JP2011515069A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011515069A5 JP2011515069A5 JP2010545049A JP2010545049A JP2011515069A5 JP 2011515069 A5 JP2011515069 A5 JP 2011515069A5 JP 2010545049 A JP2010545049 A JP 2010545049A JP 2010545049 A JP2010545049 A JP 2010545049A JP 2011515069 A5 JP2011515069 A5 JP 2011515069A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- drug conjugate
- cd79b
- cysteine
- cysteine engineered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 22
- 239000000611 antibody drug conjugate Substances 0.000 claims 22
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 22
- 235000018417 cysteine Nutrition 0.000 claims 22
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 22
- 150000001875 compounds Chemical class 0.000 claims 18
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 14
- 238000000034 method Methods 0.000 claims 13
- 229940079593 drug Drugs 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 6
- 125000005647 linker group Chemical group 0.000 claims 6
- 235000018102 proteins Nutrition 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 210000004881 tumor cell Anatomy 0.000 claims 5
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 4
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 4
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 4
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 4
- -1 free cysteine amino acids Chemical class 0.000 claims 4
- 201000009277 hairy cell leukemia Diseases 0.000 claims 4
- 206010025323 Lymphomas Diseases 0.000 claims 3
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 3
- 235000001014 amino acid Nutrition 0.000 claims 3
- 108010044540 auristatin Proteins 0.000 claims 3
- 239000003638 chemical reducing agent Substances 0.000 claims 3
- 239000000562 conjugate Substances 0.000 claims 3
- 208000019691 hematopoietic and lymphoid cell neoplasm Diseases 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 101000945318 Homo sapiens Calponin-1 Proteins 0.000 claims 2
- 101000652736 Homo sapiens Transgelin Proteins 0.000 claims 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 2
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims 2
- 102100031013 Transgelin Human genes 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 125000000732 arylene group Chemical group 0.000 claims 2
- 125000004452 carbocyclyl group Chemical group 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 235000013477 citrulline Nutrition 0.000 claims 2
- 229960002173 citrulline Drugs 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000013067 intermediate product Substances 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 239000007800 oxidant agent Substances 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 230000000306 recurrent effect Effects 0.000 claims 2
- JJAHTWIKCUJRDK-UHFFFAOYSA-N succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate Chemical compound C1CC(CN2C(C=CC2=O)=O)CCC1C(=O)ON1C(=O)CCC1=O JJAHTWIKCUJRDK-UHFFFAOYSA-N 0.000 claims 2
- 239000004474 valine Substances 0.000 claims 2
- MFRNYXJJRJQHNW-DEMKXPNLSA-N (2s)-2-[[(2r,3r)-3-methoxy-3-[(2s)-1-[(3r,4s,5s)-3-methoxy-5-methyl-4-[methyl-[(2s)-3-methyl-2-[[(2s)-3-methyl-2-(methylamino)butanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoic acid Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 MFRNYXJJRJQHNW-DEMKXPNLSA-N 0.000 claims 1
- DJQYYYCQOZMCRC-UHFFFAOYSA-N 2-aminopropane-1,3-dithiol Chemical group SCC(N)CS DJQYYYCQOZMCRC-UHFFFAOYSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- SBJKKFFYIZUCET-JLAZNSOCSA-N Dehydro-L-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(=O)C1=O SBJKKFFYIZUCET-JLAZNSOCSA-N 0.000 claims 1
