JP2011509656A5 - - Google Patents

Info

Publication number

JP2011509656A5

JP2011509656A5 JP2010541790A JP2010541790A JP2011509656A5 JP 2011509656 A5 JP2011509656 A5 JP 2011509656A5 JP 2010541790 A JP2010541790 A JP 2010541790A JP 2010541790 A JP2010541790 A JP 2010541790A JP 2011509656 A5 JP2011509656 A5 JP 2011509656A5

Authority

JP

Japan

Prior art keywords

cells

cell population

cell

tgfb

fgf

Prior art date

2009-01-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 210000004027 cell Anatomy 0.000 claims 24
• 238000000034 method Methods 0.000 claims 10
• 210000000963 osteoblast Anatomy 0.000 claims 10
• 210000004663 osteoprogenitor cell Anatomy 0.000 claims 6
• 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 4
• 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 4
• 229940126864 fibroblast growth factor Drugs 0.000 claims 4
• 210000002901 mesenchymal stem cell Anatomy 0.000 claims 4
• 102000002260 Alkaline Phosphatase Human genes 0.000 claims 3
• 108020004774 Alkaline Phosphatase Proteins 0.000 claims 3
• 206010061728 Bone lesion Diseases 0.000 claims 3
• 101000635938 Homo sapiens Transforming growth factor beta-1 proprotein Proteins 0.000 claims 3
• 102100030742 Transforming growth factor beta-1 proprotein Human genes 0.000 claims 3
• 238000012258 culturing Methods 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 102000004067 Osteocalcin Human genes 0.000 claims 2
• 108090000573 Osteocalcin Proteins 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 210000002966 serum Anatomy 0.000 claims 2
• 210000000130 stem cell Anatomy 0.000 claims 2
• 102100022464 5'-nucleotidase Human genes 0.000 claims 1
• 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
• 102100024210 CD166 antigen Human genes 0.000 claims 1
• 102100025222 CD63 antigen Human genes 0.000 claims 1
• 102100037241 Endoglin Human genes 0.000 claims 1
• 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims 1
• 102000003971 Fibroblast Growth Factor 1 Human genes 0.000 claims 1
• 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 1
• 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 1
• 108090000378 Fibroblast growth factor 3 Proteins 0.000 claims 1
• 102100028043 Fibroblast growth factor 3 Human genes 0.000 claims 1
• 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
• 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
• 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 1
• 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
• 101000980840 Homo sapiens CD166 antigen Proteins 0.000 claims 1
• 101000934368 Homo sapiens CD63 antigen Proteins 0.000 claims 1
• 101000881679 Homo sapiens Endoglin Proteins 0.000 claims 1
• 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 1
• 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
• 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 1
• 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 1
• 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
• 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 1
• 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
• 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
• 239000000853 adhesive Substances 0.000 claims 1
• 230000001070 adhesive effect Effects 0.000 claims 1
• 239000012472 biological sample Substances 0.000 claims 1
• 210000000988 bone and bone Anatomy 0.000 claims 1
• 210000001185 bone marrow Anatomy 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000000463 material Substances 0.000 claims 1
• 210000005087 mononuclear cell Anatomy 0.000 claims 1
• 210000002381 plasma Anatomy 0.000 claims 1
• 239000002243 precursor Substances 0.000 claims 1
• 239000000758 substrate Substances 0.000 claims 1
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1