JP2011517932A5 - - Google Patents
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- JP2011517932A5 JP2011517932A5 JP2010548901A JP2010548901A JP2011517932A5 JP 2011517932 A5 JP2011517932 A5 JP 2011517932A5 JP 2010548901 A JP2010548901 A JP 2010548901A JP 2010548901 A JP2010548901 A JP 2010548901A JP 2011517932 A5 JP2011517932 A5 JP 2011517932A5
- Authority
- JP
- Japan
- Prior art keywords
- mir
- biomarker
- cluster
- cells
- cll
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 37
- 239000000090 biomarker Substances 0.000 claims 36
- 238000000034 method Methods 0.000 claims 28
- 108091070501 miRNA Proteins 0.000 claims 24
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 21
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 17
- 206010028980 Neoplasm Diseases 0.000 claims 15
- 201000011510 cancer Diseases 0.000 claims 14
- 208000032839 leukemia Diseases 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 10
- 230000000692 anti-sense effect Effects 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- 201000010099 disease Diseases 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 108091074057 miR-16-1 stem-loop Proteins 0.000 claims 8
- 239000000523 sample Substances 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 102000006818 Cell Adhesion Molecule-1 Human genes 0.000 claims 5
- 108010072135 Cell Adhesion Molecule-1 Proteins 0.000 claims 5
- 239000012472 biological sample Substances 0.000 claims 5
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 239000003550 marker Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 230000004075 alteration Effects 0.000 claims 3
- 239000000063 antileukemic agent Substances 0.000 claims 3
- 238000010837 poor prognosis Methods 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 2
- 239000013068 control sample Substances 0.000 claims 2
- 230000003247 decreasing effect Effects 0.000 claims 2
- 238000011275 oncology therapy Methods 0.000 claims 2
- 238000004393 prognosis Methods 0.000 claims 2
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims 1
- 101150017888 Bcl2 gene Proteins 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 101000611943 Homo sapiens Programmed cell death protein 4 Proteins 0.000 claims 1
- 101001130308 Homo sapiens Ras-related protein Rab-21 Proteins 0.000 claims 1
- 101000633708 Homo sapiens Src kinase-associated phosphoprotein 2 Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102100040992 Programmed cell death protein 4 Human genes 0.000 claims 1
- 102000020146 Rab21 Human genes 0.000 claims 1
- 102100029213 Src kinase-associated phosphoprotein 2 Human genes 0.000 claims 1
- 102000001742 Tumor Suppressor Proteins Human genes 0.000 claims 1
- 108010040002 Tumor Suppressor Proteins Proteins 0.000 claims 1
- 230000000719 anti-leukaemic effect Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 230000001632 homeopathic effect Effects 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 238000001890 transfection Methods 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6740608P | 2008-02-28 | 2008-02-28 | |
| US61/067,406 | 2008-02-28 | ||
| PCT/US2009/035463 WO2009108856A2 (en) | 2008-02-28 | 2009-02-27 | Microrna signatures associated with human chronic lymphocytic leukemia (ccl) and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011517932A JP2011517932A (ja) | 2011-06-23 |
| JP2011517932A5 true JP2011517932A5 (https=) | 2013-03-07 |
Family
ID=41016725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010548901A Pending JP2011517932A (ja) | 2008-02-28 | 2009-02-27 | ヒト慢性リンパ球性白血病（ｃｃｌ）と関連するマイクロｒｎａシグネチャーおよびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20110052502A1 (https=) |
| EP (1) | EP2254668A4 (https=) |
| JP (1) | JP2011517932A (https=) |
| CN (1) | CN102015027A (https=) |
| AU (1) | AU2009219193A1 (https=) |
