JP2011514313A - 過分極アミノ酸及びアミノスルホン酸の製造方法 - Google Patents

過分極アミノ酸及びアミノスルホン酸の製造方法 Download PDF

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Publication number
JP2011514313A
JP2011514313A JP2010544727A JP2010544727A JP2011514313A JP 2011514313 A JP2011514313 A JP 2011514313A JP 2010544727 A JP2010544727 A JP 2010544727A JP 2010544727 A JP2010544727 A JP 2010544727A JP 2011514313 A JP2011514313 A JP 2011514313A
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Japan
Prior art keywords
acid
hyperpolarized
amino acid
aminosulfonic
salt
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JP2010544727A
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Japanese (ja)
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JP2011514313A5 (https=
Inventor
レルシュ，マチルド・エイチ
カールソン，マグナス
ジェンセン，ペルニル・アール
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GE Healthcare Ltd
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GE Healthcare Ltd
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Publication of JP2011514313A publication Critical patent/JP2011514313A/ja
Publication of JP2011514313A5 publication Critical patent/JP2011514313A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2010544727A 2008-02-04 2009-02-03 過分極アミノ酸及びアミノスルホン酸の製造方法 Pending JP2011514313A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08002001 2008-02-04
PCT/EP2009/051172 WO2009098191A2 (en) 2008-02-04 2009-02-03 Method to produce hyperpolarised amino acids and aminosulphonic acids

Publications (2)

Publication Number Publication Date
JP2011514313A true JP2011514313A (ja) 2011-05-06
JP2011514313A5 JP2011514313A5 (https=) 2013-03-14

Family

ID=40436248

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010544727A Pending JP2011514313A (ja) 2008-02-04 2009-02-03 過分極アミノ酸及びアミノスルホン酸の製造方法

Country Status (5)

Country Link
US (1) US20110008261A1 (https=)
EP (1) EP2237802A2 (https=)
JP (1) JP2011514313A (https=)
CN (1) CN101932340A (https=)
WO (1) WO2009098191A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011145297A (ja) * 2010-01-18 2011-07-28 Bruker Biospin Ag フリーラジカルの捕捉による溶解動的核分極（ｄｎｐ）を使用したｎｍｒ分光測定またはｍｒｉ測定の方法
WO2015040877A1 (ja) * 2013-09-20 2015-03-26 国立大学法人九州大学 核磁気共鳴分子センサー

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2498181A (en) 2011-12-29 2013-07-10 Bruker Biospin Gmbh Device and method for rapid dynamic nuclear polarisation
WO2013149935A1 (en) 2012-04-02 2013-10-10 Bracco Imaging Spa Hyperpolarized amino acids
US10408895B2 (en) * 2013-03-15 2019-09-10 Bruker Biospin Corporation Polarization sample geometry
US9606200B2 (en) * 2013-08-27 2017-03-28 Bruker Biospin Corporation Sample-preparation method to manipulate nuclear spin-relaxation times, including to facilitate ultralow temperature hyperpolarization
US10088536B2 (en) * 2015-03-27 2018-10-02 Bruker Biospin Corporation Sample introduction system and method for polarization
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
ES2814555T3 (es) 2016-11-28 2021-03-29 Bayer Pharma AG Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética
KR102934987B1 (ko) 2018-11-23 2026-03-09 바이엘 악티엔게젤샤프트 조영 매체의 제형 및 그의 제조 방법
CN112735799B (zh) * 2020-12-10 2022-12-20 华东理工大学 一种新型磁性材料及其制备方法
US20230400538A1 (en) * 2022-06-10 2023-12-14 GE Precision Healthcare LLC Use of lactic acid in hyperpolarization for magnetic resonance applications

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003023432A1 (en) * 2001-09-12 2003-03-20 Amersham Health As A method of using spectral-spatial exitation at magnetic resonance imaging
WO2005024440A2 (en) * 2003-08-21 2005-03-17 Massachusetts Institute Of Technology Polarizing agents for dynamic nuclear polarization
WO2007069909A2 (en) * 2005-12-16 2007-06-21 Ge Healthcare As Method to produce hyperpolarised carboxylates of organic amines
WO2007111515A2 (en) * 2006-03-29 2007-10-04 Ge Healthcare As Method to produce hyperpolarised carboxylates and sulphonates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080287774A1 (en) * 2005-11-06 2008-11-20 Rachel Katz-Brull Magnetic Resonance Imaging and Spectroscopy Means and Methods Thereof
JP5475995B2 (ja) * 2005-12-01 2014-04-16 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極（ｄｎｐ）法
KR20140144312A (ko) * 2006-08-30 2014-12-18 지이 헬스케어 에이에스 동적 핵 분극화 방법 및 이러한 방법에서 사용되는 화합물 및 조성물
WO2008086534A1 (en) * 2007-01-11 2008-07-17 Huntington Medical Research Institutes Imaging agents and methods of use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003023432A1 (en) * 2001-09-12 2003-03-20 Amersham Health As A method of using spectral-spatial exitation at magnetic resonance imaging
WO2005024440A2 (en) * 2003-08-21 2005-03-17 Massachusetts Institute Of Technology Polarizing agents for dynamic nuclear polarization
WO2007069909A2 (en) * 2005-12-16 2007-06-21 Ge Healthcare As Method to produce hyperpolarised carboxylates of organic amines
WO2007111515A2 (en) * 2006-03-29 2007-10-04 Ge Healthcare As Method to produce hyperpolarised carboxylates and sulphonates

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011145297A (ja) * 2010-01-18 2011-07-28 Bruker Biospin Ag フリーラジカルの捕捉による溶解動的核分極（ｄｎｐ）を使用したｎｍｒ分光測定またはｍｒｉ測定の方法
WO2015040877A1 (ja) * 2013-09-20 2015-03-26 国立大学法人九州大学 核磁気共鳴分子センサー

Also Published As

Publication number Publication date
US20110008261A1 (en) 2011-01-13
WO2009098191A3 (en) 2009-12-30
EP2237802A2 (en) 2010-10-13
CN101932340A (zh) 2010-12-29
WO2009098191A2 (en) 2009-08-13

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