JP2011509294A5 - - Google Patents
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- Publication number
- JP2011509294A5 JP2011509294A5 JP2010542266A JP2010542266A JP2011509294A5 JP 2011509294 A5 JP2011509294 A5 JP 2011509294A5 JP 2010542266 A JP2010542266 A JP 2010542266A JP 2010542266 A JP2010542266 A JP 2010542266A JP 2011509294 A5 JP2011509294 A5 JP 2011509294A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- aryl
- heterocyclyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 40
- 125000003118 aryl group Chemical group 0.000 claims 26
- 125000000623 heterocyclic group Chemical group 0.000 claims 24
- 150000001875 compounds Chemical class 0.000 claims 21
- 229910052739 hydrogen Inorganic materials 0.000 claims 20
- 239000001257 hydrogen Substances 0.000 claims 20
- 125000003710 aryl alkyl group Chemical group 0.000 claims 16
- 125000000753 cycloalkyl group Chemical group 0.000 claims 16
- 150000002431 hydrogen Chemical class 0.000 claims 16
- 125000003342 alkenyl group Chemical group 0.000 claims 15
- 125000004948 alkyl aryl alkyl group Chemical group 0.000 claims 15
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 13
- 125000002877 alkyl aryl group Chemical group 0.000 claims 13
- 239000002738 chelating agent Substances 0.000 claims 13
- 125000004404 heteroalkyl group Chemical group 0.000 claims 11
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 11
- 239000000032 diagnostic agent Substances 0.000 claims 10
- 229940039227 diagnostic agent Drugs 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 9
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 9
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 5
- 239000002872 contrast media Substances 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 101100006941 Caenorhabditis elegans sex-1 gene Proteins 0.000 claims 2
- 102000016942 Elastin Human genes 0.000 claims 2
- 108010014258 Elastin Proteins 0.000 claims 2
- 239000006096 absorbing agent Substances 0.000 claims 2
- 125000004981 cycloalkylmethyl group Chemical group 0.000 claims 2
- 229920002549 elastin Polymers 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- 210000003041 ligament Anatomy 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 229910021645 metal ion Inorganic materials 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 230000005298 paramagnetic effect Effects 0.000 claims 2
- 230000002285 radioactive effect Effects 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 claims 1
- 206010002329 Aneurysm Diseases 0.000 claims 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 229910052796 boron Inorganic materials 0.000 claims 1
- 238000002059 diagnostic imaging Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 230000005294 ferromagnetic effect Effects 0.000 claims 1
- 230000005251 gamma ray Effects 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 210000002254 renal artery Anatomy 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 230000037380 skin damage Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 150000003573 thiols Chemical group 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- HRJDRCMGALFOLA-GDLZYMKVSA-N N[C@H](CCc1ccccc1)C(NOCc1ccc(CNC(CN2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2)=O)cc1)=O Chemical compound N[C@H](CCc1ccccc1)C(NOCc1ccc(CNC(CN2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2)=O)cc1)=O HRJDRCMGALFOLA-GDLZYMKVSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1962708P | 2008-01-08 | 2008-01-08 | |
| US61/019,627 | 2008-01-08 | ||
| PCT/US2009/000096 WO2009089022A1 (en) | 2008-01-08 | 2009-01-08 | N-alkoxyamide conjugates as imaging agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015079425A Division JP6087386B2 (ja) | 2008-01-08 | 2015-04-08 | 造影剤としてのｎ−アルコキシアミド抱合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011509294A JP2011509294A (ja) | 2011-03-24 |
| JP2011509294A5 true JP2011509294A5 (cg-RX-API-DMAC7.html) | 2012-02-23 |
| JP5730581B2 JP5730581B2 (ja) | 2015-06-10 |
Family
ID=40456854
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010542266A Active JP5730581B2 (ja) | 2008-01-08 | 2009-01-08 | 造影剤としてのｎ−アルコキシアミド抱合体 |