- SBJKKFFYIZUCET-UHFFFAOYSA-N Dehydroascorbic acid Natural products OCC(O)C1OC(=O)C(=O)C1=O SBJKKFFYIZUCET-UHFFFAOYSA-N 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical group NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 1
- PZBFGYYEXUXCOF-UHFFFAOYSA-N TCEP Chemical compound OC(=O)CCP(CCC(O)=O)CCC(O)=O PZBFGYYEXUXCOF-UHFFFAOYSA-N 0.000 claims 1
- IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical compound CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 150000004696 coordination complex Chemical class 0.000 claims 1
- 229910000365 copper sulfate Inorganic materials 0.000 claims 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical group [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims 1
- 235000020960 dehydroascorbic acid Nutrition 0.000 claims 1
- 239000011615 dehydroascorbic acid Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 230000036210 malignancy Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- AMKBTTRWLGVRER-OFVILXPXSA-N n-[(2s)-1-[[(2s)-5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-6-(2,5-dioxopyrrol-1-yl)hexanamide Chemical compound N([C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=O)C(=O)NC=1C=CC(CO)=CC=1)C(=O)CCCCCN1C(=O)C=CC1=O AMKBTTRWLGVRER-OFVILXPXSA-N 0.000 claims 1
- 230000000269 nucleophilic effect Effects 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/023,811 US20090068178A1 (en) | 2002-05-08 | 2008-01-31 | Compositions and Methods for the Treatment of Tumor of Hematopoietic Origin |
| US12/023,811 | 2008-01-31 | ||
| PCT/US2009/030851 WO2009099719A2 (en) | 2008-01-31 | 2009-01-13 | Compositions and methods for the treatment of tumor of hematopoietic origin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011515069A JP2011515069A (ja) | 2011-05-19 |
| JP2011515069A5 true JP2011515069A5 (cg-RX-API-DMAC7.html) | 2012-03-01 |
Family
ID=40578249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010545049A Withdrawn JP2011515069A (ja) | 2008-01-31 | 2009-01-13 | 造血系起源の腫瘍の治療のための組成物と方法 |
Country Status (16)
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8709412B2 (en) * | 2001-06-29 | 2014-04-29 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of TIM receptor activity in combination with cytoreductive therapy |
| US20110045005A1 (en) | 2001-10-19 | 2011-02-24 | Craig Crowley | Compositions and methods for the treatment of tumor of hematopoietic origin |
| US20090068178A1 (en) * | 2002-05-08 | 2009-03-12 | Genentech, Inc. | Compositions and Methods for the Treatment of Tumor of Hematopoietic Origin |
| KR101438983B1 (ko) | 2003-11-06 | 2014-09-05 | 시애틀 지네틱스, 인크. | 리간드에 접합될 수 있는 모노메틸발린 화합물 |
| US20110166319A1 (en) * | 2005-02-11 | 2011-07-07 | Immunogen, Inc. | Process for preparing purified drug conjugates |
| WO2007024536A2 (en) | 2005-08-24 | 2007-03-01 | Immunogen, Inc. | Process for preparing maytansinoid antibody conjugates |
| EP2176295B1 (en) | 2007-07-16 | 2014-11-19 | Genentech, Inc. | Humanized anti-cd79b antibodies and immunoconjugates and methods of use |
| JP5469600B2 (ja) | 2007-07-16 | 2014-04-16 | ジェネンテック， インコーポレイテッド | 抗ＣＤ７９ｂ抗体及びイムノコンジュゲートとその使用方法 |
| ES2643239T3 (es) | 2008-01-31 | 2017-11-21 | Genentech, Inc. | Anticuerpos anti-CD79b e inmunoconjugados y métodos de uso |
| SG176068A1 (en) | 2009-06-03 | 2011-12-29 | Immunogen Inc | Conjugation methods |
| CN102811707A (zh) | 2010-02-08 | 2012-12-05 | 内布拉斯加大学董事委员会 | 结合生物矿物和金属的脂质体，它们的合成以及其使用方法 |
| AR080155A1 (es) * | 2010-02-10 | 2012-03-14 | Immunogen Inc | Anticuerpos anti-cd20 y su utilizacion |
| ES2581314T3 (es) * | 2010-03-02 | 2016-09-05 | Seattle Genetics, Inc. | Métodos de cribado de anticuerpos |
