CN102007223B - 用于胃癌的诊断、预后和治疗的基于微rna的方法和组合物 - Google Patents
用于胃癌的诊断、预后和治疗的基于微rna的方法和组合物 Download PDFInfo
- Publication number
- CN102007223B CN102007223B CN200980112966.1A CN200980112966A CN102007223B CN 102007223 B CN102007223 B CN 102007223B CN 200980112966 A CN200980112966 A CN 200980112966A CN 102007223 B CN102007223 B CN 102007223B
- Authority
- CN
- China
- Prior art keywords
- mir
- expression
- marker
- cells
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/205—Aptamer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6744508P | 2008-02-28 | 2008-02-28 | |
| US61/067,445 | 2008-02-28 | ||
| PCT/US2009/035458 WO2009108853A1 (en) | 2008-02-28 | 2009-02-27 | MicroRNA-BASED METHODS AND COMPOSITIONS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF GASTRIC CANCER |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102007223A CN102007223A (zh) | 2011-04-06 |
| CN102007223B true CN102007223B (zh) | 2014-06-18 |
Family
ID=41016479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980112966.1A Expired - Fee Related CN102007223B (zh) | 2008-02-28 | 2009-02-27 | 用于胃癌的诊断、预后和治疗的基于微rna的方法和组合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110034538A1 (https=) |
| EP (2) | EP2257647B1 (https=) |
| JP (1) | JP5662166B2 (https=) |
| CN (1) | CN102007223B (https=) |
| AU (1) | AU2009219190A1 (https=) |
| CA (1) | CA2716906A1 (https=) |
| WO (1) | WO2009108853A1 (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5489459B2 (ja) | 2005-08-01 | 2014-05-14 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 乳癌の診断、予後及び治療のためのマイクロrnaに基づいた方法及び組成物 |
| CA2845251A1 (en) | 2005-09-12 | 2007-03-22 | The Ohio State University Research Foundation | Compositions for the therapy of bcl2-associated cancers and methods of preparation thereof |
| JP5490413B2 (ja) | 2006-01-05 | 2014-05-14 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 膵内分泌腫瘍及び膵腺房腫瘍におけるマイクロrna発現異常 |
| EP2487258B1 (en) | 2006-01-05 | 2014-10-01 | The Ohio State University Research Foundation | MicroRNA-based methods for the diagnosis of colon, pancreas and stomach cancer |
| CN102943108B (zh) | 2006-01-05 | 2014-05-21 | 俄亥俄州立大学研究基金会 | 用于肺癌的诊断、预后和治疗的基于微小rna的方法和组合物 |
| ES2446362T3 (es) | 2006-03-20 | 2014-03-07 | The Ohio State University Research Foundation | Huellas de microARN durante megacariocipoyesis humana |
| CA2657030A1 (en) | 2006-07-13 | 2008-01-17 | The Ohio State University Research Foundation, An Instrumentality Of The State Of Ohio | Micro-rna-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases |
| CN101535505A (zh) | 2006-09-19 | 2009-09-16 | 俄亥俄州立大学研究基金会 | 慢性淋巴细胞性白血病(CLL)中受miR-29和miR-181调控的TCL1的表达 |
| EP2087135B8 (en) | 2006-11-01 | 2013-07-24 | The Ohio State University Research Foundation | Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma |
| CN105256004A (zh) | 2007-01-31 | 2016-01-20 | 俄亥俄州立大学研究基金会 | 用于急性髓细胞白血病(aml)的诊断、预后和治疗的基于微rna的方法和组合物 |
| ES2527648T3 (es) | 2007-06-08 | 2015-01-28 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Métodos para determinar el subtipo de carcinoma hepatocelular |
| EP2719773A3 (en) | 2007-06-15 | 2014-07-30 | The Ohio State University Research Foundation | miRNA as marker for acute lamphomic leucemia |
| ES2496172T3 (es) | 2007-07-31 | 2014-09-18 | The Ohio State University Research Foundation | Métodos para invertir la metilación por selección dirigida de DNMT3A y DNMT3B |
