JP2011511949A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011511949A5 JP2011511949A5 JP2010546779A JP2010546779A JP2011511949A5 JP 2011511949 A5 JP2011511949 A5 JP 2011511949A5 JP 2010546779 A JP2010546779 A JP 2010546779A JP 2010546779 A JP2010546779 A JP 2010546779A JP 2011511949 A5 JP2011511949 A5 JP 2011511949A5
- Authority
- JP
- Japan
- Prior art keywords
- alk
- inversion
- probe
- eml4
- chromosome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6542208P | 2008-02-12 | 2008-02-12 | |
| PCT/US2009/000879 WO2009102446A2 (en) | 2008-02-12 | 2009-02-12 | Fish assay for eml4 and alk fusion in lung cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011511949A JP2011511949A (ja) | 2011-04-14 |
| JP2011511949A5 true JP2011511949A5 (https=) | 2012-03-29 |
Family
ID=40957428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010546779A Pending JP2011511949A (ja) | 2008-02-12 | 2009-02-12 | 肺癌におけるｅｍｌ４とａｌｋの融合のためのｆｉｓｈアッセイ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110110923A1 (https=) |
| EP (1) | EP2255190A4 (https=) |
| JP (1) | JP2011511949A (https=) |
| AU (1) | AU2009215168A1 (https=) |
| CA (1) | CA2715380A1 (https=) |
| WO (1) | WO2009102446A2 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120208824A1 (en) | 2006-01-20 | 2012-08-16 | Cell Signaling Technology, Inc. | ROS Kinase in Lung Cancer |
| PT2450437T (pt) | 2006-04-14 | 2017-08-25 | Cell Signaling Technology Inc | Defeitos de genes e cinase alk mutante em tumores sólidos humanos |
| US8168383B2 (en) | 2006-04-14 | 2012-05-01 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| MX353308B (es) | 2008-05-21 | 2018-01-08 | Ariad Pharma Inc | Derivados fosforosos como inhibidores de cinasa. |
| EP2435584B1 (en) | 2009-05-26 | 2016-07-13 | Quest Diagnostics Investments Incorporated | Methods for detecting gene dysregulations |
| US8546552B2 (en) | 2009-12-23 | 2013-10-01 | Quest Diagnostics Investments Incorporated | TMPRSS2 for the diagnosis of prostate disease |
| WO2011130635A2 (en) * | 2010-04-16 | 2011-10-20 | Response Genetics, Inc. | Primers, probes, methods and kits for the detection of eml4-alk variants |
| EP2560640A1 (en) | 2010-04-19 | 2013-02-27 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor |
| US20120101108A1 (en) | 2010-08-06 | 2012-04-26 | Cell Signaling Technology, Inc. | Anaplastic Lymphoma Kinase In Kidney Cancer |
| JP6247934B2 (ja) * | 2011-02-04 | 2017-12-13 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 単一細胞において染色体構造および遺伝子発現を同時に検出するための方法 |
| DE102011100242A1 (de) | 2011-05-02 | 2012-11-08 | Zytovision Gmbh | Verfahren zur Detektion von Chromosomenaberration |
| EP2704572B1 (en) | 2011-05-04 | 2015-12-30 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
| EP2714038A1 (en) | 2011-05-24 | 2014-04-09 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitory compounds with mtor/pi3k inhibitors |
| CA3113672A1 (en) | 2011-07-01 | 2013-01-10 | Htg Molecular Diagnostics, Inc. | Methods of detecting gene fusions |
| CA2840986A1 (en) | 2011-07-07 | 2013-01-10 | Synta Pharmaceuticals Corp. | Treating cancer with hsp90 inhibitory compounds |
| CA2853799A1 (en) | 2011-11-02 | 2013-05-10 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors |
| JP2014534228A (ja) | 2011-11-02 | 2014-12-18 | シンタ ファーマシューティカルズ コーポレーション | 白金含有剤とｈｓｐ９０阻害剤の組合せ療法 |
