JP2011516032A5 - - Google Patents
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- JP2011516032A5 JP2011516032A5 JP2010548899A JP2010548899A JP2011516032A5 JP 2011516032 A5 JP2011516032 A5 JP 2011516032A5 JP 2010548899 A JP2010548899 A JP 2010548899A JP 2010548899 A JP2010548899 A JP 2010548899A JP 2011516032 A5 JP2011516032 A5 JP 2011516032A5
- Authority
- JP
- Japan
- Prior art keywords
- mir
- gastric cancer
- composition
- biomarker
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 27
- 206010017758 gastric cancer Diseases 0.000 claims 27
- 201000011549 stomach cancer Diseases 0.000 claims 27
- 238000000034 method Methods 0.000 claims 23
- 108091045790 miR-106b stem-loop Proteins 0.000 claims 21
- 108091085564 miR-25 stem-loop Proteins 0.000 claims 20
- 108091080167 miR-25-1 stem-loop Proteins 0.000 claims 20
- 108091083056 miR-25-2 stem-loop Proteins 0.000 claims 20
- 108091032902 miR-93 stem-loop Proteins 0.000 claims 20
- 230000014509 gene expression Effects 0.000 claims 19
- 239000000203 mixture Substances 0.000 claims 15
- 239000000090 biomarker Substances 0.000 claims 14
- 108091070501 miRNA Proteins 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 9
- 230000000692 anti-sense effect Effects 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 239000000523 sample Substances 0.000 claims 5
- 101000904152 Homo sapiens Transcription factor E2F1 Proteins 0.000 claims 4
- 102100024026 Transcription factor E2F1 Human genes 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 238000002560 therapeutic procedure Methods 0.000 claims 4
- 108010040168 Bcl-2-Like Protein 11 Proteins 0.000 claims 3
- 102000001765 Bcl-2-Like Protein 11 Human genes 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 3
- 239000003550 marker Substances 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 208000012895 Gastric disease Diseases 0.000 claims 2
- 239000003183 carcinogenic agent Substances 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 102000007372 Ataxin-1 Human genes 0.000 claims 1
- 108010032963 Ataxin-1 Proteins 0.000 claims 1
- 108010023936 Cofilin 2 Proteins 0.000 claims 1
- 102000011424 Cofilin 2 Human genes 0.000 claims 1
- 108010016788 Cyclin-Dependent Kinase Inhibitor p21 Proteins 0.000 claims 1
- 102100033270 Cyclin-dependent kinase inhibitor 1 Human genes 0.000 claims 1
- 102100022846 Histone acetyltransferase KAT2B Human genes 0.000 claims 1
- 102100033798 Homeobox protein aristaless-like 4 Human genes 0.000 claims 1
- 101001047006 Homo sapiens Histone acetyltransferase KAT2B Proteins 0.000 claims 1
- 101000779608 Homo sapiens Homeobox protein aristaless-like 4 Proteins 0.000 claims 1
- 101000994432 Homo sapiens Josephin-1 Proteins 0.000 claims 1
- 101001006886 Homo sapiens Krueppel-like factor 12 Proteins 0.000 claims 1
- 101000992394 Homo sapiens Oxysterol-binding protein-related protein 5 Proteins 0.000 claims 1
- 101001129705 Homo sapiens PH domain leucine-rich repeat-containing protein phosphatase 2 Proteins 0.000 claims 1
- 101000583178 Homo sapiens Pleckstrin homology domain-containing family M member 1 Proteins 0.000 claims 1
- 101000610204 Homo sapiens Poly(A) polymerase alpha Proteins 0.000 claims 1
- 101000709238 Homo sapiens Serine/threonine-protein kinase SIK1 Proteins 0.000 claims 1
- 101001098093 Homo sapiens Transcriptional repressor p66-beta Proteins 0.000 claims 1