| JP2010535473A (ja) | 2007-08-03 | 2010-11-25 | ズィ、オハイオウ、ステイト、ユーニヴァーサティ、リサーチ、ファウンデイシャン | ncRNAをコードする超保存領域 |
| CA2696887C (en) | 2007-08-22 | 2016-06-28 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias |
| CN102137927B (zh) | 2007-10-26 | 2014-03-12 | 俄亥俄州立大学研究基金会 | 鉴定脆性组氨酸三联体(Fhit)相互作用的方法及其用途 |
| ES2433940T3 (es) | 2008-06-11 | 2013-12-13 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Uso de la familia miR-26 como marcador predictivo del carcinoma hepatocelular y sensibilidad a la terapia |
| US8916533B2 (en) | 2009-11-23 | 2014-12-23 | The Ohio State University | Materials and methods useful for affecting tumor cell growth, migration and invasion |
| WO2012010584A1 (en) * | 2010-07-20 | 2012-01-26 | Febit Holding Gmbh | Complex mirna sets as novel biomarkers for gastric cancer |
| JP5931897B2 (ja) | 2010-11-12 | 2016-06-08 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイションThe Ohio State University Research Foundation | マイクロrna−21、ミスマッチ修復および結腸直腸癌に関連する物質および方法 |
| CA2817982C (en) | 2010-11-15 | 2020-06-30 | The Regents Of The University Of Michigan | Controlled release mucoadhesive systems |
| SG182016A1 (en) * | 2010-12-14 | 2012-07-30 | Univ Singapore | Method of detecting resistance to cancer therapy |
| WO2012122239A1 (en) | 2011-03-07 | 2012-09-13 | The Ohio State University | MUTATOR ACTIVITY INDUCED BY MICRORNA-155 (miR-155) LINKS INFLAMMATION AND CANCER |
| CA2833389C (en) * | 2011-04-18 | 2022-01-11 | Diamir, Llc | Mirna-based universal screening test (ust) |
| US8703425B2 (en) * | 2011-09-12 | 2014-04-22 | The Chinese University Of Hong Kong | Biomarker for gastric cancer |
| GB201117482D0 (en) * | 2011-10-11 | 2011-11-23 | Univ Dundee | Targetiing of miRNA precursors |
| AU2012323924A1 (en) | 2011-10-14 | 2014-05-29 | The Ohio State University | Methods and materials related to ovarian cancer |
| CA2859430A1 (en) | 2011-12-13 | 2013-06-20 | Ohio State Innovation Foundation | Methods and compositions related to mir-21 and mir-29a, exosome inhibition, and cancer metastasis |
| US8859202B2 (en) | 2012-01-20 | 2014-10-14 | The Ohio State University | Breast cancer biomarker signatures for invasiveness and prognosis |
| WO2014028762A1 (en) * | 2012-08-15 | 2014-02-20 | University Of Virginia Patent Foundation | Compositions and methods for treating peripheral arterial disease |
| WO2014097875A1 (ja) * | 2012-12-20 | 2014-06-26 | 国立大学法人鳥取大学 | 新規の脱分化誘導方法を用いた多能性幹細胞化 |
| CN106460068B (zh) | 2014-06-16 | 2024-08-23 | 东丽株式会社 | 胃癌的检测试剂盒或装置以及检测方法 |
| CN104013975A (zh) * | 2014-06-16 | 2014-09-03 | 山东大学 | Fbxo31基因及其相关产物在制备胃癌治疗药物中的应用 |
| EP4137586B1 (en) | 2014-08-07 | 2026-04-22 | Agency for Science, Technology and Research | Microrna biomarker for the diagnosis of gastric cancer |
| CN104293923A (zh) * | 2014-09-19 | 2015-01-21 | 浙江大学 | 荧光定量PCR检测组织中miR-100含量的试剂盒及其应用 |
| CN106591428B (zh) * | 2016-09-23 | 2021-06-11 | 宁波大学 | 一种胃癌新型分子标记物hsa_circ_0001017的检测及应用 |
| CN106636334B (zh) * | 2016-10-09 | 2020-07-03 | 山东大学 | microRNA标志物组及其在制备检测胃癌淋巴结转移试剂盒中的应用 |
| CN106755513B (zh) * | 2017-02-08 | 2018-10-19 | 泰山医学院 | 一种胃癌的lncRNA标志物 |
| US11576873B2 (en) | 2017-03-31 | 2023-02-14 | The Curators Of The University Of Missouri | Compositions for the treatment of drug-resistant tumors and methods of use thereof |