| JP2015079425A Expired - Fee Related JP6087386B2 (ja) | 2008-01-08 | 2015-04-08 | 造影剤としてのｎ−アルコキシアミド抱合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015079425A Expired - Fee Related JP6087386B2 (ja) | 2008-01-08 | 2015-04-08 | 造影剤としてのｎ−アルコキシアミド抱合体 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US8361438B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2240206B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5730581B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR101595324B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN103965128B (cg-RX-API-DMAC7.html) |
| AU (2) | AU2009204427B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0907612A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2711426C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2629340T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL206846A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2010007501A (cg-RX-API-DMAC7.html) |
| TW (1) | TWI465251B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009089022A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201005130B (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3209821B2 (ja) | 1993-03-31 | 2001-09-17 | 日立ビアメカニクス株式会社 | 消耗電極式ガスシールドアーク溶接の出力制御方法およびその溶接装置 |
| US8361438B2 (en) | 2008-01-08 | 2013-01-29 | Lantheus Medical Imaging, Inc. | N-alkoxyamide conjugates as imaging agents |
| EP2451776B1 (en) | 2009-07-08 | 2019-09-18 | Lantheus Medical Imaging, Inc. | N-alkoxyamide conjugates as imaging agents |
| DK3050878T3 (da) | 2013-09-24 | 2021-12-06 | Fujifilm Corp | Ny nitrogenholdig forbindelse eller salt deraf, eller metalkompleks deraf |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5122885A (en) * | 1974-08-13 | 1976-02-23 | Sagami Chem Res | Ashiru ll aminosan oo chikanhidorokisamidono seizohoho |
| JPS5910322B2 (ja) | 1975-07-30 | 1984-03-08 | 三井東圧化学株式会社 | 殺草剤 |
| HU175152B (hu) | 1976-12-30 | 1980-05-28 | Richter Gedeon Vegyeszet | Sposob poluchenija peptidov s gastrin-aktivnost'ju, soderzhahhikh amino-oksi-kisloty |
| US4859777A (en) * | 1981-07-01 | 1989-08-22 | Eastman Kodak Company | Terpyridine chelating agents |
| US4957939A (en) * | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
| EP0247156B1 (en) * | 1985-11-18 | 1993-06-23 | Access Pharmaceuticals Inc. | Polychelating agents for image and spectral enhancement (and spectral shift) |
| DE3768523D1 (de) | 1986-02-18 | 1991-04-18 | Squibb & Sons Inc | ((2,2,2-trichloroethoxy)methoxy)amin. |
| US5064956A (en) * | 1987-06-24 | 1991-11-12 | The Dow Chemical Company | Process for preparing mono-n-alkylated polyazamacrocycles |
| JP2573006B2 (ja) * | 1987-12-17 | 1997-01-16 | 富士薬品工業株式会社 | 新規なヒドロキサム酸誘導体 |
| IT1224627B (it) * | 1988-04-12 | 1990-10-04 | Guidotti & C Spa Labor | Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono. |
| US5087440A (en) * | 1989-07-31 | 1992-02-11 | Salutar, Inc. | Heterocyclic derivatives of DTPA used for magnetic resonance imaging |
| US5089043A (en) * | 1989-11-09 | 1992-02-18 | Shionogi & Co., Ltd. | Heterocyclic oxy-phenoxyacetic acid derivatives and their use as herbicides |
| JPH0491070A (ja) * | 1990-08-06 | 1992-03-24 | Kanebo Ltd | カリックスアレーン誘導体 |
| US5225173A (en) * | 1991-06-12 | 1993-07-06 | Idaho Research Foundation, Inc. | Methods and devices for the separation of radioactive rare earth metal isotopes from their alkaline earth metal precursors |
| US5274129A (en) * | 1991-06-12 | 1993-12-28 | Idaho Research Foundation, Inc. | Hydroxamic acid crown ethers |
| GB9115375D0 (en) * | 1991-07-17 | 1991-09-04 | Salutar Inc | Compounds |
| US5639746A (en) * | 1994-12-29 | 1997-06-17 | The Procter & Gamble Company | Hydroxamic acid-containing inhibitors of matrix metalloproteases |
| TW319763B (cg-RX-API-DMAC7.html) * | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| JP3356289B2 (ja) * | 1995-06-26 | 2002-12-16 | コンキャット リミティド | 第一遷移系列元素に対してキレート化親和性および選択性のある化合物とその医療および診断への使用 |
| AU711755B2 (en) * | 1995-07-26 | 1999-10-21 | Pfizer Inc. | N-(aroyl)glycine hydroxamic acid derivatives and related compounds |
| US6461587B1 (en) * | 1999-03-22 | 2002-10-08 | Schering Aktiengesellschaft | Perfluoroalkylamides, their production and their use in diagnosis |
| US6989139B2 (en) * | 2000-02-15 | 2006-01-24 | Bristol-Myers Squibb Pharma Company | Matrix metalloproteinase inhibitors |
