JP2011507497A5 - - Google Patents
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- Publication number
- JP2011507497A5 JP2011507497A5 JP2010538788A JP2010538788A JP2011507497A5 JP 2011507497 A5 JP2011507497 A5 JP 2011507497A5 JP 2010538788 A JP2010538788 A JP 2010538788A JP 2010538788 A JP2010538788 A JP 2010538788A JP 2011507497 A5 JP2011507497 A5 JP 2011507497A5
- Authority
- JP
- Japan
- Prior art keywords
- her2 binding
- binding polypeptide
- amino acid
- polypeptide
- polypeptide according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 32
- 229920001184 polypeptide Polymers 0.000 claims 31
- 102000004196 processed proteins & peptides Human genes 0.000 claims 31
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 20
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 125000000539 amino acid group Chemical group 0.000 claims 5
- 238000002560 therapeutic procedure Methods 0.000 claims 5
- 239000002738 chelating agent Substances 0.000 claims 4
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 4
- 238000003745 diagnosis Methods 0.000 claims 3
- 235000018417 cysteine Nutrition 0.000 claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 2
- 238000002059 diagnostic imaging Methods 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- -1 mercaptoacetyl Chemical group 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims 1
- 108700011201 Streptococcus IgG Fc-binding Proteins 0.000 claims 1
- WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical group OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 229960003330 pentetic acid Drugs 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07150395.7 | 2007-12-21 | ||
| EP07150395A EP2072525A1 (en) | 2007-12-21 | 2007-12-21 | New polypeptides having affinity for HER2 |
| PCT/EP2008/068167 WO2009080810A1 (en) | 2007-12-21 | 2008-12-22 | New polypeptides having affinity for her2 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014211333A Division JP2015061838A (ja) | 2007-12-21 | 2014-10-16 | Ｈｅｒ２に対する親和性を有する新規なポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011507497A JP2011507497A (ja) | 2011-03-10 |
| JP2011507497A5 true JP2011507497A5 (https=) | 2012-01-19 |
| JP5913807B2 JP5913807B2 (ja) | 2016-04-27 |
Family
ID=39148791
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010538788A Active JP5913807B2 (ja) | 2007-12-21 | 2008-12-22 | Ｈｅｒ２に対する親和性を有する新規なポリペプチド |
| JP2014211333A Pending JP2015061838A (ja) | 2007-12-21 | 2014-10-16 | Ｈｅｒ２に対する親和性を有する新規なポリペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014211333A Pending JP2015061838A (ja) | 2007-12-21 | 2014-10-16 | Ｈｅｒ２に対する親和性を有する新規なポリペプチド |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8501909B2 (https=) |
| EP (2) | EP2072525A1 (https=) |
| JP (2) | JP5913807B2 (https=) |
| CN (2) | CN101952302B (https=) |
| AU (1) | AU2008339976B2 (https=) |
| CA (1) | CA2709915C (https=) |
| DK (1) | DK2235044T3 (https=) |
| ES (1) | ES2440919T3 (https=) |
| HK (1) | HK1202880A1 (https=) |
| PL (1) | PL2235044T3 (https=) |
| WO (1) | WO2009080810A1 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2077272A1 (en) | 2007-12-21 | 2009-07-08 | Affibody AB | Polypeptide libraries with a predetermined scaffold |
| US9187535B2 (en) | 2007-12-19 | 2015-11-17 | Affibody Ab | Polypeptide derived from protein A and able to bind PDGF |
| EP2072525A1 (en) * | 2007-12-21 | 2009-06-24 | Affibody AB | New polypeptides having affinity for HER2 |
| AU2009282413B2 (en) | 2008-08-11 | 2014-07-17 | Nektar Therapeutics | Multi-arm polymeric alkanoate conjugates |
