JP2011514155A5 - - Google Patents

Info

Publication number

JP2011514155A5

JP2011514155A5 JP2010547265A JP2010547265A JP2011514155A5 JP 2011514155 A5 JP2011514155 A5 JP 2011514155A5 JP 2010547265 A JP2010547265 A JP 2010547265A JP 2010547265 A JP2010547265 A JP 2010547265A JP 2011514155 A5 JP2011514155 A5 JP 2011514155A5

Authority

JP

Japan

Prior art keywords

coli

modified

protein

bioconjugate

expression system

Prior art date

2009-02-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108090000623 proteins and genes Proteins 0.000 claims 16
• 102000004169 proteins and genes Human genes 0.000 claims 15
• 229960005486 vaccine Drugs 0.000 claims 14
• 241000894006 Bacteria Species 0.000 claims 13
• 150000004676 glycans Chemical class 0.000 claims 13
• 229920001282 polysaccharide Polymers 0.000 claims 13
• 239000005017 polysaccharide Substances 0.000 claims 13
• 235000018102 proteins Nutrition 0.000 claims 10
• 241000588724 Escherichia coli Species 0.000 claims 8
• 108091035707 Consensus sequence Proteins 0.000 claims 7
• 239000000427 antigen Substances 0.000 claims 7
• 108091007433 antigens Proteins 0.000 claims 7
• 102000036639 antigens Human genes 0.000 claims 7
• 230000001580 bacterial effect Effects 0.000 claims 7
• 239000002773 nucleotide Substances 0.000 claims 7
• 125000003729 nucleotide group Chemical group 0.000 claims 7
• 150000001413 amino acids Chemical class 0.000 claims 6
• 241000607768 Shigella Species 0.000 claims 5
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 4
• 241000589517 Pseudomonas aeruginosa Species 0.000 claims 4
• 235000001014 amino acid Nutrition 0.000 claims 4
• 229940024606 amino acid Drugs 0.000 claims 4
• 230000000890 antigenic effect Effects 0.000 claims 4
• 108010089072 Dolichyl-diphosphooligosaccharide-protein glycotransferase Proteins 0.000 claims 3
• 230000015572 biosynthetic process Effects 0.000 claims 3
• 108091008053 gene clusters Proteins 0.000 claims 3
• 238000003786 synthesis reaction Methods 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 108010060123 Conjugate Vaccines Proteins 0.000 claims 2
• 108091000069 Cystinyl Aminopeptidase Proteins 0.000 claims 2
• 241001621104 Escherichia coli O6 Species 0.000 claims 2
• 108700023372 Glycosyltransferases Proteins 0.000 claims 2
• 102100020872 Leucyl-cystinyl aminopeptidase Human genes 0.000 claims 2
• 108010090127 Periplasmic Proteins Proteins 0.000 claims 2
• 241000607764 Shigella dysenteriae Species 0.000 claims 2
• 210000001744 T-lymphocyte Anatomy 0.000 claims 2
• 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 2
• 229940031670 conjugate vaccine Drugs 0.000 claims 2
• 230000002068 genetic effect Effects 0.000 claims 2
• 230000002503 metabolic effect Effects 0.000 claims 2
• 239000013612 plasmid Substances 0.000 claims 2
• OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical compound C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 claims 1
• 241000028472 Escherichia coli O121 Species 0.000 claims 1
• 241001333951 Escherichia coli O157 Species 0.000 claims 1
• 241000205834 Escherichia coli O16 Species 0.000 claims 1
• 241000059478 Escherichia coli O75 Species 0.000 claims 1
• 241000129943 Escherichia coli O83 Species 0.000 claims 1
• 241000205838 Escherichia coli O9 Species 0.000 claims 1
• 102000051366 Glycosyltransferases Human genes 0.000 claims 1
• 230000004988 N-glycosylation Effects 0.000 claims 1
• 241000147000 Shigella flexneri 2a Species 0.000 claims 1
• 241001353153 Shigella flexneri 3a Species 0.000 claims 1
• 241000072345 Shigella flexneri 3b Species 0.000 claims 1
• 241001353149 Shigella flexneri 6 Species 0.000 claims 1
• 241000607760 Shigella sonnei Species 0.000 claims 1
• 241000282898 Sus scrofa Species 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 208000001848 dysentery Diseases 0.000 claims 1
• 230000000369 enteropathogenic effect Effects 0.000 claims 1
• 239000002095 exotoxin Substances 0.000 claims 1
• 231100000776 exotoxin Toxicity 0.000 claims 1
• 102000035122 glycosylated proteins Human genes 0.000 claims 1
• 108091005608 glycosylated proteins Proteins 0.000 claims 1
• 102000045442 glycosyltransferase activity proteins Human genes 0.000 claims 1
• 108700014210 glycosyltransferase activity proteins Proteins 0.000 claims 1
• 239000001963 growth medium Substances 0.000 claims 1
• 150000002632 lipids Chemical class 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 230000001717 pathogenic effect Effects 0.000 claims 1
• 238000005215 recombination Methods 0.000 claims 1
• 230000006798 recombination Effects 0.000 claims 1
• 229940007046 shigella dysenteriae Drugs 0.000 claims 1