JP2011516064A5 - - Google Patents

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JP2011516064A5
JP2011516064A5 JP2011502993A JP2011502993A JP2011516064A5 JP 2011516064 A5 JP2011516064 A5 JP 2011516064A5 JP 2011502993 A JP2011502993 A JP 2011502993A JP 2011502993 A JP2011502993 A JP 2011502993A JP 2011516064 A5 JP2011516064 A5 JP 2011516064A5
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Japan
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nucleic acid
protein
well
cells
antibody
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JP2011502993A
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Japanese (ja)
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JP5749156B2 (ja
JP2011516064A (ja
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Priority claimed from PCT/US2009/002122 external-priority patent/WO2009123762A2/en
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JP2011502993A 2008-04-05 2009-04-03 生理活性物質の生産のための単一細胞を選抜する方法 Active JP5749156B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7298508P 2008-04-05 2008-04-05
US61/072,985 2008-04-05
US14157908P 2008-12-30 2008-12-30
US61/141,579 2008-12-30
PCT/US2009/002122 WO2009123762A2 (en) 2008-04-05 2009-04-03 Method of screening single cells for the production of biologically active agents

Publications (3)

Publication Number Publication Date
JP2011516064A JP2011516064A (ja) 2011-05-26
JP2011516064A5 true JP2011516064A5 (enExample) 2012-05-24
JP5749156B2 JP5749156B2 (ja) 2015-07-15

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JP2011502993A Active JP5749156B2 (ja) 2008-04-05 2009-04-03 生理活性物質の生産のための単一細胞を選抜する方法

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US (4) US8309035B2 (enExample)
EP (1) EP2260112A4 (enExample)
JP (1) JP5749156B2 (enExample)
KR (1) KR101679869B1 (enExample)
CN (1) CN102046809A (enExample)
AU (1) AU2009232353B2 (enExample)
BR (1) BRPI0906544A2 (enExample)
CA (1) CA2720472C (enExample)
WO (3) WO2009123756A1 (enExample)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776553B2 (en) 2005-09-16 2010-08-17 Presidents And Fellows Of Harvard College Screening assays and methods
MX352987B (es) * 2007-10-02 2017-12-15 Theranos Ip Co Llc Dispositivos modulares de punto de cuidado y usos de los mismos.
WO2009123756A1 (en) * 2008-04-05 2009-10-08 Single Cell Technology, Inc. Multi-well system
US20110237445A1 (en) * 2008-10-10 2011-09-29 Picovitro Ab Genetic analysis in microwells
US8569046B2 (en) * 2009-02-20 2013-10-29 Massachusetts Institute Of Technology Microarray with microchannels
US8691509B2 (en) 2009-04-02 2014-04-08 Fluidigm Corporation Multi-primer amplification method for barcoding of target nucleic acids
EP2625320B1 (en) * 2010-10-08 2019-03-27 President and Fellows of Harvard College High-throughput single cell barcoding
EP2658999B1 (en) 2010-12-30 2019-03-13 Life Technologies Corporation Models for analyzing data from sequencing-by-synthesis operations
CA2825196C (en) 2011-01-21 2021-01-05 Theranos, Inc. Systems and methods for sample use maximization
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