| US9402831B2 (en) | 2011-11-14 | 2016-08-02 | Synta Pharmaceutical Corp. | Combination therapy of HSP90 inhibitors with BRAF inhibitors |
| PL2838998T3 (pl) | 2012-04-18 | 2018-04-30 | Cell Signaling Technology, Inc. | EGFR i ROS1 w nowotworze |
| WO2013169401A1 (en) | 2012-05-05 | 2013-11-14 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
| WO2013170182A1 (en) | 2012-05-11 | 2013-11-14 | Synta Pharmaceuticals Corp. | Treating cancer with an hsp90 inhibitory compound |
| AR092982A1 (es) | 2012-10-11 | 2015-05-13 | Isis Pharmaceuticals Inc | Modulacion de la expresion de receptores androgenicos |
| RU2509153C1 (ru) * | 2012-11-28 | 2014-03-10 | Федеральное государственное бюджетное учреждение "Российский онкологический научный центр имени Н.Н. Блохина" Российской академии медицинских наук (ФГБУ "РОНЦ им. Н.Н. Блохина" РАМН) | Способ анализа транслокаций eml4-alk, ассоциированных с чувствительностью рака легкого к противоопухолевой таргетной терапии |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| US11045468B2 (en) * | 2014-02-04 | 2021-06-29 | Astellas Pharma Inc. | Pharmaceutical composition comprising diamino heterocyclic carboxamide compound as active ingredient |
| HK1244436A1 (zh) | 2015-02-09 | 2018-08-10 | Synta Pharmaceuticals Corp. | 治疗癌症的hsp90抑制剂和pd-1抑制剂的组合疗法 |
| CN105368962A (zh) * | 2015-12-18 | 2016-03-02 | 河南赛诺特生物技术有限公司 | 肺癌alk基因重排快速检测荧光探针及制备方法 |
| CN105543353A (zh) * | 2015-12-30 | 2016-05-04 | 广州安必平医药科技股份有限公司 | Alk基因和eml4基因检测探针及其制备方法和试剂盒 |
| KR101923852B1 (ko) | 2017-02-24 | 2018-11-29 | 재단법인 대구경북첨단의료산업진흥재단 | 혈액 뇌관문을 통과할 수 있는 화합물을 유효성분으로 함유하는 뇌암의 예방 또는 치료용 약학적 조성물 |
| CN108998503B (zh) * | 2018-08-17 | 2022-04-05 | 中山康源基因技术科技有限公司 | 一种Oligo探针及其制备方法与应用 |
| CN110066876A (zh) * | 2019-06-06 | 2019-07-30 | 徐州医科大学 | 一种用于癌症诊断的分子标志物 |
| JP7510998B2 (ja) * | 2019-08-05 | 2024-07-04 | 北京基石生命科技有限公司 | 肺がん固形腫瘍の初代細胞と肺がん胸水の初代腫瘍細胞の培養方法およびキット |
| JP7385191B2 (ja) * | 2019-08-30 | 2023-11-22 | 学校法人同志社 | Ｅｍｌ４－ａｌｋ阻害ペプチドおよびこれを含む肺がん治療薬 |
| KR102449858B1 (ko) * | 2021-07-08 | 2022-09-30 | 가톨릭대학교 산학협력단 | 암 세포 판정을 위한 핵이미지 선별 장치 및 핵이미지 선별 방법 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5756696A (en) * | 1986-01-16 | 1998-05-26 | Regents Of The University Of California | Compositions for chromosome-specific staining |
| US6344315B1 (en) * | 1986-01-16 | 2002-02-05 | The Regents Of The University Of California | Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17 |
| US6280929B1 (en) * | 1986-01-16 | 2001-08-28 | The Regents Of The University Of California | Method of detecting genetic translocations identified with chromosomal abnormalities |
| US5447841A (en) * | 1986-01-16 | 1995-09-05 | The Regents Of The Univ. Of California | Methods for chromosome-specific staining |
| AU647741B2 (en) * | 1989-12-01 | 1994-03-31 | Regents Of The University Of California, The | Methods and compositions for chromosome-specific staining |
| US5491224A (en) * | 1990-09-20 | 1996-02-13 | Bittner; Michael L. | Direct label transaminated DNA probe compositions for chromosome identification and methods for their manufacture |
| US5529925A (en) * | 1993-12-03 | 1996-06-25 | St. Jude Children's Research Hospital | Nucleic acid sequences and fusion proteins present in human t(2;5) lymphoma |
| US6573043B1 (en) * | 1998-10-07 | 2003-06-03 | Genentech, Inc. | Tissue analysis and kits therefor |
