PL2229433T3 - Osteogenne różnicowanie komórek macierzystych szpiku kostnego i mezenchymalnych komórek macierzystych z zastosowaniem kombinacji czynników wzrostu - Google Patents

Osteogenne różnicowanie komórek macierzystych szpiku kostnego i mezenchymalnych komórek macierzystych z zastosowaniem kombinacji czynników wzrostu

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Publication number
PL2229433T3
PL2229433T3 PL09700353T PL09700353T PL2229433T3 PL 2229433 T3 PL2229433 T3 PL 2229433T3 PL 09700353 T PL09700353 T PL 09700353T PL 09700353 T PL09700353 T PL 09700353T PL 2229433 T3 PL2229433 T3 PL 2229433T3
Authority
PL
Poland
Prior art keywords
stem cells
combination
bone marrow
growth factors
osteogenic differentiation
Prior art date
Application number
PL09700353T
Other languages
English (en)
Polish (pl)
Inventor
Cindy Badoer
Enrico Bastianelli
Xavier Pesesse
Original Assignee
Bone Therapeutics Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bone Therapeutics Sa filed Critical Bone Therapeutics Sa
Publication of PL2229433T3 publication Critical patent/PL2229433T3/pl

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0664—Dental pulp stem cells, Dental follicle stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
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    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
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    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0688—Cells from the lungs or the respiratory tract
    • C12N5/0689—Stem cells; Progenitors
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/113—Acidic fibroblast growth factor (aFGF, FGF-1)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/148—Transforming growth factor alpha [TGF-a]
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells

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  • Pulmonology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Surgical Instruments (AREA)
PL09700353T 2008-01-11 2009-01-09 Osteogenne różnicowanie komórek macierzystych szpiku kostnego i mezenchymalnych komórek macierzystych z zastosowaniem kombinacji czynników wzrostu PL2229433T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08000458 2008-01-11
PCT/EP2009/050209 WO2009087213A1 (en) 2008-01-11 2009-01-09 Osteogenic differentiation of bone marrow stem cells and mesenchymal stem cells using a combination of growth factors
EP09700353.7A EP2229433B1 (en) 2008-01-11 2009-01-09 Osteogenic differentiation of bone marrow stem cells and mesenchymal stem cells using a combination of growth factors

Publications (1)

Publication Number Publication Date
PL2229433T3 true PL2229433T3 (pl) 2018-01-31

Family

ID=39415339

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09700353T PL2229433T3 (pl) 2008-01-11 2009-01-09 Osteogenne różnicowanie komórek macierzystych szpiku kostnego i mezenchymalnych komórek macierzystych z zastosowaniem kombinacji czynników wzrostu

Country Status (13)

Country Link
US (3) US20100278788A1 (enExample)
EP (1) EP2229433B1 (enExample)
JP (1) JP5524079B2 (enExample)
KR (3) KR101920128B1 (enExample)
CN (2) CN101945993A (enExample)
AU (2) AU2009203682B2 (enExample)
CA (1) CA2710571C (enExample)
DK (1) DK2229433T3 (enExample)
ES (1) ES2650235T3 (enExample)
NO (1) NO2229433T3 (enExample)
PL (1) PL2229433T3 (enExample)
PT (1) PT2229433T (enExample)
WO (1) WO2009087213A1 (enExample)

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Publication number Priority date Publication date Assignee Title
BRPI0921726B8 (pt) 2008-10-31 2021-07-27 Synthes Gmbh método para preparar uma composição de implante para promover o crescimento ósseo em um mamífero
EP4086338A1 (en) 2011-03-17 2022-11-09 Minerva Biotechnologies Corporation Method for making pluripotent stem cells
CN103857788A (zh) 2011-10-11 2014-06-11 骨治疗公司 生长和分化因子8(gdf-8)的用途
WO2013059373A2 (en) 2011-10-17 2013-04-25 Minerva Biotechnologies Corporation Media for stem cell proliferation and induction
CA2983373C (en) * 2015-04-23 2018-12-11 Bone Therapeutics S.A. In vitro preservation of therapeutic cells
CA3030866A1 (en) 2016-07-21 2018-01-25 Sanbio, Inc. Msc growth predictor assays
AU2018351804B2 (en) 2017-10-20 2020-07-09 Bone Therapeutics Sa Methods for differentiating mesenchymal stem cells
KR20210076018A (ko) 2018-09-25 2021-06-23 본 테라퓨틱스 소시에테아노님 체외 분화 세포의 골형성능을 판정하기 위한 방법 및 용도
BR112021005697A2 (pt) 2018-09-25 2021-06-22 Bone Therapeutics Sa métodos para obter células derivadas de células-tronco mesenquimais (msc) de linhagem condro-osteoblástica a partir de msc, populações de células derivadas de msc de linhagem condro-osteoblástica e formulação farmacêutica
CN111357990A (zh) * 2019-12-26 2020-07-03 浙江欧谱生物科技有限公司 增加骨量的保健食品组合物及其应用

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
US5837539A (en) * 1990-11-16 1998-11-17 Osiris Therapeutics, Inc. Monoclonal antibodies for human mesenchymal stem cells
US5811094A (en) * 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5972703A (en) * 1994-08-12 1999-10-26 The Regents Of The University Of Michigan Bone precursor cells: compositions and methods
US5736396A (en) * 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US5827740A (en) * 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells
AU6144698A (en) * 1997-02-05 1998-08-25 Case Western Reserve University Stimulatory effects of bfgf and bmp-2 on osteogenic differentiation of mesenchymal stem cells
US20070275462A1 (en) * 2003-10-02 2007-11-29 Hall Christopher L Human Prostate Cancer Cell Factor(s) that Induce Stem Cell Commitment and Osteogenesis
JP2006346420A (ja) * 2005-06-13 2006-12-28 Univ Nagoya 移植材料及び骨質改善剤
WO2007002210A2 (en) * 2005-06-20 2007-01-04 Bresagen, Inc. Embryonic stem cell culture compositions and methods of use thereof
TW200726474A (en) * 2005-07-15 2007-07-16 Cognate Therapeutics Inc The immunophenotype and immunogenicity of human adipose derived cells
US8337827B2 (en) * 2006-02-16 2012-12-25 Universite Libre de Bruxelies Method for osteogenic differentiation of bone marrow stem cells (BMSC) and uses thereof

Also Published As

Publication number Publication date
AU2014204491A1 (en) 2014-08-07
ES2650235T3 (es) 2018-01-17
NO2229433T3 (enExample) 2018-02-17
KR20160039699A (ko) 2016-04-11
DK2229433T3 (da) 2017-11-13
CA2710571C (en) 2017-11-07
JP2011509656A (ja) 2011-03-31
CA2710571A1 (en) 2009-07-16
CN104250633A (zh) 2014-12-31
KR20180086305A (ko) 2018-07-30
AU2009203682A1 (en) 2009-07-16
US20200407688A1 (en) 2020-12-31
US20130266544A1 (en) 2013-10-10
AU2009203682B2 (en) 2014-07-03
AU2014204491B2 (en) 2016-03-24
WO2009087213A1 (en) 2009-07-16
EP2229433B1 (en) 2017-09-20
KR20100126680A (ko) 2010-12-02
US20100278788A1 (en) 2010-11-04
KR101920128B1 (ko) 2018-11-19
CN101945993A (zh) 2011-01-12
EP2229433A1 (en) 2010-09-22
JP5524079B2 (ja) 2014-06-18
PT2229433T (pt) 2017-12-12

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