JP2011511949A5 - - Google Patents
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- Publication number
- JP2011511949A5 JP2011511949A5 JP2010546779A JP2010546779A JP2011511949A5 JP 2011511949 A5 JP2011511949 A5 JP 2011511949A5 JP 2010546779 A JP2010546779 A JP 2010546779A JP 2010546779 A JP2010546779 A JP 2010546779A JP 2011511949 A5 JP2011511949 A5 JP 2011511949A5
- Authority
- JP
- Japan
- Prior art keywords
- alk
- inversion
- probe
- eml4
- chromosome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6542208P | 2008-02-12 | 2008-02-12 | |
| PCT/US2009/000879 WO2009102446A2 (en) | 2008-02-12 | 2009-02-12 | Fish assay for eml4 and alk fusion in lung cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011511949A JP2011511949A (ja) | 2011-04-14 |
| JP2011511949A5 true JP2011511949A5 (https=) | 2012-03-29 |
Family
ID=40957428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010546779A Pending JP2011511949A (ja) | 2008-02-12 | 2009-02-12 | 肺癌におけるｅｍｌ４とａｌｋの融合のためのｆｉｓｈアッセイ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110110923A1 (https=) |
| EP (1) | EP2255190A4 (https=) |
| JP (1) | JP2011511949A (https=) |
| AU (1) | AU2009215168A1 (https=) |
| CA (1) | CA2715380A1 (https=) |
| WO (1) | WO2009102446A2 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120208824A1 (en) | 2006-01-20 | 2012-08-16 | Cell Signaling Technology, Inc. | ROS Kinase in Lung Cancer |
| US8168383B2 (en) | 2006-04-14 | 2012-05-01 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
| EP2450437B1 (en) | 2006-04-14 | 2017-05-17 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
| PT2300013T (pt) | 2008-05-21 | 2017-10-31 | Ariad Pharma Inc | Derivados de fósforo como inibidores de cinases |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| US8426133B2 (en) | 2009-05-26 | 2013-04-23 | Quest Diagnostics Investments Incorporated | Methods for detecting gene dysregulation by intragenic differential expression |
| WO2011079191A1 (en) | 2009-12-23 | 2011-06-30 | Quest Diagnostics Investments Incorporated | Tmprss2 for the diagnosis of prostate disease |
| AR080913A1 (es) * | 2010-04-16 | 2012-05-16 | Response Genetics | Cebadores, sondas, metodos y conjuntos de elementos para la deteccion de variantes de eml4- alk |
| US9205086B2 (en) | 2010-04-19 | 2015-12-08 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a Hsp90 inhibitory compounds and a EGFR inhibitor |
| US20120101108A1 (en) | 2010-08-06 | 2012-04-26 | Cell Signaling Technology, Inc. | Anaplastic Lymphoma Kinase In Kidney Cancer |
| AU2012211957B2 (en) * | 2011-02-04 | 2017-02-23 | The Trustees Of The University Of Pennsylvania | A method for detecting chromosome structure and gene expression simultaneously in single cells |
| DE102011100242A1 (de) * | 2011-05-02 | 2012-11-08 | Zytovision Gmbh | Verfahren zur Detektion von Chromosomenaberration |
| US9834518B2 (en) | 2011-05-04 | 2017-12-05 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
| WO2012162372A1 (en) | 2011-05-24 | 2012-11-29 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitory compounds with mtor/p13k inhibitors |
| ES2578370T3 (es) | 2011-07-01 | 2016-07-26 | HTG Molecular Diagnostics, Inc | Métodos para detectar fusiones génicas |
| JP2014520808A (ja) * | 2011-07-07 | 2014-08-25 | シンタ ファーマシューティカルズ コーポレーション | Ｈｓｐ９０阻害化合物を用いた癌の治療 |
| EP2773345A1 (en) | 2011-11-02 | 2014-09-10 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors |
| AU2012332424A1 (en) | 2011-11-02 | 2014-06-05 | Synta Pharmaceuticals Corp. | Combination therapy of Hsp90 inhibitors with platinum-containing agents |
| WO2013074594A1 (en) | 2011-11-14 | 2013-05-23 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitors with braf inhibitors |
| DK2838998T3 (en) | 2012-04-18 | 2018-01-15 | Cell Signaling Technology Inc | EGFR AND ROS1 IN CANCER |
| US20150166591A1 (en) | 2012-05-05 | 2015-06-18 | Ariad Pharmaceuticals, Inc. | Methods and compositions for raf kinase mediated diseases |
| WO2013170182A1 (en) | 2012-05-11 | 2013-11-14 | Synta Pharmaceuticals Corp. | Treating cancer with an hsp90 inhibitory compound |
| US9175291B2 (en) | 2012-10-11 | 2015-11-03 | Isis Pharmaceuticals Inc. | Modulation of androgen receptor expression |
