JP2011515495A

JP2011515495A - オピエートアゴニスト及びアゴニスト−アンタゴニストの乱用抑制経皮製剤

オピエートアゴニスト及びアゴニスト−アンタゴニストの乱用抑制経皮製剤 Download PDF

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Publication number: JP2011515495A
Authority: JP; Japan
Prior art keywords: opioid; antagonist; prodrug; opioid agonist; abuse
Prior art date: 2008-03-26
Legal status : Pending

Application number

JP2011502067A

Other languages

English (en)

Japanese (ja)

Other versions

JP2011515495A5 (OSRAM

Inventor

リンスティンチコーム，オウドラ

リーバンクス，スタン

Original Assignee

オールトランツインコーポレイティド

Priority date

2008-03-26

Filing date

2009-03-26

Publication date

2011-05-19

2009-03-26 Application filed by オールトランツインコーポレイティド filed Critical オールトランツインコーポレイティド

2011-05-19 Publication of JP2011515495A publication Critical patent/JP2011515495A/ja

2012-05-24 Publication of JP2011515495A5 publication Critical patent/JP2011515495A5/ja

Status Pending legal-status Critical Current

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239000005557 antagonist Substances 0.000 title claims description 106
239000003402 opiate agonist Substances 0.000 title claims description 87
238000002360 preparation method Methods 0.000 title 1
239000000203 mixture Substances 0.000 claims abstract description 152
239000000651 prodrug Substances 0.000 claims abstract description 130
229940002612 prodrug Drugs 0.000 claims abstract description 130
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229960003086 naltrexone Drugs 0.000 claims abstract description 111
RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims abstract description 102
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238000000034 method Methods 0.000 claims abstract description 37
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239000003814 drug Substances 0.000 claims description 46
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UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 claims description 7
WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 7
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