DK2702146T3 (en) * 2011-04-28 2019-03-11 Univ Leland Stanford Junior IDENTIFICATION OF POLYNUCLEOTIDES CONNECTED WITH A SAMPLE
SG194745A1 (en) 2011-05-20 2013-12-30 Fluidigm Corp Nucleic acid encoding reactions
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
EP2791358B1 (en) * 2011-12-13 2017-06-14 Single Cell Technology, Inc. Method of screening a plurality of single secreting cells for functional activity
CA2861387A1 (en) 2012-02-02 2013-08-08 Invenra, Inc. High throughput screen for biologically active polypeptides
US9646132B2 (en) * 2012-05-11 2017-05-09 Life Technologies Corporation Models for analyzing data from sequencing-by-synthesis operations
UA118441C2 (uk) 2012-10-08 2019-01-25 Протена Біосаєнсиз Лімітед Антитіло, що розпізнає альфа-синуклеїн
US9951131B2 (en) 2013-07-12 2018-04-24 Prothena Biosciences Limited Antibodies that recognize IAPP
WO2015004632A1 (en) 2013-07-12 2015-01-15 Neotope Biosciences Limited Antibodies that recognize iapp
TWI503172B (zh) * 2013-09-03 2015-10-11 Nat Univ Tsing Hua 量測組件
JP6303347B2 (ja) * 2013-09-11 2018-04-04 大日本印刷株式会社 検体画像管理システム及び検体画像管理プログラム
JP5583830B1 (ja) 2013-09-27 2014-09-03 日本瓦斯株式会社 Ｌｐガスメータの指針値入力チェックシステムおよび方法
WO2015155694A1 (en) 2014-04-08 2015-10-15 Prothena Biosciences Limited Blood-brain barrier shuttles containing antibodies recognizing alpha-synuclein
WO2016037051A1 (en) 2014-09-04 2016-03-10 Theranos, Inc. Pathogen and antimicrobial resistance testing
CN104561231B (zh) * 2015-01-23 2017-01-25 中国科学院重庆绿色智能技术研究院 一种测定浮游藻类细胞比增殖速率的方法
US10676783B2 (en) * 2015-03-31 2020-06-09 Toray Industries, Inc. Analysis chip
CN114015569A (zh) * 2015-04-21 2022-02-08 通用自动化实验技术公司 用于高通量微生物学应用的高分辨率系统、试剂盒、设备和方法
CA3006994A1 (en) 2015-12-16 2017-06-22 Fluidigm Corporation High-level multiplex amplification
US11053288B2 (en) 2016-02-04 2021-07-06 Trianni, Inc. Enhanced production of immunoglobulins
EP3909679B1 (en) * 2016-08-10 2022-11-30 Roche Diagnostics GmbH Plate with wells for chemical or biological reactions, and method for multiple imaging of such a plate by means of an imaging system
CN110168069A (zh) * 2016-10-19 2019-08-23 通用自动化实验技术公司 用于筛选微生物和其他高通量微生物学应用的高分辨率系统、试剂盒、设备和方法
JP7356351B2 (ja) 2016-12-12 2023-10-04 エクセラ・バイオサイエンシーズ・インコーポレイテッド マイクロキャピラリーアレイを使用したスクリーニングのための方法およびシステム
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP3562796B1 (en) 2016-12-30 2023-04-19 Xcella Biosciences, Inc. Multi-stage sample recovery system
CN107219351A (zh) * 2017-06-08 2017-09-29 广东省生物资源应用研究所 一种基于单细胞芯片技术的抗体筛选方法
JP2019100940A (ja) * 2017-12-06 2019-06-24 東ソー株式会社 未分化細胞を高感度に検出および回収する方法
US12385033B2 (en) 2018-05-02 2025-08-12 The General Hospital Corporation High-resolution spatial macromolecule abundance assessment
US12116415B2 (en) 2018-10-09 2024-10-15 Single Cell Technology, Inc. Anti-BCMA antibodies
ES2987081T3 (es) 2018-12-06 2024-11-13 Xcella Biosciences Inc Carga lateral de arreglos de microcapilares
WO2021242804A1 (en) * 2020-05-26 2021-12-02 Bio-Rad Laboratories, Inc. Apparatus and method for fast digital detection
EP4305190A4 (en) 2021-03-11 2025-03-26 Iggenix, Inc. METHODS AND SYSTEMS FOR PREDICTING AN ALLERGIC REACTION
CN113066539A (zh) * 2021-03-22 2021-07-02 上海商汤智能科技有限公司 预测方法及相关装置、设备