| RU2509153C1 (ru) * | 2012-11-28 | 2014-03-10 | Федеральное государственное бюджетное учреждение "Российский онкологический научный центр имени Н.Н. Блохина" Российской академии медицинских наук (ФГБУ "РОНЦ им. Н.Н. Блохина" РАМН) | Способ анализа транслокаций eml4-alk, ассоциированных с чувствительностью рака легкого к противоопухолевой таргетной терапии |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| CA2938818C (en) | 2014-02-04 | 2023-03-07 | Astellas Pharma Inc. | Pharmaceutical composition comprising diamino heterocyclic carboxamide compound as active ingredient |
| BR112017016973A2 (pt) | 2015-02-09 | 2018-04-03 | Synta Pharmaceuticals Corp. | terapia de combinação de inibidores de hsp90 e inibidores de pd-1 para tratamento de câncer |
| CN105368962A (zh) * | 2015-12-18 | 2016-03-02 | 河南赛诺特生物技术有限公司 | 肺癌alk基因重排快速检测荧光探针及制备方法 |
| CN105543353A (zh) * | 2015-12-30 | 2016-05-04 | 广州安必平医药科技股份有限公司 | Alk基因和eml4基因检测探针及其制备方法和试剂盒 |
| KR101923852B1 (ko) | 2017-02-24 | 2018-11-29 | 재단법인 대구경북첨단의료산업진흥재단 | 혈액 뇌관문을 통과할 수 있는 화합물을 유효성분으로 함유하는 뇌암의 예방 또는 치료용 약학적 조성물 |
| CN108998503B (zh) * | 2018-08-17 | 2022-04-05 | 中山康源基因技术科技有限公司 | 一种Oligo探针及其制备方法与应用 |
| CN110066876A (zh) * | 2019-06-06 | 2019-07-30 | 徐州医科大学 | 一种用于癌症诊断的分子标志物 |
| US20220267735A1 (en) * | 2019-08-05 | 2022-08-25 | Genex Health Co., Ltd | Method for culturing primary cells from solid tumor of lung cancer and primary tumor cells from pleural effusion of lung cancer and auxiliary reagents |
| JP7385191B2 (ja) * | 2019-08-30 | 2023-11-22 | 学校法人同志社 | Ｅｍｌ４－ａｌｋ阻害ペプチドおよびこれを含む肺がん治療薬 |
| KR102449858B1 (ko) * | 2021-07-08 | 2022-09-30 | 가톨릭대학교 산학협력단 | 암 세포 판정을 위한 핵이미지 선별 장치 및 핵이미지 선별 방법 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6344315B1 (en) * | 1986-01-16 | 2002-02-05 | The Regents Of The University Of California | Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17 |
| US5447841A (en) * | 1986-01-16 | 1995-09-05 | The Regents Of The Univ. Of California | Methods for chromosome-specific staining |
| US6280929B1 (en) * | 1986-01-16 | 2001-08-28 | The Regents Of The University Of California | Method of detecting genetic translocations identified with chromosomal abnormalities |
| US5756696A (en) * | 1986-01-16 | 1998-05-26 | Regents Of The University Of California | Compositions for chromosome-specific staining |
| AU647741B2 (en) * | 1989-12-01 | 1994-03-31 | Regents Of The University Of California, The | Methods and compositions for chromosome-specific staining |
| US5491224A (en) * | 1990-09-20 | 1996-02-13 | Bittner; Michael L. | Direct label transaminated DNA probe compositions for chromosome identification and methods for their manufacture |
| US5529925A (en) * | 1993-12-03 | 1996-06-25 | St. Jude Children's Research Hospital | Nucleic acid sequences and fusion proteins present in human t(2;5) lymphoma |
| US6573043B1 (en) * | 1998-10-07 | 2003-06-03 | Genentech, Inc. | Tissue analysis and kits therefor |
| US7288529B2 (en) * | 2003-04-24 | 2007-10-30 | New York University | ALK protein tyrosine kinase, cells and methods embodying and using same |
| US8062897B2 (en) * | 2003-07-21 | 2011-11-22 | Aureon Laboratories, Inc. | Diagnostic histopathology using multiplex gene expression FISH |
| JP3884462B2 (ja) * | 2005-10-14 | 2007-02-21 | 株式会社ファースト | 高速画像探索方法 |
| EP2450437B1 (en) * | 2006-04-14 | 2017-05-17 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
| EP1914240B1 (en) * | 2006-10-11 | 2009-12-02 | Astellas Pharma Inc. | EML4-ALK fusion gene |
| CA2598893C (en) * | 2006-10-11 | 2012-04-10 | Astellas Pharma Inc. | Eml4-alk fusion gene |
| CN101466721B (zh) * | 2007-04-13 | 2013-08-21 | 细胞信号技术公司 | 在人实体瘤中的基因缺损和突变体alk激酶 |
-
2009
- 2009-02-12 WO PCT/US2009/000879 patent/WO2009102446A2/en not_active Ceased
- 2009-02-12 EP EP09711258A patent/EP2255190A4/en not_active Withdrawn
- 2009-02-12 AU AU2009215168A patent/AU2009215168A1/en not_active Abandoned
- 2009-02-12 CA CA2715380A patent/CA2715380A1/en not_active Abandoned
- 2009-02-12 JP JP2010546779A patent/JP2011511949A/ja active Pending
- 2009-02-12 US US12/867,336 patent/US20110110923A1/en not_active Abandoned
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