| WO2012054748A2 (en) | 2010-10-22 | 2012-04-26 | Seattle Genetics, Inc. | Synergistic effects between auristatin-based antibody drug conjugates and inhibitors of the pi3k-akt mtor pathway |
| CN103717262B (zh) | 2011-03-29 | 2017-09-15 | 伊缪诺金公司 | 通过一步法制备类美登素抗体缀合物 |
| EP2694111B1 (en) * | 2011-04-01 | 2016-08-10 | Wyeth LLC | Antibody-drug conjugates |
| ES2887208T3 (es) | 2012-05-15 | 2021-12-22 | Concortis Biosystems Corp | Conjugados de fármacos y usos de los mismos |
| WO2014022592A1 (en) * | 2012-08-02 | 2014-02-06 | Jn Biosciences Llc | Antibodies or fusion proteins multimerized via cysteine mutation and a mu tailpiece |
| MX359599B (es) | 2012-10-04 | 2018-09-12 | Immunogen Inc | Uso de una membrana de pvdf para purificar conjugados de agentes de unión celular y agentes citotóxicos. |
| IN2015DN03203A (cg-RX-API-DMAC7.html) * | 2012-10-04 | 2015-10-02 | Immunogen Inc | |
| US10260089B2 (en) | 2012-10-29 | 2019-04-16 | The Research Foundation Of The State University Of New York | Compositions and methods for recognition of RNA using triple helical peptide nucleic acids |
| BR112015012458A2 (pt) | 2012-11-29 | 2018-02-06 | Bayer Healthcare Llc | anticorpos monoclonais humanizados contra a proteína c ativada e usos destes |
| RU2015129800A (ru) | 2012-12-21 | 2017-01-30 | Биоэллаенс К. В. | Гидрофильные саморазрушающиеся линкеры и их конъюгаты |
| WO2014124316A2 (en) | 2013-02-08 | 2014-08-14 | Irm Llc | Specific sites for modifying antibodies to make immunoconjugates |
| MY183572A (en) | 2013-03-15 | 2021-02-26 | Regeneron Pharma | Biologically active molecules, conjugates thereof, and therapeutic uses |
| TW201945032A (zh) * | 2013-03-15 | 2019-12-01 | 德商艾伯維德國有限及兩合公司 | 抗-egfr抗體藥物結合物調配物 |
| NZ712012A (en) | 2013-04-16 | 2020-04-24 | Genentech Inc | Pertuzumab variants and evaluation thereof |
| TWI646108B (zh) | 2013-08-01 | 2019-01-01 | 艾澤西公司 | 結合至ｃｄ３７蛋白質之抗體藥物結合物（ａｄｃ） |
| MX2016001862A (es) | 2013-08-12 | 2016-08-03 | Genentech Inc | Compuestos de conjugado anticuerpo-farmaco dimerico de 1-(clorometil)-2,3-dihidro-1h-benzo[e]indol, y metodos de uso y tratamiento. |
| CN105530942B (zh) * | 2013-08-26 | 2019-10-11 | 瑞泽恩制药公司 | 一种包含大环内酯类非对映体的药物组合物、其制备方法和用途 |
| RU2016134258A (ru) | 2013-10-15 | 2018-02-28 | Сорренто Терапьютикс Инк. | Конъюгат лекарственного средства с направляющей молекулой и двумя различными лекарственными средствами |
| CA3187392A1 (en) | 2013-10-15 | 2015-04-23 | Seagen Inc. | Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics |
| BR112016013258A2 (pt) | 2013-12-16 | 2018-01-16 | Genentech Inc | composto conjugado anticorpo-droga, composição farmacêutica, método para tratar câncer e kit |
| EP3082877B1 (en) | 2013-12-17 | 2019-08-28 | Novartis AG | Cytotoxic peptides and conjugates thereof |
| CN106573956A (zh) | 2014-06-13 | 2017-04-19 | 诺华股份有限公司 | 澳瑞他汀衍生物及其缀合物 |
| US9950077B2 (en) | 2014-06-20 | 2018-04-24 | Bioalliance C.V. | Anti-folate receptor alpha (FRA) antibody-drug conjugates and methods of using thereof |
| MA40321A (fr) | 2014-08-06 | 2021-04-14 | Astellas Pharma Inc | Nouvelle anticorp anti-ig(beta) humain |
| CA2958882A1 (en) * | 2014-09-02 | 2016-03-10 | Immunogen, Inc. | Methods for formulating antibody drug conjugate compositions |
| EP3262071B8 (en) | 2014-09-23 | 2022-05-18 | F. Hoffmann-La Roche AG | Method of using anti-cd79b immunoconjugates |
| LT3227336T (lt) | 2014-12-05 | 2019-09-25 | F. Hoffmann-La Roche Ag | Anti-cd79b antikūnai ir jų naudojimo būdai |
| CN107849090A (zh) | 2015-01-28 | 2018-03-27 | 索伦托医疗有限公司 | 抗体药物偶联物 |
| CN106153935B (zh) * | 2015-03-26 | 2018-05-08 | 广州瑞博奥生物科技有限公司 | 一种定量检测CD79α的酶联免疫试剂盒 |
