JP2011507488A5 - - Google Patents
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- Publication number
- JP2011507488A5 JP2011507488A5 JP2010530537A JP2010530537A JP2011507488A5 JP 2011507488 A5 JP2011507488 A5 JP 2011507488A5 JP 2010530537 A JP2010530537 A JP 2010530537A JP 2010530537 A JP2010530537 A JP 2010530537A JP 2011507488 A5 JP2011507488 A5 JP 2011507488A5
- Authority
- JP
- Japan
- Prior art keywords
- complementary
- oligonucleotide
- tandem
- target polynucleotide
- tandem repeats
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091034117 Oligonucleotide Proteins 0.000 claims 58
- 108091033319 polynucleotide Proteins 0.000 claims 34
- 239000002157 polynucleotide Substances 0.000 claims 34
- 102000040430 polynucleotide Human genes 0.000 claims 34
- 230000000295 complement effect Effects 0.000 claims 33
- 238000000034 method Methods 0.000 claims 33
- 239000000523 sample Substances 0.000 claims 29
- 230000000903 blocking effect Effects 0.000 claims 16
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 11
- 238000002844 melting Methods 0.000 claims 6
- 230000008018 melting Effects 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 125000006850 spacer group Chemical group 0.000 claims 6
- 238000009396 hybridization Methods 0.000 claims 5
- 108700028369 Alleles Proteins 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 238000011880 melting curve analysis Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0720675A GB0720675D0 (en) | 2007-10-22 | 2007-10-22 | Oligonucleotides and uses thereof |
| GB0720675.8 | 2007-10-22 | ||
| GB0815113.6 | 2008-08-19 | ||
| GB0815113A GB0815113D0 (en) | 2008-08-19 | 2008-08-19 | Oligonucleotides and uses thereof |
| PCT/GB2008/003555 WO2009053679A1 (en) | 2007-10-22 | 2008-10-21 | Oligonucleotides and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011507488A JP2011507488A (ja) | 2011-03-10 |
| JP2011507488A5 true JP2011507488A5 (cg-RX-API-DMAC7.html) | 2011-12-08 |
| JP5604302B2 JP5604302B2 (ja) | 2014-10-08 |
Family
ID=40202890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010530537A Expired - Fee Related JP5604302B2 (ja) | 2007-10-22 | 2008-10-21 | オリゴヌクレオチドおよびその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9404148B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2217719B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5604302B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101896623B (cg-RX-API-DMAC7.html) |
| AT (1) | ATE516371T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008315791B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2703227C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2395240T3 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ584739A (cg-RX-API-DMAC7.html) |
| PT (1) | PT2217719E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009053679A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA035311B1 (ru) | 2009-02-13 | 2020-05-27 | Икс-Чем, Инк. | Способ маркировки днк-кодируемых химических библиотек |
| JP5716217B2 (ja) * | 2009-12-15 | 2015-05-13 | 公益財団法人ヒューマンサイエンス振興財団 | 長鎖繰返し配列を含有する遺伝子又は遺伝子産物の選択又は優先的回収方法 |
| GB201010237D0 (en) | 2010-06-18 | 2010-07-21 | Lgc Ltd | Methods and apparatuses |
| CA2820715C (en) * | 2010-12-16 | 2020-03-31 | Bio-Rad Laboratories, Inc. | Universal reference dye for quantitative amplification |
| EP2663651B1 (en) * | 2011-01-14 | 2018-06-20 | Genefirst Limited | Methods, compositions, and kits for determing the presence/absence of a variant nucleic acid sequence |
| US10865409B2 (en) | 2011-09-07 | 2020-12-15 | X-Chem, Inc. | Methods for tagging DNA-encoded libraries |
| GB201116131D0 (en) * | 2011-09-19 | 2011-11-02 | Epistem Ltd | Probe |