| US7288529B2 (en) * | 2003-04-24 | 2007-10-30 | New York University | ALK protein tyrosine kinase, cells and methods embodying and using same |
| US8062897B2 (en) * | 2003-07-21 | 2011-11-22 | Aureon Laboratories, Inc. | Diagnostic histopathology using multiplex gene expression FISH |
| JP3884462B2 (ja) * | 2005-10-14 | 2007-02-21 | 株式会社ファースト | 高速画像探索方法 |
| PT2450437T (pt) * | 2006-04-14 | 2017-08-25 | Cell Signaling Technology Inc | Defeitos de genes e cinase alk mutante em tumores sólidos humanos |
| ES2458497T3 (es) * | 2006-04-14 | 2014-05-05 | Cell Signaling Technology, Inc. | Defectos de genes y quinasa ALK mutante en tumores sólidos humanos |
| CA2598893C (en) * | 2006-10-11 | 2012-04-10 | Astellas Pharma Inc. | Eml4-alk fusion gene |
| EP1914240B1 (en) * | 2006-10-11 | 2009-12-02 | Astellas Pharma Inc. | EML4-ALK fusion gene |
-
2009
- 2009-02-12 EP EP09711258A patent/EP2255190A4/en not_active Withdrawn
- 2009-02-12 WO PCT/US2009/000879 patent/WO2009102446A2/en not_active Ceased
- 2009-02-12 CA CA2715380A patent/CA2715380A1/en not_active Abandoned
- 2009-02-12 AU AU2009215168A patent/AU2009215168A1/en not_active Abandoned
- 2009-02-12 JP JP2010546779A patent/JP2011511949A/ja active Pending
- 2009-02-12 US US12/867,336 patent/US20110110923A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011511949A5 (https=) | ||
| AU2023226698B2 (en) | Oligonucleotide probes and uses thereof | |
| CN106244698B (zh) | 一种动物源性成分检测试剂盒 | |
| Yao et al. | Specific and simultaneous detection of micro RNA 21 and let-7a by rolling circle amplification combined with lateral flow strip | |
| US20230039899A1 (en) | In situ rna analysis using probe pair ligation | |
| CA2962075C (en) | USE OF FGFR MUTANT GENE PANELS IN IDENTIFYING CANCER PATIENTS WHO WILL BE SENSITIVE TO TREATMENT WITH AN FGFR INHIBITOR | |
| EP3041931B1 (en) | Site-specific nuclease single-cell assay targeting gene regulatory elements to silence gene expression | |
| DK2500436T3 (en) | A method, probe and kit for in situ hybridization of DNA and use thereof | |
| JP6223451B2 (ja) | がんの診断及び治療方法 | |
| Muralidharan et al. | Long-term male-specific chronic pain via telomere-and p53‑mediated spinal cord cellular senescence | |
| US11180812B2 (en) | Use of DNA in circulating exosomes as a diagnostic marker for metastatic disease | |
| JP2009523410A (ja) | 遺伝子転写に対するｆｇｆｒ３の阻害剤の効果 | |
| ES2767853T3 (es) | Detección de la restricción de cadena ligera de inmunoglobulina por hibridación in situ de ARN | |
| Ju et al. | A novel intronic circular RNA, circGNG7, inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82 | |
| JP2014533114A5 (https=) | ||
| KR20220124112A (ko) | Tut4/7 발현 조절인자를 포함하는 암 예방 또는 치료용 약학적 조성물 | |
| Shi et al. | Fluorescence in situ hybridization for microRNA detection in archived oral cancer tissues | |
| JP2014523440A (ja) | 合成致死性および癌の治療 | |
| US20200208224A1 (en) | Use Of FGFR Mutant Gene Panels In Identifying Cancer Patients That Will Be Responsive To Treatment With An FGFR Inhibitor | |
| JPWO2018123764A1 (ja) | 神経芽腫の微小残存病変を評価するために用いられる試薬、およびそれを用いた生体試料の分析方法 | |
| CN109628594A (zh) | 一种与肝癌相关的长链非编码rna及其应用 | |
| JP7669344B2 (ja) | 標的分析に関連する方法および組成物 | |
| US10787711B2 (en) | Method for differentiating between lung squamous cell carcinoma and lung adenocarcinoma | |
| CN104212884B (zh) | 胰腺神经内分泌肿瘤易感基因位点及检测方法和试剂盒 | |
| CN107142332A (zh) | 一种酶性DNA机器用于miRNA检测的方法 |