| CN107217055B (zh) * | 2017-06-26 | 2019-01-18 | 生工生物工程(上海)股份有限公司 | 一种癌症诊断芯片及其试剂盒 |
| CN107641653B (zh) * | 2017-10-20 | 2021-02-19 | 南方医科大学南方医院 | Macc1-as1探针在制备用于预测胃癌临床预后的诊断试剂中的应用 |
| CN108546757B (zh) * | 2018-03-05 | 2021-09-07 | 上海长海医院 | Zfpm2-as1在制备胃癌诊断试剂或试剂盒中的应用 |
| KR102100124B1 (ko) * | 2018-08-31 | 2020-05-15 | 한국표준과학연구원 | 질량 분석법을 이용한 생체 분자의 고감도 및 고특이적 검출 방법 |
| SG11202106638UA (en) * | 2018-12-19 | 2021-07-29 | Agency Science Tech & Res | Method of diagnosing gastric cancers using micrornas |
| CN117683885A (zh) * | 2019-04-30 | 2024-03-12 | 觅瑞实验室私人有限公司 | 一种检测胃癌的miRNA标志物组合及试剂盒 |
| CN111471764B (zh) * | 2019-12-27 | 2023-09-15 | 陈锦飞 | 一种用于筛查或辅助诊断胃癌的生物标志物组合及其试剂盒和应用 |
| CN111139299B (zh) * | 2020-01-08 | 2021-12-17 | 浙江大学 | Josd2蛋白在制备治疗恶性肿瘤药物中的应用 |
| CN111471683B (zh) * | 2020-04-15 | 2021-09-07 | 湖南省科域生物医药科技有限公司 | miR-93-5p作为诊断和治疗胃癌标志物的应用 |
| CN114678121B (zh) * | 2022-05-30 | 2022-09-09 | 上海芯超生物科技有限公司 | 一种hp球形变诊断模型的构建方法及系统 |
| WO2025245056A1 (en) * | 2024-05-20 | 2025-11-27 | City Of Hope | Gastric cancer rna biomarkers and uses thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007081740A2 (en) * | 2006-01-05 | 2007-07-19 | The Ohio State University Research Foundation | Micrornarna-based methods and compositions for the diagnosis and treatment of solid cancers |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1837495A (en) * | 1994-10-13 | 1996-05-06 | Horus Therapeutics, Inc. | Computer assisted methods for diagnosing diseases |
| US6303323B1 (en) * | 1997-10-21 | 2001-10-16 | Cancer Research Campaign Technology Limited | Detection of dysplastic or neoplastic cells using anti-MCM5 antibodies |
| US6891031B2 (en) * | 2000-02-18 | 2005-05-10 | The Regents Of The University Of California | Coordinate cytokine regulatory sequences |
| US7455995B2 (en) * | 2001-11-09 | 2008-11-25 | The Ohio State University Research Foundation | BAALC expression as a diagnostic marker for acute leukemia |
| AU2002231843A1 (en) * | 2002-02-12 | 2003-09-04 | Nokia Corporation | Method for controlling data transmission, and data transmission system |
| WO2004071464A2 (en) * | 2003-02-12 | 2004-08-26 | Johns Hopkins University School Of Medicine | Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells |
| US20050069918A1 (en) * | 2003-05-29 | 2005-03-31 | Francois Claret | JAB1 as a prognostic marker and a therapeutic target for human cancer |
| US8106180B2 (en) * | 2003-08-07 | 2012-01-31 | Whitehead Institute For Biomedical Research | Methods and products for expression of micro RNAs |
| US20050164252A1 (en) * | 2003-12-04 | 2005-07-28 | Yeung Wah Hin A. | Methods using non-genic sequences for the detection, modification and treatment of any disease or improvement of functions of a cell |
| US20060134639A1 (en) * | 2004-04-06 | 2006-06-22 | Huffel Christophe V | Method for the determination of cellular transcriptional regulation |
| CN101056991A (zh) * | 2004-04-20 | 2007-10-17 | 基因耐克生物医学制品有限公司 | 检测ncRNA的方法 |
| EP2290071B1 (en) * | 2004-05-28 | 2014-12-31 | Asuragen, Inc. | Methods and compositions involving microRNA |
| KR20070058441A (ko) * | 2004-07-01 | 2007-06-08 | 유니버시티 오브 피츠버그 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 면역억제성 엑소솜 |
| JP2008511678A (ja) * | 2004-09-02 | 2008-04-17 | イェール ユニバーシティ | マイクロrnaによるオンコジーンの調節 |