| US10648030B2 (en) * | 2012-01-13 | 2020-05-12 | Affymetrix, Inc. | Methods of determining the presence or absence of a plurality of target polynucleotides in a sample |
| US20130183666A1 (en) * | 2012-01-18 | 2013-07-18 | Marc N. Feiglin | Partial genotyping by differential hybridization |
| DK2872680T3 (en) | 2012-07-13 | 2018-07-09 | X Chem Inc | DNA-encoded libraries with coding oligonucleotide compounds that cannot be read with polymerases |
| US9437397B2 (en) * | 2013-06-27 | 2016-09-06 | Varian Semiconductor Equipment Associates, Inc. | Textured silicon liners in substrate processing systems |
| WO2015120406A1 (en) | 2014-02-07 | 2015-08-13 | University Of Iowa Research Foundation | Oligonucleotide-based probes and methods for detection of microbes |
| US11118216B2 (en) | 2015-09-08 | 2021-09-14 | Affymetrix, Inc. | Nucleic acid analysis by joining barcoded polynucleotide probes |
| JP6685138B2 (ja) * | 2016-01-27 | 2020-04-22 | シスメックス株式会社 | 核酸増幅の精度管理方法、精度管理用試薬およびその試薬キット |
| US10718017B2 (en) * | 2016-03-31 | 2020-07-21 | Arizona Board Of Regents On Behalf Of Arizona State University | Probes and methods for measuring tandem repeats |
| EP3688181A4 (en) | 2017-09-29 | 2021-06-16 | University of Iowa Research Foundation | COMPOSITIONS AND METHOD OF DETECTING DIGITAL NUCLEASES |
| EP4010481A4 (en) | 2019-08-09 | 2023-09-20 | Nutcracker Therapeutics, Inc. | MICROFLUIDIC DEVICE AND METHODS OF USE |
| WO2021081194A1 (en) * | 2019-10-22 | 2021-04-29 | Bio-Rad Laboratories, Inc. | Measurement of molecular interactions at single molecule level using substrates that enhance fluorescence detection |
| CN110951878B (zh) * | 2019-12-20 | 2023-02-28 | 北京优迅医学检验实验室有限公司 | 与基因组稳定性相关的微卫星位点的筛选方法、筛选装置及应用 |
| CN115943218B (zh) * | 2020-03-03 | 2025-05-09 | 根特大学 | 基于水解的探针和str基因分型的方法 |
| WO2025235787A1 (en) * | 2024-05-10 | 2025-11-13 | Standard BioTools Inc. | Methods and compositions for the analysis of nucleic acids |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| US6207373B1 (en) * | 1998-02-25 | 2001-03-27 | Nanogen, Inc. | Methods for determining nature of repeat units in DNA |
| US6465183B2 (en) * | 1999-07-01 | 2002-10-15 | Agilent Technologies, Inc. | Multidentate arrays |
| ES2269365T3 (es) * | 2000-03-29 | 2007-04-01 | Lgc Limited | Baliza de hibridacion y metodo de deteccion y discriminacion rapidas de secuencias. |
| JP3844996B2 (ja) | 2000-11-15 | 2006-11-15 | エフ．ホフマン−ラ ロシュ アーゲー | 反復性ｐｃｒ産物の融解曲線解析方法 |
| US20060008823A1 (en) * | 2004-05-12 | 2006-01-12 | Kemp Jennifer T | DNA profiling and SNP detection utilizing microarrays |
| GB0514889D0 (en) | 2005-07-20 | 2005-08-24 | Lgc Ltd | Oligonucleotides |
| US7977108B2 (en) * | 2005-07-25 | 2011-07-12 | Roche Molecular Systems, Inc. | Method for detecting a mutation in a repetitive nucleic acid sequence |
| CN101421406B (zh) * | 2006-02-13 | 2016-08-31 | 孟山都技术有限公司 | 用于产生改变的种子油组成的核酸构建体和方法 |
-
2008
- 2008-10-21 CA CA2703227A patent/CA2703227C/en not_active Expired - Fee Related
- 2008-10-21 PT PT08842916T patent/PT2217719E/pt unknown
- 2008-10-21 CN CN2008801199852A patent/CN101896623B/zh not_active Expired - Fee Related
- 2008-10-21 NZ NZ584739A patent/NZ584739A/en not_active IP Right Cessation
- 2008-10-21 US US12/738,977 patent/US9404148B2/en not_active Expired - Fee Related
- 2008-10-21 WO PCT/GB2008/003555 patent/WO2009053679A1/en not_active Ceased
- 2008-10-21 AU AU2008315791A patent/AU2008315791B2/en not_active Ceased
- 2008-10-21 EP EP08842916A patent/EP2217719B1/en not_active Not-in-force
- 2008-10-21 AT AT08842916T patent/ATE516371T1/de active
- 2008-10-21 JP JP2010530537A patent/JP5604302B2/ja not_active Expired - Fee Related
- 2008-10-21 ES ES08842916T patent/ES2395240T3/es active Active