- 101000837574 Homo sapiens Ubiquitin-conjugating enzyme E2 W Proteins 0.000 claims 1
- 101000964479 Homo sapiens Zinc finger and BTB domain-containing protein 18 Proteins 0.000 claims 1
- 101000781856 Homo sapiens Zinc finger protein 512B Proteins 0.000 claims 1
- 101000931371 Homo sapiens Zinc finger protein ZFPM2 Proteins 0.000 claims 1
- 102100032732 Josephin-1 Human genes 0.000 claims 1
- 102100027792 Krueppel-like factor 12 Human genes 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 101150079937 NEUROD1 gene Proteins 0.000 claims 1
- 108700020297 NeuroD Proteins 0.000 claims 1
- 102100032063 Neurogenic differentiation factor 1 Human genes 0.000 claims 1
- 102100032148 Oxysterol-binding protein-related protein 5 Human genes 0.000 claims 1
- 102100031136 PH domain leucine-rich repeat-containing protein phosphatase 2 Human genes 0.000 claims 1
- 102100030349 Pleckstrin homology domain-containing family M member 1 Human genes 0.000 claims 1
- 102100040155 Poly(A) polymerase alpha Human genes 0.000 claims 1
- 102100032771 Serine/threonine-protein kinase SIK1 Human genes 0.000 claims 1
- 102100037556 Transcriptional repressor p66-beta Human genes 0.000 claims 1
- 102000001742 Tumor Suppressor Proteins Human genes 0.000 claims 1
- 108010040002 Tumor Suppressor Proteins Proteins 0.000 claims 1
- 102100028700 Ubiquitin-conjugating enzyme E2 W Human genes 0.000 claims 1
- 102100040762 Zinc finger and BTB domain-containing protein 18 Human genes 0.000 claims 1
- 102100036647 Zinc finger protein 512B Human genes 0.000 claims 1
- 102100020996 Zinc finger protein ZFPM2 Human genes 0.000 claims 1
- 239000013068 control sample Substances 0.000 claims 1
- 230000001934 delay Effects 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000001632 homeopathic effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 108091059456 miR-92-1 stem-loop Proteins 0.000 claims 1
- 108091084336 miR-92-2 stem-loop Proteins 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6744508P | 2008-02-28 | 2008-02-28 | |
| US61/067,445 | 2008-02-28 | ||
| PCT/US2009/035458 WO2009108853A1 (en) | 2008-02-28 | 2009-02-27 | MicroRNA-BASED METHODS AND COMPOSITIONS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF GASTRIC CANCER |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011516032A JP2011516032A (ja) | 2011-05-26 |
| JP2011516032A5 true JP2011516032A5 (https=) | 2013-03-21 |
| JP5662166B2 JP5662166B2 (ja) | 2015-01-28 |
Family
ID=41016479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010548899A Expired - Fee Related JP5662166B2 (ja) | 2008-02-28 | 2009-02-27 | 胃癌の診断、予後診断及び治療のためのマイクロｒｎａに基づいた方法及び組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110034538A1 (https=) |
| EP (2) | EP2257647B1 (https=) |
| JP (1) | JP5662166B2 (https=) |
| CN (1) | CN102007223B (https=) |
| AU (1) | AU2009219190A1 (https=) |
| CA (1) | CA2716906A1 (https=) |
| WO (1) | WO2009108853A1 (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103820562B (zh) | 2005-08-01 | 2015-05-13 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
| JP2009507918A (ja) | 2005-09-12 | 2009-02-26 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | Ｂｃｌ２関連癌の診断及び療法のための組成物及び方法 |
| US7670840B2 (en) | 2006-01-05 | 2010-03-02 | The Ohio State University Research Foundation | Micro-RNA expression abnormalities of pancreatic, endocrine and acinar tumors |
