JP2011510024A - デュロキセチンの遅延放出医薬組成物 - Google Patents
デュロキセチンの遅延放出医薬組成物 Download PDFInfo
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- JP2011510024A JP2011510024A JP2010543345A JP2010543345A JP2011510024A JP 2011510024 A JP2011510024 A JP 2011510024A JP 2010543345 A JP2010543345 A JP 2010543345A JP 2010543345 A JP2010543345 A JP 2010543345A JP 2011510024 A JP2011510024 A JP 2011510024A
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- duloxetine
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- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229960002900 methylcellulose Drugs 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- XLPUOLALFJLHTG-UHFFFAOYSA-N octadecyl dihydrogen phosphate;sodium Chemical compound [Na].CCCCCCCCCCCCCCCCCCOP(O)(O)=O XLPUOLALFJLHTG-UHFFFAOYSA-N 0.000 description 1
- 238000003921 particle size analysis Methods 0.000 description 1
- 238000010951 particle size reduction Methods 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 229960000540 polacrilin potassium Drugs 0.000 description 1
- 229920002959 polymer blend Polymers 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- WVWZXTJUCNEUAE-UHFFFAOYSA-M potassium;1,2-bis(ethenyl)benzene;2-methylprop-2-enoate Chemical compound [K+].CC(=C)C([O-])=O.C=CC1=CC=CC=C1C=C WVWZXTJUCNEUAE-UHFFFAOYSA-M 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 238000004879 turbidimetry Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2008900332A AU2008900332A0 (en) | 2008-01-25 | Delayed Release Composition and Compound | |
| PCT/AU2009/000028 WO2009092129A1 (en) | 2008-01-25 | 2009-01-09 | Delayed release pharmaceutical composition of duloxetine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011510024A true JP2011510024A (ja) | 2011-03-31 |
| JP2011510024A5 JP2011510024A5 (enExample) | 2012-02-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010543345A Pending JP2011510024A (ja) | 2008-01-25 | 2009-01-09 | デュロキセチンの遅延放出医薬組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110070299A1 (enExample) |
| EP (1) | EP2240173A4 (enExample) |
| JP (1) | JP2011510024A (enExample) |
| CN (1) | CN101939004A (enExample) |
| AU (1) | AU2009206204B2 (enExample) |
| CA (1) | CA2712282A1 (enExample) |
| WO (1) | WO2009092129A1 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017226640A (ja) * | 2016-06-23 | 2017-12-28 | キョーリンリメディオ株式会社 | デュロキセチンまたは薬学的に許容されるその塩を有効成分とする医薬組成物 |
| JP2018203671A (ja) * | 2017-06-06 | 2018-12-27 | ニプロ株式会社 | 経口医薬製剤 |
| JP2019052101A (ja) * | 2017-09-13 | 2019-04-04 | アリメント工業株式会社 | 多層被覆製剤 |
| JP2020029447A (ja) * | 2018-06-25 | 2020-02-27 | 大原薬品工業株式会社 | 腸溶性高分子及び抗付着剤を含有する顆粒 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8663661B2 (en) | 2009-12-23 | 2014-03-04 | Ratiopharm Gmbh | Solid pharmaceutical dosage form of ticagrelor |
| CN102908331A (zh) * | 2011-08-01 | 2013-02-06 | 浙江九洲药物科技有限公司 | 一种盐酸度洛西汀肠溶胶囊及其制备方法 |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| CN102579403B (zh) * | 2011-12-26 | 2013-08-21 | 天津市嵩锐医药科技有限公司 | 盐酸度洛西汀药物组合物 |
| US8313774B1 (en) * | 2012-06-26 | 2012-11-20 | Magnifica Inc. | Oral solid composition |
| CN103127023B (zh) * | 2013-03-01 | 2014-08-27 | 河北天成药业股份有限公司 | 一种盐酸度洛西汀肠溶片及其制备方法 |
| GR1008228B (el) * | 2013-04-23 | 2014-06-16 | "Φαρματεν Α.Β.Ε.Ε.", | Φαρμακευτικο σκευασμα περιεχον ενα διπλο αναστολεα επαναπροσληψης και μεθοδος για την παρασκευη αυτου |
| CN103393615B (zh) * | 2013-07-24 | 2015-07-15 | 海南华益泰康药业有限公司 | 一种度洛西汀肠溶小丸及其制备方法 |
| CN104414993A (zh) * | 2013-08-20 | 2015-03-18 | 天津药物研究院 | 一种盐酸度洛西汀肠溶微丸胶囊及其制备方法 |
| WO2021126098A1 (en) * | 2019-12-18 | 2021-06-24 | Santa Farma İlaç Sanayi̇ A.Ş. | Gastro-resistant pellet comprising duloxetine |
| CN116617189B (zh) * | 2023-07-26 | 2023-09-26 | 四川尚锐生物医药有限公司 | 一种盐酸度洛西汀缓释胶囊及其制备方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002024160A2 (en) * | 2000-09-21 | 2002-03-28 | Phase 2 Discovery, Inc. | Long acting antidepressant microparticles |
| JP2003522139A (ja) * | 2000-02-10 | 2003-07-22 | ビーピーエスアイ ホールディングス，インコーポレーテッド | アクリル系の腸溶性コーティング組成物 |
