CN101932340A - 生产超极化的氨基酸和氨基磺酸的方法 - Google Patents

生产超极化的氨基酸和氨基磺酸的方法 Download PDF

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Publication number
CN101932340A
CN101932340A CN2009801037778A CN200980103777A CN101932340A CN 101932340 A CN101932340 A CN 101932340A CN 2009801037778 A CN2009801037778 A CN 2009801037778A CN 200980103777 A CN200980103777 A CN 200980103777A CN 101932340 A CN101932340 A CN 101932340A
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CN
China
Prior art keywords
acid
hyperpolarized
amino acid
sample
sulfamic
Prior art date
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Pending
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CN2009801037778A
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English (en)
Chinese (zh)
Inventor
M·H·莱彻
M·卡尔森
P·R·詹森
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GE Healthcare Ltd
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GE Healthcare Ltd
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Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of CN101932340A publication Critical patent/CN101932340A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2009801037778A 2008-02-04 2009-02-03 生产超极化的氨基酸和氨基磺酸的方法 Pending CN101932340A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08002001 2008-02-04
EP08002001.9 2008-02-04
PCT/EP2009/051172 WO2009098191A2 (en) 2008-02-04 2009-02-03 Method to produce hyperpolarised amino acids and aminosulphonic acids

Publications (1)

Publication Number Publication Date
CN101932340A true CN101932340A (zh) 2010-12-29

Family

ID=40436248

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801037778A Pending CN101932340A (zh) 2008-02-04 2009-02-03 生产超极化的氨基酸和氨基磺酸的方法

Country Status (5)

Country Link
US (1) US20110008261A1 (https=)
EP (1) EP2237802A2 (https=)
JP (1) JP2011514313A (https=)
CN (1) CN101932340A (https=)
WO (1) WO2009098191A2 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2348327B1 (en) * 2010-01-18 2013-11-27 Bruker BioSpin AG Method for NMR measurements using dissolution dynamic nuclear polarization (DNP) with elimination of free radicals
GB2498181A (en) 2011-12-29 2013-07-10 Bruker Biospin Gmbh Device and method for rapid dynamic nuclear polarisation
WO2013149935A1 (en) 2012-04-02 2013-10-10 Bracco Imaging Spa Hyperpolarized amino acids
US10408895B2 (en) * 2013-03-15 2019-09-10 Bruker Biospin Corporation Polarization sample geometry
US9606200B2 (en) * 2013-08-27 2017-03-28 Bruker Biospin Corporation Sample-preparation method to manipulate nuclear spin-relaxation times, including to facilitate ultralow temperature hyperpolarization
JPWO2015040877A1 (ja) * 2013-09-20 2017-03-02 国立大学法人九州大学 核磁気共鳴分子センサー
US10088536B2 (en) * 2015-03-27 2018-10-02 Bruker Biospin Corporation Sample introduction system and method for polarization
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
ES2814555T3 (es) 2016-11-28 2021-03-29 Bayer Pharma AG Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética
KR102934987B1 (ko) 2018-11-23 2026-03-09 바이엘 악티엔게젤샤프트 조영 매체의 제형 및 그의 제조 방법
CN112735799B (zh) * 2020-12-10 2022-12-20 华东理工大学 一种新型磁性材料及其制备方法
US20230400538A1 (en) * 2022-06-10 2023-12-14 GE Precision Healthcare LLC Use of lactic acid in hyperpolarization for magnetic resonance applications

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0122049D0 (en) * 2001-09-12 2001-10-31 Nycomed Imaging As Method
US7351402B2 (en) * 2003-08-21 2008-04-01 Massachusetts Institute Of Technology Polarizing agents for dynamic nuclear polarization
US20080287774A1 (en) * 2005-11-06 2008-11-20 Rachel Katz-Brull Magnetic Resonance Imaging and Spectroscopy Means and Methods Thereof
JP5475995B2 (ja) * 2005-12-01 2014-04-16 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極（ｄｎｐ）法
PL1962912T3 (pl) * 2005-12-16 2013-03-29 Ge Healthcare As Sposób wytwarzania hiperpolaryzowanych karboksylanów amin organicznych
US20100233096A1 (en) * 2006-03-29 2010-09-16 Lerche Mathilde H Method to produce hyperpolarised carboxylates and sulphonates
KR20140144312A (ko) * 2006-08-30 2014-12-18 지이 헬스케어 에이에스 동적 핵 분극화 방법 및 이러한 방법에서 사용되는 화합물 및 조성물
WO2008086534A1 (en) * 2007-01-11 2008-07-17 Huntington Medical Research Institutes Imaging agents and methods of use thereof

Also Published As

Publication number Publication date
US20110008261A1 (en) 2011-01-13
WO2009098191A3 (en) 2009-12-30
EP2237802A2 (en) 2010-10-13
JP2011514313A (ja) 2011-05-06
WO2009098191A2 (en) 2009-08-13

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SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20101229