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4642284A (en) * 1983-06-13 1987-02-10 Scripps Clinic And Research Foundation Method and system for detection of complement pathway activation
US4876194A (en) * 1986-07-22 1989-10-24 Hightech Receptor Ab Protein L and subfragments thereof, with immunoglobulin binding activity, a process for preparing thereof, reagent kit, pharmaceutical composition and a peptococcus magnus strain
US5110556A (en) * 1986-10-28 1992-05-05 Costar Corporation Multi-well test plate
US5679564A (en) * 1994-10-05 1997-10-21 Antex Biologics, Inc. Methods for producing enhanced antigenic campylobacter bacteria and vaccines
US6091001A (en) * 1995-03-29 2000-07-18 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
US6329139B1 (en) * 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US5866330A (en) * 1995-09-12 1999-02-02 The Johns Hopkins University School Of Medicine Method for serial analysis of gene expression
US7062219B2 (en) * 1997-01-31 2006-06-13 Odyssey Thera Inc. Protein fragment complementation assays for high-throughput and high-content screening
US6548263B1 (en) 1997-05-29 2003-04-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
JP4313861B2 (ja) * 1997-08-01 2009-08-12 キヤノン株式会社 プローブアレイの製造方法
US6177282B1 (en) * 1997-08-12 2001-01-23 Mcintyre John A. Antigens embedded in thermoplastic
US6232066B1 (en) * 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
US6083682A (en) * 1997-12-19 2000-07-04 Glaxo Group Limited System and method for solid-phase parallel synthesis of a combinatorial collection of compounds
US6565813B1 (en) * 1998-02-04 2003-05-20 Merck & Co., Inc. Virtual wells for use in high throughput screening assays
US6087103A (en) 1998-03-04 2000-07-11 Lifespan Biosciences, Inc. Tagged ligand arrays for identifying target-ligand interactions
US20030027214A1 (en) * 1999-02-17 2003-02-06 Kamb Carl Alexander Methods for substrate-ligand interaction screening
SG121902A1 (en) * 2000-01-11 2006-05-26 Maxygen Inc Integrated systems for diversity generation and screening
US6818758B2 (en) * 2000-02-22 2004-11-16 Applera Corporation Estrogen receptor beta variants and methods of detection thereof
US6794141B2 (en) * 2000-12-22 2004-09-21 Arcturus Bioscience, Inc. Nucleic acid amplification
US6800453B2 (en) * 2001-01-23 2004-10-05 President And Fellows Of Harvard College Nucleic-acid programmable protein arrays
AU2002314715B2 (en) * 2001-02-16 2006-07-27 Ciphergen Biosystems, Inc. Method for correlating gene expression profiles with protein expression profiles
CN1527720A (zh) * 2001-05-11 2004-09-08 Ү³��ѧ 利用蛋白组芯片全面分析蛋白活性
WO2003016574A1 (en) * 2001-08-16 2003-02-27 Zhifeng Shao Analysis of gene expression profiles using sequential hybridization
JP4754746B2 (ja) * 2001-09-28 2011-08-24 オリンパス株式会社 棒状担体およびこれを具備するシリンダー反応容器
US7521053B2 (en) * 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
US20050142539A1 (en) * 2002-01-14 2005-06-30 William Herman Targeted ligands
CA2473376A1 (en) * 2002-01-16 2003-07-31 Dynal Biotech Asa Method for isolating nucleic acids and protein from a single sample
US20040137644A1 (en) * 2002-08-28 2004-07-15 Kimon Angelides Screening for cell-targeting ligands attached to metal nanoshells for use in target-cell killing
WO2004051266A1 (ja) * 2002-11-14 2004-06-17 Atsushi Muraguchi 抗原特異的リンパ球検出用マイクロウェルアレイチップ、抗原特異的リンパ球の検出法及び製造方法、並びに抗原特異的リンパ球抗原受容体遺伝子のクローニング方法
JP3723882B2 (ja) * 2002-11-14 2005-12-07 篤 村口 抗原特異的リンパ球検出用マイクロウェルアレイチップ、抗原特異的リンパ球の検出法及び製造方法
JP3738308B2 (ja) * 2002-11-29 2006-01-25 篤 村口 抗原特異的リンパ球抗原受容体遺伝子のクローニング方法
US8574590B2 (en) 2003-07-30 2013-11-05 Integral Molecular, Inc. Lipoparticles comprising proteins, methods of making, and using the same
US20060223194A1 (en) * 2005-04-01 2006-10-05 Viorica Lopez-Avila Methods of screening for post-translationally modified proteins
WO2006132970A2 (en) * 2005-06-03 2006-12-14 Kohne David E Method for producing improved gene expression analysis and gene expression analysis comparison assay results
US7776553B2 (en) 2005-09-16 2010-08-17 Presidents And Fellows Of Harvard College Screening assays and methods
EP1966603A4 (en) 2005-12-30 2009-08-19 Bio Layer Pty Ltd FIXING MOLECULES
US8021877B2 (en) * 2006-04-10 2011-09-20 Massachusetts Institute Of Technology Particle patterning chip
US20080004185A1 (en) * 2006-06-12 2008-01-03 Antara Biosciences Inc. Three dimensional array
AU2007260676A1 (en) * 2006-06-14 2007-12-21 Artemis Health, Inc. Rare cell analysis using sample splitting and DNA tags
US20080124721A1 (en) 2006-06-14 2008-05-29 Martin Fuchs Analysis of rare cell-enriched samples
WO2008093098A2 (en) * 2007-02-02 2008-08-07 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
MX352987B (es) * 2007-10-02 2017-12-15 Theranos Ip Co Llc Dispositivos modulares de punto de cuidado y usos de los mismos.
US8304245B2 (en) 2007-11-02 2012-11-06 Children's Hospital And Research Center At Oakland Microfluidic flow lysometer device, system and method
WO2009123756A1 (en) * 2008-04-05 2009-10-08 Single Cell Technology, Inc. Multi-well system
BR112013004691A2 (pt) * 2010-08-30 2017-11-21 Dow Agrosciences Llc construto de dna de ativação gênica marcada de milho, população marcada de plantas de milho, método para geração da mesma e método para gerar uma planta de milho marcada

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