JP2011514313A5 - - Google Patents
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- Publication number
- JP2011514313A5 JP2011514313A5 JP2010544727A JP2010544727A JP2011514313A5 JP 2011514313 A5 JP2011514313 A5 JP 2011514313A5 JP 2010544727 A JP2010544727 A JP 2010544727A JP 2010544727 A JP2010544727 A JP 2010544727A JP 2011514313 A5 JP2011514313 A5 JP 2011514313A5
- Authority
- JP
- Japan
- Prior art keywords
- hyperpolarized
- amino acid
- mixture
- acid
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 19
- 150000001413 amino acids Chemical class 0.000 claims 16
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical compound NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 claims 8
- -1 carboxylate salts Chemical class 0.000 claims 4
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 239000008365 aqueous carrier Substances 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000002872 contrast media Substances 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 3
- 229910021645 metal ion Inorganic materials 0.000 claims 3
- 230000005298 paramagnetic effect Effects 0.000 claims 3
- 230000010287 polarization Effects 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 239000011877 solvent mixture Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- HASOCNVOKPSUEI-UHFFFAOYSA-N [Cl-].[NH4+].S(N)(O)(=O)=O Chemical compound [Cl-].[NH4+].S(N)(O)(=O)=O HASOCNVOKPSUEI-UHFFFAOYSA-N 0.000 claims 1
- 150000003863 ammonium salts Chemical class 0.000 claims 1
- 239000003125 aqueous solvent Substances 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 238000000099 in vitro assay Methods 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- OHSJPLSEQNCRLW-UHFFFAOYSA-N triphenylmethyl radical Chemical compound C1=CC=CC=C1[C](C=1C=CC=CC=1)C1=CC=CC=C1 OHSJPLSEQNCRLW-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08002001 | 2008-02-04 | ||
| PCT/EP2009/051172 WO2009098191A2 (en) | 2008-02-04 | 2009-02-03 | Method to produce hyperpolarised amino acids and aminosulphonic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011514313A JP2011514313A (ja) | 2011-05-06 |
| JP2011514313A5 true JP2011514313A5 (https=) | 2013-03-14 |
Family
ID=40436248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010544727A Pending JP2011514313A (ja) | 2008-02-04 | 2009-02-03 | 過分極アミノ酸及びアミノスルホン酸の製造方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20110008261A1 (https=) |
| EP (1) | EP2237802A2 (https=) |
| JP (1) | JP2011514313A (https=) |
| CN (1) | CN101932340A (https=) |
| WO (1) | WO2009098191A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2348327B1 (en) * | 2010-01-18 | 2013-11-27 | Bruker BioSpin AG | Method for NMR measurements using dissolution dynamic nuclear polarization (DNP) with elimination of free radicals |
| GB2498181A (en) | 2011-12-29 | 2013-07-10 | Bruker Biospin Gmbh | Device and method for rapid dynamic nuclear polarisation |
| WO2013149935A1 (en) | 2012-04-02 | 2013-10-10 | Bracco Imaging Spa | Hyperpolarized amino acids |
| US10408895B2 (en) * | 2013-03-15 | 2019-09-10 | Bruker Biospin Corporation | Polarization sample geometry |
| US9606200B2 (en) * | 2013-08-27 | 2017-03-28 | Bruker Biospin Corporation | Sample-preparation method to manipulate nuclear spin-relaxation times, including to facilitate ultralow temperature hyperpolarization |
| JPWO2015040877A1 (ja) * | 2013-09-20 | 2017-03-02 | 国立大学法人九州大学 | 核磁気共鳴分子センサー |
| US10088536B2 (en) * | 2015-03-27 | 2018-10-02 | Bruker Biospin Corporation | Sample introduction system and method for polarization |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| ES2814555T3 (es) | 2016-11-28 | 2021-03-29 | Bayer Pharma AG | Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética |
| KR102934987B1 (ko) | 2018-11-23 | 2026-03-09 | 바이엘 악티엔게젤샤프트 | 조영 매체의 제형 및 그의 제조 방법 |
| CN112735799B (zh) * | 2020-12-10 | 2022-12-20 | 华东理工大学 | 一种新型磁性材料及其制备方法 |
| US20230400538A1 (en) * | 2022-06-10 | 2023-12-14 | GE Precision Healthcare LLC | Use of lactic acid in hyperpolarization for magnetic resonance applications |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0122049D0 (en) * | 2001-09-12 | 2001-10-31 | Nycomed Imaging As | Method |
| US7351402B2 (en) * | 2003-08-21 | 2008-04-01 | Massachusetts Institute Of Technology | Polarizing agents for dynamic nuclear polarization |
| US20080287774A1 (en) * | 2005-11-06 | 2008-11-20 | Rachel Katz-Brull | Magnetic Resonance Imaging and Spectroscopy Means and Methods Thereof |
| JP5475995B2 (ja) * | 2005-12-01 | 2014-04-16 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 動的核分極（ｄｎｐ）法 |
| PL1962912T3 (pl) * | 2005-12-16 | 2013-03-29 | Ge Healthcare As | Sposób wytwarzania hiperpolaryzowanych karboksylanów amin organicznych |
| US20100233096A1 (en) * | 2006-03-29 | 2010-09-16 | Lerche Mathilde H | Method to produce hyperpolarised carboxylates and sulphonates |
| KR20140144312A (ko) * | 2006-08-30 | 2014-12-18 | 지이 헬스케어 에이에스 | 동적 핵 분극화 방법 및 이러한 방법에서 사용되는 화합물 및 조성물 |
| WO2008086534A1 (en) * | 2007-01-11 | 2008-07-17 | Huntington Medical Research Institutes | Imaging agents and methods of use thereof |
-
2009
- 2009-02-03 JP JP2010544727A patent/JP2011514313A/ja active Pending
- 2009-02-03 WO PCT/EP2009/051172 patent/WO2009098191A2/en not_active Ceased
- 2009-02-03 US US12/864,521 patent/US20110008261A1/en not_active Abandoned
- 2009-02-03 CN CN2009801037778A patent/CN101932340A/zh active Pending
- 2009-02-03 EP EP09707879A patent/EP2237802A2/en not_active Withdrawn
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