| MX386328B (es) | 2015-03-27 | 2025-03-18 | Regeneron Pharma | Derivados de maitansinoide, conjugados de los mismos, y metodos de uso. |
| MA44334A (fr) | 2015-10-29 | 2018-09-05 | Novartis Ag | Conjugués d'anticorps comprenant un agoniste du récepteur de type toll |
| WO2017087391A1 (en) | 2015-11-17 | 2017-05-26 | Bayer Healthcare, Llc | Epitope of optimized humanized monoclonal antibodies against activated protein c and uses thereof |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| CA3006000A1 (en) | 2015-12-04 | 2017-06-08 | Seattle Genetics, Inc. | Conjugates of quaternized tubulysin compounds |
| MX395252B (es) | 2016-01-08 | 2025-03-25 | Altrubio Inc | Anticuerpos tetravalentes anti ligando-1 de glicoproteina p-selectina (psgl-1) y usos de estos. |
| MX390630B (es) | 2016-01-25 | 2025-03-21 | Regeneron Pharma | Derivados de maitansinoide, conjugados de los mismos y metodos de uso. |
| JP7073266B2 (ja) | 2016-03-25 | 2022-05-23 | シージェン インコーポレイテッド | Ｐｅｇ化薬物リンカー及びその中間体を調製するためのプロセス |
| CN110352074B (zh) | 2017-02-28 | 2024-07-16 | 思进股份有限公司 | 用于偶联的半胱氨酸突变抗体 |
| US11730822B2 (en) | 2017-03-24 | 2023-08-22 | Seagen Inc. | Process for the preparation of glucuronide drug-linkers and intermediates thereof |
| CN109893538B (zh) * | 2017-12-07 | 2021-05-07 | 苏州凯祥生物科技有限公司 | 聚炔类在降尿酸中的新用途 |
| MY209791A (en) | 2019-01-28 | 2025-08-04 | Tuojie Biotech Shanghai Co Ltd | Anti-cd79b antibody, antigen-binding fragment thereof, and pharmaceutical use thereof |
| CN111675762B (zh) * | 2019-03-11 | 2023-12-01 | 凯惠科技发展(上海)有限公司 | 一种含半胱氨酸的抗体、药物偶联物及其应用 |
| BR112023001359A2 (pt) | 2020-07-27 | 2023-02-14 | Tuojie Biotech Shanghai Co Ltd | Conjugado de anticorpo-fármaco anti-cd79b, método de preparação do mesmo e uso farmacêutico do mesmo |
| TW202302648A (zh) * | 2021-03-12 | 2023-01-16 | 美商健生生物科技公司 | Cd79b抗體於自體免疫治療應用之用途 |
| US20240339220A1 (en) * | 2021-07-15 | 2024-10-10 | Nx Prenatal Inc. | Longitudinal predictive model for predicting adverse gestational outcomes |
| US20240367065A1 (en) * | 2021-09-10 | 2024-11-07 | Sony Group Corporation | Autonomous mobile body, information processing method, and program |
| EP4634227A1 (en) * | 2022-12-13 | 2025-10-22 | Seagen Inc. | Site-specific engineered cysteine antibody drug conjugates |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4137230A (en) * | 1977-11-14 | 1979-01-30 | Takeda Chemical Industries, Ltd. | Method for the production of maytansinoids |
| US4265814A (en) * | 1978-03-24 | 1981-05-05 | Takeda Chemical Industries | Matansinol 3-n-hexadecanoate |
| US4307016A (en) * | 1978-03-24 | 1981-12-22 | Takeda Chemical Industries, Ltd. | Demethyl maytansinoids |
| JPS5562090A (en) * | 1978-10-27 | 1980-05-10 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55164687A (en) * | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS5566585A (en) * | 1978-11-14 | 1980-05-20 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| US4256746A (en) * | 1978-11-14 | 1981-03-17 | Takeda Chemical Industries | Dechloromaytansinoids, their pharmaceutical compositions and method of use |
| JPS55102583A (en) * | 1979-01-31 | 1980-08-05 | Takeda Chem Ind Ltd | 20-acyloxy-20-demethylmaytansinoid compound |
| JPS55162791A (en) * | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
| JPS55164685A (en) * | 1979-06-08 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55164686A (en) * | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| US4309428A (en) * | 1979-07-30 | 1982-01-05 | Takeda Chemical Industries, Ltd. | Maytansinoids |
| JPS5645483A (en) * | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
| EP0028683A1 (en) * | 1979-09-21 | 1981-05-20 | Takeda Chemical Industries, Ltd. | Antibiotic C-15003 PHO and production thereof |
