1998-02-10 2000-01-18 Hoffmann-La Roche Ag Pyrrolidine and piperidine derivatives and treatment of neurodegenerative disorders
TWI254043B (en) * 1999-06-08 2006-05-01 Hoffmann La Roche Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor
EP1070708B1 (en) * 1999-07-21 2004-01-14 F. Hoffmann-La Roche Ag Triazole derivatives
ES2225553T3 (es) * 2000-04-20 2005-03-16 F. Hoffmann-La Roche Ag Derivados de pirrolidina y piperidina y su empleo para el tratamiento de trastornos neurodegenerativos.
US6432985B2 (en) * 2000-04-25 2002-08-13 Hoffmann-La Roche Inc. Neuroprotective substituted piperidine compounds with activity as NMDA NR2B subtype selective antagonists
AU2001296994A1 (en) * 2000-10-06 2002-04-15 Regents Of The University Of California Nmda receptor channel blocker with neuroprotective activity
CA2617104A1 (en) * 2005-07-29 2007-02-08 Regents Of The University Of Minnesota Amyloid beta receptor and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005532326A (ja) * 2002-05-16 2005-10-27 エフ.ホフマン−ラ ロシュ アーゲー Nmdaレセプターブロッカーとしての(イミダゾール−1−イル−メチル)−ピリダジン

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017525700A (ja) * 2014-08-15 2017-09-07 ヤンセン ファーマシューティカルズ,インコーポレーテッド ピラゾール類
JP2019504854A (ja) * 2016-02-10 2019-02-21 ヤンセン ファーマシューティカ エヌ.ベー. Nr2b選択的nmda調節因子としての置換1,2,3−トリアゾール

Also Published As

Publication number Publication date
JP2016094430A (ja) 2016-05-26
KR20100135847A (ko) 2010-12-27
IL207835A0 (en) 2010-12-30
WO2009118187A1 (en) 2009-10-01
CA2719749A1 (en) 2009-10-01
RU2010143864A (ru) 2012-05-10
BRPI0909378A2 (pt) 2015-10-06
NZ588698A (en) 2012-06-29
AU2009228660A1 (en) 2009-10-01
MX2010009649A (es) 2010-12-17
AU2009228660B2 (en) 2012-11-29
ZA201006587B (en) 2012-02-29
US20110053951A1 (en) 2011-03-03
JP2014098018A (ja) 2014-05-29
RU2499598C2 (ru) 2013-11-27
CN101977606A (zh) 2011-02-16
EP2254580A1 (en) 2010-12-01

Similar Documents

Publication Publication Date Title
JP2016094430A (ja) Nmdanr2b−サブタイプ選択的アンタゴニストを使用する障害の処置方法
Li et al. Craving correlates with mesolimbic responses to heroin-related cues in short-term abstinence from heroin: an event-related fMRI study
Vernon et al. Effect of chronic antipsychotic treatment on brain structure: a serial magnetic resonance imaging study with ex vivo and postmortem confirmation
Poels et al. Imaging glutamate in schizophrenia: review of findings and implications for drug discovery
Mattay et al. Dopaminergic modulation of cortical function in patients with Parkinson's disease
Stenkrona et al. 5-HTT and 5-HT1A receptor occupancy of the novel substance vortioxetine (Lu AA21004). A PET study in control subjects
Gironell et al. Gaba and serotonin molecular neuroimaging in essential tremor: a clinical correlation study
Okita et al. Emotion dysregulation and amygdala dopamine D2-type receptor availability in methamphetamine users
Bremner et al. Effects of phenytoin on memory, cognition and brain structure in post-traumatic stress disorder: a pilot study
Sabaroedin et al. Frontostriatothalamic effective connectivity and dopaminergic function in the psychosis continuum
Wingen et al. Sustained attention and serotonin: a pharmaco‐fMRI study
Musella et al. Cladribine interferes with IL-1β synaptic effects in experimental multiple sclerosis
Del Bianco et al. Long-term efficacy and safety of lacosamide and levetiracetam monotherapy in elderly patients with focal epilepsy: a retrospective study
Van Marle et al. Subchronic duloxetine administration alters the extended amygdala circuitry in healthy individuals
Littlewood et al. Using the BOLD MR signal to differentiate the stereoisomers of ketamine in the rat
Easton et al. Guanfacine produces differential effects in frontal cortex compared with striatum: assessed by phMRI BOLD contrast
AU2011285703B2 (en) Methods and pharmaceutical compositions for treating adverse or deleterious sequellae of traumatic brain injury
Huang et al. The relationship between the alterations in metabolite levels in the dorsolateral prefrontal cortex and clinical symptoms of patients with first-episode schizophrenia: a one year follow-up study
Nizamudeen et al. An overview of the rare and life-threatening adverse effects of levetiracetam
Price 2021 SNMMI Highlights Lecture: Neuroscience
Engeli NEUROBIOLOGICAL ADAPTATIONS AND PHARMACOLOGICAL INTERVENTIONS IN COCAINE ADDICTION: THE ROLE OF GLUTAMATE
KR20260010409A (ko) 브루톤 티로신 키나아제의 억제제를 이용한 재발성 다발성 경화증의 치료 방법
Kessler et al. Occupancy of cortical and substantia Nigra DA D2 receptors by typical and atypical antipsychotic drugs
Dornbierer Repurposing gamma-hydroxybutyrate for neuropsychiatric disorders? Examining its effects on sleep neurophysiology, neuro-immune interaction and brain metabolites in healthy men
Marner et al. Communication Among Neurons: Quantitative Measures in Aging and Disease

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20111109

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20111109

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130514

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130814

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130821

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130911

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20131008