JP2011516037A5 - - Google Patents

Info

Publication number

JP2011516037A5

JP2011516037A5 JP2010550627A JP2010550627A JP2011516037A5 JP 2011516037 A5 JP2011516037 A5 JP 2011516037A5 JP 2010550627 A JP2010550627 A JP 2010550627A JP 2010550627 A JP2010550627 A JP 2010550627A JP 2011516037 A5 JP2011516037 A5 JP 2011516037A5

Authority

JP

Japan

Prior art keywords

ins

seq

binding agent

fragment

assay

Prior art date

2009-03-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000011230 binding agent Substances 0.000 claims 17
• 238000003556 assay Methods 0.000 claims 12
• 239000012634 fragment Substances 0.000 claims 11
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
• 239000012472 biological sample Substances 0.000 claims 6
• 238000012544 monitoring process Methods 0.000 claims 6
• 239000000523 sample Substances 0.000 claims 5
• 229920001184 polypeptide Polymers 0.000 claims 4
• 108090000765 processed proteins & peptides Proteins 0.000 claims 4
• 102000004196 processed proteins & peptides Human genes 0.000 claims 4
• 125000003275 alpha amino acid group Chemical group 0.000 claims 3
• 239000000427 antigen Substances 0.000 claims 3
• 102000036639 antigens Human genes 0.000 claims 3
• 108091007433 antigens Proteins 0.000 claims 3
• 238000000672 surface-enhanced laser desorption--ionisation Methods 0.000 claims 3
• 206010012601 diabetes mellitus Diseases 0.000 claims 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical group N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 239000002773 nucleotide Substances 0.000 claims 2
• 125000003729 nucleotide group Chemical group 0.000 claims 2
• 238000002965 ELISA Methods 0.000 claims 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
• 208000013875 Heart injury Diseases 0.000 claims 1
• 102000004877 Insulin Human genes 0.000 claims 1
• 108090001061 Insulin Proteins 0.000 claims 1
• 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
• 230000001154 acute effect Effects 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• 239000008103 glucose Substances 0.000 claims 1
• 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
• 238000010166 immunofluorescence Methods 0.000 claims 1
• 229940125396 insulin Drugs 0.000 claims 1
• 239000003550 marker Substances 0.000 claims 1
• 238000004949 mass spectrometry Methods 0.000 claims 1
• 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims 1
• 238000005259 measurement Methods 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 238000002360 preparation method Methods 0.000 claims 1
• 238000003127 radioimmunoassay Methods 0.000 claims 1
• 239000000758 substrate Substances 0.000 claims 1