| JPS5645485A (en) * | 1979-09-21 | 1981-04-25 | Takeda Chem Ind Ltd | Production of c-15003pnd |
| WO1982001188A1 (en) * | 1980-10-08 | 1982-04-15 | Takeda Chemical Industries Ltd | 4,5-deoxymaytansinoide compounds and process for preparing same |
| US4450254A (en) * | 1980-11-03 | 1984-05-22 | Standard Oil Company | Impact improvement of high nitrile resins |
| US4315929A (en) * | 1981-01-27 | 1982-02-16 | The United States Of America As Represented By The Secretary Of Agriculture | Method of controlling the European corn borer with trewiasine |
| US4313946A (en) * | 1981-01-27 | 1982-02-02 | The United States Of America As Represented By The Secretary Of Agriculture | Chemotherapeutically active maytansinoids from Trewia nudiflora |
| JPS57192389A (en) * | 1981-05-20 | 1982-11-26 | Takeda Chem Ind Ltd | Novel maytansinoid |
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5618920A (en) * | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US4975278A (en) * | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
| US5208020A (en) * | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US6150584A (en) * | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6075181A (en) * | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5644033A (en) * | 1992-12-22 | 1997-07-01 | Health Research, Inc. | Monoclonal antibodies that define a unique antigen of human B cell antigen receptor complex and methods of using same for diagnosis and treatment |
| JPH0719832A (ja) * | 1993-06-21 | 1995-01-20 | Canon Inc | 複数画像の対応点抽出方法 |
| CA2173150C (en) * | 1993-10-01 | 2004-11-30 | Kyoichi Sakakibara | Novel peptide derivatives |
| US6172213B1 (en) * | 1997-07-02 | 2001-01-09 | Genentech, Inc. | Anti-IgE antibodies and method of improving polypeptides |
| US6248564B1 (en) * | 1997-08-29 | 2001-06-19 | Harvard University | Mutant MHC class I molecules |
| US20040001827A1 (en) * | 2002-06-28 | 2004-01-01 | Dennis Mark S. | Serum albumin binding peptides for tumor targeting |
| EP1240337B1 (en) * | 1999-12-24 | 2006-08-23 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| US20020150573A1 (en) * | 2000-11-10 | 2002-10-17 | The Rockefeller University | Anti-Igalpha-Igbeta antibody for lymphoma therapy |
| US20040018194A1 (en) * | 2000-11-28 | 2004-01-29 | Francisco Joseph A. | Recombinant anti-CD30 antibodies and uses thereof |
| US20110045005A1 (en) * | 2001-10-19 | 2011-02-24 | Craig Crowley | Compositions and methods for the treatment of tumor of hematopoietic origin |
| US20050238650A1 (en) * | 2002-04-17 | 2005-10-27 | Genentech, Inc. | Compositions and methods for the treatment of tumor of hematopoietic origin |
| US20070207142A1 (en) * | 2002-05-08 | 2007-09-06 | Genentech, Inc. | Compositions and methods for the treatment of tumor of hematopoietic origin |
| US20090068178A1 (en) * | 2002-05-08 | 2009-03-12 | Genentech, Inc. | Compositions and Methods for the Treatment of Tumor of Hematopoietic Origin |
| US20110042260A1 (en) * | 2003-04-10 | 2011-02-24 | Craig Crowley | Compositions and methods for the treatment of tumor of hematopoietic origin |
| US8088387B2 (en) * | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| KR101438983B1 (ko) * | 2003-11-06 | 2014-09-05 | 시애틀 지네틱스, 인크. | 리간드에 접합될 수 있는 모노메틸발린 화합물 |
| NZ547558A (en) * | 2003-11-17 | 2009-06-26 | Genentech Inc | Compositions and methods for the treatment of tumor of hematopoietic origin |
| AU2005216251B2 (en) * | 2004-02-23 | 2011-03-10 | Genentech, Inc. | Heterocyclic self-immolative linkers and conjugates |
| RU2404810C9 (ru) * | 2004-06-01 | 2015-06-20 | Дженентек, Инк. | Конъюгаты антитело-лекарственное средство и способы |
