JP2011513437A5 - - Google Patents
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- Publication number
- JP2011513437A5 JP2011513437A5 JP2010550000A JP2010550000A JP2011513437A5 JP 2011513437 A5 JP2011513437 A5 JP 2011513437A5 JP 2010550000 A JP2010550000 A JP 2010550000A JP 2010550000 A JP2010550000 A JP 2010550000A JP 2011513437 A5 JP2011513437 A5 JP 2011513437A5
- Authority
- JP
- Japan
- Prior art keywords
- moiety
- cancerous cells
- compound
- prooxidant
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 26
- 210000004027 cell Anatomy 0.000 claims 23
- 230000003244 pro-oxidative effect Effects 0.000 claims 13
- 230000001939 inductive effect Effects 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- 230000002438 mitochondrial effect Effects 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 7
- 210000003470 mitochondria Anatomy 0.000 claims 6
- 230000000861 pro-apoptotic effect Effects 0.000 claims 6
- 230000034994 death Effects 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 230000006907 apoptotic process Effects 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical group OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000003642 reactive oxygen metabolite Substances 0.000 claims 3
- LCFWOFKPFDWYLR-CEFNRUSXSA-N alpha-tocopheryloxyacetic acid Chemical compound OC(=O)COC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C LCFWOFKPFDWYLR-CEFNRUSXSA-N 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 2
- -1 triphenylphosphonium cation Chemical class 0.000 claims 2
- 150000003712 vitamin E derivatives Chemical class 0.000 claims 2
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims 1
- IELOKBJPULMYRW-NJQVLOCASA-N D-alpha-Tocopheryl Acid Succinate Chemical group OC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C IELOKBJPULMYRW-NJQVLOCASA-N 0.000 claims 1
- ZAKOWWREFLAJOT-ADUHFSDSSA-N [2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] acetate Chemical group CC(=O)OC1=C(C)C(C)=C2OC(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-ADUHFSDSSA-N 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 235000017471 coenzyme Q10 Nutrition 0.000 claims 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 125000002889 tridecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229940035936 ubiquinone Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2008901261 | 2008-03-14 | ||
| AU2008901261A AU2008901261A0 (en) | 2008-03-14 | Mitochondrially Delivered Anti-Cancer Compounds | |
| PCT/AU2009/000312 WO2009111846A1 (en) | 2008-03-14 | 2009-03-16 | Mitochondrially delivered anti-cancer compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011513437A JP2011513437A (ja) | 2011-04-28 |
| JP2011513437A5 true JP2011513437A5 (https=) | 2013-05-02 |
| JP5616798B2 JP5616798B2 (ja) | 2014-10-29 |
Family
ID=41064682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010550000A Active JP5616798B2 (ja) | 2008-03-14 | 2009-03-16 | ミトコンドリア由来の抗ガン化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | USRE47300E1 (https=) |
| EP (1) | EP2265623B1 (https=) |
| JP (1) | JP5616798B2 (https=) |
| KR (1) | KR101642157B1 (https=) |
| CA (1) | CA2734208C (https=) |
| NZ (1) | NZ602579A (https=) |
| WO (1) | WO2009111846A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103764026B (zh) | 2011-04-14 | 2016-10-19 | 艾伦斯生物科技有限公司 | 用于肝细胞癌的诊断、预后、监测和治疗的方法 |
| WO2012174287A1 (en) * | 2011-06-15 | 2012-12-20 | The Board Of Regents Of The University Of Texas System | Luminescent nanoparticle compositions |
| HK1200459A1 (en) | 2011-09-19 | 2015-08-07 | Gencia Corporation | Modified creatine compounds |
