JP2011516065A - Ｅｐａｓ１阻害剤の組成物および使用 - Google Patents

Ｅｐａｓ１阻害剤の組成物および使用 Download PDF

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JP2011516065A
JP2011516065A JP2011502994A JP2011502994A JP2011516065A JP 2011516065 A JP2011516065 A JP 2011516065A JP 2011502994 A JP2011502994 A JP 2011502994A JP 2011502994 A JP2011502994 A JP 2011502994A JP 2011516065 A JP2011516065 A JP 2011516065A
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nucleic acid
epas1
nucleotides
cancer
cells
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JP2011516065A5 (https=
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マーク イー． デイビス，
ジェレミー ディー． ヘイデル，
ジョアンナ イー−チン リュー，
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カランド ファーマシューティカルズ， インコーポレイテッド
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Publication of JP2011516065A publication Critical patent/JP2011516065A/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/122—Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2011502994A 2008-04-04 2009-04-03 Ｅｐａｓ１阻害剤の組成物および使用 Pending JP2011516065A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12306908P 2008-04-04 2008-04-04
US61/123,069 2008-04-04
PCT/US2009/002125 WO2009123764A2 (en) 2008-04-04 2009-04-03 Compositions and use of epas1 inhibitors

Publications (2)

Publication Number Publication Date
JP2011516065A true JP2011516065A (ja) 2011-05-26
JP2011516065A5 JP2011516065A5 (https=) 2012-05-24

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JP2011502994A Pending JP2011516065A (ja) 2008-04-04 2009-04-03 Ｅｐａｓ１阻害剤の組成物および使用

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US (1) US8114983B2 (https=)
EP (1) EP2283133A2 (https=)
JP (1) JP2011516065A (https=)
KR (1) KR20100127880A (https=)
CN (1) CN102037123A (https=)
AU (1) AU2009232355A1 (https=)
BR (1) BRPI0911332A2 (https=)
CA (1) CA2720473A1 (https=)
IL (1) IL208403A0 (https=)
WO (1) WO2009123764A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016511256A (ja) * 2013-02-28 2016-04-14 アローヘッド リサーチ コーポレイション Ｅｐａｓ１関連疾患を治療するための有機組成物
WO2017146227A1 (ja) * 2016-02-25 2017-08-31 国立大学法人九州大学 アトピー性皮膚炎モデル非ヒト動物及びその使用
JP2018516595A (ja) * 2015-05-29 2018-06-28 アローヘッド ファーマシューティカルズ インコーポレイテッド Ｈｉｆ２αの遺伝子発現を阻害する組成物及び方法

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US20080176958A1 (en) 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
WO2012174224A2 (en) * 2011-06-17 2012-12-20 Calando Pharmaceuticals, Inc. Methods for administering nucleic acid-based therapeutics
SI3366775T2 (sl) * 2011-11-18 2025-12-31 Alnylam Pharmaceuticals, Inc. Modificirana sredstva RNAI
US20140094432A1 (en) 2012-10-02 2014-04-03 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
CN103993016B (zh) * 2014-04-25 2015-12-30 浙江大学 Hif2a基因突变体及其检测与应用
US9730867B2 (en) 2016-01-06 2017-08-15 The Procter & Gamble Company Methods of forming a slurry with microcapsules formed from phosphate esters
US9732303B2 (en) 2016-01-06 2017-08-15 The Procter & Gamble Company Microcapsules formed from phosphate esters and compositions containing same
US10154947B2 (en) 2016-01-06 2018-12-18 The Procter & Gamble Company Antiperspirant composition
WO2019075419A1 (en) * 2017-10-13 2019-04-18 Dicerna Pharmaceuticals, Inc. METHODS AND COMPOSITIONS FOR INHIBITING LDHA EXPRESSION
EP3713644B1 (en) 2017-11-20 2024-08-07 University of Georgia Research Foundation, Inc. Compositions and methods for modulating hif-2a to improve muscle generation and repair
US20210002641A1 (en) * 2018-03-16 2021-01-07 The Regents Of The University Of Michigan Compositions and methods for treating graves disease
SG11202105577TA (en) * 2019-01-09 2021-06-29 Arrowhead Pharmaceuticals Inc Rnai agents for inhibiting expression of hif-2 alpha (epas1), compositions thereof, and methods of use
CN110251486A (zh) * 2019-07-31 2019-09-20 中山大学 可用于治疗银屑病的阳离子聚合物及颗粒
CN119662652B (zh) * 2024-12-24 2025-09-02 中国人民解放军总医院 一种启动子及其应用

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JP2016511256A (ja) * 2013-02-28 2016-04-14 アローヘッド リサーチ コーポレイション Ｅｐａｓ１関連疾患を治療するための有機組成物
JP2019089836A (ja) * 2013-02-28 2019-06-13 アローヘッド ファーマシューティカルズ インコーポレイテッド Ｅｐａｓ１関連疾患を治療するための有機組成物
JP2018516595A (ja) * 2015-05-29 2018-06-28 アローヘッド ファーマシューティカルズ インコーポレイテッド Ｈｉｆ２αの遺伝子発現を阻害する組成物及び方法
JP2022001576A (ja) * 2015-05-29 2022-01-06 アローヘッド ファーマシューティカルズ インコーポレイテッド Ｈｉｆ２αの遺伝子発現を阻害する組成物及び方法
JP7021076B2 (ja) 2015-05-29 2022-02-16 アローヘッド ファーマシューティカルズ インコーポレイテッド Ｈｉｆ２αの遺伝子発現を阻害する組成物及び方法
JP2023158214A (ja) * 2015-05-29 2023-10-26 アローヘッド ファーマシューティカルズ インコーポレイテッド Ｈｉｆ２αの遺伝子発現を阻害する組成物及び方法
WO2017146227A1 (ja) * 2016-02-25 2017-08-31 国立大学法人九州大学 アトピー性皮膚炎モデル非ヒト動物及びその使用
JPWO2017146227A1 (ja) * 2016-02-25 2018-12-20 国立大学法人九州大学 アトピー性皮膚炎モデル非ヒト動物及びその使用
US11213020B2 (en) 2016-02-25 2022-01-04 Kyushu University, National University Corporation Atopic dermatitis model non-human animal and use thereof

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US20100010071A1 (en) 2010-01-14
CN102037123A (zh) 2011-04-27
AU2009232355A1 (en) 2009-10-08
US8114983B2 (en) 2012-02-14
EP2283133A2 (en) 2011-02-16
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WO2009123764A2 (en) 2009-10-08
IL208403A0 (en) 2010-12-30

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