JP2011513732A - 複数のプロセスストリームのクロマトグラフィによる監視および制御 - Google Patents
複数のプロセスストリームのクロマトグラフィによる監視および制御 Download PDFInfo
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
- G01N35/1097—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers characterised by the valves
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N2001/2893—Preparing calibration standards
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N2030/042—Standards
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
- G01N2030/201—Injection using a sampling valve multiport valves, i.e. having more than two ports
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
- G01N2030/202—Injection using a sampling valve rotary valves
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
- G01N2030/207—Injection using a sampling valve with metering cavity, e.g. sample loop
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N2030/382—Flow patterns flow switching in a single column
- G01N2030/385—Flow patterns flow switching in a single column by switching valves
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
Description
Claims (9)
- 試料ループを含み、LCカラムと流体連通している出力ポートと、移動相供給ラインと流体連通している入力ポートとを有する注入弁と、
試料ポンプと、
少なくとも2つの医薬品と関連づけられた少なくとも2つの標準供給源と、
試料ポンプを、少なくとも2つの標準供給源、試料注入弁、および少なくとも2つの医薬品に関連づけられた少なくとも2つの医薬品製造プロセスラインに、流体的かつ選択可能に接続する、選択弁とを含む、分析装置。 - 試料ポンプがシリンジを含む、請求項1に記載の装置。
- 注入弁が6ポート弁をさらに含む、請求項1に記載の装置。
- 選択弁が7ポート選択弁を含む、請求項1に記載の装置。
- 少なくとも2つの標準供給源が異なる濃度の溶液を有する、請求項1に記載の装置。
- 少なくとも2つの標準供給源のそれぞれが、少なくとも2つの医薬品のうちの1つを含む、請求項1に記載の装置。
- 注入弁、選択弁、および試料ポンプを制御する手段をさらに含む、請求項1に記載の装置。
- 装置のLC部分の故障を検出する手段をさらに含む、請求項7に記載の装置。
- 医薬品製造プロセスを制御する方法であって、
試料ループを含み、LCカラムと流体連通している出力ポートと、移動相供給ラインと流体連通している入力ポートとを有する試料注入弁と、
試料ポンプと、
少なくとも2つの医薬品と関連づけられた少なくとも2つの標準供給源と、
試料ポンプを、少なくとも2つの標準供給源、試料注入弁、および少なくとも2つの医薬品に関連づけられた少なくとも2つの医薬品製造プロセスラインに、流体的かつ選択可能に接続する、選択弁とを含む装置を提供するステップと、
少なくとも2つの標準供給源および少なくとも2つの医薬品製造プロセスラインを流れる物質を、交互に繰り返し試料採取するように、選択弁を切り替えるステップとを含む、方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3267608P | 2008-02-29 | 2008-02-29 | |
US61/032,676 | 2008-02-29 | ||
PCT/US2009/035047 WO2009111228A2 (en) | 2008-02-29 | 2009-02-25 | Chromatography-based monitoring and control of multiple process streams |
Publications (2)
Publication Number | Publication Date |
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JP2011513732A true JP2011513732A (ja) | 2011-04-28 |
JP5358588B2 JP5358588B2 (ja) | 2013-12-04 |
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Application Number | Title | Priority Date | Filing Date |
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JP2010548828A Active JP5358588B2 (ja) | 2008-02-29 | 2009-02-25 | 複数のプロセスストリームのクロマトグラフィによる監視および制御 |
Country Status (4)
Country | Link |
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US (1) | US8343774B2 (ja) |
EP (1) | EP2257356B1 (ja) |
JP (1) | JP5358588B2 (ja) |
WO (1) | WO2009111228A2 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020106280A (ja) * | 2018-12-26 | 2020-07-09 | 日本分光株式会社 | 試料注入装置 |
WO2021241357A1 (ja) | 2020-05-29 | 2021-12-02 | 株式会社日立ハイテク | 自動分析装置の制御方法 |
Families Citing this family (10)
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EP3208272B1 (en) | 2005-11-08 | 2020-01-08 | Vertex Pharmaceuticals Incorporated | Heterocyclic modulators of atp-binding cassette transporters |
CN102171560B (zh) | 2008-10-03 | 2014-06-04 | 爱科来株式会社 | 分析装置及其控制方法 |
NZ602838A (en) | 2010-04-07 | 2015-06-26 | Vertex Pharma | Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid and administration thereof |
US10156551B2 (en) * | 2014-09-12 | 2018-12-18 | Waters Technologies Corporation | Sampling systems and methods of using the same |
RU2691136C2 (ru) * | 2014-11-18 | 2019-06-11 | Вертекс Фармасьютикалз Инкорпорейтед | Способ проведения высокопроизводительной тестовой высокоэффективной жидкостной хроматографии |
US9857339B2 (en) | 2015-01-06 | 2018-01-02 | Waters Technologies Corporation | Automated sampling and reaction system for high pressure liquid chromatography and other types of detection |
EP3642613B1 (en) * | 2017-06-19 | 2021-03-31 | Waters Technologies Corporation | Online dilution for a liquid chromatography system using a sample metering pump |
US11441978B1 (en) * | 2018-04-12 | 2022-09-13 | Elemental Scientific, Inc. | Automatic evaporative sample preparation |
EP3617701A1 (en) | 2018-08-27 | 2020-03-04 | F. Hoffmann-La Roche AG | Sample injector with sample loop and buffer loop |
US11709154B2 (en) * | 2019-10-17 | 2023-07-25 | Aisti Science Co., Ltd. | Liquid chromatograph including passage switch valve |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020106280A (ja) * | 2018-12-26 | 2020-07-09 | 日本分光株式会社 | 試料注入装置 |
WO2021241357A1 (ja) | 2020-05-29 | 2021-12-02 | 株式会社日立ハイテク | 自動分析装置の制御方法 |
Also Published As
Publication number | Publication date |
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US8343774B2 (en) | 2013-01-01 |
WO2009111228A3 (en) | 2010-01-07 |
US20110020939A1 (en) | 2011-01-27 |
EP2257356A4 (en) | 2011-07-27 |
JP5358588B2 (ja) | 2013-12-04 |
EP2257356B1 (en) | 2016-12-14 |
WO2009111228A2 (en) | 2009-09-11 |
EP2257356A2 (en) | 2010-12-08 |
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