AU2008339976B2 - New polypeptides having affinity for HER2 - Google Patents

New polypeptides having affinity for HER2 Download PDF

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Publication number
AU2008339976B2
AU2008339976B2 AU2008339976A AU2008339976A AU2008339976B2 AU 2008339976 B2 AU2008339976 B2 AU 2008339976B2 AU 2008339976 A AU2008339976 A AU 2008339976A AU 2008339976 A AU2008339976 A AU 2008339976A AU 2008339976 B2 AU2008339976 B2 AU 2008339976B2
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AU
Australia
Prior art keywords
her2
polypeptide according
radionuclide
cancer
affibody
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AU2008339976A
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AU2008339976A1 (en
Inventor
Lars Abrahmsen
Joachim Feldwisch
Nina Herne
Christofer Lendel
Vladimir Tolmachev
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2008339976A 2007-12-21 2008-12-22 New polypeptides having affinity for HER2 Active AU2008339976B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07150395.7 2007-12-21
EP07150395A EP2072525A1 (en) 2007-12-21 2007-12-21 New polypeptides having affinity for HER2
PCT/EP2008/068167 WO2009080810A1 (en) 2007-12-21 2008-12-22 New polypeptides having affinity for her2

Publications (2)

Publication Number Publication Date
AU2008339976A1 AU2008339976A1 (en) 2009-07-02
AU2008339976B2 true AU2008339976B2 (en) 2013-05-30

Family

ID=39148791

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008339976A Active AU2008339976B2 (en) 2007-12-21 2008-12-22 New polypeptides having affinity for HER2

Country Status (11)

Country Link
US (2) US8501909B2 (https=)
EP (2) EP2072525A1 (https=)
JP (2) JP5913807B2 (https=)
CN (2) CN101952302B (https=)
AU (1) AU2008339976B2 (https=)
CA (1) CA2709915C (https=)
DK (1) DK2235044T3 (https=)
ES (1) ES2440919T3 (https=)
HK (1) HK1202880A1 (https=)
PL (1) PL2235044T3 (https=)
WO (1) WO2009080810A1 (https=)

