PL1989295T3 - Różnicowanie osteogenne komórek macierzystych szpiku kostnego oraz komórki i populacje osteoprogenitorowe lub osteoblastyczne - Google Patents

Różnicowanie osteogenne komórek macierzystych szpiku kostnego oraz komórki i populacje osteoprogenitorowe lub osteoblastyczne

Info

Publication number
PL1989295T3
PL1989295T3 PL07711561.6T PL07711561T PL1989295T3 PL 1989295 T3 PL1989295 T3 PL 1989295T3 PL 07711561 T PL07711561 T PL 07711561T PL 1989295 T3 PL1989295 T3 PL 1989295T3
Authority
PL
Poland
Prior art keywords
bmsc
stem cells
bone marrow
marrow stem
osteogenic differentiation
Prior art date
Application number
PL07711561.6T
Other languages
English (en)
Inventor
Dominique Egrise
Valérie GANGJI
Jean-Philippe Hauzeur
Micheline Lambermont
Michel Toungouz
Original Assignee
Université Libre de Bruxelles
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Université Libre de Bruxelles filed Critical Université Libre de Bruxelles
Publication of PL1989295T3 publication Critical patent/PL1989295T3/pl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/70—Undefined extracts
    • C12N2500/80—Undefined extracts from animals
    • C12N2500/84—Undefined extracts from animals from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PL07711561.6T 2006-02-16 2007-02-16 Różnicowanie osteogenne komórek macierzystych szpiku kostnego oraz komórki i populacje osteoprogenitorowe lub osteoblastyczne PL1989295T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2006001427 2006-02-16
PCT/EP2007/001360 WO2007093431A1 (en) 2006-02-16 2007-02-16 A method for osteogenic differentiation of bone marrow stem cells (bmsc) and uses thereof

Publications (1)

Publication Number Publication Date
PL1989295T3 true PL1989295T3 (pl) 2021-02-22

Family

ID=36223371

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07711561.6T PL1989295T3 (pl) 2006-02-16 2007-02-16 Różnicowanie osteogenne komórek macierzystych szpiku kostnego oraz komórki i populacje osteoprogenitorowe lub osteoblastyczne

Country Status (10)

