JP2011515470A - 臍帯血細胞を用いた脳損傷の処置 - Google Patents
臍帯血細胞を用いた脳損傷の処置 Download PDFInfo
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015501835A (ja) * | 2011-12-14 | 2015-01-19 | イエダ リサーチ アンド ディベロップメント カンパニー リミテッド | 中枢神経系の損傷の治療のためのヒト単球亜集団 |
| WO2015174087A1 (ja) * | 2014-05-16 | 2015-11-19 | 公益財団法人先端医療振興財団 | 脳梗塞の予防及び／又は治療の為の医薬 |
| WO2017204231A1 (ja) * | 2016-05-24 | 2017-11-30 | 国立大学法人 東京大学 | 臍帯由来細胞を含む脳障害の治療剤 |
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| US9694038B2 (en) * | 2000-04-06 | 2017-07-04 | Wayne P. Franco | Combination growth factor therapy and cell therapy for treatment of acute and chronic diseases of the organs |
| CN103599129A (zh) * | 2013-11-07 | 2014-02-26 | 唐明淇 | 一种人干细胞组合物在制备用于治疗阿尔茨海默症的药物中的用途 |
| CN108269615A (zh) * | 2018-03-14 | 2018-07-10 | 南宁市第人民医院 | 一种脐血pH值与婴幼儿脑损伤的关系评价方法 |
| CA3144081A1 (en) * | 2019-08-20 | 2021-02-25 | Stemcyte Inc. | Use of therapeutic compositions comprising umbilical cord blood for treating cardiovascular disease or brain injury |
Citations (1)
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| US20010038836A1 (en) * | 2000-04-04 | 2001-11-08 | Matthew During | Application of myeloid-origin cells to the nervous system |
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| US4965204A (en) | 1984-02-06 | 1990-10-23 | The Johns Hopkins University | Human stem cells and monoclonal antibodies |
| US4714680B1 (en) | 1984-02-06 | 1995-06-27 | Univ Johns Hopkins | Human stem cells |
| US5087570A (en) | 1988-05-10 | 1992-02-11 | Weissman Irving L | Homogeneous mammalian hematopoietic stem cell composition |
| US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| EP1263930A4 (en) | 2000-03-09 | 2004-07-21 | Saneron Ccel Therapeutics Inc | HUMAN CORD BLOOD BLOOD AS A SOURCE FOR NEURAL TISSUE FOR HEALING THE BRAIN AND BACK MARK |
| US8062837B2 (en) | 2002-02-14 | 2011-11-22 | Stemcyte, Inc. | Plasma-depleted, not erythrocyte-depleted, cord blood compositions and method of making |
| US7875272B2 (en) | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| DE10330216A1 (de) | 2003-07-03 | 2005-01-20 | Jensen, Arne Wilhelm Oluf, Prof. Dr. | Verwendung von Stammzellen aus Nabelschnurblut zur Verhinderung von Hirnschäden infolge Sauerstoffmangel und zur Neuroprotektion |
| WO2005112959A2 (en) | 2004-05-17 | 2005-12-01 | Regents Of The University Of Minnesota | Use of umbilical cord blood stem cells to treat ischemic event |
| US20060264365A1 (en) | 2005-05-18 | 2006-11-23 | Hung Li | Treatment of brain tissue damage |
| US7569545B2 (en) | 2005-05-20 | 2009-08-04 | Academia Sinica | Methods of increasing neurotrophic factor expression |