| US20120165650A1 (en) | 2010-12-22 | 2012-06-28 | General Electric Company | Her2 binders |
| WO2010120514A2 (en) | 2009-03-31 | 2010-10-21 | The Trustees Of The University Of Pennsylvania | Antigen-binding proteins comprising recombinant protein scaffolds |
| EP2496598B1 (en) | 2009-11-04 | 2017-08-02 | Affibody AB | Her3 binding polypeptides |
| CA2789738C (en) * | 2010-03-08 | 2021-03-09 | Ge Healthcare Bio-Sciences Ab | Immunoglobulin g fc region binding polypeptide |
| DE102010026061A1 (de) | 2010-06-30 | 2012-01-05 | Siemens Aktiengesellschaft | 11C-markiertes Peptid zur Detektion eines Tumors, der einen Her2/neu-Rezeptor exprimiert |
| TWI486617B (zh) * | 2010-10-21 | 2015-06-01 | Iner Aec Executive Yuan | 一種測定對鎝（Ｔｃ－９９ｍ）與錸（Ｒｅ－１８６、Ｒｅ－１８８）具有穩定錯合力之含硫螯合劑在凍晶劑中之含量與均一性的固態樣品分析技術 |
| WO2012088422A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
| WO2012088445A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
| NZ612161A (en) * | 2010-12-22 | 2015-04-24 | Gen Electric | Radiolabled her2 binding peptides |
| US9061080B2 (en) | 2010-12-22 | 2015-06-23 | Ge Healthcare Limited | HER2 binding peptides labeled with aluminium-[18] fluoride complexed by NOTA |
| RU2013128360A (ru) * | 2010-12-22 | 2015-01-27 | ДжиИ ХЕЛТКЕР ЛИМИТЕД | Her2-связывающие белки, меченые 18f-содержащим кремнийорганическим соединением |
| CN102690345B (zh) * | 2011-03-24 | 2014-03-19 | 江苏靶标生物医药研究所有限公司 | 人膜联蛋白v变体及其表达、制备和应用 |
| US20140088021A1 (en) | 2011-05-27 | 2014-03-27 | Nektar Therapeutics | Water-Soluble Polymer-Linked Binding Moiety and Drug Compounds |
| EP3511339B1 (en) | 2012-02-20 | 2025-04-09 | IPC Research, LLC | Polypeptides binding to human complement c5 |
| WO2014013016A1 (en) | 2012-07-20 | 2014-01-23 | Affibody Ab | Method for determining the her2 status of a malignancy |
| JP6440618B2 (ja) * | 2012-10-05 | 2018-12-19 | アフィボディ・アーベー | Ｈｅｒ３結合ポリペプチド |
| WO2014076179A1 (en) | 2012-11-14 | 2014-05-22 | Affibody Ab | New polypeptide |
| KR20160055728A (ko) * | 2013-06-27 | 2016-05-18 | 지이 헬쓰케어 리미티드 | Her2 결합제의 용도 |
| BR112016003142A2 (pt) | 2013-08-28 | 2017-10-17 | Swedish Orphan Biovitrum Ab Publ | ligação de polipeptídeos estáveis ao c5 do complemento humano |
| MX367423B (es) | 2013-08-28 | 2019-08-21 | Affibody Ab | Polipeptidos de union a c5. |
| JP6935195B2 (ja) | 2014-03-11 | 2021-09-15 | モレキュラー テンプレーツ, インク.Molecular Templates, Inc. | 結合領域、志賀毒素ａサブユニットのエフェクター領域、及びカルボキシ末端小胞体局在化シグナルモチーフを含むタンパク質 |
| ES2809729T3 (es) | 2014-03-11 | 2021-03-05 | Molecular Templates Inc | Proteínas que comprenden regiones efectoras de la subunidad A de la toxina Shiga próximas al extremo amino terminal y regiones de unión de tipo inmunoglobulina de reconocimiento celular capaces de unirse específicamente a HER2/neu/ErbB2 |
| CN104292308B (zh) * | 2014-08-22 | 2017-09-15 | 广州安辰医药科技有限公司 | 肿瘤抗原环肽 |
| CA2964958A1 (en) | 2014-10-31 | 2016-05-06 | The Trustees Of The University Of Pennsylvania | Methods and compositions for modified t cells |
| CA2969067A1 (en) * | 2014-11-25 | 2016-06-02 | Bristol-Myers Squibb Company | Novel pd-l1 binding polypeptides for imaging |
| CN107207379B (zh) | 2014-11-25 | 2021-08-10 | 百时美施贵宝公司 | 用于生物制品的18f-放射性标记的方法和组合物 |
| EP3303373B1 (en) | 2015-05-30 | 2020-04-08 | Molecular Templates, Inc. | De-immunized, shiga toxin a subunit scaffolds and cell-targeting molecules comprising the same |
| KR20180030085A (ko) | 2015-07-26 | 2018-03-21 | 몰레큘러 템플레이츠, 인코퍼레이션. | 시가 독소 a 서브유닛 작동체 및 cd8+ t-세포 에피토프를 포함하는 세포-표적화 분자 |