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US20120165650A1 (en) 2010-12-22 2012-06-28 General Electric Company Her2 binders
WO2010120514A2 (en) 2009-03-31 2010-10-21 The Trustees Of The University Of Pennsylvania Antigen-binding proteins comprising recombinant protein scaffolds
EP2496598B1 (en) 2009-11-04 2017-08-02 Affibody AB Her3 binding polypeptides
CA2789738C (en) * 2010-03-08 2021-03-09 Ge Healthcare Bio-Sciences Ab Immunoglobulin g fc region binding polypeptide
DE102010026061A1 (de) 2010-06-30 2012-01-05 Siemens Aktiengesellschaft 11C-markiertes Peptid zur Detektion eines Tumors, der einen Her2/neu-Rezeptor exprimiert
TWI486617B (zh) * 2010-10-21 2015-06-01 Iner Aec Executive Yuan 一種測定對鎝（Ｔｃ－９９ｍ）與錸（Ｒｅ－１８６、Ｒｅ－１８８）具有穩定錯合力之含硫螯合劑在凍晶劑中之含量與均一性的固態樣品分析技術
WO2012088422A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
WO2012088445A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
NZ612161A (en) * 2010-12-22 2015-04-24 Gen Electric Radiolabled her2 binding peptides
US9061080B2 (en) 2010-12-22 2015-06-23 Ge Healthcare Limited HER2 binding peptides labeled with aluminium-[18] fluoride complexed by NOTA
RU2013128360A (ru) * 2010-12-22 2015-01-27 ДжиИ ХЕЛТКЕР ЛИМИТЕД Her2-связывающие белки, меченые 18f-содержащим кремнийорганическим соединением
CN102690345B (zh) * 2011-03-24 2014-03-19 江苏靶标生物医药研究所有限公司 人膜联蛋白v变体及其表达、制备和应用
US20140088021A1 (en) 2011-05-27 2014-03-27 Nektar Therapeutics Water-Soluble Polymer-Linked Binding Moiety and Drug Compounds
EP3511339B1 (en) 2012-02-20 2025-04-09 IPC Research, LLC Polypeptides binding to human complement c5
WO2014013016A1 (en) 2012-07-20 2014-01-23 Affibody Ab Method for determining the her2 status of a malignancy
JP6440618B2 (ja) * 2012-10-05 2018-12-19 アフィボディ・アーベー Ｈｅｒ３結合ポリペプチド
WO2014076179A1 (en) 2012-11-14 2014-05-22 Affibody Ab New polypeptide
KR20160055728A (ko) * 2013-06-27 2016-05-18 지이 헬쓰케어 리미티드 Her2 결합제의 용도
BR112016003142A2 (pt) 2013-08-28 2017-10-17 Swedish Orphan Biovitrum Ab Publ ligação de polipeptídeos estáveis ao c5 do complemento humano
MX367423B (es) 2013-08-28 2019-08-21 Affibody Ab Polipeptidos de union a c5.
JP6935195B2 (ja) 2014-03-11 2021-09-15 モレキュラー テンプレーツ, インク.Molecular Templates, Inc. 結合領域、志賀毒素ａサブユニットのエフェクター領域、及びカルボキシ末端小胞体局在化シグナルモチーフを含むタンパク質
ES2809729T3 (es) 2014-03-11 2021-03-05 Molecular Templates Inc Proteínas que comprenden regiones efectoras de la subunidad A de la toxina Shiga próximas al extremo amino terminal y regiones de unión de tipo inmunoglobulina de reconocimiento celular capaces de unirse específicamente a HER2/neu/ErbB2
CN104292308B (zh) * 2014-08-22 2017-09-15 广州安辰医药科技有限公司 肿瘤抗原环肽
CA2964958A1 (en) 2014-10-31 2016-05-06 The Trustees Of The University Of Pennsylvania Methods and compositions for modified t cells
CA2969067A1 (en) * 2014-11-25 2016-06-02 Bristol-Myers Squibb Company Novel pd-l1 binding polypeptides for imaging
CN107207379B (zh) 2014-11-25 2021-08-10 百时美施贵宝公司 用于生物制品的18f-放射性标记的方法和组合物
EP3303373B1 (en) 2015-05-30 2020-04-08 Molecular Templates, Inc. De-immunized, shiga toxin a subunit scaffolds and cell-targeting molecules comprising the same
KR20180030085A (ko) 2015-07-26 2018-03-21 몰레큘러 템플레이츠, 인코퍼레이션. 시가 독소 a 서브유닛 작동체 및 cd8+ t-세포 에피토프를 포함하는 세포-표적화 분자
US10994033B2 (en) 2016-06-01 2021-05-04 Bristol-Myers Squibb Company Imaging methods using 18F-radiolabeled biologics
JP7016323B2 (ja) 2016-06-01 2022-02-21 ブリストル－マイヤーズ スクイブ カンパニー Ｐｄ－ｌ１結合ポリペプチドを用いるｐｅｔ造影
MX2019008840A (es) 2017-01-25 2019-09-09 Molecular Templates Inc Moleculas con direccion hacia las celulas que comprenden efectores de la sub-unidad a de la toxina shiga desinmunizados y epitopos de las celulas t cd8+.
CN110612117B (zh) 2018-04-17 2024-04-12 分子模板公司 包含去免疫化的志贺毒素a亚基支架的her2靶向分子
EP4077368A1 (en) 2019-12-18 2022-10-26 Bracco Imaging SPA Anti-her2 polypeptides derivatives as new diagnostic molecular probes
WO2021122726A1 (en) 2019-12-18 2021-06-24 Bracco Imaging Spa Anti-her2 polypeptides derivatives as new diagnostic molecular probes
CN112220931B (zh) * 2020-10-16 2022-03-08 上海交通大学 用于肿瘤主动靶向治疗的亲和体-细胞毒素偶联物及其纳米颗粒、制备方法、应用
EP4291251B1 (en) * 2021-02-15 2025-02-19 Affibody AB Her2-binding polypeptide
CN112999369B (zh) * 2021-03-03 2022-02-25 江苏元本生物科技有限公司 一种her2亲合体放射性核素标记物组合物及其应用
CN116063397B (zh) * 2022-07-04 2025-05-02 中国药科大学 一类靶向her2蛋白的多肽及其在制备多肽偶联药物中的应用
CN117430670A (zh) * 2022-07-20 2024-01-23 中国科学院上海药物研究所 一种her2靶向肽分子及其应用
TW202416938A (zh) 2022-08-10 2024-05-01 日商興和股份有限公司 親和體微胞(affibody micelle)藥物複合體
TW202545983A (zh) 2024-01-25 2025-12-01 瑞典商艾菲博迪公司 新穎多肽

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WO2005003156A1 (en) * 2003-07-04 2005-01-13 Affibody Ab Polypeptides having binding affinity for her2

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US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
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Also Published As

Publication number Publication date
JP2011507497A (ja) 2011-03-10
JP2015061838A (ja) 2015-04-02
US8501909B2 (en) 2013-08-06
CN101952302A (zh) 2011-01-19
HK1153207A1 (en) 2012-03-23
CN101952302B (zh) 2014-11-12
JP5913807B2 (ja) 2016-04-27
EP2235044A1 (en) 2010-10-06
EP2072525A1 (en) 2009-06-24
EP2235044B1 (en) 2013-10-09
US20130280164A1 (en) 2013-10-24
CA2709915A1 (en) 2009-07-02
CA2709915C (en) 2016-05-24
HK1202880A1 (en) 2015-10-09
PL2235044T3 (pl) 2014-03-31
US20110020223A1 (en) 2011-01-27
ES2440919T3 (es) 2014-01-31
CN104327179A (zh) 2015-02-04
DK2235044T3 (da) 2014-01-06
US8883120B2 (en) 2014-11-11
AU2008339976A1 (en) 2009-07-02
WO2009080810A1 (en) 2009-07-02

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