Country Link
US (1) US8337827B2 (pl)
JP (1) JP5170443B2 (pl)
KR (1) KR20080109726A (pl)
CN (1) CN101384707A (pl)
CA (1) CA2640794C (pl)
DK (1) DK1989295T3 (pl)
ES (1) ES2830525T3 (pl)
PL (1) PL1989295T3 (pl)
PT (1) PT1989295T (pl)
WO (1) WO2007093431A1 (pl)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008109866A (ja) * 2006-10-30 2008-05-15 Jms Co Ltd 培地添加剤、この培地添加剤を含む培地、及びこの培地を用いた細胞の培養方法
US8062364B1 (en) 2007-04-27 2011-11-22 Knee Creations, Llc Osteoarthritis treatment and device
US20100272696A1 (en) * 2007-12-21 2010-10-28 Bone Therapeutics S.A. Human Bone-Forming Cells In The Treatment of Inflammatory Rheumatic Diseases
US20100278788A1 (en) * 2008-01-11 2010-11-04 Bone Therapeutics, S.A. Osteogenic Differentiation Of Bone Marrow Stem Cells And Mesenchymal Stem Cells Using A Combination Of Growth Factors
KR20110013450A (ko) * 2008-05-07 2011-02-09 본 테라퓨틱스 소시에테아노님 간엽 줄기 세포 및 골-형성 세포
PT2297304T (pt) * 2008-05-07 2017-10-27 Bone Therapeutics Sa Células que formam osso humano no tratamento de estados clínicos e doenças ósseas associadas a imunodeficiência e imunossupressão
US9090678B2 (en) * 2008-08-18 2015-07-28 Mesoblast, Inc. Monoclonal antibody STRO-4
BRPI0921726B8 (pt) * 2008-10-31 2021-07-27 Synthes Gmbh método para preparar uma composição de implante para promover o crescimento ósseo em um mamífero
US20120093782A1 (en) * 2009-05-13 2012-04-19 Grove Robert I Enhanced Hematopoietic Stem Cell Engraftment
EP2258413A1 (en) 2009-06-04 2010-12-08 Université Catholique de Louvain Multi-dimensional biomaterial and method for producing the same.
WO2012048755A1 (en) 2010-10-15 2012-04-19 Université Libre de Bruxelles Er-alpha-17p peptide, effects on stem cell differentiation
WO2012139131A1 (en) * 2011-04-08 2012-10-11 The Regents Of The University Of Michigan Autologous human adult pluripotent very small embryonic-like (hvsel) stem cell regeneration of bone and cartilage
CN103857788A (zh) 2011-10-11 2014-06-11 骨治疗公司 生长和分化因子8(gdf-8)的用途
US20130243736A1 (en) * 2012-01-27 2013-09-19 Sapporo Medical University Replacement of bone marrow niche cells for treatment of various diseases
US9486483B2 (en) * 2013-10-18 2016-11-08 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
CN103611193B (zh) * 2013-11-26 2015-05-27 中山大学 一种碳酸钙微球-细胞外基质复合材料及其制备方法和应用
KR101518651B1 (ko) * 2013-12-31 2015-05-07 동국대학교 산학협력단 골 및 신생혈관 형성능이 향상된 줄기세포 공배양 방법
CA2983373C (en) 2015-04-23 2018-12-11 Bone Therapeutics S.A. In vitro preservation of therapeutic cells
AU2017204355B2 (en) 2016-07-08 2021-09-09 Mako Surgical Corp. Scaffold for alloprosthetic composite implant
AU2018351804B2 (en) 2017-10-20 2020-07-09 Bone Therapeutics Sa Methods for differentiating mesenchymal stem cells
KR20210076018A (ko) 2018-09-25 2021-06-23 본 테라퓨틱스 소시에테아노님 체외 분화 세포의 골형성능을 판정하기 위한 방법 및 용도
BR112021005697A2 (pt) 2018-09-25 2021-06-22 Bone Therapeutics Sa métodos para obter células derivadas de células-tronco mesenquimais (msc) de linhagem condro-osteoblástica a partir de msc, populações de células derivadas de msc de linhagem condro-osteoblástica e formulação farmacêutica
KR20200036459A (ko) 2018-09-28 2020-04-07 (주)링크옵틱스 녹색 형광결합 CD133 단백질의 발현을 통한 전립선암 세포의 in vitro 및 in vivo 골전이 방법
WO2022081909A1 (en) * 2020-10-14 2022-04-21 Ossium Health, Inc. Systems and methods for extraction and cryopreservation of bone marrow
CN113599500A (zh) * 2021-08-04 2021-11-05 天津医科大学朱宪彝纪念医院(天津医科大学代谢病医院、天津代谢病防治中心) 一种治疗骨骼代谢性疾病的药物及其应用
CN118918249B (zh) * 2024-07-15 2025-04-29 首都医科大学附属北京积水潭医院 一种基于双层光谱ct的三物质模型的构建方法及骨密度和骨髓脂肪含量定量分析系统

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US5736396A (en) 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US8075880B2 (en) * 1999-01-11 2011-12-13 Steward St. Elizabeth's Medical Center Of Boston, Inc. Compositions and methods for regulating angiogenesis
AU6144698A (en) 1997-02-05 1998-08-25 Case Western Reserve University Stimulatory effects of bfgf and bmp-2 on osteogenic differentiation of mesenchymal stem cells
US20030021771A1 (en) * 2001-07-06 2003-01-30 Chunhui Xu Osteoblast precursors from human embryonic stem cells
JP2005532810A (ja) * 2002-07-16 2005-11-04 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム 組織修復および組織形成のために間葉性幹細胞を移植する方法

Also Published As

Publication number Publication date
WO2007093431A1 (en) 2007-08-23
DK1989295T3 (da) 2020-09-28
CA2640794A1 (en) 2007-08-23
US20090081169A1 (en) 2009-03-26
US8337827B2 (en) 2012-12-25
CA2640794C (en) 2015-04-14
ES2830525T3 (es) 2021-06-03
JP2009526534A (ja) 2009-07-23
PT1989295T (pt) 2020-10-29
KR20080109726A (ko) 2008-12-17
JP5170443B2 (ja) 2013-03-27
CN101384707A (zh) 2009-03-11

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