CA2719740C - Treatment of brain damage using umbilical cord blood cells - Google Patents

Treatment of brain damage using umbilical cord blood cells Download PDF

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Publication number
CA2719740C
CA2719740C CA2719740A CA2719740A CA2719740C CA 2719740 C CA2719740 C CA 2719740C CA 2719740 A CA2719740 A CA 2719740A CA 2719740 A CA2719740 A CA 2719740A CA 2719740 C CA2719740 C CA 2719740C
Authority
CA
Canada
Prior art keywords
cell population
cord blood
umbilical cord
use according
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2719740A
Other languages
English (en)
French (fr)
Other versions
CA2719740A1 (en
Inventor
Shinn-Zong Lin
Woei-Cherng Shyu
Hung Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
StemCyte Inc
Original Assignee
StemCyte Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by StemCyte Inc filed Critical StemCyte Inc
Publication of CA2719740A1 publication Critical patent/CA2719740A1/en
Application granted granted Critical
Publication of CA2719740C publication Critical patent/CA2719740C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Zoology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2719740A 2008-03-28 2009-03-26 Treatment of brain damage using umbilical cord blood cells Expired - Fee Related CA2719740C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7217308P 2008-03-28 2008-03-28
US61/072,173 2008-03-28
PCT/US2009/001915 WO2009120368A2 (en) 2008-03-28 2009-03-26 Treatment of brain damage using umbilical cord blood cells

Publications (2)

Publication Number Publication Date
CA2719740A1 CA2719740A1 (en) 2009-10-01
CA2719740C true CA2719740C (en) 2018-11-20

Family

ID=41114539

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2719740A Expired - Fee Related CA2719740C (en) 2008-03-28 2009-03-26 Treatment of brain damage using umbilical cord blood cells

Country Status (10)

Country Link
US (1) US11318170B2 (enExample)
EP (1) EP2282748B1 (enExample)
JP (4) JP2011515470A (enExample)
CN (1) CN102036671A (enExample)
AU (1) AU2009229153B2 (enExample)
CA (1) CA2719740C (enExample)
IL (1) IL208406A0 (enExample)
SG (1) SG191701A1 (enExample)
TW (2) TW201636033A (enExample)
WO (1) WO2009120368A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9694038B2 (en) * 2000-04-06 2017-07-04 Wayne P. Franco Combination growth factor therapy and cell therapy for treatment of acute and chronic diseases of the organs
WO2013088441A1 (en) * 2011-12-14 2013-06-20 Yeda Research And Development Co. Ltd Human monocyte sub-population for treatment of central nervous system injury
CN103599129A (zh) * 2013-11-07 2014-02-26 唐明淇 一种人干细胞组合物在制备用于治疗阿尔茨海默症的药物中的用途
JPWO2015174087A1 (ja) * 2014-05-16 2017-04-20 公益財団法人先端医療振興財団 脳梗塞の予防及び/又は治療の為の医薬
JP7126703B2 (ja) * 2016-05-24 2022-08-29 国立大学法人 東京大学 臍帯由来細胞を含む脳障害の治療剤
CN108269615A (zh) * 2018-03-14 2018-07-10 南宁市第人民医院 一种脐血pH值与婴幼儿脑损伤的关系评价方法
CN114466655A (zh) * 2019-08-20 2022-05-10 永生生技股份有限公司 心血管疾病的治疗

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965204A (en) 1984-02-06 1990-10-23 The Johns Hopkins University Human stem cells and monoclonal antibodies
US4714680B1 (en) 1984-02-06 1995-06-27 Univ Johns Hopkins Human stem cells
US5087570A (en) 1988-05-10 1992-02-11 Weissman Irving L Homogeneous mammalian hematopoietic stem cell composition
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
EP1263930A4 (en) 2000-03-09 2004-07-21 Saneron Ccel Therapeutics Inc HUMAN CORD BLOOD BLOOD AS A SOURCE FOR NEURAL TISSUE FOR HEALING THE BRAIN AND BACK MARK
US20010038836A1 (en) * 2000-04-04 2001-11-08 Matthew During Application of myeloid-origin cells to the nervous system
US8062837B2 (en) 2002-02-14 2011-11-22 Stemcyte, Inc. Plasma-depleted, not erythrocyte-depleted, cord blood compositions and method of making
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
DE10330216A1 (de) 2003-07-03 2005-01-20 Jensen, Arne Wilhelm Oluf, Prof. Dr. Verwendung von Stammzellen aus Nabelschnurblut zur Verhinderung von Hirnschäden infolge Sauerstoffmangel und zur Neuroprotektion
WO2005112959A2 (en) 2004-05-17 2005-12-01 Regents Of The University Of Minnesota Use of umbilical cord blood stem cells to treat ischemic event
US20060264365A1 (en) 2005-05-18 2006-11-23 Hung Li Treatment of brain tissue damage
US7569545B2 (en) 2005-05-20 2009-08-04 Academia Sinica Methods of increasing neurotrophic factor expression
SG10202001007TA (en) 2005-09-23 2020-03-30 Tigenix Sau Cell populations having immunoregulatory activity, method for isolation and uses
US7427597B2 (en) 2005-11-21 2008-09-23 Academia Sinica Method of treating brain tissue damages
US8329166B2 (en) 2005-12-16 2012-12-11 Academia Sinica Pluripotent olfactory stem cells
JP2012527480A (ja) 2009-05-21 2012-11-08 ステムサイト インコーポレイテッド 脳組織の損傷の細胞療法

Also Published As

Publication number Publication date
AU2009229153B2 (en) 2015-06-11
JP6138090B2 (ja) 2017-05-31
TW201636033A (zh) 2016-10-16
SG191701A1 (en) 2013-07-31
AU2009229153A1 (en) 2009-10-01
EP2282748A2 (en) 2011-02-16
JP2017031158A (ja) 2017-02-09
TW200948370A (en) 2009-12-01
JP2011515470A (ja) 2011-05-19
TWI593417B (zh) 2017-08-01
US11318170B2 (en) 2022-05-03
JP6401757B2 (ja) 2018-10-10
EP2282748A4 (en) 2012-01-11
WO2009120368A3 (en) 2010-01-07
JP6655123B2 (ja) 2020-02-26
US20110256107A1 (en) 2011-10-20
JP2018154634A (ja) 2018-10-04
CN102036671A (zh) 2011-04-27
JP2014237677A (ja) 2014-12-18
IL208406A0 (en) 2010-12-30
CA2719740A1 (en) 2009-10-01
EP2282748B1 (en) 2016-11-09
WO2009120368A2 (en) 2009-10-01

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