CN102007223B - 用于胃癌的诊断、预后和治疗的基于微rna的方法和组合物 - Google Patents
用于胃癌的诊断、预后和治疗的基于微rna的方法和组合物 Download PDFInfo
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- CN102007223B CN102007223B CN200980112966.1A CN200980112966A CN102007223B CN 102007223 B CN102007223 B CN 102007223B CN 200980112966 A CN200980112966 A CN 200980112966A CN 102007223 B CN102007223 B CN 102007223B
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- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
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- C12N2310/141—MicroRNAs, miRNAs
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- C12Q2600/00—Oligonucleotides characterized by their use
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- C12Q2600/00—Oligonucleotides characterized by their use
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6744508P | 2008-02-28 | 2008-02-28 | |
| US61/067,445 | 2008-02-28 | ||
| PCT/US2009/035458 WO2009108853A1 (en) | 2008-02-28 | 2009-02-27 | MicroRNA-BASED METHODS AND COMPOSITIONS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF GASTRIC CANCER |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102007223A CN102007223A (zh) | 2011-04-06 |
| CN102007223B true CN102007223B (zh) | 2014-06-18 |
Family
ID=41016479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980112966.1A Expired - Fee Related CN102007223B (zh) | 2008-02-28 | 2009-02-27 | 用于胃癌的诊断、预后和治疗的基于微rna的方法和组合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110034538A1 (https=) |
| EP (2) | EP2257647B1 (https=) |
| JP (1) | JP5662166B2 (https=) |
| CN (1) | CN102007223B (https=) |
| AU (1) | AU2009219190A1 (https=) |
| CA (1) | CA2716906A1 (https=) |
| WO (1) | WO2009108853A1 (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103820562B (zh) | 2005-08-01 | 2015-05-13 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
| JP2009507918A (ja) | 2005-09-12 | 2009-02-26 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | Bcl2関連癌の診断及び療法のための組成物及び方法 |
| US7670840B2 (en) | 2006-01-05 | 2010-03-02 | The Ohio State University Research Foundation | Micro-RNA expression abnormalities of pancreatic, endocrine and acinar tumors |
| ES2553442T3 (es) | 2006-01-05 | 2015-12-09 | The Ohio State University Research Foundation | Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón |
| EP1969147B1 (en) | 2006-01-05 | 2014-07-30 | The Ohio State University Research Foundation | microRNA-based methods for the diagnosis of stomach cancer |
| EP2369011A1 (en) | 2006-03-20 | 2011-09-28 | The Ohio State University Research Foundation | Microrna fingerprints during human megakaryocytopoiesis |
| EP2041317A4 (en) | 2006-07-13 | 2009-10-14 | Univ Ohio State Res Found | METHODS AND COMPOSITIONS BASED ON MICRO-RNA FOR THE DIAGNOSIS AND TREATMENT OF COLON CANCER RELATED DISEASES |
| EP2061907B1 (en) | 2006-09-19 | 2011-11-23 | The Ohio State University Research Foundation | Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181 |
| US8252538B2 (en) | 2006-11-01 | 2012-08-28 | The Ohio State University | MicroRNA expression signature for predicting survival and metastases in hepatocellular carcinoma |
| WO2008094545A2 (en) | 2007-01-31 | 2008-08-07 | The Ohio State University Research Foundation | Mic orna-based methods and compositions for the treatment of acute myeloid leukemia |
| ES2537349T3 (es) | 2007-06-08 | 2015-06-05 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Métodos para determinar un subtipo de carcinoma hepatocelular |
| CN101918424A (zh) | 2007-06-15 | 2010-12-15 | 俄亥俄州立大学研究基金会 | 用于靶向由Drosha介导的微小RNA加工的致癌ALL-1融合蛋白 |
| CN101809169B (zh) | 2007-07-31 | 2013-07-17 | 俄亥俄州立大学研究基金会 | 通过靶向dnmt3a和dnmt3b恢复甲基化的方法 |
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| EP2307028B1 (en) | 2008-06-11 | 2013-10-02 | The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services | Use of mir-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy |
| AU2010321555B2 (en) | 2009-11-23 | 2015-10-15 | The Ohio State University | Materials and methods useful for affecting tumor cell growth, migration and invasion |
| WO2012010584A1 (en) * | 2010-07-20 | 2012-01-26 | Febit Holding Gmbh | Complex mirna sets as novel biomarkers for gastric cancer |
