JP2011506393A5 - - Google Patents

Info

Publication number

JP2011506393A5

JP2011506393A5 JP2010537432A JP2010537432A JP2011506393A5 JP 2011506393 A5 JP2011506393 A5 JP 2011506393A5 JP 2010537432 A JP2010537432 A JP 2010537432A JP 2010537432 A JP2010537432 A JP 2010537432A JP 2011506393 A5 JP2011506393 A5 JP 2011506393A5

Authority

JP

Japan

Prior art keywords

substituted

unsubstituted

hydrogen

group

compound according

Prior art date

2008-12-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001875 compounds Chemical class 0.000 claims 19
• 229910052739 hydrogen Inorganic materials 0.000 claims 12
• 239000001257 hydrogen Substances 0.000 claims 12
• 125000000217 alkyl group Chemical group 0.000 claims 8
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
• 150000002431 hydrogen Chemical class 0.000 claims 6
• 239000000651 prodrug Substances 0.000 claims 6
• 229940002612 prodrug Drugs 0.000 claims 6
• 150000003839 salts Chemical class 0.000 claims 6
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 4
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
• 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims 3
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
• 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims 2
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
• 125000006239 protecting group Chemical group 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 125000001118 alkylidene group Chemical group 0.000 claims 1
• 125000000304 alkynyl group Chemical group 0.000 claims 1
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 125000004432 carbon atom Chemical group C* 0.000 claims 1
• 125000000753 cycloalkyl group Chemical group 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 125000001072 heteroaryl group Chemical group 0.000 claims 1
• 125000000623 heterocyclic group Chemical group 0.000 claims 1
• 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 1
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
• 125000005358 mercaptoalkyl group Chemical group 0.000 claims 1
• 125000004092 methylthiomethyl group Chemical group [H]C([H])([H])SC([H])([H])* 0.000 claims 1
• 229910052760 oxygen Inorganic materials 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 125000005493 quinolyl group Chemical group 0.000 claims 1
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• 229910052717 sulfur Inorganic materials 0.000 claims 1
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1