| ES2553442T3 (es) | 2006-01-05 | 2015-12-09 | The Ohio State University Research Foundation | Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón |
| EP1969147B1 (en) | 2006-01-05 | 2014-07-30 | The Ohio State University Research Foundation | microRNA-based methods for the diagnosis of stomach cancer |
| EP2369011A1 (en) | 2006-03-20 | 2011-09-28 | The Ohio State University Research Foundation | Microrna fingerprints during human megakaryocytopoiesis |
| EP2041317A4 (en) | 2006-07-13 | 2009-10-14 | Univ Ohio State Res Found | METHODS AND COMPOSITIONS BASED ON MICRO-RNA FOR THE DIAGNOSIS AND TREATMENT OF COLON CANCER RELATED DISEASES |
| EP2061907B1 (en) | 2006-09-19 | 2011-11-23 | The Ohio State University Research Foundation | Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181 |
| US8252538B2 (en) | 2006-11-01 | 2012-08-28 | The Ohio State University | MicroRNA expression signature for predicting survival and metastases in hepatocellular carcinoma |
| WO2008094545A2 (en) | 2007-01-31 | 2008-08-07 | The Ohio State University Research Foundation | Mic orna-based methods and compositions for the treatment of acute myeloid leukemia |
| ES2537349T3 (es) | 2007-06-08 | 2015-06-05 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Métodos para determinar un subtipo de carcinoma hepatocelular |
| CN101918424A (zh) | 2007-06-15 | 2010-12-15 | 俄亥俄州立大学研究基金会 | 用于靶向由Drosha介导的微小RNA加工的致癌ALL-1融合蛋白 |
| CN101809169B (zh) | 2007-07-31 | 2013-07-17 | 俄亥俄州立大学研究基金会 | 通过靶向dnmt3a和dnmt3b恢复甲基化的方法 |
| EP2653561B1 (en) | 2007-08-03 | 2016-03-02 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncRNAs |
| EP3028708A1 (en) | 2007-08-22 | 2016-06-08 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias |
| CA2703707A1 (en) | 2007-10-26 | 2009-04-30 | The Ohio State University Research Foundation | Methods for identifying fragile histidine triad (fhit) interaction and uses thereof |
| EP2307028B1 (en) | 2008-06-11 | 2013-10-02 | The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services | Use of mir-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy |
| AU2010321555B2 (en) | 2009-11-23 | 2015-10-15 | The Ohio State University | Materials and methods useful for affecting tumor cell growth, migration and invasion |
| WO2012010584A1 (en) * | 2010-07-20 | 2012-01-26 | Febit Holding Gmbh | Complex mirna sets as novel biomarkers for gastric cancer |
| ES2606146T3 (es) | 2010-11-12 | 2017-03-22 | The Ohio State University Research Foundation | Métodos relacionados con microARN-21 y reparación de desapareamiento en cáncer colorrectal |
| CN103313706A (zh) | 2010-11-15 | 2013-09-18 | 俄亥俄州立大学研究基金会 | 控制释放粘膜粘合系统 |
| SG182016A1 (en) * | 2010-12-14 | 2012-07-30 | Univ Singapore | Method of detecting resistance to cancer therapy |
| US8664192B2 (en) | 2011-03-07 | 2014-03-04 | The Ohio State University | Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer |
| RU2626540C2 (ru) * | 2011-04-18 | 2017-07-28 | Диамир, Ллс | Способы обнаружения патологических изменений в органе или системе органов |
| US8703425B2 (en) * | 2011-09-12 | 2014-04-22 | The Chinese University Of Hong Kong | Biomarker for gastric cancer |
| GB201117482D0 (en) * | 2011-10-11 | 2011-11-23 | Univ Dundee | Targetiing of miRNA precursors |