| ES2606146T3 (es) | 2010-11-12 | 2017-03-22 | The Ohio State University Research Foundation | Métodos relacionados con microARN-21 y reparación de desapareamiento en cáncer colorrectal |
| CN103313706A (zh) | 2010-11-15 | 2013-09-18 | 俄亥俄州立大学研究基金会 | 控制释放粘膜粘合系统 |
| SG182016A1 (en) * | 2010-12-14 | 2012-07-30 | Univ Singapore | Method of detecting resistance to cancer therapy |
| US8664192B2 (en) | 2011-03-07 | 2014-03-04 | The Ohio State University | Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer |
| RU2626540C2 (ru) * | 2011-04-18 | 2017-07-28 | Диамир, Ллс | Способы обнаружения патологических изменений в органе или системе органов |
| US8703425B2 (en) * | 2011-09-12 | 2014-04-22 | The Chinese University Of Hong Kong | Biomarker for gastric cancer |
| GB201117482D0 (en) * | 2011-10-11 | 2011-11-23 | Univ Dundee | Targetiing of miRNA precursors |
| EP2766500A4 (en) | 2011-10-14 | 2015-10-14 | Univ Ohio State | METHOD AND MATERIALS IN CONNECTION WITH EGG CANCER |
| AU2012352265B2 (en) | 2011-12-13 | 2017-02-16 | Ohio State Innovation Foundation | Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis |
| US8859202B2 (en) | 2012-01-20 | 2014-10-14 | The Ohio State University | Breast cancer biomarker signatures for invasiveness and prognosis |
| US9845465B2 (en) | 2012-08-15 | 2017-12-19 | University Of Virginia Patent Foundation | Compositions and methods for treating peripheral arterial disease |
| JPWO2014097875A1 (ja) * | 2012-12-20 | 2017-01-12 | 国立大学法人鳥取大学 | 新規の脱分化誘導方法を用いた多能性幹細胞化 |
| EP4718079A2 (en) | 2014-06-16 | 2026-04-01 | Toray Industries, Inc. | Stomach cancer biomarker and detection method |
| CN104013975A (zh) * | 2014-06-16 | 2014-09-03 | 山东大学 | Fbxo31基因及其相关产物在制备胃癌治疗药物中的应用 |
| EP3177739B1 (en) | 2014-08-07 | 2019-10-23 | Agency For Science, Technology And Research | Microrna biomarker for the diagnosis of gastric cancer |
| CN104293923A (zh) * | 2014-09-19 | 2015-01-21 | 浙江大学 | 荧光定量PCR检测组织中miR-100含量的试剂盒及其应用 |
| CN106591428B (zh) * | 2016-09-23 | 2021-06-11 | 宁波大学 | 一种胃癌新型分子标记物hsa_circ_0001017的检测及应用 |
| CN106636334B (zh) * | 2016-10-09 | 2020-07-03 | 山东大学 | microRNA标志物组及其在制备检测胃癌淋巴结转移试剂盒中的应用 |
| CN106755513B (zh) * | 2017-02-08 | 2018-10-19 | 泰山医学院 | 一种胃癌的lncRNA标志物 |
| US11576873B2 (en) | 2017-03-31 | 2023-02-14 | The Curators Of The University Of Missouri | Compositions for the treatment of drug-resistant tumors and methods of use thereof |
| CN107217055B (zh) * | 2017-06-26 | 2019-01-18 | 生工生物工程(上海)股份有限公司 | 一种癌症诊断芯片及其试剂盒 |
| CN107641653B (zh) * | 2017-10-20 | 2021-02-19 | 南方医科大学南方医院 | Macc1-as1探针在制备用于预测胃癌临床预后的诊断试剂中的应用 |
| CN108546757B (zh) * | 2018-03-05 | 2021-09-07 | 上海长海医院 | Zfpm2-as1在制备胃癌诊断试剂或试剂盒中的应用 |
| KR102100124B1 (ko) * | 2018-08-31 | 2020-05-15 | 한국표준과학연구원 | 질량 분석법을 이용한 생체 분자의 고감도 및 고특이적 검출 방법 |
| WO2020130944A1 (en) * | 2018-12-19 | 2020-06-25 | Agency For Science, Technology And Research | Method of diagnosing gastric cancers using micrornas |
| CN117683886A (zh) * | 2019-04-30 | 2024-03-12 | 觅瑞实验室私人有限公司 | 一种检测胃癌的miRNA标志物组合及试剂盒 |
| CN111471764B (zh) * | 2019-12-27 | 2023-09-15 | 陈锦飞 | 一种用于筛查或辅助诊断胃癌的生物标志物组合及其试剂盒和应用 |
| CN111139299B (zh) * | 2020-01-08 | 2021-12-17 | 浙江大学 | Josd2蛋白在制备治疗恶性肿瘤药物中的应用 |
| CN111471683B (zh) * | 2020-04-15 | 2021-09-07 | 湖南省科域生物医药科技有限公司 | miR-93-5p作为诊断和治疗胃癌标志物的应用 |
| CN114678121B (zh) * | 2022-05-30 | 2022-09-09 | 上海芯超生物科技有限公司 | 一种hp球形变诊断模型的构建方法及系统 |
| WO2025245056A1 (en) * | 2024-05-20 | 2025-11-27 | City Of Hope | Gastric cancer rna biomarkers and uses thereof |
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- 2009-02-27 AU AU2009219190A patent/AU2009219190A1/en not_active Abandoned
- 2009-02-27 EP EP09713926.5A patent/EP2257647B1/en not_active Not-in-force
- 2009-02-27 WO PCT/US2009/035458 patent/WO2009108853A1/en not_active Ceased
- 2009-02-27 JP JP2010548899A patent/JP5662166B2/ja not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2009108853A1 (en) | 2009-09-03 |
| JP2011516032A (ja) | 2011-05-26 |
| CA2716906A1 (en) | 2009-09-03 |
| EP2257647B1 (en) | 2016-09-14 |
| AU2009219190A1 (en) | 2009-09-03 |
| JP5662166B2 (ja) | 2015-01-28 |
| EP3064584A2 (en) | 2016-09-07 |
| EP3064584A3 (en) | 2016-12-07 |
| EP2257647A4 (en) | 2011-08-03 |
| US20110034538A1 (en) | 2011-02-10 |
| EP2257647A1 (en) | 2010-12-08 |
| CN102007223A (zh) | 2011-04-06 |
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