| CA (1) | CA2717026A1 (https=) |
| WO (1) | WO2009108856A2 (https=) |
Families Citing this family (85)
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| CN103820562B (zh) | 2005-08-01 | 2015-05-13 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
| JP2009507918A (ja) | 2005-09-12 | 2009-02-26 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | Ｂｃｌ２関連癌の診断及び療法のための組成物及び方法 |
| ES2553442T3 (es) | 2006-01-05 | 2015-12-09 | The Ohio State University Research Foundation | Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón |
| EP1969147B1 (en) | 2006-01-05 | 2014-07-30 | The Ohio State University Research Foundation | microRNA-based methods for the diagnosis of stomach cancer |
| US7670840B2 (en) | 2006-01-05 | 2010-03-02 | The Ohio State University Research Foundation | Micro-RNA expression abnormalities of pancreatic, endocrine and acinar tumors |
| EP2369011A1 (en) | 2006-03-20 | 2011-09-28 | The Ohio State University Research Foundation | Microrna fingerprints during human megakaryocytopoiesis |
| EP2041317A4 (en) | 2006-07-13 | 2009-10-14 | Univ Ohio State Res Found | METHODS AND COMPOSITIONS BASED ON MICRO-RNA FOR THE DIAGNOSIS AND TREATMENT OF COLON CANCER RELATED DISEASES |
| EP2061907B1 (en) | 2006-09-19 | 2011-11-23 | The Ohio State University Research Foundation | Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181 |
| US8252538B2 (en) | 2006-11-01 | 2012-08-28 | The Ohio State University | MicroRNA expression signature for predicting survival and metastases in hepatocellular carcinoma |
| WO2008094545A2 (en) | 2007-01-31 | 2008-08-07 | The Ohio State University Research Foundation | Mic orna-based methods and compositions for the treatment of acute myeloid leukemia |
| ES2537349T3 (es) | 2007-06-08 | 2015-06-05 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Métodos para determinar un subtipo de carcinoma hepatocelular |
| CN101918424A (zh) | 2007-06-15 | 2010-12-15 | 俄亥俄州立大学研究基金会 | 用于靶向由Drosha介导的微小RNA加工的致癌ALL-1融合蛋白 |
| CN101809169B (zh) | 2007-07-31 | 2013-07-17 | 俄亥俄州立大学研究基金会 | 通过靶向dnmt3a和dnmt3b恢复甲基化的方法 |
| EP2653561B1 (en) | 2007-08-03 | 2016-03-02 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncRNAs |
| EP3028708A1 (en) | 2007-08-22 | 2016-06-08 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias |
| CA2703707A1 (en) | 2007-10-26 | 2009-04-30 | The Ohio State University Research Foundation | Methods for identifying fragile histidine triad (fhit) interaction and uses thereof |
| EP2307028B1 (en) | 2008-06-11 | 2013-10-02 | The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services | Use of mir-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy |
| JP2013534824A (ja) * | 2010-06-24 | 2013-09-09 | ジ・オハイオ・ステート・ユニバーシティ | 標的化されたｍｉＲ−２９発現によりマウスにおいてモデル化された慢性リンパ性白血病 |
| EP2622076A1 (en) * | 2010-09-30 | 2013-08-07 | University of Zürich | Treatment of b-cell lymphoma with microrna |
| ES2606146T3 (es) | 2010-11-12 | 2017-03-22 | The Ohio State University Research Foundation | Métodos relacionados con microARN-21 y reparación de desapareamiento en cáncer colorrectal |
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-
2009
- 2009-02-27 CA CA2717026A patent/CA2717026A1/en not_active Abandoned
- 2009-02-27 AU AU2009219193A patent/AU2009219193A1/en not_active Abandoned
- 2009-02-27 US US12/919,904 patent/US20110052502A1/en not_active Abandoned
- 2009-02-27 EP EP20090715356 patent/EP2254668A4/en not_active Ceased
- 2009-02-27 JP JP2010548901A patent/JP2011517932A/ja active Pending
- 2009-02-27 CN CN2009801145645A patent/CN102015027A/zh active Pending
- 2009-02-27 WO PCT/US2009/035463 patent/WO2009108856A2/en not_active Ceased
-
2012
- 2012-06-28 US US13/536,837 patent/US20120283310A1/en not_active Abandoned
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