| US10994033B2 (en) | 2016-06-01 | 2021-05-04 | Bristol-Myers Squibb Company | Imaging methods using 18F-radiolabeled biologics |
| JP7016323B2 (ja) | 2016-06-01 | 2022-02-21 | ブリストル－マイヤーズ スクイブ カンパニー | Ｐｄ－ｌ１結合ポリペプチドを用いるｐｅｔ造影 |
| MX2019008840A (es) | 2017-01-25 | 2019-09-09 | Molecular Templates Inc | Moleculas con direccion hacia las celulas que comprenden efectores de la sub-unidad a de la toxina shiga desinmunizados y epitopos de las celulas t cd8+. |
| CN110612117B (zh) | 2018-04-17 | 2024-04-12 | 分子模板公司 | 包含去免疫化的志贺毒素a亚基支架的her2靶向分子 |
| EP4077368A1 (en) | 2019-12-18 | 2022-10-26 | Bracco Imaging SPA | Anti-her2 polypeptides derivatives as new diagnostic molecular probes |
| WO2021122726A1 (en) | 2019-12-18 | 2021-06-24 | Bracco Imaging Spa | Anti-her2 polypeptides derivatives as new diagnostic molecular probes |
| CN112220931B (zh) * | 2020-10-16 | 2022-03-08 | 上海交通大学 | 用于肿瘤主动靶向治疗的亲和体-细胞毒素偶联物及其纳米颗粒、制备方法、应用 |
| EP4291251B1 (en) * | 2021-02-15 | 2025-02-19 | Affibody AB | Her2-binding polypeptide |
| CN112999369B (zh) * | 2021-03-03 | 2022-02-25 | 江苏元本生物科技有限公司 | 一种her2亲合体放射性核素标记物组合物及其应用 |
| CN116063397B (zh) * | 2022-07-04 | 2025-05-02 | 中国药科大学 | 一类靶向her2蛋白的多肽及其在制备多肽偶联药物中的应用 |
| CN117430670A (zh) * | 2022-07-20 | 2024-01-23 | 中国科学院上海药物研究所 | 一种her2靶向肽分子及其应用 |
| TW202416938A (zh) | 2022-08-10 | 2024-05-01 | 日商興和股份有限公司 | 親和體微胞(affibody micelle)藥物複合體 |
| TW202545983A (zh) | 2024-01-25 | 2025-12-01 | 瑞典商艾菲博迪公司 | 新穎多肽 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
| US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| CA2531238C (en) * | 2003-07-04 | 2015-02-24 | Affibody Ab | Polypeptides having binding affinity for her2 |
| SE0301987D0 (sv) * | 2003-07-04 | 2003-07-04 | Affibody Ab | New polypeptide |
| GB0524788D0 (en) * | 2005-12-05 | 2006-01-11 | Affibody Ab | Polypeptides |
| US8124725B2 (en) * | 2007-12-19 | 2012-02-28 | General Electric Company | PDGF-Rβ binders |
| US8937047B2 (en) | 2007-12-19 | 2015-01-20 | General Electric Company | Biokinetics of fast-clearing polypeptides |
| EP2077272A1 (en) | 2007-12-21 | 2009-07-08 | Affibody AB | Polypeptide libraries with a predetermined scaffold |
| ES2373832T3 (es) | 2007-12-19 | 2012-02-09 | Affibody Ab | Polipéptido derivado de proteína a y capaz de unirse a pdgf. |
| EP2072525A1 (en) * | 2007-12-21 | 2009-06-24 | Affibody AB | New polypeptides having affinity for HER2 |
-
2007
- 2007-12-21 EP EP07150395A patent/EP2072525A1/en not_active Withdrawn
-
2008
- 2008-12-22 JP JP2010538788A patent/JP5913807B2/ja active Active
- 2008-12-22 ES ES08864430.7T patent/ES2440919T3/es active Active
- 2008-12-22 PL PL08864430T patent/PL2235044T3/pl unknown
- 2008-12-22 CA CA2709915A patent/CA2709915C/en active Active
- 2008-12-22 CN CN200880126835.4A patent/CN101952302B/zh active Active
- 2008-12-22 EP EP08864430.7A patent/EP2235044B1/en active Active
- 2008-12-22 CN CN201410529294.7A patent/CN104327179A/zh active Pending
- 2008-12-22 WO PCT/EP2008/068167 patent/WO2009080810A1/en not_active Ceased
- 2008-12-22 AU AU2008339976A patent/AU2008339976B2/en active Active
- 2008-12-22 DK DK08864430.7T patent/DK2235044T3/da active
- 2008-12-22 US US12/735,068 patent/US8501909B2/en active Active
-
2011
- 2011-07-13 HK HK15103379.8A patent/HK1202880A1/xx unknown
-
2013
- 2013-06-27 US US13/928,522 patent/US8883120B2/en active Active
-
2014
- 2014-10-16 JP JP2014211333A patent/JP2015061838A/ja active Pending
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