| US7642348B2 (en) * | 2004-10-04 | 2010-01-05 | Rosetta Genomics Ltd | Prostate cancer-related nucleic acids |
| US7571055B2 (en) * | 2004-10-13 | 2009-08-04 | Regents Of The University Of Minnesota | Systemic lupus erythematosus |
| CA2857881A1 (en) * | 2004-11-12 | 2006-12-28 | Asuragen, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
| US8071306B2 (en) * | 2005-01-25 | 2011-12-06 | Merck Sharp & Dohme Corp. | Methods for quantitating small RNA molecules |
| CA2597767A1 (en) * | 2005-02-11 | 2006-08-17 | Wisconsin Alumni Research Foundation | Mir-155 assay |
| US20070213292A1 (en) * | 2005-08-10 | 2007-09-13 | The Rockefeller University | Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof |
| US20070092882A1 (en) * | 2005-10-21 | 2007-04-26 | Hui Wang | Analysis of microRNA |
| US8445198B2 (en) * | 2005-12-01 | 2013-05-21 | Medical Prognosis Institute | Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy |
| JP5490413B2 (ja) * | 2006-01-05 | 2014-05-14 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 膵内分泌腫瘍及び膵腺房腫瘍におけるマイクロrna発現異常 |
| CN102943108B (zh) * | 2006-01-05 | 2014-05-21 | 俄亥俄州立大学研究基金会 | 用于肺癌的诊断、预后和治疗的基于微小rna的方法和组合物 |
| CA2648132C (en) * | 2006-04-03 | 2019-05-28 | Santaris Pharma A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
| CA2657030A1 (en) * | 2006-07-13 | 2008-01-17 | The Ohio State University Research Foundation, An Instrumentality Of The State Of Ohio | Micro-rna-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases |
| JP2010510964A (ja) * | 2006-09-19 | 2010-04-08 | アシュラジェン インコーポレイテッド | 治療的介入の標的としての、miR−15、miR−26、miR−31、miR−145、miR−147、miR−188、miR−215、miR−216、miR−331、mmu−miR−292−3pによって調節される遺伝子および経路 |
| WO2008073920A2 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Mir-21 regulated genes and pathways as targets for therapeutic intervention |
| CA2699418A1 (en) * | 2007-02-27 | 2008-09-04 | Moshe Oren | Composition and methods for modulating cell proliferation and cell death |
| EP2126584B1 (en) * | 2007-03-16 | 2012-12-19 | CovalX AG | Direct mass spectrometric analysis of drug candidates targeting protein complexes |
| WO2009015357A1 (en) * | 2007-07-25 | 2009-01-29 | University Of Louisville Research Foundation, Inc. | Exosome-associated microrna as a diagnostic marker |
| CA2696887C (en) * | 2007-08-22 | 2016-06-28 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias |
| US20090239818A1 (en) * | 2007-09-07 | 2009-09-24 | Cheng Jin Q | Effective treatment of ovarian cancer using triciribine and related compounds |
| US20100305188A1 (en) * | 2007-10-03 | 2010-12-02 | Kyowa Hakko Kirin Co., Ltd. | Nucleic acid capable of regulating the proliferation of cell |
| EP2623599B1 (en) * | 2007-10-04 | 2019-01-02 | Roche Innovation Center Copenhagen A/S | Micromirs |
| EP2217248B1 (en) * | 2007-10-29 | 2016-11-30 | Regulus Therapeutics Inc. | Targeting micrornas for the treatment of liver cancer |
| EP2245199B1 (en) * | 2008-02-01 | 2013-11-13 | The General Hospital Corporation | Use of microvesicles in diagnosis, prognosis and treatment of medical diseases and conditions |
| US20110054009A1 (en) * | 2008-02-28 | 2011-03-03 | The Ohio State University Research Foundation | MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Prostate Related Disorders |