| WO2013181488A2 (en) * | 2012-06-01 | 2013-12-05 | The Ohio State University Research Foundation | Inhibition of leukemic stem cells by pp2a activating agents |
| PT2989110T (pt) * | 2013-04-24 | 2018-11-15 | Jira Neuzil | Derivados de tamoxifeno para o tratamento de doenças neoplásicas, especialmente com nível elevado de proteína her2 |
| US10953110B2 (en) | 2014-04-25 | 2021-03-23 | Board Of Regents, The University Of Texas System | Dual emissive metal nanoparticles as ratiometric pH indicators |
| WO2016144637A1 (en) * | 2015-03-06 | 2016-09-15 | The Children's Hospital Of Philadelphia | Tocopheryloxyacetate ester-based co-drug conjugates |
| CZ307146B6 (cs) * | 2015-03-31 | 2018-02-07 | Kkcg Se | Trifenylfosfoniové analogy biguanidu, způsob jejich přípravy a jejich použití jako léčiva |
| US20180318324A1 (en) | 2015-11-04 | 2018-11-08 | Prescient Pharma Llc | Anti-aging compositions and methods for using same |
| KR102361131B1 (ko) * | 2020-02-25 | 2022-02-10 | 경희대학교 산학협력단 | 항생제 내성 균주에 대해 항균활성을 갖는 항균용 조성물 |
| TW202233246A (zh) * | 2020-10-22 | 2022-09-01 | 南韓商白雁生物技術公司 | 含有抗癌劑之粒線體及其用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030069208A1 (en) * | 1997-11-25 | 2003-04-10 | University Of Otago | Mitochondrially targeted antioxidants |
| US6331532B1 (en) * | 1998-11-25 | 2001-12-18 | University Of Otago | Mitochondrially targeted antioxidants |
| KR100847678B1 (ko) | 2000-02-11 | 2008-07-23 | 리서치 디벨럽먼트 파운데이션 | 토코페롤, 토코트리에놀, 다른 크로만 및 측쇄 유도체, 및이들의 용도 |
| AUPQ605800A0 (en) * | 2000-03-06 | 2000-03-30 | Silverbrook Research Pty Ltd | Printehead assembly |
| WO2002093063A1 (en) * | 2001-05-17 | 2002-11-21 | Imperial College Innovations Limited | Production and processing plant with a rigid pipe portion curving in three dimensions |
| BRPI0413742B8 (pt) | 2003-08-22 | 2021-05-25 | Antipodean Pharmaceuticals Inc | composto antioxidante quimicamente estável, composição farmacêutica, método de redução do estresse oxidativo em uma célula in vitro e métodos de preparo e de síntese do referido composto antioxidante |
| CN1925853B (zh) * | 2004-07-28 | 2011-01-26 | 陈献 | 琥珀酸α-生育酚酯及其类似物和盐的稳定注射组合物 |
| KR100556527B1 (ko) * | 2004-11-04 | 2006-03-06 | 삼성전자주식회사 | 트렌치 소자 분리막 형성 방법 및 불휘발성 메모리 장치의제조 방법 |
| WO2006094203A1 (en) | 2005-03-02 | 2006-09-08 | Northeastern University | Mitochondriotropic phospholipid vesicles |
| RU2318500C2 (ru) | 2005-10-18 | 2008-03-10 | Общество С Ограниченной Ответственностью "Митотехнология" | Способ воздействия на организм путем адресной доставки биологически активных веществ в митохондрии, фармацевтическая композиция для его осуществления и соединение, применяемое для этой цели |
| NZ575920A (en) | 2006-09-15 | 2012-08-31 | Stephen John Ralph | Pro-oxidant anti-cancer compounds |
| JP4930026B2 (ja) * | 2006-12-13 | 2012-05-09 | 富士ゼロックス株式会社 | 積層体、無端状ベルト、定着装置及び画像形成装置 |
| DE102007025423A1 (de) | 2007-05-30 | 2008-12-04 | Friedrich-Schiller-Universität Jena | Triphenylphosphonium-Derivate zum gezielten Transport und Freisetzen von Substanzen in Mitochondrien sowie Verfahren zu deren Verwendung |
-
2009
- 2009-03-16 NZ NZ602579A patent/NZ602579A/en not_active IP Right Cessation
- 2009-03-16 US US14/955,297 patent/USRE47300E1/en not_active Expired - Fee Related
- 2009-03-16 JP JP2010550000A patent/JP5616798B2/ja active Active
- 2009-03-16 WO PCT/AU2009/000312 patent/WO2009111846A1/en not_active Ceased
- 2009-03-16 EP EP09720005.9A patent/EP2265623B1/en not_active Not-in-force
- 2009-03-16 KR KR1020107022874A patent/KR101642157B1/ko active Active
- 2009-03-16 US US12/922,525 patent/US8598145B2/en not_active Ceased
- 2009-03-16 CA CA2734208A patent/CA2734208C/en active Active
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