| US6656448B1 (en) | 2000-02-15 | 2003-12-02 | Bristol-Myers Squibb Pharma Company | Matrix metalloproteinase inhibitors |
| US20020002152A1 (en) * | 2000-04-14 | 2002-01-03 | Craig Richard A. | Hydrazide and alkoxyamide angiogenesis inhibitors |
| JP2004530654A (ja) * | 2001-02-23 | 2004-10-07 | ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー | アテローム硬化症および脆弱性プラークを画像診断するための標識マクロファージスカベンジャー受容体拮抗薬 |
| JP4590157B2 (ja) * | 2001-03-21 | 2010-12-01 | アイシス イノヴェイション リミテッド | アッセイ、方法および手段 |
| TWI240632B (en) | 2001-07-30 | 2005-10-01 | Epix Medical Inc | Purified peptides for peptide-based multimeric targeted contrast agents |
| EP1641495A4 (en) * | 2003-05-23 | 2009-02-25 | Epix Pharm Inc | OPTICALLY PURE AND ENRICHED ISOMERS OF CHEATING LIGANDS AND CONTRASTANTS |
| JP2007521254A (ja) * | 2003-06-25 | 2007-08-02 | ゲルベ | 診断画像用化合物 |
| WO2005020973A2 (en) | 2003-08-29 | 2005-03-10 | The University Of Houston System | Compositions having antimycrobial activity including a hydroxamate or a hydroxamate and a hydroxylamine |
| US20050106100A1 (en) * | 2003-09-03 | 2005-05-19 | Harris Thomas D. | Compounds containing matrix metalloproteinase substrates and methods of their use |
| WO2005084179A2 (en) | 2003-12-01 | 2005-09-15 | Immunomedics, Inc. | Improved method for preparing conjugates of proteins and chelating agents |
| US20070142417A1 (en) * | 2005-05-11 | 2007-06-21 | Aventis Pharmaceuticals Inc | Substantially Pure 2-{[2-(2-Methylamino-Pyrimidin-4-YL)-1H-Indole-5-Carbonyl]-Amino}-3-Phenylpyridin-2-YL-Amino)-Propionic Acid as an IkB Kinase Inhibitor |
| WO2007005491A1 (en) * | 2005-06-30 | 2007-01-11 | Bristol-Myers Squibb Pharma Company | Hydrazide conjugates as imaging agents |
| US7618957B2 (en) * | 2005-07-15 | 2009-11-17 | Bayer Schering Pharma Aktiengesellschaft | Perfluoroalkyl-containing complexes, process for their production as well as their use |
| DE102005033902B3 (de) * | 2005-07-15 | 2007-04-05 | Schering Ag | Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel |
| US8361438B2 (en) * | 2008-01-08 | 2013-01-29 | Lantheus Medical Imaging, Inc. | N-alkoxyamide conjugates as imaging agents |
| WO2011000532A2 (de) | 2009-07-03 | 2011-01-06 | Archimica Gmbh | Verfahren zur enantioselektiven addition von organometallischen kohlenstoffnukleophilen an trifluormethylketone und verwendung des verfahrens in der synthese von hiv reverse transcriptase inhibitoren |
| EP2451776B1 (en) | 2009-07-08 | 2019-09-18 | Lantheus Medical Imaging, Inc. | N-alkoxyamide conjugates as imaging agents |
-
2009
- 2009-01-08 US US12/350,628 patent/US8361438B2/en active Active
- 2009-01-08 KR KR1020107017602A patent/KR101595324B1/ko not_active Expired - Fee Related
- 2009-01-08 CN CN201410136402.4A patent/CN103965128B/zh not_active Expired - Fee Related
- 2009-01-08 AU AU2009204427A patent/AU2009204427B2/en not_active Ceased
- 2009-01-08 JP JP2010542266A patent/JP5730581B2/ja active Active
- 2009-01-08 TW TW098100454A patent/TWI465251B/zh not_active IP Right Cessation
- 2009-01-08 ES ES09700768.6T patent/ES2629340T3/es active Active
- 2009-01-08 MX MX2010007501A patent/MX2010007501A/es active IP Right Grant
- 2009-01-08 BR BRPI0907612-3A patent/BRPI0907612A2/pt not_active Application Discontinuation
- 2009-01-08 KR KR1020167003565A patent/KR101861025B1/ko not_active Expired - Fee Related
- 2009-01-08 CA CA2711426A patent/CA2711426C/en active Active
- 2009-01-08 WO PCT/US2009/000096 patent/WO2009089022A1/en not_active Ceased
- 2009-01-08 EP EP09700768.6A patent/EP2240206B1/en active Active
- 2009-01-08 CN CN200980108357.9A patent/CN101970015B/zh not_active Expired - Fee Related
-
2010
- 2010-07-06 IL IL206846A patent/IL206846A/en active IP Right Grant
- 2010-07-19 ZA ZA2010/05130A patent/ZA201005130B/en unknown
-
2012
- 2012-12-21 US US13/723,333 patent/US8852553B2/en active Active
-
2014
- 2014-01-02 AU AU2014200012A patent/AU2014200012C1/en not_active Ceased
- 2014-09-02 US US14/474,566 patent/US9266846B2/en active Active
-
2015
- 2015-04-08 JP JP2015079425A patent/JP6087386B2/ja not_active Expired - Fee Related
- 2015-12-21 US US14/977,249 patent/US9732047B2/en active Active
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