| WO2009111375A2 (en) * | 2008-03-01 | 2009-09-11 | Abraxis Bioscience, Llc | Treatment, diagnostic, and method for discovering antagonist using sparc specific mirnas |
| EP2268832A2 (en) * | 2008-03-06 | 2011-01-05 | Asuragen, INC. | Microrna markers for recurrence of colorectal cancer |
| WO2009147525A1 (en) * | 2008-06-04 | 2009-12-10 | Karolinska Institutet Innovations Ab | Skin cancer associated micrornas |
| US20100021734A1 (en) * | 2008-07-22 | 2010-01-28 | Covalent Materials Corporation | Ceramic particles and producing method thereof |
| KR101031305B1 (ko) * | 2008-07-23 | 2011-04-29 | 국립암센터 | 마이크로rna-21 저해제를 포함하는 방사선 민감성증진용 조성물 |
| US20100179213A1 (en) * | 2008-11-11 | 2010-07-15 | Mirna Therapeutics, Inc. | Methods and Compositions Involving miRNAs In Cancer Stem Cells |
| AU2009322907B2 (en) * | 2008-12-05 | 2016-05-05 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis and treatment of ovarian cancer |
-
2009
- 2009-02-27 WO PCT/US2009/035458 patent/WO2009108853A1/en not_active Ceased
- 2009-02-27 CA CA2716906A patent/CA2716906A1/en not_active Abandoned
- 2009-02-27 EP EP09713926.5A patent/EP2257647B1/en not_active Not-in-force
- 2009-02-27 US US12/919,893 patent/US20110034538A1/en not_active Abandoned
- 2009-02-27 JP JP2010548899A patent/JP5662166B2/ja not_active Expired - Fee Related
- 2009-02-27 AU AU2009219190A patent/AU2009219190A1/en not_active Abandoned
- 2009-02-27 CN CN200980112966.1A patent/CN102007223B/zh not_active Expired - Fee Related
- 2009-02-27 EP EP16165519.6A patent/EP3064584A3/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007081740A2 (en) * | 2006-01-05 | 2007-07-19 | The Ohio State University Research Foundation | Micrornarna-based methods and compositions for the diagnosis and treatment of solid cancers |
Non-Patent Citations (3)
| Title |
|---|
| 《 MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression》;Ivanovska I, et al;《Mol Cell Bio》;20080122(第7期);2167-74 * |
| 《 Molecular Evolution of a microRNA Claster》;Tanzer A, et al.;《J Mol Biol》;20040528;第339卷(第2期);327-335 * |
| 《Processing of intronic miroRNAs》;Kim YK et al;《EMBO》;20070125;第26卷(第3期);第777页左栏第1-2行、图3B * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009219190A1 (en) | 2009-09-03 |
| US20110034538A1 (en) | 2011-02-10 |
| EP2257647A1 (en) | 2010-12-08 |
| JP5662166B2 (ja) | 2015-01-28 |
| EP2257647B1 (en) | 2016-09-14 |
| WO2009108853A1 (en) | 2009-09-03 |
| CN102007223A (zh) | 2011-04-06 |
| CA2716906A1 (en) | 2009-09-03 |
| JP2011516032A (ja) | 2011-05-26 |
| EP3064584A2 (en) | 2016-09-07 |
| EP2257647A4 (en) | 2011-08-03 |
| EP3064584A3 (en) | 2016-12-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102007223B (zh) | 用于胃癌的诊断、预后和治疗的基于微rna的方法和组合物 | |
| CN102027129B (zh) | 用于前列腺相关病症的诊断、预后和治疗的基于微rna的方法和组合物 | |
| AU2009322907B2 (en) | MicroRNA-based methods and compositions for the diagnosis and treatment of ovarian cancer | |
| Del Vescovo et al. | MicroRNAs as lung cancer biomarkers | |
| AU2009219203B2 (en) | MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia (AML) and uses thereof | |
| JP2010535473A (ja) | ncRNAをコードする超保存領域 | |
| JP2010535782A (ja) | Dnmt3a及びdnmt3bを標的にすることによるメチル化を元に戻す方法 | |
| CN102015027A (zh) | 与人慢性淋巴细胞性白血病(ccl)相关的微rna特征和其用途 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140618 Termination date: 20180227 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |