JP2011507514A5 - - Google Patents
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- JP2011507514A5 JP2011507514A5 JP2010539474A JP2010539474A JP2011507514A5 JP 2011507514 A5 JP2011507514 A5 JP 2011507514A5 JP 2010539474 A JP2010539474 A JP 2010539474A JP 2010539474 A JP2010539474 A JP 2010539474A JP 2011507514 A5 JP2011507514 A5 JP 2011507514A5
- Authority
- JP
- Japan
- Prior art keywords
- vsv
- protein
- seq
- heat shock
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000711975 Vesicular stomatitis virus Species 0.000 claims 51
- 108091006027 G proteins Proteins 0.000 claims 30
- 102000030782 GTP binding Human genes 0.000 claims 30
- 108091000058 GTP-Binding Proteins 0.000 claims 30
- 230000035939 shock Effects 0.000 claims 27
- 210000004027 cell Anatomy 0.000 claims 22
- 150000007523 nucleic acids Chemical group 0.000 claims 21
- 238000000034 method Methods 0.000 claims 19
- 230000001939 inductive effect Effects 0.000 claims 18
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 18
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 16
- 230000002238 attenuated effect Effects 0.000 claims 16
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 8
- 108020004705 Codon Proteins 0.000 claims 7
- 239000013612 plasmid Substances 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 230000001276 controlling effect Effects 0.000 claims 4
- 210000005220 cytoplasmic tail Anatomy 0.000 claims 4
- 230000003612 virological effect Effects 0.000 claims 4
- 101150082239 G gene Proteins 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- 230000002950 deficient Effects 0.000 claims 3
- 244000052769 pathogen Species 0.000 claims 3
- 230000001717 pathogenic effect Effects 0.000 claims 3
- 241000701022 Cytomegalovirus Species 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 2
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 claims 2
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 claims 2
- 101710141454 Nucleoprotein Proteins 0.000 claims 2
- 102000009572 RNA Polymerase II Human genes 0.000 claims 2
- 108010009460 RNA Polymerase II Proteins 0.000 claims 2
- 108700041558 Vesicular stomatitis virus M Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 239000002299 complementary DNA Substances 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 241000710929 Alphavirus Species 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 101001065501 Escherichia phage MS2 Lysis protein Proteins 0.000 claims 1
- 241000711950 Filoviridae Species 0.000 claims 1
- 206010064571 Gene mutation Diseases 0.000 claims 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 1
- 241000725303 Human immunodeficiency virus Species 0.000 claims 1
- 241000342334 Human metapneumovirus Species 0.000 claims 1
- 241000701806 Human papillomavirus Species 0.000 claims 1
- 101710085938 Matrix protein Proteins 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 101710127721 Membrane protein Proteins 0.000 claims 1
- 208000005647 Mumps Diseases 0.000 claims 1
- 241000713112 Orthobunyavirus Species 0.000 claims 1
- 101710181008 P protein Proteins 0.000 claims 1
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims 1
- 101710177166 Phosphoprotein Proteins 0.000 claims 1
- 241000711798 Rabies lyssavirus Species 0.000 claims 1
- 241000725643 Respiratory syncytial virus Species 0.000 claims 1
- 241000700584 Simplexvirus Species 0.000 claims 1
- 101710137500 T7 RNA polymerase Proteins 0.000 claims 1
- 238000009395 breeding Methods 0.000 claims 1
- 230000001488 breeding effect Effects 0.000 claims 1
- 230000000120 cytopathologic effect Effects 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 230000007547 defect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004520 electroporation Methods 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 244000000010 microbial pathogen Species 0.000 claims 1
- 208000010805 mumps infectious disease Diseases 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 230000025308 nuclear transport Effects 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000001243 protein synthesis Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 230000002103 transcriptional effect Effects 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
- 230000014616 translation Effects 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- 210000003501 vero cell Anatomy 0.000 claims 1
Images
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1535307P | 2007-12-20 | 2007-12-20 | |
| PCT/US2008/013817 WO2009085172A1 (en) | 2007-12-20 | 2008-12-18 | Methods for packaging propagation-defective vesicular stomatitis virus vectors using a stable cell line that expresses g protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011507514A JP2011507514A (ja) | 2011-03-10 |
| JP2011507514A5 true JP2011507514A5 (https=) | 2012-02-09 |
Family
ID=40418917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010539474A Pending JP2011507514A (ja) | 2007-12-20 | 2008-12-18 | Ｇタンパク質を発現する安定な細胞系を用いた、繁殖欠損水疱性口内炎ウイルスベクターをパッケージングする方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20090162321A1 (https=) |
| EP (1) | EP2225264A1 (https=) |
| JP (1) | JP2011507514A (https=) |
| AR (1) | AR069885A1 (https=) |
| AU (1) | AU2008343919B2 (https=) |
| CA (1) | CA2710166A1 (https=) |
| CL (1) | CL2008003821A1 (https=) |
| WO (1) | WO2009085172A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5675789B2 (ja) * | 2009-06-08 | 2015-02-25 | ザ ユニバーシティー オブ ウェスタン オンタリオＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｗｅｓｔｅｒｎ Ｏｎｔａｒｉｏ | 免疫接種のための発現ベクターとしての水疱性口内炎ウイルスの異なる複数の抗原型 |
| US9610346B2 (en) * | 2012-03-23 | 2017-04-04 | International Aids Vaccine Initiative | Recombinant viral vectors |
| CN111344008A (zh) * | 2017-09-15 | 2020-06-26 | 俄亥俄州创新基金会 | 用于预防呼吸道合胞病毒(rsv)感染的疫苗及其制备和使用方法 |
| WO2019070704A1 (en) * | 2017-10-02 | 2019-04-11 | Georgia Tech Research Corporation | METHODS AND COMPOSITIONS FOR ENGINEERING SYNTHESIS BIOLOGICAL SWITCHES FOR REMOTE CONTROL OF BIOLOGICAL ACTIVITY |
| CN109750006A (zh) * | 2019-01-14 | 2019-05-14 | 青岛农业大学 | 一种犬瘟热病毒复制缺陷毒株及其构建方法 |
| CN112430582B (zh) * | 2020-12-04 | 2022-05-03 | 北京艺妙神州医药科技有限公司 | 一种慢病毒稳定包装细胞系及其制备方法 |
| CN115725657B (zh) * | 2022-09-16 | 2024-06-04 | 中国科学院广州生物医药与健康研究院 | 一种节段化的水泡性口炎病毒载体及其制备方法和应用 |
| CN117051040B (zh) * | 2023-08-15 | 2024-10-01 | 北京百普赛斯生物科技股份有限公司 | Vsv△g复制缺陷型病毒制备及应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5168062A (en) * | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| US6596529B1 (en) * | 1997-05-02 | 2003-07-22 | Uab Research Foundation | Manipulation of negative stranded RNA viruses by rearrangement of their genes and uses thereof |
| JP4198195B2 (ja) * | 1997-05-02 | 2008-12-17 | ザ ユーエイビー リサーチ ファンデイション | 負鎖ｒｎａウイルスの、それらの遺伝子の再配列による弱毒化およびそれらの使用 |
| EP1478750B1 (en) * | 1999-11-23 | 2012-08-08 | Mayo Foundation For Medical Education And Research | Gene expression by positive feedback activation of a cell type-specific promoter |
| EP1633860A2 (en) * | 2003-06-09 | 2006-03-15 | Wyeth | IMPROVED METHOD FOR THE RECOVERY OF NON-SEGMENTED, NEGATIVE-STRANDED RNA VIRUSES FROM cDNA |
| US8008268B2 (en) * | 2006-07-25 | 2011-08-30 | Merial Limited | Vaccines against vesicular stomatitis |
-
2008
- 2008-12-16 US US12/335,778 patent/US20090162321A1/en not_active Abandoned
- 2008-12-18 WO PCT/US2008/013817 patent/WO2009085172A1/en not_active Ceased
- 2008-12-18 JP JP2010539474A patent/JP2011507514A/ja active Pending
- 2008-12-18 CA CA2710166A patent/CA2710166A1/en not_active Abandoned
- 2008-12-18 AU AU2008343919A patent/AU2008343919B2/en not_active Ceased
- 2008-12-18 EP EP08867848A patent/EP2225264A1/en not_active Withdrawn
- 2008-12-19 CL CL2008003821A patent/CL2008003821A1/es unknown
- 2008-12-19 AR ARP080105638A patent/AR069885A1/es unknown
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