WO2012147107A3 - Novel & improved processes for preparing indoline derivatives and its pharmaceutical composition - Google Patents

Novel & improved processes for preparing indoline derivatives and its pharmaceutical composition Download PDF

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Publication number
WO2012147107A3
WO2012147107A3 PCT/IN2012/000314 IN2012000314W WO2012147107A3 WO 2012147107 A3 WO2012147107 A3 WO 2012147107A3 IN 2012000314 W IN2012000314 W IN 2012000314W WO 2012147107 A3 WO2012147107 A3 WO 2012147107A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical composition
novel
improved processes
indoline derivatives
preparing
Prior art date
Application number
PCT/IN2012/000314
Other languages
French (fr)
Other versions
WO2012147107A2 (en
Inventor
Srinivasan Thirumalai Rajan
Sajja Eswaraiah
Mummadi Venkatesh
Elevathingal Nicholas Madhu
Original Assignee
Msn Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msn Laboratories Limited filed Critical Msn Laboratories Limited
Publication of WO2012147107A2 publication Critical patent/WO2012147107A2/en
Publication of WO2012147107A3 publication Critical patent/WO2012147107A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed are processes for the preparation of 1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl} amino)propyl] -2,3-dihydro-lH-indole-7-carboxamide compound represented by the following structural formula-1 and it's pharmaceutical composition. (I)
PCT/IN2012/000314 2011-04-29 2012-04-27 Novel & improved processes for the preparation of indoline derivatives and its pharmaceutical composition WO2012147107A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IN1480/CHE/2011 2011-04-29
IN1480CH2011 2011-04-29
IN588CH2012 2012-02-17
IN588/CHE/2012 2012-02-17
IN1628/CHE/2012 2012-04-25
IN1628CH2012 2012-04-25

Publications (2)

Publication Number Publication Date
WO2012147107A2 WO2012147107A2 (en) 2012-11-01
WO2012147107A3 true WO2012147107A3 (en) 2012-12-20

Family

ID=47072838

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2012/000314 WO2012147107A2 (en) 2011-04-29 2012-04-27 Novel & improved processes for the preparation of indoline derivatives and its pharmaceutical composition

Country Status (1)

Country Link
WO (1) WO2012147107A2 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140243383A1 (en) * 2011-08-24 2014-08-28 Cadila Healthcare Limited Pharmaceutical compositions of silodosin
CN105102429A (en) 2013-04-09 2015-11-25 曼康德研究中心 N-haloalkylindoline intermediates, process and use in preparation of silodosin and derivatives thereof
CN103265470B (en) * 2013-05-29 2015-10-28 华润赛科药业有限责任公司 A kind of synthetic method of silodosin dialkylate
WO2015058020A1 (en) 2013-10-17 2015-04-23 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
MX2016004941A (en) 2013-10-17 2016-06-28 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds.
US9102655B2 (en) 2013-10-17 2015-08-11 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
MX2016004940A (en) 2013-10-17 2016-06-28 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds.
CN105636440A (en) 2013-10-17 2016-06-01 美国陶氏益农公司 Processes for the preparation of pesticidal compounds
WO2015058023A1 (en) 2013-10-17 2015-04-23 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
CN105636441B (en) 2013-10-17 2018-06-15 美国陶氏益农公司 The method for preparing Pesticidal compound
KR101725393B1 (en) * 2014-07-24 2017-04-27 주식회사 경보제약 Manufacturing method for Silodosin and new intermediate thereof
US9029556B1 (en) 2014-07-31 2015-05-12 Dow Argosciences Llc Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine
CA2954631A1 (en) 2014-07-31 2016-02-04 Dow Agrosciences Llc Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
US9029555B1 (en) 2014-07-31 2015-05-12 Dow Agrosciences Llc Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine
CA2958058A1 (en) 2014-08-19 2016-02-25 Dow Agrosciences Llc Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
KR20170058388A (en) 2014-09-12 2017-05-26 다우 아그로사이언시즈 엘엘씨 Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
WO2016042441A1 (en) 2014-09-18 2016-03-24 Mankind Research Centre A novel process for the preparation of considerably pure silodosin
JP2016088847A (en) * 2014-10-30 2016-05-23 株式会社トクヤマ Method for producing (-)-1-(3-hydroxypropyl)-5-[[(2r)-2-({2-[2-(2,2,2-trifluoro ethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1h-indole-7-carboxamide])
CN104557662B (en) * 2014-12-26 2017-01-25 华润赛科药业有限责任公司 Synthesis method of silodosin dialkyl compound
US9356405B1 (en) 2015-03-05 2016-05-31 Sony Corporation Connector tongue element for an electrical connector plug receptacle and a method for producing the same
ES2607639B1 (en) 2015-09-30 2018-02-28 Urquima, S.A Maleic acid salt of a silodosin intermediate
WO2018125817A1 (en) 2016-12-29 2018-07-05 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
WO2018125815A1 (en) 2016-12-29 2018-07-05 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
EP3354283B1 (en) 2017-06-20 2019-08-07 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical capsule composition comprising silodosin

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387603A (en) * 1992-12-02 1995-02-07 Kissei Pharmaceutical Co., Ltd. 1,5,7-trisubstituted indoline compounds and salts thereof
JP2002265444A (en) * 2001-03-08 2002-09-18 Kissei Pharmaceut Co Ltd 1-(3-benzyloxypropyl)-5-(2-substituted propyl) indoline derivative and method for using the same
JP2006188470A (en) * 2005-01-07 2006-07-20 Kissei Pharmaceut Co Ltd Indoline derivative and method for producing the same
CN101048376A (en) * 2004-10-27 2007-10-03 橘生药品工业株式会社 Indoline compound and process for producing the same
CN101993405A (en) * 2009-08-27 2011-03-30 浙江华海药业股份有限公司 Indoline derivative as well as preparation method and application thereof
CN101993407A (en) * 2009-08-27 2011-03-30 浙江华海药业股份有限公司 Indoline compound for preparing silodosin and preparation method thereof
WO2011124704A1 (en) * 2010-04-09 2011-10-13 Ratiopharm Gmbh Process for preparing an intermediate for silodosin
WO2012014186A1 (en) * 2010-07-30 2012-02-02 Ranbaxy Laboratories Limited Process for the preparation of silodosin and its novel intermediates

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387603A (en) * 1992-12-02 1995-02-07 Kissei Pharmaceutical Co., Ltd. 1,5,7-trisubstituted indoline compounds and salts thereof
JP2002265444A (en) * 2001-03-08 2002-09-18 Kissei Pharmaceut Co Ltd 1-(3-benzyloxypropyl)-5-(2-substituted propyl) indoline derivative and method for using the same
CN101048376A (en) * 2004-10-27 2007-10-03 橘生药品工业株式会社 Indoline compound and process for producing the same
JP2006188470A (en) * 2005-01-07 2006-07-20 Kissei Pharmaceut Co Ltd Indoline derivative and method for producing the same
CN101993405A (en) * 2009-08-27 2011-03-30 浙江华海药业股份有限公司 Indoline derivative as well as preparation method and application thereof
CN101993407A (en) * 2009-08-27 2011-03-30 浙江华海药业股份有限公司 Indoline compound for preparing silodosin and preparation method thereof
WO2011124704A1 (en) * 2010-04-09 2011-10-13 Ratiopharm Gmbh Process for preparing an intermediate for silodosin
WO2012014186A1 (en) * 2010-07-30 2012-02-02 Ranbaxy Laboratories Limited Process for the preparation of silodosin and its novel intermediates

Also Published As

Publication number Publication date
WO2012147107A2 (en) 2012-11-01

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