| DK1926813T4 (da) | 2005-09-23 | 2019-08-19 | Tigenix S A U | Cellepopulationer med immunregulatorisk aktivitet, fremgangsmåde til isolering og anvendelser |
| US7427597B2 (en) | 2005-11-21 | 2008-09-23 | Academia Sinica | Method of treating brain tissue damages |
| US8329166B2 (en) | 2005-12-16 | 2012-12-11 | Academia Sinica | Pluripotent olfactory stem cells |
| CN102448474A (zh) | 2009-05-21 | 2012-05-09 | 史坦赛特股份有限公司 | 脑组织损伤之细胞治疗 |
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Patent Citations (1)
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| US20010038836A1 (en) * | 2000-04-04 | 2001-11-08 | Matthew During | Application of myeloid-origin cells to the nervous system |
Non-Patent Citations (6)
| Title |
|---|
| JPN6013038939; ＰＯＭＹＪＥ，Ｊ． ｅｔ ａｌ: 'Ｄｉｆｆｅｒｅｎｔ ｅｘｐｒｅｓｓｉｏｎ ｏｆ ａｎｇｉｏｇｅｎｉｃ ｇｅｎｅｓ ｉｎ ＣＤ１３３＋／ＣＤ３４＋ ｃｅｌｌ ｆｒａｃｔｉｏｎ ｄｅｒｉｖｅｄ ｆｒｏｍ ｃｏｒｄ ｂｌｏｏｄ ａｎｄ ａ' Ｅｘｐｅｒｉｍｅｎｔａｌ Ｈｅｍａｔｏｌｏｇｙ Ｖｏｌ．３１， Ｎｏ．７, 2003, ｐ．２０９ * |
| JPN6013038941; Ｉｎｆｌａｍｍａｔｉｏｎ ａｎｄ Ｒｅｇｅｎｅｒａｔｉｏｎ Ｖｏｌ．２３， Ｎｏ．３, 2003, ｐ．１８１-１８５ * |
| JPN6013038943; 人工血液 Ｖｏｌ．１４， Ｎｏ．４, 2007, ｐ．１０８-１１２ * |
| JPN7013002938; Ｓｔｒｏｋｅ Ｖｏｌ．３２, 2001, ｐ．２６８２-２６８８ * |
| JPN7013002939; Ｃｅｌｌ Ｔｒａｎｓｐｌａｎｔａｔｉｏｎ Ｖｏｌ．１１, 2002, ｐ．２７５-２８１ * |
| JPN7013002940; Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｉｎｖｅｓｔｉｇａｔｉｏｎ Ｖｏｌ．１１４， Ｎｏ．３, 2004, ｐ．３３０-３３８ * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015501835A (ja) * | 2011-12-14 | 2015-01-19 | イエダ リサーチ アンド ディベロップメント カンパニー リミテッド | 中枢神経系の損傷の治療のためのヒト単球亜集団 |
| WO2015174087A1 (ja) * | 2014-05-16 | 2015-11-19 | 公益財団法人先端医療振興財団 | 脳梗塞の予防及び／又は治療の為の医薬 |
| WO2017204231A1 (ja) * | 2016-05-24 | 2017-11-30 | 国立大学法人 東京大学 | 臍帯由来細胞を含む脳障害の治療剤 |
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| CA2719740A1 (en) | 2009-10-01 |
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| TW201636033A (zh) | 2016-10-16 |
| EP2282748A2 (en) | 2011-02-16 |
| CA2719740C (en) | 2018-11-20 |
| JP2014237677A (ja) | 2014-12-18 |
| JP2018154634A (ja) | 2018-10-04 |
| EP2282748A4 (en) | 2012-01-11 |
| JP6401757B2 (ja) | 2018-10-10 |
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| AU2009229153B2 (en) | 2015-06-11 |
| US20110256107A1 (en) | 2011-10-20 |
| TW200948370A (en) | 2009-12-01 |
| AU2009229153A1 (en) | 2009-10-01 |
| JP6138090B2 (ja) | 2017-05-31 |
| IL208406A0 (en) | 2010-12-30 |
| EP2282748B1 (en) | 2016-11-09 |
| WO2009120368A3 (en) | 2010-01-07 |
| US11318170B2 (en) | 2022-05-03 |
| SG191701A1 (en) | 2013-07-31 |
| WO2009120368A2 (en) | 2009-10-01 |
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