JP2011516038A5 - - Google Patents

Info

Publication number

JP2011516038A5

JP2011516038A5 JP2010550628A JP2010550628A JP2011516038A5 JP 2011516038 A5 JP2011516038 A5 JP 2011516038A5 JP 2010550628 A JP2010550628 A JP 2010550628A JP 2010550628 A JP2010550628 A JP 2010550628A JP 2011516038 A5 JP2011516038 A5 JP 2011516038A5

Authority

JP

Japan

Prior art keywords

grn

binding agent

assay

seq

antibody

Prior art date

2009-03-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000011230 binding agent Substances 0.000 claims 17
• 238000003556 assay Methods 0.000 claims 12
• 239000012634 fragment Substances 0.000 claims 9
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
• 239000012472 biological sample Substances 0.000 claims 6
• 238000012544 monitoring process Methods 0.000 claims 6
• 239000000523 sample Substances 0.000 claims 5
• 229920001184 polypeptide Polymers 0.000 claims 4
• 108090000765 processed proteins & peptides Proteins 0.000 claims 4
• 102000004196 processed proteins & peptides Human genes 0.000 claims 4
• 125000003275 alpha amino acid group Chemical group 0.000 claims 3
• 239000000427 antigen Substances 0.000 claims 3
• 102000036639 antigens Human genes 0.000 claims 3
• 108091007433 antigens Proteins 0.000 claims 3
• 238000000672 surface-enhanced laser desorption--ionisation Methods 0.000 claims 3
• 206010012601 diabetes mellitus Diseases 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 239000002773 nucleotide Substances 0.000 claims 2
• 125000003729 nucleotide group Chemical group 0.000 claims 2
• 238000002965 ELISA Methods 0.000 claims 1
• 101800001586 Ghrelin Proteins 0.000 claims 1
• 102400000442 Ghrelin-28 Human genes 0.000 claims 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
• 208000013875 Heart injury Diseases 0.000 claims 1
• 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
• 230000001154 acute effect Effects 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical group C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 claims 1
• 239000008103 glucose Substances 0.000 claims 1
• 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
• 238000010166 immunofluorescence Methods 0.000 claims 1
• 239000003550 marker Substances 0.000 claims 1
• 238000004949 mass spectrometry Methods 0.000 claims 1
• 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims 1
• 238000005259 measurement Methods 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 238000002360 preparation method Methods 0.000 claims 1
• 238000003127 radioimmunoassay Methods 0.000 claims 1
• 239000000758 substrate Substances 0.000 claims 1