| WO2003094900A1 (en) * | 2002-05-13 | 2003-11-20 | Alexza Molecular Delivery Corporation | Delivery of drug amines through an inhalation route |
| JP2006508978A (ja) * | 2002-11-19 | 2006-03-16 | イーライ・リリー・アンド・カンパニー | デュロキセチンを用いる胃腸障害の処置 |
| WO2007034503A2 (en) * | 2005-06-20 | 2007-03-29 | Cadila Healthcare Limited | Controlled release dosage formulation of duloxetine |
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| US4956388A (en) * | 1986-12-22 | 1990-09-11 | Eli Lilly And Company | 3-aryloxy-3-substituted propanamines |
| US5009895A (en) * | 1990-02-02 | 1991-04-23 | Merck & Co., Inc. | Sustained release with high and low viscosity HPMC |
| US5362886A (en) | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
| US5508276A (en) * | 1994-07-18 | 1996-04-16 | Eli Lilly And Company | Duloxetine enteric pellets |
| ZA977967B (en) * | 1996-09-23 | 1999-03-04 | Lilly Co Eli | Combination therapy for treatment of psychoses |
| EP1171417B1 (en) * | 1999-04-09 | 2005-11-09 | Eli Lilly And Company | Methods for preparing 3-aryloxy-3-arylpropylamines and intermediates thereof |
| UA80393C2 (uk) * | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці |
| US7625932B2 (en) * | 2003-10-08 | 2009-12-01 | Eli Lilly And Company | Pyrrole and pyrazole derivatives as potentiators of glutamate receptors |
| US20050250838A1 (en) * | 2004-05-04 | 2005-11-10 | Challapalli Prasad V | Formulation for sustained delivery |
| CN101132777A (zh) * | 2004-12-20 | 2008-02-27 | 科利吉姆制药公司 | 用于睡眠障碍的药物组合物 |
| EP1976844A4 (en) | 2006-01-06 | 2010-11-03 | Msn Lab Ltd | IMPROVED METHOD FOR PURE DULOXETIN HYDROCHLORIDE |
| EP1820800A1 (en) * | 2006-02-17 | 2007-08-22 | KRKA, tovarna zdravil, d.d., Novo mesto | Crystalline forms of duloxetine hydrochloride and processes for their preparation |
| CA2651716A1 (en) * | 2006-05-22 | 2007-12-06 | Gershon Kolatkar | Duloxetine hydrochloride delayed release formulations |
| US20110008439A1 (en) * | 2006-12-27 | 2011-01-13 | Lek Pharmaceuticals D.D. | Duloxetin composition |
-
2009
- 2009-01-09 CN CN2009801017187A patent/CN101939004A/zh active Pending
- 2009-01-09 JP JP2010543345A patent/JP2011510024A/ja active Pending
- 2009-01-09 US US12/863,882 patent/US20110070299A1/en not_active Abandoned
- 2009-01-09 CA CA2712282A patent/CA2712282A1/en not_active Abandoned
- 2009-01-09 EP EP20090704911 patent/EP2240173A4/en not_active Ceased
- 2009-01-09 AU AU2009206204A patent/AU2009206204B2/en not_active Ceased
- 2009-01-09 WO PCT/AU2009/000028 patent/WO2009092129A1/en not_active Ceased
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| JP2003522139A (ja) * | 2000-02-10 | 2003-07-22 | ビーピーエスアイ ホールディングス，インコーポレーテッド | アクリル系の腸溶性コーティング組成物 |
| WO2002024160A2 (en) * | 2000-09-21 | 2002-03-28 | Phase 2 Discovery, Inc. | Long acting antidepressant microparticles |
| WO2003094900A1 (en) * | 2002-05-13 | 2003-11-20 | Alexza Molecular Delivery Corporation | Delivery of drug amines through an inhalation route |
| JP2006508978A (ja) * | 2002-11-19 | 2006-03-16 | イーライ・リリー・アンド・カンパニー | デュロキセチンを用いる胃腸障害の処置 |
| WO2007034503A2 (en) * | 2005-06-20 | 2007-03-29 | Cadila Healthcare Limited | Controlled release dosage formulation of duloxetine |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017226640A (ja) * | 2016-06-23 | 2017-12-28 | キョーリンリメディオ株式会社 | デュロキセチンまたは薬学的に許容されるその塩を有効成分とする医薬組成物 |
| JP2018203671A (ja) * | 2017-06-06 | 2018-12-27 | ニプロ株式会社 | 経口医薬製剤 |
| JP2019052101A (ja) * | 2017-09-13 | 2019-04-04 | アリメント工業株式会社 | 多層被覆製剤 |
| JP7046323B2 (ja) | 2017-09-13 | 2022-04-04 | アリメント工業株式会社 | 多層被覆製剤 |
| JP2020029447A (ja) * | 2018-06-25 | 2020-02-27 | 大原薬品工業株式会社 | 腸溶性高分子及び抗付着剤を含有する顆粒 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009092129A8 (en) | 2009-10-22 |
| CN101939004A (zh) | 2011-01-05 |
| AU2009206204B2 (en) | 2015-03-19 |
| US20110070299A1 (en) | 2011-03-24 |
| WO2009092129A1 (en) | 2009-07-30 |
| AU2009206204A1 (en) | 2009-07-30 |
| EP2240173A4 (en) | 2013-07-17 |
| EP2240173A1 (en) | 2010-10-20 |
| CA2712282A1 (en) | 2009-07-30 |
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