| CN104447992A (zh) * | 2004-09-23 | 2015-03-25 | 健泰科生物技术公司 | 半胱氨酸改造的抗体和偶联物 |
| EP2176295B1 (en) * | 2007-07-16 | 2014-11-19 | Genentech, Inc. | Humanized anti-cd79b antibodies and immunoconjugates and methods of use |
| JP5469600B2 (ja) * | 2007-07-16 | 2014-04-16 | ジェネンテック， インコーポレイテッド | 抗ＣＤ７９ｂ抗体及びイムノコンジュゲートとその使用方法 |
| ES2643239T3 (es) * | 2008-01-31 | 2017-11-21 | Genentech, Inc. | Anticuerpos anti-CD79b e inmunoconjugados y métodos de uso |
-
2008
- 2008-01-31 US US12/023,811 patent/US20090068178A1/en not_active Abandoned
-
2009
- 2009-01-13 CA CA2712518A patent/CA2712518A1/en not_active Abandoned
- 2009-01-13 BR BRPI0908854A patent/BRPI0908854A2/pt not_active IP Right Cessation
- 2009-01-13 NZ NZ587652A patent/NZ587652A/xx not_active IP Right Cessation
- 2009-01-13 RU RU2010136303/10A patent/RU2010136303A/ru not_active Application Discontinuation
- 2009-01-13 AU AU2009210627A patent/AU2009210627A1/en not_active Abandoned
- 2009-01-13 MX MX2010008199A patent/MX2010008199A/es active IP Right Grant
- 2009-01-13 CN CN2009801110932A patent/CN102014964A/zh active Pending
- 2009-01-13 WO PCT/US2009/030851 patent/WO2009099719A2/en not_active Ceased
- 2009-01-13 EP EP09707533A patent/EP2247312A2/en not_active Withdrawn
- 2009-01-13 KR KR1020107019272A patent/KR20100128286A/ko not_active Withdrawn
- 2009-01-13 JP JP2010545049A patent/JP2011515069A/ja not_active Withdrawn
- 2009-01-16 CL CL2009000082A patent/CL2009000082A1/es unknown
- 2009-01-16 PE PE2009000055A patent/PE20091404A1/es not_active Application Discontinuation
- 2009-01-16 AR ARP090100153A patent/AR071829A1/es not_active Application Discontinuation
-
2010
- 2010-07-13 IL IL206970A patent/IL206970A0/en unknown
- 2010-09-09 US US12/878,920 patent/US20110070243A1/en not_active Abandoned
- 2010-10-12 US US12/902,434 patent/US20110206658A1/en not_active Abandoned
-
2017
- 2017-01-13 US US15/406,583 patent/US20170362318A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011515069A5 (cg-RX-API-DMAC7.html) | ||
| JP2011514146A5 (cg-RX-API-DMAC7.html) | ||
| JP2011504460A5 (cg-RX-API-DMAC7.html) | ||
| RU2010136303A (ru) | Композиции и способы лечения опухолей гематопоэтического происхождения | |
| RU2010119937A (ru) | Антитела против tenb2, сконструированные с цистеином, и конъюгаты антитело-лекарственное средство | |
| TWI583394B (zh) | 抗-ｇｃｃ抗體分子及其相關之組合物及方法 | |
| EP3350224B1 (en) | Monoclonal antibodies specific for fibroblast growth factor receptor 4 (fgfr4) and methods of their use | |
| RU2483080C2 (ru) | Антитела и иммуноконъюгаты и их применение | |
| JP2010526821A5 (cg-RX-API-DMAC7.html) | ||
| US10428156B2 (en) | Anti-MFI2 antibodies and methods of use | |
| RU2011144141A (ru) | АНТИТЕЛА К FcRH5, ИХ ИММУНОКОНЪЮГАТЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ | |
| US20240325557A1 (en) | Treatment of cancer | |
| RU2011144119A (ru) | АНТИТЕЛА К FcRH5, ИХ ИММУНОКОНЪЮГАТЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ | |
| JP2012522513A5 (cg-RX-API-DMAC7.html) | ||
| TW201116300A (en) | DR5 Ligand Drug Conjugates | |
| US20250297004A1 (en) | Nectin-4 binding agents | |
| RU2694688C2 (ru) | АНТИ-CD79b АНТИТЕЛА И ИММУНОКОНЪЮГАТЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ | |
| JP2013056896A5 (cg-RX-API-DMAC7.html) | ||
| JP2019506136A (ja) | 新規抗ｅｍｒ２抗体及び使用方法 | |
| TW201905000A (zh) | 含有抗globo h抗體之抗體－藥物共軛物及其用途 | |
| JP2019511199A (ja) | 新規の抗ｕｐｋ１ｂ抗体及び使用方法 | |
| AU2018285523A1 (en) | Antibody drug conjugates that bind LGR5 | |
| JP2019525727A (ja) | 新規の抗ｔｎｆｒｓｆ２１抗体及び使用方法 | |
| US20230212181A1 (en) | Double payload cancer therapeutics | |
| EP4587063A1 (en) | Anti-muc1* antibody drug complexes and uses thereof |