| EP2766500A4 (en) | 2011-10-14 | 2015-10-14 | Univ Ohio State | METHOD AND MATERIALS IN CONNECTION WITH EGG CANCER |
| AU2012352265B2 (en) | 2011-12-13 | 2017-02-16 | Ohio State Innovation Foundation | Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis |
| US8859202B2 (en) | 2012-01-20 | 2014-10-14 | The Ohio State University | Breast cancer biomarker signatures for invasiveness and prognosis |
| US9845465B2 (en) | 2012-08-15 | 2017-12-19 | University Of Virginia Patent Foundation | Compositions and methods for treating peripheral arterial disease |
| JPWO2014097875A1 (ja) * | 2012-12-20 | 2017-01-12 | 国立大学法人鳥取大学 | 新規の脱分化誘導方法を用いた多能性幹細胞化 |
| EP4718079A2 (en) | 2014-06-16 | 2026-04-01 | Toray Industries, Inc. | Stomach cancer biomarker and detection method |
| CN104013975A (zh) * | 2014-06-16 | 2014-09-03 | 山东大学 | Fbxo31基因及其相关产物在制备胃癌治疗药物中的应用 |
| EP3177739B1 (en) | 2014-08-07 | 2019-10-23 | Agency For Science, Technology And Research | Microrna biomarker for the diagnosis of gastric cancer |
| CN104293923A (zh) * | 2014-09-19 | 2015-01-21 | 浙江大学 | 荧光定量PCR检测组织中miR-100含量的试剂盒及其应用 |
| CN106591428B (zh) * | 2016-09-23 | 2021-06-11 | 宁波大学 | 一种胃癌新型分子标记物hsa_circ_0001017的检测及应用 |
| CN106636334B (zh) * | 2016-10-09 | 2020-07-03 | 山东大学 | microRNA标志物组及其在制备检测胃癌淋巴结转移试剂盒中的应用 |
| CN106755513B (zh) * | 2017-02-08 | 2018-10-19 | 泰山医学院 | 一种胃癌的lncRNA标志物 |
| US11576873B2 (en) | 2017-03-31 | 2023-02-14 | The Curators Of The University Of Missouri | Compositions for the treatment of drug-resistant tumors and methods of use thereof |
| CN107217055B (zh) * | 2017-06-26 | 2019-01-18 | 生工生物工程（上海）股份有限公司 | 一种癌症诊断芯片及其试剂盒 |
| CN107641653B (zh) * | 2017-10-20 | 2021-02-19 | 南方医科大学南方医院 | Macc1-as1探针在制备用于预测胃癌临床预后的诊断试剂中的应用 |
| CN108546757B (zh) * | 2018-03-05 | 2021-09-07 | 上海长海医院 | Zfpm2-as1在制备胃癌诊断试剂或试剂盒中的应用 |
| KR102100124B1 (ko) * | 2018-08-31 | 2020-05-15 | 한국표준과학연구원 | 질량 분석법을 이용한 생체 분자의 고감도 및 고특이적 검출 방법 |
| WO2020130944A1 (en) * | 2018-12-19 | 2020-06-25 | Agency For Science, Technology And Research | Method of diagnosing gastric cancers using micrornas |
| CN117683886A (zh) * | 2019-04-30 | 2024-03-12 | 觅瑞实验室私人有限公司 | 一种检测胃癌的miRNA标志物组合及试剂盒 |
| CN111471764B (zh) * | 2019-12-27 | 2023-09-15 | 陈锦飞 | 一种用于筛查或辅助诊断胃癌的生物标志物组合及其试剂盒和应用 |
| CN111139299B (zh) * | 2020-01-08 | 2021-12-17 | 浙江大学 | Josd2蛋白在制备治疗恶性肿瘤药物中的应用 |
| CN111471683B (zh) * | 2020-04-15 | 2021-09-07 | 湖南省科域生物医药科技有限公司 | miR-93-5p作为诊断和治疗胃癌标志物的应用 |
| CN114678121B (zh) * | 2022-05-30 | 2022-09-09 | 上海芯超生物科技有限公司 | 一种hp球形变诊断模型的构建方法及系统 |
| WO2025245056A1 (en) * | 2024-05-20 | 2025-11-27 | City Of Hope | Gastric cancer rna biomarkers and uses thereof |
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-
2009
- 2009-02-27 CA CA2716906A patent/CA2716906A1/en not_active Abandoned
- 2009-02-27 AU AU2009219190A patent/AU2009219190A1/en not_active Abandoned
- 2009-02-27 EP EP09713926.5A patent/EP2257647B1/en not_active Not-in-force
- 2009-02-27 WO PCT/US2009/035458 patent/WO2009108853A1/en not_active Ceased
- 2009-02-27 JP JP2010548899A patent/JP5662166B2/ja not_active Expired - Fee Related
- 2009-02-27 CN CN200980112966.1A patent/CN102007223B/zh not_active Expired - Fee Related
- 2009-02-27 US US12/919,893 patent/US20110034538A1/en not_active Abandoned
- 2009-02-27 EP EP16165519.6A patent/EP3064584A3/en not_active Withdrawn
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